Keywords: Obesity; Polyphenol; Adipogenesis; PPARγ; Lipid; Rice; ABTS; 2,2â²-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid; ACO; acyl-CoA oxidase; CYP4A10; cytochrome P450; AMPK; AMP-activated protein kinase; AT; adipose tissue; C/EBPâ; CAAT/enhancer-bindin
مقالات ISI (ترجمه نشده)
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Keywords: 8-OHdG; 8-hydroxy-2-deoxyguanosine; Îym; mitochondrial membrane potential; AMPK; AMP-activated protein kinase; apoB; apolipoprotein B; AST; aspartate transaminase; ALT; alanine transaminase; ATP; adenosine triphosphate; CPT-1; carnitine palmitoyl-transfe
Keywords: AKI; acute kidney injury; ATP5a1; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha 1; Bax; BCL2 associated X; BUN; blood urea nitrogen; CREA; serum creatinine; CC; creatinine clearance; CCK-8; cell counting kit-8; CD36; cluster of differenti
Keywords: Garlic; Alcoholic liver disease; Reactive oxygen species; Nrf-2; Kupffer cells; Adiponectin; AC; alcoholic cirrhosis; ACC; acetyl-CoA carboxylase; AF; alcoholic fibrosis; AFL; alcoholic fatty liver; AGE; aged garlic extract; AH; alcoholic hepatitis; ALD;
Keywords: Acox1; peroxisomal acyl-coenzyme A oxidase 1; AKT; protein kinase B; CD36; fatty acid translocase; CPT1B; carnitine palmitoyltransferase 1b; E; embryonic day; FATP; fatty acid transport protein; GDM; gestational diabetes mellitus; GLUT; glucose transporte
Keywords: TFPI-2; Conditional knockout; Atherosclerosis; Matrix metalloproteinase; PPAR-α; PPAR-γ;
Keywords: ACS; acute coronary syndrome; ACC; American College of Cardiology; AHA; American Heart Association; BMI; body mass index; CVD; cardiovascular disease; CI; confidence interval; CRP; C-reactive protein; Fib; fibrinogen; HDL-C; high-density lipoprotein chole
Keywords: AKT; protein kinase B; ALT; alanine aminotransferase; AST; Aspartate aminotransferase; HDL; high-density lipoprotein; HFD; high-fat diet; iNOS; inducible nitric oxide synthase; IL; interleukin; ipGTT; intraperitoneal glucose tolerance test; ITT; insulin t
Keywords: BALB; Balb/cJ; Bl6; C57BL/6N; DAG; diacylglycerol; FFA; free fatty acids; FAO; fatty acid oxidation; BCAA; branched-chain amino acids; WAT; white adipose tissue; BAT; brown adipose tissue; ACN; acetonitrile; PPAR-α; peroxisome proliferator-activated rece
Keywords: Akt; protein kinase B; PPAR-α; peroxisome proliferator-activated receptor alpha; TNF-α; tumor necrosis factor alpha; SREBP-1c; sterol retinol-element binding protein one c; Impaired glucose tolerance; Obesity; Cytokines; Diabetes;
AMPK activation by pterostilbene contributes to suppression of hepatic gluconeogenic gene expression and glucose production in H4IIE cells
Keywords: Pterostilbene; PPAR-α; AMPK; PEPCK; G6Pase; Gluconeogenesis;
Pedunculoside, a novel triterpene saponin extracted from Ilex rotunda, ameliorates high-fat diet induced hyperlipidemia in rats
Keywords: Triterpene saponin; Hyperlipidemia; PPAR-α; SREBP-1c; FAS; SCD-1;
Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver
Keywords: AFL; alcoholic fatty liver; ALD; alcoholic liver disease; ALT; alanine transaminase; AMPK; AMP-activated protein kinase; AST; aspartate transaminase; CMZ; chlormethiazole; CYP2E1; cytochrome P4502E1; 4-HNE; 4-hydroxynonenal; IGF-1; insulin-like growth fac
Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1α/mitochondrial biosynthesis pathway
Keywords: ADH; alcohol dehydrogenase; ALD; Alcoholic liver disease; ALDH; aldehyde dehydrogenase; CPT-1α; carnitine palmitoyl transterase-1α; CR; calorie restriction; CS; citrate synthase; CYP2E1; cytochrome P450 2E1; FASN; fatty acid synthase; NAD+; nicotinamide
