10-Boronic acid substituted camptothecin as prodrug of SN-38
Keywords: پروتئین; Boric acid; Hydrogen peroxide; Prodrug; Camptothecin; Antitumor;
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Targeting of pegylated liposomal mitomycin-C prodrug to the folate receptor of cancer cells: Intracellular activation and enhanced cytotoxicity
Keywords: پروتئین; Mitomycin-C; Liposomes; Prodrug; Folate-receptor; Targeting; Chemotherapy;
4-Azidobenzyl ferrocenylcarbamate as an anticancer prodrug activated under reductive conditions
Keywords: پروتئین; Ferrocene; Azide; Prodrug; Reduction; Cancer;
Synthesis and characterization of brain penetrant prodrug of neuroprotective D-264: Potential therapeutic application in the treatment of Parkinson's disease
Keywords: پروتئین; Parkinson's disease; Multifunctional dopamine agonist; D-264; Modified cysteine; Blood-brain barrier; Prodrug;
PEGylation of paclitaxel largely improves its safety and anti-tumor efficacy following pulmonary delivery in a mouse model of lung carcinoma
Keywords: پروتئین; BAL; bronchoalveolar lavage; DLS; dynamic light scattering; DMEM; Dulbecco's Modified Eagle Medium; PBS; phosphate-buffered saline; EPR; enhanced permeability and retention; FBS; fetal bovine serum; HBSS; Hank's balanced salt solution; HPLC; high perfor
Prochelator strategies for site-selective activation of metal chelators
Keywords: پروتئین; Copper; Iron; Metal chelation; Oxidative stress; Metal dyshomeostasis; Prodrug;
The chemistry of aminoferrocene, Fe{(η5-C5H4NH2)(η5-Cp)}: Synthesis, reactivity and applications
Keywords: پروتئین; Ferrocene; Aminoferrocene; Prodrug; Sensor; Dendrimer; Photosynthetic model;
A five-membered lactone prodrug of CBI-based analogs of the duocarmycins
Keywords: پروتئین; CC-1065; Duocarmycin; CBI; Prodrug;
Design and synthesis of imidazole N-H substituted amide prodrugs as inhibitors of hepatitis C virus replication
Keywords: پروتئین; Hepatitis C virus; NS5A; Prodrug; Daclatasvir; Pharmacokinetics;
Bioreductive deprotection of 4-nitrobenzyl group on thymine base in oligonucleotides for the activation of duplex formation
Keywords: پروتئین; Nucleic acid-based therapeutics; Prodrug; Protecting group; Hypoxia; Hybridization;
Amino acid ester prodrugs conjugated to the α-carboxylic acid group do not display affinity for the L-type amino acid transporter 1 (LAT1)
Keywords: پروتئین; LAT1; L-type amino acid transporter 1; Prodrug; Quinidine; Isoleucine
Assessing the oral bioavailability of difluorosialic acid prodrugs, potent viral neuraminidase inhibitors, using a snapshot PK screening assay
Keywords: پروتئین; Neuraminidase inhibitor; Prodrug; Difluorosialic acid; Snapshot PK screen; Bioavailability;
Half-life extension of the HIV-fusion inhibitor peptide TRI-1144 using a novel linker technology
Keywords: پروتئین; Peptide drugs; Half-life extension; Drug delivery; Pegylation; Prodrug; Combination therapy;
A prodrug strategy for the oral delivery of a poorly soluble HCV NS5B thumb pocket 1 polymerase inhibitor using self-emulsifying drug delivery systems (SEDDS)
Keywords: پروتئین; Hepatitis C virus; Prodrug; NS5B polymerase; Antiviral; Inhibitor;
Targeting thapsigargin towards tumors
Keywords: پروتئین; Thapsigargin; Sarco/endoplasmic reticulum (SERCA); Prodrug; Prostate specific antigen (PSA); Prostate specific membrane antigen (PSMA); Targeting drugs
Self-assembled drug delivery systems. Part 8: In vitro/in vivo studies of the nanoassemblies of cholesteryl-phosphonyl gemcitabine
Keywords: پروتئین; Gemcitabine (PubChem CID: 60750)Gemcitabine; Molecular self-assembly; Nanoassemblies; Phosphonate; Prodrug
Preparation of a multifunctional verapamil-loaded nano-carrier based on a self-assembling PEGylated prodrug
Keywords: پروتئین; Doxorubicin; Prodrug; Self-assembling; pH-Dependent drug release; Verapamil HCl
