Keywords: Presenilin 1; 5-HIAA; 5-hydroxyindoleacetic acid; APP; Amyloid Precursor Protein; BDNF; brain-derived neurotrophic factor; CAMKII; Ca2+/calmodulin-dependent protein kinase II; CTRL; Control diet; DHA; dehydroascorbate; DOPAC; 3,4-dihydroxyphenylacetic acid; GFAP; Glial
مقالات ISI Presenilin 1 (ترجمه نشده)
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Keywords: Presenilin 1; Alzheimer's disease; Associative learning; Generalization; Presenilin 1; Amyloid precursor protein; Mutation; Hippocampus; Early onset; Preclinical;
Keywords: Presenilin 1; AD; Alzheimer Disease; DS; Down Syndrome; Aβ; amyloid-β; HSA21; Chromosome 21; APP; Amyloid precursor protein; BACE1/2; β-site APP cleaving enzyme 1/2; βCTF; β carboxyl-terminal fragment; PSEN1; presenilin 1; APPL1; adaptor protein containing pleckst
Keywords: Presenilin 1; Oral galactose; Streptozotocin; Intracerebroventricular; Sporadic Alzheimer's disease; Memory; Glucagon-like peptide-1; 18fluorodeoxyglucose; APP; amyloid precursor protein; ATP; adenosine triphosphate; Aβ1-42; amyloid β 1-42; CMRgl; cerebral metabolic
Keywords: Presenilin 1; Aβ; amyloid-β peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; ATP; adenosine triphosphate; BBB; blood-brain barrier; CNS; central nervous system; ECM; extracellular matrix; Hsp; heat shock protein; IFN; interferon; IκB; NF-κB inhib
Keywords: Presenilin 1; AD; Alzheimer's Disease; HADACs; histone deacetylases; APP; amyloid precursor protein; SIRT1; sirtuin 1; APOE; apolipoprotein E; PSEN1; presenilin 1; PIN1; peptidyl prolyl isomerase 1; PBMCs; peripheral blood mononuclear cells; DNMTs; DNA methyltransfer
Keywords: Presenilin 1; ABAD; Aβ binding alcohol dehydrogenase; AD; Alzheimer's disease; ADAM; A Disintegrin and metalloproteinase; AICD; APP intracellular domain; APH1; anterior pharynx-defective 1; APP; amyloid precursor protein; ATP; adenosine triphosphate; Aβ; amyloid be
Keywords: Presenilin 1; AD; Alzheimer's disease; NFT; neurofibrillary tangles; hiPSC; human induced pluripotent stem cell; PHF; paired helical filament; FTD; frontotemporal dementia; NDC; non-demented control; PS-1; presenilin 1; YFP; yellow fluorescent protein; Tau; Neurofibril
Keywords: Presenilin 1; BAI1; brain-specific angiogenesis inhibitor 1; BDNF; brain derived neurotrophic factor; BRDU; bromodeoxyuridine; C3; complement component 3; CCL11; eotaxin; Cq1; complement component 1; CR3; complement receptor 3; CSF-1R; colony stimulating factor-1 recep
Keywords: Presenilin 1; Aβ; amyloid-beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APCI; atmospheric pressure chemical ionization; APOE; apolipoprotein E; APP; amyloid precursor protein; APPI; atmospheric pressure photoionization; CE; capillary electrophor
Keywords: Presenilin 1; AD; Alzheimer's disease; TLRs; toll-like receptors; AβPP; amyloid-β protein precursor; NSAIDs; non-steroidal anti-inflammatory drugs; CNS; central nervous system; TNF-α; tumor necrosis factor-α; IL-1β; interleukin 1-β; IL-6; interleukin-6; NO; nit
Keywords: Presenilin 1; Aβ; amyloid-β; AβO; Aβ oligomers; βAPP; β-amyloid precursor protein; BDNF; brain-derived neurotrophic factor; CaMKII; calcium/calmodulin-dependent protein kinase II; Cer; cerebellum; ChAT; choline acetyltransferase; Cx; cortex; CxFr; cortex frontal;
Keywords: Presenilin 1; Drp1; Dynamin-related protein1; GSK3β; Glucose synthase kinase 3 beta; CDK5; Cyclin dependent kinase 5; miRNA; micro ribonucleic acid; NMDAR; N-methyl-D-aspartate receptor; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; AD; Alzhei
Keywords: Presenilin 1; ASC; ascorbic acid; AD; Alzheimer's disease; APP; amyloid precursor protein; EEG; electroencephalography; EMG; electromyography; KA; kainic acid; MDA; malondialdehyde; PSEN1; presenilin 1; PTZ; pentylenetetrazol; SVCT2; sodium dependent vitamin C transpor
