کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5904551 | 1158009 | 2012 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ethanolic extract of seabuckthorn (Hippophae rhamnoides L) prevents high-fat diet-induced obesity in mice through down-regulation of adipogenic and lipogenic gene expression
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کلمات کلیدی
ACCHippophae rhamnoides L.PPAR-αCPT-1OGTTHDL-CPPAR-γOral glucose tolerance test - آزمون تحمل گلوکز خوراکیacetyl-CoA carboxylase - استیل کروکسی سیلازSeabuckthorn - خولان دریاhigh-fat diet - رژیم غذایی با چربی بالاnormal diet - رژیم معمولیLeptin - لپتین Lipid metabolism - متابولیسم لیپیدObesity - مرض چاقیMice - موشperoxisome proliferator-activated receptor-gamma - پراکسیزوم پرولیفراتور فعال گیرنده گاماcarnitine palmitoyltransferase-1 - کارنتین پالمیتویل ترانسفراز-1Fatty liver - کبد چرب
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Phenolic compounds and flavonoids ameliorate bodyweight, blood glucose, and serum lipid profile. Since seabuckthorn (Hippophae rhamnoides L.) is known as a rich source of isoflavones and flavonoids, we hypothesized that ethanolic extract of seabuckthorn leaves (SL) may have anti-obesity and hypoglycemic effects. To investigate the effect of ethanolic extract of SL, 32 C57BL/6J mice were randomly divided into 4 dietary groups, containing 8 mice in each group: normal diet group; high-fat diet (HD) control group; high-fat diet with SL extract, 500 mg/kg body weight (BW) (SL1) group; and high-fat diet with SL extract, 1000 mg/kg BW (SL2) group. After 13 weeks, it was observed that oral administration of SL extract significantly reduced the energy intake; BW gain; epididymal fat pad weight; hepatic triglyceride, hepatic, and serum total cholesterol levels; and serum leptin levels in the SL groups compared to the HD group. However, differences in serum triglyceride and insulin levels in the SL groups were not significant in comparison to the HD group. The hepatic mRNA expression of peroxisome proliferator-activated receptor (PPAR) α and carnitine palmitoyltransferase 1 along with PPAR-γ were significantly increased in SL groups, whereas the level of acetyl-CoA carboxylase was significantly reduced in SL groups compared to HD group. Our results indicated that SL is effective in preventing BW gain and fat accumulation in the liver; it also reduced adipose tissue mass, hepatic lipid profile, and serum leptin level in the mouse. Together, these observations suggest that SL is a potential agent to study in the management of obesity and related disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Volume 32, Issue 11, November 2012, Pages 856-864
Journal: Nutrition Research - Volume 32, Issue 11, November 2012, Pages 856-864
نویسندگان
P.B. Tirupathi Pichiah, Hye-Jung Moon, Jeong-Eun Park, Yeon-Jeong Moon, Youn-Soo Cha,