Nanoparticle-mediated delivery of a rapidly activatable prodrug of SN-38 for neuroblastoma therapy
Keywords: پروتئین; Drug delivery; Nanoparticle; Prodrug; Topoisomerase I inhibitor; Neuroblastoma
Development, validation and application of the liquid chromatography tandem mass spectrometry method for simultaneous quantification of azilsartan medoxomil (TAK-491), azilsartan (TAK-536), and its 2 metabolites in human plasma
Keywords: پروتئین; Prodrug; Azilsartan medoxomil; TAK-491; TAK-536; LC/MS/MS; Validation
The anticancer drug metabolites endoxifen and 4-hydroxy-tamoxifen induce toxic effects on Daphnia pulex in a two-generation study
Keywords: پروتئین; Tamoxifen metabolite; Prodrug; Two-generational study; Chronic effect; Measured concentration; Ecotoxicology;
Macromolecular glucocorticoid prodrug improves the treatment of dextran sulfate sodium-induced mice ulcerative colitis
Keywords: پروتئین; Inflammatory bowel diseases; Dextran sulfate sodium; Glucocorticoid; ELVIS; HPMA copolymer; Prodrug
Initial development of a cytotoxic amino-seco-CBI warhead for delivery by prodrug systems
Keywords: پروتئین; CBI; Prodrug; TEMPO; Amino-CBI; Cytotoxin;
Zanamivir Amidoxime- and N-Hydroxyguanidine-Based Prodrug Approaches to Tackle Poor Oral Bioavailability
Keywords: پروتئین; influenza A; neuraminidase inhibitor; synthesis; drug-like properties; prodrug; pharmacokinetics; bioavailability; guanidine bioisoster; amidine
Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors: Use of a carboxylate prodrug to improve bioavailability
Keywords: پروتئین; Dipeptidyl peptidase IV; Type 2 diabetes mellitus; 3H-Imidazo[4,5-c]quinolin-4(5H)-ones; Prodrug;
15 years of ATTEMPTS: A macromolecular drug delivery system based on the CPP-mediated intracellular drug delivery and antibody targeting
Keywords: پروتئین; ATTEMPTS; CPP-mediated intracellular drug delivery; Antibody targeting; Prodrug
Platinum (IV) coiled coil nanotubes selectively kill human glioblastoma cells
Keywords: پروتئین; Right handed coiled coil; RHCC; Glioblastoma; Platinum; Prodrug; Nanotubes;
Syntheses of nucleosides with 2â²-spirolactam and 2â²-spiropyrrolidine moieties as potential inhibitors of hepatitis C virus NS5B polymerase
Keywords: پروتئین; Nucleoside; Prodrug; HCV NS5B; Spiro-lactam; Spiro-pyrrolidine;
Phosphocalyculin C as a pyrophosphate protoxin of calyculin C in the marine sponge Discodermia calyx
Keywords: پروتئین; Phosphocalyculin C; Calyculin C; Discodermia calyx; Prodrug
Enhanced water-soluble derivative of PC407 as a novel potential COX-2 inhibitor injectable formulation
Keywords: پروتئین; COX-2 inhibitor; Prodrug; Solubility; Injectable formulation
Piperazinyl-oxadiazoles as selective sphingosine-1-phosphate receptor agonists
Keywords: پروتئین; KSGWFNFXGXWCGV-CQSZACIVSA-N; UFHAWINYHJZYAQ-UQKRIMTDSA-NS1P1; S1P3; Agonist; Prodrug; Lymphopenia
Validated LC–MS/MS method for the simultaneous determination of chlorambucil and its prodrug in mouse plasma and brain, and application to pharmacokinetics
Keywords: پروتئین; Chlorambucil; LC–MS/MS; Prodrug; Brain; Pharmacokinetics
Synthesis and evaluation of a pyrazinoic acid prodrug in Mycobacterium tuberculosis
Keywords: پروتئین; Antimycobacterial agent; Ester synthesis; Prodrug; Pyrazinoic acid; Tuberculostatic
Kidney–targeted drug delivery systems
Keywords: پروتئین; Kidney-targeted; Prodrug; Macromolecular carrier; Nanoparticles; Liposomes
cNMP-AMs mimic and dissect bacterial nucleotidyl cyclase toxin effects
Keywords: پروتئین; AM; acetoxymethylester; cAMP; adenosine 3â²,5â²-cyclic monophosphate; cGMP; guanosine 3â²,5â²-cyclic monophosphate; cCMP; cytidine 3â²,5â²-cyclic monophosphate; cNMP; 3â²,5â²-cyclic nucleoside monophosphate; cUMP; uridine 3â²,5â²-cyclic monophos
Beyond sofosbuvir: What opportunity exists for a better nucleoside/nucleotide to treat hepatitis C?