Keywords: Presenilin 1; AD; Alzheimer's disease; Aβ; amyloid β; Aph-1; anterior pharynx defective 1; AP; adaptor protein; APOE; apolipoprotein E; APP; amyloid precursor protein; AICD; amyloid intracellular domain; BACE-1; β-secretase beta-site amyloid precursor protein-cleavi
Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer's disease
Keywords: Presenilin 1; AChE; acetylcholine esterase; AD; Alzheimer's disease; AP1; activator protein 1; APP; amyloid precursor protein; Aβ; amyloid beta; BACE1; β-site of APP cleaving enzyme; Bax; Bcl-2-associated X protein; BBB; blood-brain barrier; Bcl-2; B-cell lymphoma
Part A: Temporal and dose-dependent transcriptional responses in the liver of fathead minnows following short term exposure to the polycyclic aromatic hydrocarbon phenanthrene
Keywords: Presenilin 1; SREBF1; sterol regulatory element binding transcription factor 1; FASN; fatty acid synthase; HSD17B12; hydroxysteroid (17-beta) dehydrogenase 12; ACACA; acetyl-CoA carboxylase alpha; CYB5A; cytochrome b5 type A (microsomal); SLC27A4; solute carrier family
NLRP3-dependent synaptic plasticity deficit in an Alzheimer's disease amyloidosis model in vivo
Keywords: Presenilin 1; AD; Alzheimer's disease; Aβ; amyloid beta; APP; amyloid precursor protein; PS1; presenilin 1; IL-1; interleukin-1β; IL-1ra; IL-1 receptor antagonist; LTP; long-term potentiation; EPSPs; excitatory postsynaptic potentials; HFS; high frequency stimulation
TDP-43 interacts with mitochondrial proteins critical for mitophagy and mitochondrial dynamics
Keywords: Presenilin 1; APP; amyloid precursor protein; VDAC1; voltage dependent anion channel 1; TDP-43; TAR DNA binding protein of 43â¯kDa; PSEN1/PS1; presenilin 1; AD; Alzheimer disease; hnRNP; heterogeneous nuclear ribonucleoprotein; ALS; amyotrophic lateral sclerosis; MND;
Diabetes mellitus and Alzheimer's disease: GSK-3β as a potential link
Keywords: Presenilin 1; 3xTg; triple-transgenic; Aβ; β-amyloid; AD; Alzheimer's disease; ADAS-cog; Alzheimer's Disease Assessment Scale-cognitive subscale; Akt; protein kinase B; APP; amyloid precursor protein; CREB; cAMP-response element binding protein; DM; diabetes mell
Genetic report abstractIdentification of a novel PSEN1 mutation (Leu232Pro) in a Korean patient with early-onset Alzheimer's disease and a family history of dementia
Keywords: Presenilin 1; Alzheimer's disease; L232P mutation; Presenilin 1; Next generation sequencing;
Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
Keywords: Presenilin 1; α-SYN; alpha synuclein; β-TrCP; β-transducin repeat containing E3 ubiquitin protein ligase; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AMPK; AMP-activated protein kinase; ARE; antioxidant response element; ASK1; apo
Reversal of high fat diet-induced obesity improves glucose tolerance, inflammatory response, β-amyloid accumulation and cognitive decline in the APP/PSEN1 mouse model of Alzheimer's disease
Keywords: Presenilin 1; HFD; high fat diet; LFD; low fat diet; HFD to LFD, REV; reversal diet; Aβ; β-amyloid; APP; amyloid Precursor Protein; PSEN1; presenilin 1; RAGE; RECEPTOR for Advanced Glycation End Products; AGE; Advanced Glycation End Products; EZM; elevated zero maze;
Novel presenilin 1 mutation (p.F386I) in a Chinese family with early-onset Alzheimer's disease
Keywords: Presenilin 1; Autosomal dominant; Chinese; Familial Alzheimer's disease; Mutation; Presenilin 1;
Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer's disease and a novel protective role for ascorbate
Keywords: Presenilin 1; SVCT; sodium-dependent vitamin C transporter; APP; amyloid precursor protein; PSEN1; presenilin 1; ASC; ascorbate; ROS; reactive oxygen species; Aβ; amyloid beta peptide; TMRE; tetramethylrhodamine, ethyl ester; Alzheimer's disease; Mitochondria; Oxida
Clinical, imaging, pathological, and biochemical characterization of a novel presenilin 1 mutation (N135Y) causing Alzheimer's disease
Keywords: Presenilin 1; Alzheimer's disease; Presenilin 1; PET scan; Elecrtoencephalography;
Alzheimer's disease: How metal ions define β-amyloid function
