دانلود مقالات ISI درباره Ptp1B + ترجمه فارسی

Diarachidonoylphosphoethanolamine induces necrosis/necroptosis of malignant pleural mesothelioma cells

Keywords: DAPE; 1,2-diarachidonoyl-sn-glycero-3-phosphoethanolamine; MPM; malignant pleural mesothelioma; PI; propidium iodide; AV; annexin V; Nec-1; necrostatin-1; ROS; reactive oxygen species; MPT; mitochondrial permeability transition; CypD; cyclophilin D; CsA;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

New insights into the posttranslational regulation of human cytosolic thioredoxin by S-palmitoylation

Keywords: Posttranslational modification; Thioredoxin; PTP1B; S-palmitoylation; InsulinACSL, long-chain acyl-CoA synthetase; 2-BP, 2-bromopalmitate; FAS, fatty acid synthase; Gluc-N, glucosamine; GSNO, S-nitroso-glutathione; HAM, hydroxylamine; pNPP, para-Nitrophen

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Light-switched inhibitors of protein tyrosine phosphatase PTP1B based on phosphonocarbonyl phenylalanine as photoactive phosphotyrosine mimetic

Keywords: Protein tyrosine phosphatases; Enzyme inhibitors; Phosphotyrosine mimetics; Protein phosphorylation; PTP1B; Photo-switchable inhibitors;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Protein tyrosine phosphatase 1B (PTP1B) is involved in the defective erythropoietic function of carbamylated erythropoietin

Keywords: Erythropoietin; Carbamylated erythropoietin; PTP1B; Cell proliferation; Tyrosine phosphatasesβcR, beta common receptor; cEpo, carbamylated erythropoietin; Epo, erythropoietin; EpoR, erythropoietin receptor; FBS, fetal bovine serum; Jak2, Janus kinase 2; M

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

A review on the possible molecular mechanism of action of N-acetylcysteine against insulin resistance and type-2 diabetes development

Keywords: N-acetyl-l-cysteine (NAC) (PubChem CID: 12035); AKT; protein kinase B; AP-1; activator protein 1; CCL2; chemokine (C-C motif) ligand 2; eNOS; endothelial nitric oxide synthase; ERK; extracellular signal-regulated kinase; FFA; free fatty acid; GLUT; gluc

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Deletion of protein tyrosine phosphatase 1b in proopiomelanocortin neurons reduces neurogenic control of blood pressure and protects mice from leptin- and sympatho-mediated hypertension

Keywords: 5HT; 5-hydroxytryptamine; ACh; acetylcholine; BP; blood pressure; DBP; diastolic blood pressure; Emax; maximum possible effect; Jak-2; janus kinase-2; l-NAME; N-nitro-l-arginine methyl ester; MAP; mean arterial pressure; NOS; nitric oxide synthase; Phe; p

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members

Keywords: 5-HT; 5-hydroxytryptamine, serotonin; A549; non-small cell lung cancer cell line; AD; Alzheimer's disease; ADPKD; autosomal dominant polycystic kidney disease; Aire; autoimmune regulator; AP-1; activator protein 1; APP; amyloid precursor protein; AREB6; Z

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Deletion of protein tyrosine phosphatase 1B rescues against myocardial anomalies in high fat diet-induced obesity: Role of AMPK-dependent autophagy

Keywords: PTP1B; High fat diet; Cardiac; Contraction; Autophagy

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Memory and PTPIP51 - A new protein in hippocampus and cerebellum

Keywords: Hippocampus; Cerebellum; PTPIP51; 14-3-3; PTP1B;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Synthesis, biological evaluation and 3D-QSAR studies of imidazolidine-2,4-dione derivatives as novel protein tyrosine phosphatase 1B inhibitors

Keywords: PTP1B; Imidazolidine-2,4-dione; Synthesis; CoMFA/CoMSIA; Docking;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Effects of hepatic protein tyrosine phosphatase 1B and methionine restriction on hepatic and whole-body glucose and lipid metabolism in mice

Keywords: GSH; Glutathione; HPRT; Hypoxanthine-guanine phosphoribosyltransferase; IR; Insulin receptor; MR; Methionine restriction; mTORC1; Mechanistic target of rapamycin complex 1; NAFLD; Non-alcoholic fatty liver disease; p70S6K; p70 ribosomal S6 kinase; PIP3; P

