Keywords: پرنسیلین; Aβ; amyloid-β-peptide; ACh; acetylcholine; Apo; apolipoprotein; APP; amyloid precursor protein; CYP; cytochrome P-450; DYRK1; dual specificity tyrosine-phosphorylation-regulated kinase 1A; GABA; γ-aminobutyric acid; GSK; glycogen synthase- kinase; HSV-
مقالات ISI پرنسیلین (ترجمه نشده)
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Keywords: پرنسیلین; Alzheimer's disease(AD); Amyloid precursor protein(APP); Olfactory system; Olfactory epithelium(OE); γ-Secretase; Presenilin;
Keywords: پرنسیلین; Aβ; beta-amyloid; APOE; apolipoprotein E; APP; amyloid precursor protein; AD; Alzheimer's disease; CRISPR; clustered regularly interspaced short palindromic repeats; DAT; dopamine transporter; ER; estrogen receptor; FAD; familial Alzheimer's disease;
Keywords: پرنسیلین; Microglia; Stress; Alzheimer's disease; Neurodegeneration; Neuroinflammation; Synaptic remodeling; Microglial phenotypes; Dark microglia; Aβ; Amyloid beta; ABCA7; ATP-binding cassette transporter A7; AD; Alzheimer's disease; APOE; Apolipoprotein E; APP;
Keywords: پرنسیلین; Down syndrome; Alzheimer's disease; Microvascular/endothelial impairment; Amyloid; Notch-1; Presenilin; Angiogenesis;
Keywords: پرنسیلین; AD; Alzheimer disease; APOE; apolipoprotein E; APP; amyloid precursor protein; CERAD; Consortium to Establish a Registry for Alzheimer's Disease; CSF; cerebrospinal fluid; DIAD; dominantly inherited Alzheimer disease; FDA; Food and Drug Administration; FD
Keywords: پرنسیلین; Presenilin; Calcium; Smooth muscle cells; Contraction; Cerebral arteries; Alzheimer's disease;
Keywords: پرنسیلین; Arachidonic acid; Alzheimer's disease; Diet; Synaptic function; Neuroinflammation; Prevention; Aβ; amyloid-β; ABCA7; ATP-binding cassette, subfamilly A member 7; ACSL; acyl-CoA synthetase; AD; Alzheimer's disease; ARA; arachidonic acid; COX; cyclooxygen
Keywords: پرنسیلین; Aging; Docosahexaenoic acid; Lipid rafts; Membrane remodeling; Neuronal membrane; Omega3 polyunsaturated fatty acids; Aβ; amyloid-β peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; CNS; central nervous system; DHA; docosahexaenoic acid;
Keywords: پرنسیلین; Aβ; β-Amyloid peptide; Aβ40; 40-amino acid isoform of β-Amyloid peptide; Aβ42; 42-amino acid isoform of β-Amyloid peptide; Aβ42/Aβ40; ratio of measured steady-state levels of Aβ42 and Aβ40; AD; Alzheimer's Disease; AICD; APP intracellular domain
Keywords: پرنسیلین; AD; Alzheimer's disease; ADCA; autosomal dominant cerebellar ataxia; AMPA receptor; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; APP; amyloid precursor protein; Atx2mut; mutant ataxin-2; Aβ peptides; amyloid beta peptides; BACE1; beta
Keywords: پرنسیلین; intramembrane proteolysis/protease; transmembrane helix; presenilin; γ-secretase; rhomboid; conformational dynamics
Keywords: پرنسیلین; Urothelial cell carcinoma of the urinary bladder; Bladder cancer; Presenilin; γ-Secretase; DAPT;
Keywords: پرنسیلین; Presenilin; Notch-1; Neurogenesis; Synaptogenesis; Brain development
Keywords: پرنسیلین; Alzheimer's disease; Amyloid; Microvascular; Endothelium; Notch; Trophic factors; Angiogenesis; Presenilin; Gamma secretase.;
Keywords: پرنسیلین; Aβ; amyloid β protein; NFT; neurofibrillary tangles; APP; amyloid precursor protein; PSs; presenilins; NICD; Notch intracellular domain; mTOR; mammalian Target of Rapamycin; PP2A; protein phosphatase 2; GSK-3; glycogen synthase kinase-3; CTFS; cytosol-s
Keywords: پرنسیلین; Antioxidant gene therapy; Brain ischemia; Neurodegenerative disorders; Oxidative stress; Virus-mediated gene delivery; ROS; ÎΨm; mitochondrial membrane potential; 3-NP; 3-nitropropionic acid; 6-OHDA; 6-hydroxydopamine; AADC; aromatic-l-amino decarboxyla
Keywords: پرنسیلین; Aβ; amyloid beta; AD; Alzheimer's disease; AICD; APP intracellular domain; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; APP; amyloid β precursor protein; Apo E; apolipoprotein E; BACE1; β-site APP converting enzyme 1; BDNF; brain derive
Keywords: پرنسیلین; Nicotine; Neuroprotection; Beta amyloid; APP; Presenilin; N2a cells; Alzheimer's disease;