Keywords: Presenilin 1; Aβ1â40; β-Amyloid, 40-residue isoform; Aβ1â42; β-Amyloid, 42-residue isoform; Aβ1â42/Aβ1â40; Ratio between levels of Aβ1â42 and Aβ1â40; ADAM; A Disintegrin And Metalloprotease, zinc peptidases, some being α-secretases; AICD; APP intra
Presenilin 1 promotes trypsin-induced neuroprotection via the PAR2/ERK signaling pathway. Effects of presenilin 1 FAD mutations
Keywords: Presenilin 1; Familial Alzheimer's disease; Presenilin 1; Neurotoxicity; Neuroprotection; Proteinase-activated receptor 2;
An early dysregulation of FAK and MEK/ERK signaling pathways precedes the β-amyloid deposition in the olfactory bulb of APP/PS1 mouse model of Alzheimer's disease
Keywords: Presenilin 1; AD; Alzheimer's disease; APP; amyloid precursor protein; BAD; Bcl2-associated agonist of cell death; Camk2a; Ca2Â +/CaM-dependent protein kinase type II subunit alpha; ERK; extracellular signal-regulated kinase; FAK; focal adhesion kinase; Gdap1; ganglios
PPARγ agonist pioglitazone improves cerebellar dysfunction at pre-Aβ deposition stage in APPswe/PS1dE9 Alzheimer's disease model mice
Keywords: Presenilin 1; Alzheimer's disease; Protein phosphorylation; CRMP; Mouse; Cerebellum; APP; amyloid precursor protein; BSA; bovine serum albumin; Cdk5; cyclin dependent kinase 5; CRMP2; collapsin response mediator protein 2; GSK3β; glycogen synthase kinase 3β; PS1; pre
Astrocytes in physiological aging and Alzheimer's disease
Keywords: Presenilin 1; 3xTg-AD; triple transgenic mice model of Alzheimer's disease; AD; Alzheimer's disease; APP; amyloid precursor protein; ATP; adenosine triphosphate; CA1; Cornu Ammonis 1; CNS; Central nervous system; DG; dentate gyrus; GABA; γ-aminobutyric acid; GFAP;
Reduction of increased calcineurin activity rescues impaired homeostatic synaptic plasticity in presenilin 1 M146V mutant
Keywords: Presenilin 1; AMPA receptor; Calcineurin; Homeostatic synaptic plasticity; Alzheimer's disease; Presenilin 1;
Evolving brain structural changes in PSEN1 mutation carriers
Keywords: Presenilin 1; Alzheimer's disease; Biomarkers; Cortical thickness; Presenilin 1; Presymptomatic;
Molecular dynamics simulation study reveals potential substrate entry path into γ-secretase/presenilin-1
Keywords: Presenilin 1; PS1; presenilin 1; APP; amyloid precursor protein; AD; Alzheimer's disease; NTF; N-terminal Fragment; CTF; C-terminal Fragment; TM; transmembrane domain; POPC; 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; POPE; 1-palmitoyl-2-oleoyl-sn-glycero-3-pho
Association between variant amyloid deposits and motor deficits in FAD-associated presenilin-1 mutations: A systematic review
Keywords: Presenilin 1; Systematic review; Familial Alzheimer's disease; Presenilin 1; Variant AD; Amyloid plaques; Variant amyloid deposits; Cotton wool plaques; CPW; Diffuse plaques; Motor deficits; Spastic paraparesis;
Peripheral leukocyte expression of the potential biomarker proteins Bdnf, Sirt1, and Psen1 is not regulated by promoter methylation in Alzheimer's disease patients
Keywords: Presenilin 1; Alzheimer disease; Biomarkers; Brain derived neurotrophic factor; DNA methylation; Presenilin 1; Sirtuin 1; AD; Alzheimer's disease; APP; amyloid precursor protein; CpG; cytosine-guanine; MMSE; Mini-Mental State Examination; MCI; mild cognitive impairme
Autophagy in neurodegenerative diseases: From pathogenic dysfunction to therapeutic modulation
Keywords: Presenilin 1; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APP; amyloid precursor protein; ATP; adenosine triphosphate; Bci3; Bax cannel inhibitor 3; cAMP; cyclic adenosine monophosphate; CMA; chaperone-mediated autophagy; DLB; dement
A novel presenilin 1 mutation (Ala275Val) as cause of early-onset familial Alzheimer disease
Keywords: Presenilin 1; Early-onset Alzheimer disease; Presenilin 1; Missense mutation; Cosegregation analysis;
Region-specific metabolic alterations in the brain of the APP/PS1 transgenic mice of Alzheimer's disease
