Keywords: Aβ; amyloid beta peptides; anMan; anhydromannose; APP; amyloid precursor protein; DAPI; 4,6-diaminido-2-phenylindole; DFMO; α-difluoromethylornithine; DMEM; Dulbecco minimal essential medium; Gpc-1; glypican-1; HS; heparan sulfate; MEF; mouse embryonic
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Keywords: Alzheimer's disease; Type two diabetes; Tg2576; 3xTg-AD; Insulin resistance; Glucose tolerance test; Aging; Neurodegeneration; Energy metabolism;
Keywords: Aluminum; Melatonin; Behavior; Tg2576; Alzheimer disease;
Nucleolin is a nuclear target of heparan sulfate derived from glypican-1
Keywords: anMan/AM; anhydromannose; DAPI; 4,6-diamidino-2-phenylindole; Gpc; glypican; HS; heparan sulfate; mAb; monoclonal antibody; MEF; mouse embryonic fibroblast; NO; nitric oxide; SH; thiol; SNO; S-nitrosothiol; Tg2576; transgenic Alzheimer mouse; WT; wild-typ
Cytochrome b561, copper, β-cleaved amyloid precursor protein and niemann-pick C1 protein are involved in ascorbate-induced release and membrane penetration of heparan sulfate from endosomal S-nitrosylated glypican-1
Keywords: Aβ; amyloid β peptide; anMan; anhydromannose; APP; amyloid precursor protein; β-CTF; C-terminal fragment of APP generated by β-cleavage; γ-CTF; C-terminal fragment of APP generated by γ-cleavage; CYB561A3; A3 variant of cytochrome b561; GAG; glycosa
Regular articleThe expression and activity of KV3.4 channel subunits are precociously upregulated in astrocytes exposed to Aβ oligomers and in astrocytes of Alzheimer's disease Tg2576 mice
Keywords: Astrocyte; KV3.4 potassium channel; Alzheimer's disease; Aβ-oligomers; Aβ1-42; GFAP; Tg2576;
Featured ArticleEarly pathologic amyloid induces hypersynchrony of BOLD resting-state networks in transgenic mice and provides an early therapeutic window before amyloid plaque deposition
Keywords: Amyloidosis; Alzheimer's disease; Transgenic mouse models; BOLD functional connectivity; Resting-state fMRI; Hypersynchrony; TG2576; PDAPP;
Noninvasive evaluation of nicotinic acetylcholine receptor availability in mouse brain using single-photon emission computed tomography with [123I]5IA
Keywords: Single-photon emission computed tomography (SPECT); Nicotinic acetylcholine receptor (nAChR); Mouse; 5-[123I]iodo-3-(2(S)-azetidinylmethoxy)pyridine ([123I]5IA); Tg2576; Alzheimer's disease;
Research reportThe selective positive allosteric M1 muscarinic receptor modulator PQCA attenuates learning and memory deficits in the Tg2576 Alzheimer's disease mouse model
Keywords: Alzheimer's disease; Tg2576; Muscarinic; Cognition; Novel Object Recognition; Working memory;
5-HT1B and other related serotonergic proteins are altered in APPswe mutation
Keywords: AD; Alzheimer's disease; 5-HT; 5-hydroxytryptamine; SERT; serotonin transporter; PS; presenilin; SLC6A4; salute family 6A4; PET; positron emission tomography; GAPDH; glyceraldehydes 3-phoshate dehydrogenase; IHC; immunohistochemistry; APPswe; APP Swedis
CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid
Keywords: Aβ; β-amyloid; AD; Alzheimer's Disease; AICD; APP Intracellular Domain; APP; Amyloid Precursor Protein; ARG1; Arginase 1; CHF5074; 1-(3â²,4â²-dichloro-2-fluoro[1,1â²-biphenyl]-4-yl)-cyclopropanecarboxylic acid; FIZZ1; Found in Inflammatory Zone; GS
The problem of genotype and sex differences in life expectancy in transgenic AD mice
Keywords: AD; Alzheimer's disease; APP; amyloid precursor protein; B6; C57BL/6J; C3; C3He/J; D2; DBA/2J; MCI; mild cognitive impairment; Lifespan; D85; 3xTg-AD; 5xFAD; SAMP8; JNPL3; Tg2576; Mice; Sex differences; Genotype; Alzheimer's; Life expectancy;