Prenatal and childhood exposure to per- and polyfluoroalkyl substances (PFASs) and child cognition
Keywords: ADHD; attention deficit hyperactivity disorder; CDC; Centers for Disease Control and Prevention; DAG; Directed Acyclic Graph; EtFOSAA; 2-(N-ethyl-perfluorooctane sulfonamido) acetate; FOSA; perfluorooctane sulfonamide; GFR; glomerular filtration rate; GM;
Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway
Keywords: ASC; apoptosis-associated speck-like protein; CPT-1; carnitine palmitoyl transferase-1; GST; glutathione S-transferase; HO-1; hemeoxygenase-1; H2O2; hydrogen peroxide; IL; interleukin; Keap1; Kelch-like ECH-associated protein 1; MDA; malondialdehyde; miR-
Oleoylethanolamide increases the expression of PPAR-Î and reduces appetite and body weight in obese people: A clinical trial
Keywords: Appetite; Anthropometric measurements; Energy homeostasis; Obesity; Oleoylethanolamide; PPAR-α;
Histamine-deficient mice do not respond to the antidepressant-like effects of oleoylethanolamide
Keywords: Histidine decarboxylase; PPAR-α; CREB; Tail suspension test; In vivo microdialysis; Imipramine;
Urine metabolomics shows an induction of fatty acids metabolism in healthy adult volunteers after supplementation with green coffee (Coffea robusta L.) bean extract
Keywords: Green coffee; Metabolomics; Urine; Caffeoyl quinic acid; GCBE; Green coffee bean extract; CGA; Chlorogenic acid; PPAR-α; Peroxisome proliferator-activated receptors α; 8-OHdG; 8-Hydroxydeoxyguanosine; LC; Liquid Chromatography; MS; Mass Spectrometry; UP
Protective roles of fenofibrate against cisplatin-induced ototoxicity by the rescue of peroxisomal and mitochondrial dysfunction
Keywords: Cisplatin; Fenofibrate; NADPH Oxidase Isoforms; PPAR-α; Ototoxicity; ABR; auditory brainstem responses; ACOX1; peroxisome acyl-coenzyme A oxidase 1; ARF; acute renal failure; AKI; acute kidney injury; B-FABP; brain-type fatty acid binding protein; COX5A1
Citreoviridin induces triglyceride accumulation in hepatocytes through inhibiting PPAR-α in vivo and in vitro
Keywords: Citreoviridin; Liver; Triglyceride accumulation; PPAR-α; TC/HDL-C ratio;
Research PaperThe interaction between alpha 7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-α represents a new antinociceptive signaling pathway in mice
Keywords: nAChRs; α7 nicotinic acetylcholine receptors; PPAR-α; nuclear peroxisome proliferator-activated receptors type-α; PAMs; positive allosteric modulators; ago-PAMs; ago-allosteric ligands; PEA; palmitoylethanolamide; OEA; oleoylethanolamide; CB1 and CB2;
Ablation of β,β-carotene-9â²,10â²-oxygenase 2 remodels the hypothalamic metabolome leading to metabolic disorders in mice
Keywords: ACC; acetyl-CoA carboxylase; AgRP; agouti-related protein; AKT; protein kinase B; AMPK; AMP-activated protein kinase; BCAA; branched-chain amino acid; BCO2; β,β-carotene-9â²,10â²-oxygenase2; CPT; carnitine palmitoyltransferase; GCS; glutamyl cysteine
d-Psicose, a sugar substitute, suppresses body fat deposition by altering networks of inflammatory response and lipid metabolism in C57BL/6J-ob/ob mice
Keywords: Abcd2; ATP-binding cassette, sub-family D, member 2; aP2; adipocyte protein 2; C/EBP-α; CCAAT/enhancer-binding protein-alpha; CPT-1; carnitine palmitoyltransferase-1; FAS; fatty acid synthase; FC; fold change; Fgf21; fibroblast growth factor 21; Fos; FBJ
Treatment with Fenofibrate plus a low dose of Benznidazole attenuates cardiac dysfunction in experimental Chagas disease
Keywords: Trypanosoma cruzi; Heart dysfunction; PPAR-α; Fenofibrate treatment; Inflammatory mediators;
The protective effect of 1alpha, 25-dihydroxyvitamin d3 and metformin on liver in type 2 diabetic rats