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2015 سفارش ترجمه

Protein tyrosine phosphatase 1B (PTP1B): A key regulator and therapeutic target in liver diseases

Keywords: PTKs; protein tyrosine kinases; PTPs; protein tyrosine phosphatases; PTP1B; protein tyrosine phosphatase 1B; NAFLD; non-alcoholic fatty liver disease; HCC; hepatocellular carcinoma; DSPs; dual specificity phosphatases; LMW; low molecular weight; RPTPs; tr

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2015 سفارش ترجمه

Synthesis and biological evaluation of novel thiadiazole amides as potent Cdc25B and PTP1B inhibitors

Keywords: Thiadiazole amides; Cdc25B; PTP1B; Cancer; Type-2 diabetes and obesity;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

New compounds from acid hydrolyzed products of the fruits of Momordica charantia L. and their inhibitory activity against protein tyrosine phosphatas 1B

Keywords: Cucurbitane-type triterpene sapogenins; Momordica charantia L.; X-ray techniques; PTP1B;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Tanzawaic acid derivatives from a marine isolate of Penicillium sp. (SF-6013) with anti-inflammatory and PTP1B inhibitory activities

Keywords: Marine-derived fungus; Penicillium; Anti-inflammatory; PTP1B;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Reversible oxidation of PRL family protein-tyrosine phosphatases

Keywords: Cys; cysteine; DTNB; 5,5′-dithiobis-2-nitrobenzoic acid; DTT; dithiothreitol; GSH; glutathione; IPTG; isopropyl-β-d-thiogalactopyranoside; MKP; MAP kinase phosphatase; NADPH; nicotinamide adenine dinucleotide phosphate; NEM; N-ethlymaleimide; PIP3; pho

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin

Keywords: ACh; acetylthiocholine iodide; AChE; acetylcholinesterase; AGEs; advanced glycation endproducts; AR; aldose reductase; ARI; aldose reductase inhibitor; AMT; 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine hydrochloride; AD; Alzheimer's disease; Aβ; amyloi

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

An overview of mechanisms of redox signaling

Keywords: cAMP; adenosine monophosphate; ASK1; apoptosis signal-regulating kinase-1; P-SNP; cyclic sulfenyl amide; GSH; glutathione (reduced); GSSG; glutathione (oxidized); GPx; glutathione peroxidase(s); GST; glutathione S-transferase(s); GS; glutathione thiyl rad

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Oleanane triterpenes as protein tyrosine phosphatase 1B (PTP1B) inhibitors from Camellia japonica

Keywords: Camellia japonica; Theaceae; 3,4-seco-Oleanane; PTP1B; Lineweaver-Burk plot; Breast cancer; MDA-MB-231;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Design, synthesis and docking study of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as inhibitors of protein tyrosine phosphatase 1B

Keywords: Thiazolidinediones; PTP1B; Synthesis; Docking study;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Modulation in the expression of SHP-1, SHP-2 and PTP1B due to the inhibition of MAPKs, cAMP and neutrophils early on in the development of cerulein-induced acute pancreatitis in rats

Keywords: Experimental acute pancreatitis; SHP-1; SHP-2; PTP1B; MAPK inhibition; Infiltration inhibition;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Hepatic protein tyrosine phosphatase 1B (PTP1B) deficiency protects against obesity-induced endothelial dysfunction

Keywords: PTP1B; Insulin resistance; Endothelial dysfunction; Tyrosine phosphatase; eNOS

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Discovery of biaryl-4-carbonitriles as antihyperglycemic agents that may act through AMPK-p38 MAPK pathway

Keywords: Biaryls; PTP1B; Glucose uptake; Gene expression; Anti-hyperglycemic activity

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop

Keywords: PTP; protein tyrosine phosphatase; pNPP; p-nitrophenyl phosphate; MUP; 4-methylumbelliferyl phosphate; DiFMUP; 6,8-difluoro-4-methylumbelliferyl phosphate; OPLT; o-phospho-l-tyrosine; HRP; horseradish peroxidase; IPTG; isopropyl-thio-β-d-galactopyranosid

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

The known interactome of PTPIP51 in HaCaT cells-Inhibition of kinases and receptors

