کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6281029 | 1615105 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
5-HT1B and other related serotonergic proteins are altered in APPswe mutation
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کلمات کلیدی
SLC6A45-HTTg25765-HT1B5-hydroxytryptamineGAPDHImmunohistochemistry - ایمونوهیستوشیمیIHC - ایمونوهیستوشیمیAlzheimer’s disease - بیماری آلزایمرAPPswe - تان سوanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancePositron emission tomography - توموگرافی گسیل پوزیترونSERT - سختSerotonin - سروتونینserotonin transporter - سروتونین حمل کنندهwild type - نوع وحشیPET - پتPresenilin - پرنسیلین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Serotonergic dysfunction is implicated in Alzheimer's disease (AD). In addition, reductions in brain of both monoamine synthesis and release have been reported. Serotonin 1B receptors (5-HT1B), along with serotonin transporter (SERT) are among the regulators of extracellular 5-HT levels. We investigated the effect of the familial AD APP (Amyloid precursor protein) K670N/M671L double mutation, APP Swedish mutation (APPswe), on the expression of 5-HT1B, SERT, MAOA, p11 and 5-HT and its metabolite 5-HIAA in SH-SY5Y human neuroblastoma cell line stably transfected with APPswe mutation. In addition, hippocampal expressions of 5-HT1B and SERT were assessed in wild type and transgenic mice expressing APPswe mutation (Tg2576) at different age groups. We found a reduction of 5-HT1B as well as SERT in both APPswe in vitro and ex vivo. P11 and 5HT were also reduced, whereas 5HT turnover and MAOA were increased. Our results indicate that APPswe induced decreased 5-HT1B expression and 5-HT release, as well as increased MAOA activity and 5-HT breakdown. Further studies to explore the detailed mechanism behind reduced 5-HT1B and SERT in AD and their clinical implications are needed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 594, 6 May 2015, Pages 137-143
Journal: Neuroscience Letters - Volume 594, 6 May 2015, Pages 137-143
نویسندگان
Walid Tajeddinn, Torbjörn Persson, Silvia Maioli, Javier Calvo-Garrido, Cristina Parrado-Fernandez, Takashi Yoshitake, Jan Kehr, Paul Francis, Bengt Winblad, Kina Höglund, Angel Cedazo-Minguez, Dag Aarsland,