Keywords: Diabetic liver; 1α,25(OH)2D3; Metformin; PPAR-α; NFkB; PCNA; Caspase-3;
Targeting P-selectin glycoprotein ligand-1/P-selectin interactions as a novel therapy for metabolic syndrome
Keywords: PSGL-1; P-selectin glycoprotein ligand-1; JNK; c-Jun N-terminal kinases; NF-κB; nuclear factor-κB; ACE-I; angiotensin converting enzyme inhibitors; TLR2; toll-like receptor 2; SPM; specialized pro-resolving mediator; PPAR-α; peroxisome proliferator-act
Oleic acid-derived oleoylethanolamide: A nutritional science perspective
Keywords: ABHD4; α/β-hydrolase domain-containing protein 4; AEA; arachidonoylethanolamide; A:G; android-to-gynoid; CHO; carbohydrate; DHEA; docosahexaenoylethanolamide; DXA; dual-energy X-ray absorptiometry; E; energy; EEA; elaidoylethanolamide; FAAH; fatty acid
Design, synthesis and biological evaluation of potent FAAH inhibitors
Keywords: FAAH inhibitor; AEA; PEA; Cannabinoid receptors; PPAR-α;
Perfluoroalkyl substance serum concentrations and immune response to FluMist vaccination among healthy adults
Keywords: CI; confidence interval; ELISA; enzyme-linked immunosorbent assay; G-CSF; granulocyte colony-stimulating factor; GM-CSF; granulocyte-monocyte colony-stimulating factor; HAI; hemagglutination inhibition; IFN-α2; interferon-α2; IFN-γ; interferon-γ; IHC;
PPARα agonist, fenofibrate, ameliorates age-related renal injury
Keywords: Aging; Kidney; PPAR-α; SIRT1; AMPK; Oxidative stress;
Peroxisome proliferator-activated receptor-α stimulation by clofibrate favors an antioxidant and vasodilator environment in a stressed left ventricle
Keywords: Target organ damage; PPAR-α; Stressed left ventricle;
Systemic administration of WY-14643, a selective synthetic agonist of peroxisome proliferator activator receptor-alpha, alters spinal neuronal firing in a rodent model of neuropathic pain
Keywords: PPAR-α; WY-14643; Wide dynamic range neurones; Spinal; Neuropathic pain; Allodynia;
Cloning and characterization of SREBP-1 and PPAR-α in Japanese seabass Lateolabrax japonicus, and their gene expressions in response to different dietary fatty acid profiles
Keywords: Japanese seabass; SREBP-1; PPAR-α; Gene expression; Dietary fatty acids;
Interaction between the protective effects of cannabidiol and palmitoylethanolamide in experimental model of multiple sclerosis in C57BL/6 mice
Keywords: Î9-THC; delta-9-tetrahydrocannabinol; AEA; anandamide; ALS; amyotrophic lateral sclerosis; AMT; anandamide membrane transporter; ANOVA; analysis of variance; CBD; cannabidiol; CBs; Cannabinoids; CFA; complete Freund's adjuvant; CNS; central nervous sys
Sodium tanshinone IIA sulfonate ameliorates ischemia-induced myocardial inflammation and lipid accumulation in Beagle dogs through NLRP3 inflammasome
Keywords: NLRP3; MI injury; JAK2-STAT3 inflammatory pathway; Insulin signaling pathway; PPAR-α;
Sirtuins in vascular diseases: Emerging roles and therapeutic potential
Keywords: ACE; angiotensin converting enzyme; AICAR; 5-amino-4-imidazolecarboxamide riboside; AMPK; AMP-activated protein kinase; Ang II; angiotensin II; ApoE; apolipoprotein E; AT1R; angiotensin II type 1 receptor; ATM; ataxia telangiectasia mutated; ATP; adenosin
ReviewMother's nutritional miRNA legacy: Nutrition during pregnancy and its possible implications to develop cardiometabolic disease in later life
Keywords: CVD; cardiovascular disease; miRNAs; microRNAs; HF diet; high-fat diet; LP diet; low-protein diet; mRNA; messenger RNA; Ppar-α; peroxisome proliferator-activated receptor alpha; cpt-1a; carnitine palmitoyltransferase 1A; Igf2; insulin-like grow factor 2;