Impaired retention in AβPP Swedish mice six months after oral exposure to chlorpyrifos
Keywords: Chlorpyrifos; Mice; Tg2576; Memory; Amyloid beta protein; Neurodegeneration
PDE9A inhibition rescues amyloid beta-induced deficits in synaptic plasticity and cognition
Keywords: PDE9; LTP; cGMP; Alzheimer's disease; BAY 73-6691; Amyloid beta; Object location task; tg2576; Hippocampus; Cognition;
Expression of Ambra1 in mouse brain during physiological and Alzheimer type aging
Keywords: Ambra1; Autophagy; Brain; Hippocampus; Neocortex; Neuron; Glia; Neurodegeneration; Aging; Alzheimer's disease; Tg2576;
Transient enriched housing before amyloidosis onset sustains cognitive improvement in Tg2576 mice
Keywords: Alzheimer's disease; Transgenic mice; Enriched environment; Amyloid; Learning and memory; Hippocampus; Brain cognitive reserve; Tg2576; Calbindin; Neuropeptide Y;
Early temporal short-term memory deficits in double transgenic APP/PS1 mice
Keywords: Operant learning; DRL; Short-term memory; Tg2576; PS1dE9; Amyloid precursor protein; Presenilin 1; Hippocampus;
c-Fos expression reveals aberrant neural network activity during cued fear conditioning in APPswe transgenic mice
Keywords: c-Fos; Tg2576; Amygdala; Hippocampus; Amyloid; Fear
Increased expression of miRNA-146a in Alzheimer's disease transgenic mouse models
Keywords: 5xFAD; Alzheimer's disease; CAY10512; Curcumin; miRNA-146a; Neurodegeneration; NF-кB; PDTC; Tg2576; Transgenic models of Alzheimer's disease
A novel operant testing regimen for multi-construct cognitive characterization of a murine model of Alzheimer’s amyloid-related behavioral impairment
Keywords: Learning; Memory; Operant; Tg2576; Transgenic
Effect size of reference memory deficits in the Morris water maze in Tg2576 mice
Keywords: Tg2576; Alzheimer's disease; Sample size; Effect size; Morris water maze
Mice expressing the Swedish APP mutation on a 129 genetic background demonstrate consistent behavioral deficits and pathological markers of Alzheimer's disease
Keywords: Alzheimer's disease; Transgenic; Tg2576; Behavior; Mice
Ameliorative effects of yokukansan, a traditional Japanese medicine, on learning and non-cognitive disturbances in the Tg2576 mouse model of Alzheimer's disease
Keywords: Yokukansan; Alzheimer's disease; Non-cognitive defects; BPSD; Tg2576
Effect of a short- and long-term treatment with Ginkgo biloba extract on Amyloid Precursor Protein Levels in a transgenic mouse model relevant to Alzheimer’s disease
Keywords: Ginkgo biloba; Alzheimer’s disease; Tg2576; Amyloid precursor protein; α-Secretase
Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease
Keywords: Alzheimer's disease; Voluntary exercise; Forced exercise; Tg2576; Object recognition; Hippocampal volume
Dystrophic neurites in TgCRND8 and Tg2576 mice mimic human pathological brain aging
Keywords: Dystrophic neurites; Hyperphosphorylated-tau; Alpha-internexin; Neurofilament; TgCRND8; Tg2576; Preclinical Alzheimer's disease; Pathological aging
Progressive impairment in olfactory working memory in a mouse model of Mild Cognitive Impairment
Keywords: Alzheimer's disease; Mild Cognitive Impairment; Tg2576; Olfaction; Working memory; Aging
Plaque-bearing mice with reduced levels of oligomeric amyloid-β assemblies have intact memory function
Keywords: amyloid; memory; Alzheimer's disease; Tg2576; oligomer, plaquesAD, Alzheimer's disease; Aβ, amyloid-β; APP, amyloid precursor protein; BSA, bovine serum albumin; SDS, sodium dodecyl sulfate; TBST, Tris-buffered saline–Tween20
Effects of the genetic background on cognitive performances of TG2576 mice
Keywords: Tg2576; Transgenic mouse; Genetic background; Elevated plus maze; Morris navigation task; Contextual and cued fear conditioning;
Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition
Keywords: Exercise; Tg2576; Alzheimer disease; CXCL1; CXCL12; Cognition; Running; AD model; Inflammation; Neuroinflammation
CD40 ligation mediates plaque-associated tau phosphorylation in β-amyloid overproducing mice
Keywords: Alzheimer's disease; Amyloid; CD40; CD40 ligand; Mice; Transgenic; Tg2576; Microtubule-associated protein tau; Hyperphosphorylated tau; cdk5; Dystrophic neurite
Peripheral elevation of IGF-1 fails to alter Aβ clearance in multiple in vivo models
Keywords: Aβ; Alzheimer's disease; IGF-1; Clearance; Tg2576; Tau
Age-dependent and -independent behavioral deficits in Tg2576 mice
Keywords: Tg2576 mice; Alzheimer's disease; Mouse; Learning; Memory; Tg2576; Paddling; Y-maze; Amyloid; APPswe
Reduced serum level of antibodies against amyloid β peptide is associated with aging in Tg2576 mice
Keywords: Alzheimer’s disease; Amyloid plaque; Aβ; Anti-Aβ autoantibody; Immunoglobulin; Tg2576
Intact spatial learning in adult Tg2576 mice
Keywords: Hippocampus; Striatum; Memory systems; Abeta; Tg2576; Place learning; Cue learning
Calpastatin levels affect calpain activation and calpain proteolytic activity in APP transgenic mouse model of Alzheimer's disease
Keywords: Alzheimer's disease; Mutant-APP transgenic mouse; Tg2576; Calpain; Calpastatin; Protein degradation
Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse
Keywords: Exercise; Alzheimer's; Tg2576; Aging; RAWM; Intervention
Reduced CXCL12/CXCR4 results in impaired learning and is downregulated in a mouse model of Alzheimer disease
Keywords: Chemokine; CXCL12; AMD3100; Tg2576; Learning; Inflammation; Cognition; Brain; AD; GeneChip
Furin is an endogenous regulator of α-secretase associated APP processing
Keywords: Alzheimer’s disease; Furin; α-Secretase; ADAM10; TACE; Tg2576; Aβ
Deletion of vitamin E enhances phenotype of Alzheimer disease model mouse
Keywords: Alzheimer disease; Vitamin E; α-Tocopherol; Lipid peroxidation; Oxidative stress; Aβ; Plaque; Cognitive dysfunction; Tg2576
Enhanced accumulation of tau in doubly transgenic mice expressing mutant βAPP and presenilin-1
Keywords: Alzheimer's disease; Doubly transgenic mouse; Presenilin-1; Tau; Aβ; Tg2576;
Metallothionein-I and -III expression in animal models of Alzheimer disease
Keywords: metallothionein-I; metallothionein-III; Alzheimer's disease; Tg2576; TgCRND8; TgSwDI; AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; β-amyloid; Aβ42; amyloid beta 42; ALS; amyotrophic lateral sclerosis; GFAP; glial fibrillary acid pro
Pharmacological and molecular enhancement of learning in aging and Alzheimer’s disease
Keywords: Afterhyperpolarization; BACE; Calcium channel; Cholinesterase inhibitor; Muscarinic; TG2576; Eyeblink conditioning
Soluble Aβ and cognitive function in aged F-344 rats and Tg2576 mice
Keywords: Soluble β amyloid; Aging; Tg2576; Scopolamine; Cognitive function; Morris water maze; Contextual fear conditioning
Amyloid peptide attenuates the proteasome activity in neuronal cells
Keywords: Tg2576; Proteasome; Chymotrypsin-like activity; Amyloid β-peptide;
Detection of age-dependent brain injury in a mouse model of brain amyloidosis associated with Alzheimer's disease using magnetic resonance diffusion tensor imaging
Keywords: Alzheimer's disease (AD); Diffusion tensor imaging (DTI); APPsw; Tg2576; White matter; Axial diffusivity; Radial diffusivity;
Impaired Pavlovian cued fear conditioning in Tg2576 mice expressing a human mutant amyloid precursor protein gene
Keywords: Alzheimer's disease; Fear conditioning; Tg2576; Context; Cued; Amyloid;