Keywords: پرنسیلین; FBS; fetal bovine serum; CTF; carboxyl-terminal fragment; ICD; intracellular domain; RIP; regulated intramembrane proteolysis; PS; presenilin; ADAM; a disintegrin and metalloprotease; TAPI; tumor necrosis factor-α protease inhibitor; TRAIL; TNF-related a
Keywords: پرنسیلین; Cholesterol; γ-secretase; MAM; Neurodegeneration; Phospholipids; Presenilin;
Keywords: پرنسیلین; AD; Alzheimer disease; Aβ; amyloid-β; APP; amyloid-β protein precursor; ADDL; Aβ-derived diffusible ligand; ApoE4; apolipoprotein E; COX; cytochrome c oxidase; DLP1, aka Drp1; dynamin-like protein 1; ETC; electron transport chain; LHON; Leber's heredi
Keywords: پرنسیلین; 7,8-DHF; 7,8-dihydroxyflavone; Aβ; amyloid beta; AchE; acetylcholine-esterase; ABCA1; ATP-binding cassette transporter 1; APP; amyloid precursor protein; Akt; protein kinase B; ApoE; apolipoprotein E; AAV/Aβ; adeno-associated viral vector carrying Aβ c
Simulating the γ-secretase enzyme: Recent advances and future directions
Keywords: پرنسیلین; γ-secretase; Presenilin; Amyloid-β peptide; Alzheimer's disease; Molecular dynamics; Computational approaches;
Apelin, a promising target for Alzheimer disease prevention and treatment
Keywords: پرنسیلین; Alzheimer disease; Apelin; Amyloid beta; Central nervous system; Oxidative stress; AAA; Abdominal aortic aneurysm; ABCA1; ATP-binding cassette transporter A1; ACE; Angiotensin converting enzyme; ACh; Acetylcholine; AChE; Acetyl choline esterase; AD; Alzhe
Pathophysiological consequences of isoform-specific IP3 receptor mutations
Keywords: پرنسیلین; ALS; amyotrophic lateral sclerosis; Bcl-2; B-cell lymphoma-2; CA8; carbonic anhydrase 8 (carbonic anhydrase-related protein); CSCC; cervical squamous cell carcinoma; CTT; C-terminal tail; DKO; double knockout; FAD; familial Alzheimer's disease; GS; Gilles
The interactions of p53 with tau and AÃ as potential therapeutic targets for Alzheimer's disease
Keywords: پرنسیلین; AD; Alzheimer's disease; AICD; amyloid precursor protein intracellular domain; Aβ; amyloid β peptides; ApoE; apolipoprotein E; APP; amyloid precursor proteins; BACE1; β-site APP cleaving enzyme 1; BIN1; bridging integrator 1; CBP; CREB-binding protei
Presenilin 1 mutations influence processing and trafficking of the ApoE receptor apoER2
Keywords: پرنسیلین; Alzheimer's disease; ApoER2; γ-Secretase; Lipoprotein receptor; Presenilin; Protein processing; Protein trafficking;
Synergistic inhibition of Aβ production by combinations of γ-secretase modulators
Keywords: پرنسیلین; Alzheimer; Amyloid; Combination index; Lasalocid; Presenilin; Synergism;
Integrated late onset Alzheimer's disease (LOAD) susceptibility genes: Cholesterol metabolism and trafficking perspectives
Keywords: پرنسیلین; Aβ; Amyloid-β; AD; Alzheimer's disease; ApoE; Apolipoprotein E; APP; Amyloid precursor protein; BBB; Blood brain barrier; CLU; Clusterin; CNS; Central nervous system; CSF; Cerebrospinal fluid; DMN; Default mode network; EOAD; Early onset Alzheimer's dis
N-glycan and Alzheimer's disease
Keywords: پرنسیلین; Aβ; amyloid-β; AD; Alzheimer's disease; APOE; apolipoprotein E; APP; amyloid precursor protein; BACE1; β-site APP cleaving enzyme-1; DAP12; DNAX-activating protein of 12 kD; GnT-III; N-acetylglucosaminyltransferase-III; NFT; neurofibrillary tangle; PS
Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein
Keywords: پرنسیلین; ADAM10; Tetraspanin; APP; Presenilin;
Posttranslational proteolytic processing of Leda-1/Pianp involves cleavage by MMPs, ADAM10/17 and gamma-secretase
Keywords: پرنسیلین; Gamma secretase; Proteolysis; ADAM; Immune regulation; Nervous system; Leda-1; liver endothelial differentiation-associated protein-1; Pianp; PILR alpha associated neural protein; PILR; paired immunoglobin-like type 2 receptor; AJAP-1; adherens-junction-a
Beyond γ-secretase activity: The multifunctional nature of presenilins in cell signalling pathways
Keywords: پرنسیلین; Presenilin; γ-Secretase; Alzheimer's disease; Wnt signalling; Calcium homeostasis; Apoptosis; Protein trafficking; Autophagy;
5-HT1B and other related serotonergic proteins are altered in APPswe mutation
Keywords: پرنسیلین; AD; Alzheimer's disease; 5-HT; 5-hydroxytryptamine; SERT; serotonin transporter; PS; presenilin; SLC6A4; salute family 6A4; PET; positron emission tomography; GAPDH; glyceraldehydes 3-phoshate dehydrogenase; IHC; immunohistochemistry; APPswe; APP Swedis
