کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6280641 | 1615094 | 2015 | 21 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Peripheral leukocyte expression of the potential biomarker proteins Bdnf, Sirt1, and Psen1 is not regulated by promoter methylation in Alzheimer's disease patients
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کلمات کلیدی
Sirt1APPCpGMMSEsirtuin 1PSEN1presenilin 1 - Presenilin 1mild cognitive impairment - اختلال شناختی خفیفAlzheimer's disease - بیماری آلزایمرAlzheimer disease - بیماری آلزایمرbrain derived neurotrophic factor - عامل مغز استخوان مغز استخوان استDNA methylation - متیلاسیون DNAMini-Mental State Examination - معاینه دولتی مینی روانشناسیBiomarkers - نشانگر زیستی یا بیومارکرMCI - همراه اولamyloid precursor protein - پروتئین پیش ماده آمیلوئی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Peripheral leukocyte expression of the potential biomarker proteins Bdnf, Sirt1, and Psen1 is not regulated by promoter methylation in Alzheimer's disease patients Peripheral leukocyte expression of the potential biomarker proteins Bdnf, Sirt1, and Psen1 is not regulated by promoter methylation in Alzheimer's disease patients](/preview/png/6280641.png)
چکیده انگلیسی
Bdnf promoter methylation levels did not differ between AD patients and controls. Similarly, Sirt1 promoter revealed minimal levels of methylation which did not display significant differences between groups. No significant difference was revealed between AD patients and controls also in Psen1 methylation, showing a large variability of values among subjects. Although peripheral Bdnf expression is associated with differential promoter methylation in psychiatric and neurological disorders, our results suggest that different mechanisms take place in AD. The finding that the control of Sirt1 protein levels in blood is not exerted through the repression of mRNA expression by promoter hypermethylation is in agreement with previous data. In contrast, other studies reported that Psen1 methylation may be increased or decreased in AD patients, suggesting that additional studies are required. In conclusion, this study shows that peripheral levels of the potential AD biomarker proteins Bdnf, Sirt1, and Psen1 are not regulated by different promoter methylation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 605, 25 September 2015, Pages 44-48
Journal: Neuroscience Letters - Volume 605, 25 September 2015, Pages 44-48
نویسندگان
Lucia Carboni, Francesca Lattanzio, Sanzio Candeletti, Elisa Porcellini, Elena Raschi, Federico Licastro, Patrizia Romualdi,