Biological evaluation and structural insights for design of subtype-selective peroxisome proliferator activated receptor-α (PPAR-α) agonists
Keywords: Molecular docking; PPAR-α; Pharmacophore; Virtual screening;
Litchi chinensis: medicinal uses, phytochemistry, and pharmacology
Keywords: Aq; aqueous; A549; human lung cancer; ABTS; 2,2â²-Azinobis(3-ethylbenzothiazoline-6-sulfonate); ADP; adenosine diphosphate; AGS; human gastric epithelial; ADPRTL1; ADP-ribosyltransferase (NAD+poly (ADP-ribose) polymerase)-like 1); ADAM9; metalloproteinas
The local corticotropin-releasing hormone receptor 2 signalling pathway partly mediates hypoxia-induced increases in lipolysis via the cAMP-protein kinase A signalling pathway in white adipose tissue
Keywords: Hypoxia; Corticotropin-releasing hormone receptor 2; White adipose tissue; Lipolysis; CRHR2; corticotrophin-releasing hormone receptor type 2; Ucn2; urocortin 2; Ucn3; urocortin 3; WAT; white adipose tissue; BAT; brown adipose tissue; PKA; protein kinase
PPAR-α agonist fenofibrate protects against the damaging effects of MPTP in a rat model of Parkinson's disease
Keywords: Dopamine; Fenofibrate; MPTP; Parkinson's disease; PPAR-α;
Cardiomyocyte specific peroxisome proliferator-activated receptor-α overexpression leads to irreversible damage in ischemic murine heart
Keywords: Diabetes; PPAR-α; Ischemia/reperfusion; Apoptosis; Chemokines; Inflammation; Remodeling;
trans-Caryophyllene is a natural agonistic ligand for peroxisome proliferator-activated receptor-α
Keywords: PPAR; peroxisome proliferator-activated receptor; LBD; ligand-binding domain; SPR; surface plasmon resonance; TR-FRET; time-resolved fluorescent resonance energy transfer; TG; triglyceride; HTG; hypertriglyceridemia; RXR; retinoid X receptor; EO; essentia
Reversal of high-fat diet-induced hepatic steatosis by n-3 LCPUFA: role of PPAR-α and SREBP-1c
Keywords: n-3 Long-chain polyunsaturated fatty acid; High fat diet; Liver steatosis; PPAR-α; SREBP-1c;
Profibrotic effect of miR-33a with Akt activation in hepatic stellate cells
Keywords: Hepatic stellate cells; miR-33a; TGF-β1; α-smooth muscle actin; PI3K/Akt; PPAR-α;
Garlic oil alleviated ethanol-induced fat accumulation via modulation of SREBP-1, PPAR-α, and CYP2E1
Keywords: GO; garlic oil; SREBP-1c; sterol regulatory element binding protein-1c; PPAR-α; peroxisome proliferators-activated receptor-α; CYP2E1; cytochrome P4502E1; FAS; fatty acid synthase; AFL; alcoholic fatty liver; ALD; alcoholic liver diseases; DADS; diallyl
Synthesis and biological evaluation of ester prodrugs of benzafibrate as orally active hypolipidemic agents
Keywords: Benzafibrate; Prodrugs; Hypolipidemic activity; Physicochemical properties; HPLC; high performance liquid chromatography; GC; gas chromatograph; API; active pharmaceutical ingredient; DMAc; dimethylacetamide; Ar; aryl; PPAR-α; peroxisome proliferator-act
Ethanolic extract of seabuckthorn (Hippophae rhamnoides L) prevents high-fat diet-induced obesity in mice through down-regulation of adipogenic and lipogenic gene expression
Keywords: Hippophae rhamnoides L.; Seabuckthorn; Obesity; Leptin; Lipid metabolism; Fatty liver; Mice; ACC; Acetyl-CoA Carboxylase; CPT-1; Carnitine palmitoyltransferase-1; HD; High-fat diet; HDL-C; High-density lipoprotein- cholesterol; ND; Normal diet; OGTT; Oral
Reduced Expression of UGT1A1 in Intestines of Humanized UGT1 Mice via Inactivation of NF-κB Leads to Hyperbilirubinemia
Keywords: Nursing; Mouse Model; Neonatal Jaundice; Gene Regulation; AhR; aryl hydrocarbon receptor; BIND; bilirubin-induced neurological dysfunction; CAR; constitutive androstane receptor; Cyp; cytochrome P450; GI; gastrointestinal; IKK; IκB kinase; LPS; lipopolys