A ubiquitin-binding CUE domain in presenilin-1 enables interaction with K63-linked polyubiquitin chains
Keywords: پرنسیلین; Presenilin; γ-Secretase; Ubiquitin; CUE domain; Signaling
Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways
Keywords: پرنسیلین; Alzheimer; Abeta; Amyloid; Tau; Genetics; Next generation sequencing; PICALM; SORL1; EPHA1; APOE; APP; Vaccine; Secretase; Nicastrin; Presenilin; PSEN1; Neurodegeneration; Dementia;
Herbs to curb cyclic nucleotide phosphodiesterase and their potential role in Alzheimer's disease
Keywords: پرنسیلین; cAMP; cyclic adenosine monophosphate; cGMP; cyclic guanosine monophosphate; AD; Alzheimer's disease; PDE; phosphodiesterases; Aβ; amyloid beta; NFTs; neurofibrillary tangles; FAD; familial Alzheimer's disease; SAD; sporadic Alzheimer's disease; APP
Identification of PSEN2 mutation p.N141I in Argentine pedigrees with early-onset familial Alzheimer's disease
Keywords: پرنسیلین; Alzheimer's disease; Presenilin; Mutation; Volga German; South America; Dementia;
Podoplanin is a substrate of presenilin-1/γ-secretase
Keywords: پرنسیلین; PDPN; podoplanin; fl-PDPN; full-length PDPN; EC; extracellular; TM; transmembrane; CT; cytoplasmic; ERM; ezrin radixin moesin; CTF; C-terminal fragment; ICD; intracellular domain; PS; presenilin; MEF; mouse embryonic fibroblast; RIP; regulated intramembra
Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations
Keywords: پرنسیلین; APP; amyloid precursor protein; Aβ; amyloid-β peptide; AICD; amyloid precursor protein intracellular domain; AD; Alzheimer disease; FAD; familial AD; TMD; transmembrane domains; PS; presenilin; NTF; N-terminal fragment; CTF; C-terminal fragment; ER; end
Previously not recognized deletion in presenilin-1 (p.Leu174del.) in a patient with early-onset familial Alzheimer's disease
Keywords: پرنسیلین; Familial Alzheimer's disease; Early-onset Alzheimer's disease; Frontotemporal dementia; Presenilin; PSEN1 mutation;
Leptin regulates amyloid β production via the γ-secretase complex
Keywords: پرنسیلین; Leptin; Presenilin; γ-secretase; β-amyloid; Alzheimer's disease;
Transient knockdown of presenilin-1 provokes endoplasmic reticulum stress related formation of autophagosomes in HepG2 cells
Keywords: پرنسیلین; Presenilin; Endoplasmic reticulum; Autophagy; ER stress; PI3K; Calcium;
D. melanogaster, mitochondria and neurodegeneration: small model organism, big discoveries
Keywords: پرنسیلین; AD; Alzeheimer's disease; ADOA; Autosomal dominant optic atrophy; AP; Amyloid plaque; APP; Amyloid precursor protein; Aβ; Amino acids amyloid β-peptides; CaMKIIa; Calcium/calmodulin dependent protein kinase II alpha; CMTIIa; Charcot-Marie-Tooth type
Presenilins are novel substrates for TRAF6-mediated ubiquitination
Keywords: پرنسیلین; AD; Alzheimer's disease; AICD; APP intracellular domain; APH-1; anterior pharynx-defective-1; APP; Amyloid precursor protein; Aβ; Amyloid β; C99; 99-amino acid APP C-terminal fragment; ER; Endoplasmic reticulum; FAD; Familial Alzheimer's disease; HEK293
Axonal degeneration in Alzheimer's disease: When signaling abnormalities meet the axonal transport system
Keywords: پرنسیلین; Alzheimer's disease; Axonal transport; Synapse; Kinase; Phosphatase; Amyloid; Presenilin; Tau; Kinesin; Dynein; Signaling; Amyloid; ApoE; GSK3; CK2
Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors
Keywords: پرنسیلین; Presenilin; EphrinB; BDNF; EphB; TrkB; Neuroprotection; Neurodegeneration; Glutamate excitotoxicity
A fast growing spectrum of biological functions of γ-secretase in development and disease
Keywords: پرنسیلین; γ-Secretase, regulated intramembrane proteolysis; Presenilin; APP; Notch; Alzheimer
The γ-secretase inhibitor DAPT increases the levels of gangliosides at neuritic terminals of differentiating PC12 cells
Keywords: پرنسیلین; Aβ; amyloidβ-peptide; AD; Alzheimer disease; APP; β-amyloid precursor protein; ESI; electrospray ionization; GAβ; ganglioside-bound Aβ; LC; liquid chromatography; MRM; multiple reaction monitoring; MS; mass spectrometry; MS/MS; tandem mass spectromet