Keywords: PTPIP51; FAM82A2; Dasatinib; Gefitinib; PTP1B;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

The H+-ATP synthase: A gate to ROS-mediated cell death or cell survival

Keywords: AIF; apoptosis inducing factor; Akt; v-Akt murine thymoma viral oncogene; AP-1; activator protein 1; ARE; antioxidant responsive element; ASK1; apoptosis signal-regulated kinase 1; ATM; ataxia telangiectasia mutated; Duox; Dual oxidase enzymes; DUSP3; dua

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Identification of novel PTP1B inhibitors by pharmacophore based virtual screening, scaffold hopping and docking

Keywords: PTP1B inhibitors; Pharmacophore modeling; Scaffold hopping; Docking; Synthesis and biological activity; PTP1B; protein tyrosine phosphatise-1B; QSAR; quantitative structure activity relationship; PBVS; pharmacophore based virtual screening; SAR; structure

دانلود رایگان متن کامل مقاله ISI 101 صفحه سال انتشار : 2014 سفارش ترجمه

Euryspongins A-C, three new unique sesquiterpenes from a marine sponge Euryspongia sp.

Keywords: Euryspongin; Sesquiterpene; Marine sponge; Euryspongia sp.; PTP1B;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Bioactive polyhydroxylated steroids from the Hainan soft coral Sinularia depressa Tixier-Durivault

Keywords: Soft coral; Sinularia depressa; Steroid; Neuroprotective; Antibacterial; PTP1B;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Protein tyrosine phosphatase 1B inhibitory effect by dammarane-type triterpenes from hydrolyzate of total Gynostemma pentaphyllum saponins

Keywords: Triterpenes; Saponins from Gynostemma pentaphyllum; PTP1B;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Design and synthesis of 2-substituted benzoxazoles as novel PTP1B inhibitors

Keywords: WQDHPFPKNCWHIS-UHFFFAOYSA-N; IJDLNMTUHVMZCI-UHFFFAOYSA-N; KFMRBVMJRRFUHY-UHFFFAOYSA-N; NYOWHLFZRKAXFQ-UHFFFAOYSA-N; GWJYQDLLRWEELL-UHFFFAOYSA-N; CYEDVATYPJMRNV-UHFFFAOYSA-N; Benzimidazole; Benzoxazole; Oxamic acids; PTP1B; Diabetes; pTyr mimetics;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Design, synthesis and molecular modelling studies of novel 3-acetamido-4-methyl benzoic acid derivatives as inhibitors of protein tyrosine phosphatase 1B

Keywords: Diabetes; PTP1B; Acetamido benzoic acid derivatives; Molecular modelling; Lead optimization;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Reversal of dexamethasone induced insulin resistance in 3T3L1 adipocytes by 3β-taraxerol of Mangifera indica

Keywords: DEX; dexamethasone; DMEM; Dulbecco's modified Eagle's medium; ELISA; enzyme linked immunosorbent assay; FCS; fetal calf serum; GLUT 4; glucose transporter 4; GS; glycogen synthase; GSK3β; glycogen synthase kinase beta; IR β; insulin receptor beta; IRS1;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Modulation of cellular insulin signaling and PTP1B effects by lipid metabolites in skeletal muscle cells

Keywords: FFAs; free fatty acids; PTP1B; protein tyrosine phosphatase 1B; C14:0; myristic acid; C16:0; palmitic acid; C16:1; palmitoleic acid; C18:0; stearic acid; C18:1; oleic acid; C18:2; linoleic acid; C2 to C24; ceramide C2 to ceramide C24; TAGs; triglycerides;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

A 1H NMR metabolic profiling to the assessment of protein tyrosine phosphatase 1B role in liver regeneration after partial hepatectomy

Keywords: PTP1B; Diabetes; Liver regeneration; 1H NMR spectroscopy; Metabolomic;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes

Keywords: AICAR; 5-amino-4-imidazole-carboxamideriboside; ACC; acetyl-CoA carboxylase; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; CRP; C-reactive protein; HP; haptoglobin; IKK; IkappaB kinase; IL-6; Interleukin-6; IL6Rα; IL-6 receptor subun

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Modulation by Syk of Bcl-2, calcium and the calpain-calpastatin proteolytic system in human breast cancer cells