Keywords: Presenilin 1; AD; Alzheimer's disease; GC-MS; gas chromatography-mass spectrometry; UPLC-MS; ultra-high performance liquid chromatography-mass spectrometry; APP; amyloid precursor protein; PS1; presenilin 1; TG; transgenic; WT; wild type; QC; quality control; P
Hydrogen sulfide improves spatial memory impairment and decreases production of Aβ in APP/PS1 transgenic mice
Keywords: Presenilin 1; Hydrogen sulfide; Beta-site amyloid precursor protein cleaving enzyme 1; A disintegrin metalloprotease; Presenilin 1; Amyloid beta; Alzheimer’s disease
Novel presenilin mutations within Moroccan patients with Early-Onset Alzheimer's Disease
Keywords: Presenilin 1; AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; beta-amyloid; EOAD; Early-Onset Alzheimer's Disease; FAD; familial Alzheimer's disease; MRI; Magnetic Resonance Imaging; MMSE; Mini-Mental State Examination; PS1; presenilin 1; PS2; prese
Inactivation of brain Cofilin-1 by age, Alzheimer's disease and γ-secretase
Keywords: Presenilin 1; AD; Alzheimer's disease; APP; amyloid precursor protein; APP/PS1; APPKM670/671NL/PS1L166P transgenic mice; APPKO; amyloid precursor protein knockout mice; Aβ; Amyloid-β peptides; Cofilin1; Cofilin isoform 1; CpdE; Compound E; DIV; days in vitro; DMSO; d
Human apolipoprotein E4 modulates the expression of Pin1, Sirtuin 1, and Presenilin 1 in brain regions of targeted replacement apoE mice
Keywords: Presenilin 1; AD; Alzheimer's disease; apoE; apoliporpotein E; apoE TR mice; human apoE3- and apoE4-targeted replacement mice; APP; amyloid precursor protein; Aβ; amyloid beta peptide; BDNF; Brain-derived Neurotrophic Factor; DDCt; Delta-Delta Ct; EDTA; ethylenedi
Presenilin-1 influences processing of the acetylcholinesterase membrane anchor PRiMA
Keywords: Presenilin 1; Alzheimer's disease; γ-Secretase; Presenilin 1; Acetylcholinesterase; PRiMA;
RanBP9 overexpression accelerates loss of dendritic spines in a mouse model of Alzheimer's disease
Keywords: Presenilin 1; AD; Alzheimer's disease; APP; Amyloid precursor protein; LRP; low-density lipoprotein receptor-related protein; LTD; long-term depression; LTP; long-term potentiation; MAP2; Microtubule associated protein 2; NP40; Nonidet-P40; PFA; Paraformaldehyde; PS1;
Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit
Keywords: Presenilin 1; Aβ; β-amyloid; AD; Alzheimer's disease; APP; amyloid precursor protein; APdE9; transgenic mice expressing APP695 protein with Swedish mutation and human presenilin 1 gene with exon 9 deletion; BM; bone marrow; BrdU; 5-Bromo-2â²-deoxyuridine; CCL; CC ch
GAB2 polymorphism rs2373115 confers susceptibility to sporadic Alzheimer's disease
Keywords: Presenilin 1; AD; Alzheimer's disease; APOE; apolipoprotein E; APP; amyloid precursor protein; CI; confidence interval; CNKI; China National Knowledge Infrastructure; DSM; Diagnostic and Statistical Manual of Mental Disorders; FAD; familial Alzheimer's disease; GAB2; G
Dysregulation of brain olfactory and taste receptors in AD, PSP and CJD, and AD-related model
Keywords: Presenilin 1; AD; Alzheimer's disease; ADYLC3; adenylyl cyclase 3; ATP; adenosine triphosphate; cAMP; cyclic adenosine monophosphate; CJD; Creutzfeldt-Jakob disease; CNG; cyclic nucleotide-gated; Gnal; olfactory G protein; GUS-β; β-glucuronidase; HSD; Honestly Si
Autophagy, polyphenols and healthy ageing
Keywords: Presenilin 1; AD; Alzheimer's disease; AMP; adenosine monophosphate; AMPK; adenosine monophosphate activated protein kinase; APP; amyloid beta precursor protein; Atg; autophagy (related gene); ATP; adenosine triphosphate; AV; autophagic vacuoles; Aβ; amyloid beta; Bcl
Les aspects génétiques de la maladie d’Alzheimer (Revue)
Keywords: Presenilin 1; Maladie d’Alzheimer; Génétique; Amyloid-β protein precursor; Préséniline 1; Préséniline 2; Apolipoprotein E4 AllèleAlzheimer's disease; Genetic; Amyloid-β protein precursor; Presenilin 1; Presenilin 2; Apolipoprotein E4 Allele