Keywords: پروتئین; Sofosbuvir; GS-7977; Sovaldi™; HCV nucleotide polymerase inhibitors; Prodrug; Hepatitis C
Synthesis, characterization, and in vitro evaluation of artesunate-β-cyclodextrin conjugates as novel anti-cancer prodrugs
Keywords: پروتئین; Artesunate; β-Cyclodextrin; Conjugate; Prodrug; Carrier; Anti-cancer;
Photosensitive Pt(IV)-azide prodrug-loaded nanoparticles exhibit controlled drug release and enhanced efficacy in vivo
Keywords: پروتئین; Photosensitive chemotherapy; Platinum drugs; Drug delivery; Prodrug; Cisplatin; Nanomedicine;
Synthesis and biological evaluation of glaucocalyxin A derivatives as potential anticancer agents
Keywords: پروتئین; Glaucocalyxin A; Glaucocalyxin A derivatives; Antitumor; Prodrug; Structure activity relationship
Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of pyrrolopiperidinone acetic acids as CRTh2 antagonists
Keywords: پروتئین; CRTh2 antagonist; Receptor residence time; Structure-activity relationship (SAR); Structure-kinetic relationship (SKR); Permeability; Prodrug;
l-Carnitine ester of prednisolone: Pharmacokinetic and pharmacodynamic evaluation of a type I prodrug
Keywords: پروتئین; Prednisolone; l-Carnitine; Prodrug; Asthma; Pharmacokinetics–pharmacodynamics
Biological conversion of aripiprazole lauroxil − An N-acyloxymethyl aripiprazole prodrug
Keywords: پروتئین; Prodrug; Aripiprazole; Long acting injections; Aripiprazole lauroxil; N-acyloxyalkyl prodrug; Bioconversion
“Switch off/switch on” regulation of drug cytotoxicity by conjugation to a cell targeting peptide
Keywords: پروتئین; Amino acid platform; Controlled drug release; Peptide–drug conjugates; Prodrug; Solid phase organic synthesis
N-Acyl-phosphoramidates as potential novel form of gemcitabine prodrugs
Keywords: پروتئین; Gemcitabine; Prodrug; Cytotoxicity; Anticancer therapy; DNA polymerase inhibitor;
Investigation of amino acid conjugates of (S)-1-[1-(4-aminobenzoyl)-2,3-dihydro-1H-indol-6-sulfonyl]-4-phenyl-imidazolidin-2-one (DW2282) as water soluble anticancer prodrugs
Keywords: پروتئین; Prodrug; Amino acid conjugates; Imidazolidinone; Anti-cancer
Ruthenium dihydroxybipyridine complexes are tumor activated prodrugs due to low pH and blue light induced ligand release
Keywords: پروتئین; Prodrug; Anti-cancer; Ruthenium; Polypyridyl; Light-activated; pH-selective
Comparative toxicity and efficacy of engineered anthrax lethal toxin variants with broad anti-tumor activities
Keywords: پروتئین; Prodrug; Cancer; Melanoma; Bacterial cytotoxin; Protease;
Fe-salphen complexes from intracellular pH-triggered degradation of Fe3O4@Salphen-InIII CPPs for selectively killing cancer cells
Keywords: پروتئین; Coordination polymer; Magnetic nanoparticle; Metal complex; Prodrug; Target drug delivery;
Calorimetry and Langmuir–Blodgett studies on the interaction of a lipophilic prodrug of LHRH with biomembrane models
Keywords: پروتئین; Lipoamino acids; Prodrug; Calorimetry; DSC; Langmuir–Blodgett film; Drug–membrane interaction; Liposomes; DMPC
Synthesis and evaluation of 18F labeled FET prodrugs for tumor imaging
Keywords: پروتئین; ASC; alanine-serine-cysteine preferring amino acid transporter system; ASCT2; system ASC transporter subtype 2; BCH; 2-amino-bicylo[2.2.1]heptane-2-carboxylic acid; FACBC; 3-[18F]fluoro-cyclobutyl-1-carboxylic acid; FC; flash chromatography; FDG; 2-[18F]f
A Novel Strategy for ADME Screening of Prodrugs: Combined Use of Serum and Hepatocytes to Integrate Bioactivation and Clearance, and Predict Exposure to Both Active and Prodrug to the Systemic Circulation
Keywords: پروتئین; prodrug; active drug; screening strategy; serum; hepatocytes; absorption; bioavailability; in vitro models; exposure;