Keywords: Syk; Calpain; Calpastatin; PTP1B; NF-κB; Bcl-2;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Store-operated Ca2+ entry in hippocampal neurons: Regulation by protein tyrosine phosphatase PTP1B

Keywords: Store operated calcium channels; SOCC; Store operated calcium entry; SOCE; Tyrosine phosphorylation; Protein tyrosine phosphatase 1B; PTP1B; Fura-2; Hippocampal; Neurons; Calcium;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis and evaluation of copper complexes of Schiff-base condensates from 5-substituted-2-hydroxybenzaldehyde and 2-substituted-benzenamine as selective inhibitors of protein tyrosine phosphatases

Keywords: Copper complexes; Protein tyrosine phosphatases; Selective inhibitor; Schiff base; CSD; Cambridge Structural Database; ESI-MS; electrospray ionization mass spectra; Hcpmp; 4-chloro-2-((phenylimino)methyl)phenol; Hnpmp; 4-bromo-2-((phenylimino)methyl)pheno

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2013 سفارش ترجمه

Novel vanadyl complexes of acetoacetanilide: Synthesis, characterization and inhibition of proteintyrosine phosphatase

Keywords: Vanadium complexes; Acetoacetanilide; β-Diketone; Bismaltolatooxovanadium(IV); BMOV; PTP1B

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition

Keywords: Phosphatase; Cytokine signaling; Protein–protein interaction; Crystal structure; JAK-STAT; PTP1B

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Control of ALK (wild type and mutated forms) phosphorylation: Specific role of the phosphatase PTP1B

Keywords: ALK; Mutated receptors; Phosphorylation; Phosphatase; PTP1B

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis and biological evaluation of oleanolic acid derivatives as PTP1B inhibitors

Keywords: Oleanolic acid derivatives; PTP1B; Insulin-sensitizing response; Regioselective oxidation; IC50 value

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

CB1 cannabinoid receptors promote maximal FAK catalytic activity by stimulating cooperative signaling between receptor tyrosine kinases and integrins in neuronal cells

Keywords: 2-AG; 2-arachidonoylglycerol; BSA; bovine serum albumin; CB1; CB1 cannabinoid receptor; Csk; C-terminal Src kinase; DAGL; diacylglycerol lipase; DTT; dithiothreitol; ECM; extracellular matrix; ERK1/2; extracellular signal-regulated kinases 1 and 2; EGFR;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Microbial transformation of ursolic acid by Syncephalastrum racemosum (Cohn) Schroter AS 3.264

Keywords: Biotransformation; PTP1B; Syncephalastrum racemosum; Triterpenoids; Ursolic acid;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Norditerpenoids from Agathis macrophylla

Keywords: Agathis macrophylla; Norditerpenoids; PTP1B; Cytotoxicity

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Knockout of SOD1 alters murine hepatic glycolysis, gluconeogenesis, and lipogenesis

Keywords: AMPK; AMP-activated protein kinase; GK; glucokinase; GPX1; Se-glutathione peroxidase 1; JNK2; c-Jun NH2-terminal kinase; MAPK; mitogen-activated protein kinase; MS; metabolic syndrome; NEFA; nonesterified fatty acid; PEPCK; phosphoenolpyruvate carboxykina

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Redox signaling loops in the unfolded protein response

Keywords: AGR2; anterior gradient 2; ARE; antioxidant responsive element; ATF4; activating transcription factor-4; ATF6; activating transcription factor-6; ASK1; apoptosis signal-regulating kinase-1; BI-1; BAX inhibitor-1; BiP; immunoglobulin heavy chain-binding pr

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Dietary cystine level affects metabolic rate and glycaemic control in adult mice

Keywords: Cysteine; Cystine; Sulfur amino acids; Adiposity; PTP1b; Metabolic rate; Energy expenditure; Glucose tolerance; Insulin sensitivity;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Redox modification of cell signaling in the cardiovascular system

Keywords: AngII; angiotensin II; ASK1; apoptosis signal-regulating kinase 1; BDNF; brain-derived neurotrophic factor; BH4; tetrahydrobiopterin; CaMKII; Ca2+/calmodulin-dependent protein kinase II; cGMP; cyclic guanosine monophosphate; ETC; electron transport chain;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه