Spatial regulation of signaling by the coordinated action of the protein tyrosine kinases MET and FER
Keywords: FER; MET; PTP1B; Endocytosis; Ovarian cancer;
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Inhibition of protein tyrosine phosphatase 1B by flavonoids: A structure - activity relationship study
Keywords: Diabetes mellitus; PTP1B inhibition; Flavonoids; Enzymatic inhibition type; DM; Diabetes mellitus; GLUT4; glucose transporter 4; IR; insulin receptor; IRS; insulin receptor substrates; Km; Michaelis constant; PKB; protein kinase B; pNPP; p-nitrophenyl pho
Tanshinone IIA suppresses FcεRI-mediated mast cell signaling and anaphylaxis by activation of the Sirt1/LKB1/AMPK pathway
Keywords: ACC; acetyl-CoA carboxylase; Ac-Lys; acetylated lysine; AMPK; AMP-activated protein kinase; BMMCs; bone marrow-derived mast cells; HSA; human serum albumin; IKK; IκB kinase; IL-6; interleukin-6; JNK; c-Jun N-terminal kinase; LAT; linker for activation of
Comprehensive review on flavonoids biological activities of Erythrina plant species
Keywords: 5-LOX; 5-lipoxygenase; AMPK; adenosine monophosphate-activated protein kinase; Bax; Bcl-2-associated X protein; BC; lymphoma cell line; Bcl-2; B-cell CLL/lymphoma 2; Caco2; human epithelial colorectal adenocarcinoma cells; CCRF-CEM; T lymphoblastoid cell
Scaffold-based novel SHP2 allosteric inhibitors design using Receptor-Ligand pharmacophore model, virtual screening and molecular dynamics
Keywords: SPB; structure based pharmacophore; ADMET; absorption, distribution, metabolism, excretion, and toxicity; TCPTP; T cell protein-tyrosinephosphatase; PTP1B; protein tyrosine phosphatase 1B; NS; Noonan Syndrome; JMML; juvenile myelomonocytic leukemia; AML;
ERK1/2 activated PHLPP1 induces skeletal muscle ER stress through the inhibition of a novel substrate AMPK
Keywords: 2-NBDG; 2-(N-[7-nitrobenz-2-oxa-1,3-diazol-4-yl]amino)-2-deoxyglucose; AICAR; 5-aminoimidazole-4-carboxamide-1-b-d-ribofuranoside; AMPK; AMP-activated protein kinase; AS160; Akt Substrate of 160â¯kDa; ATF4; Activating Transcription Factor 4; AUC; area un
The chemistry and pharmacology of Ligularia przewalskii: A review
Keywords: A375; human melanoma cells; ABTS; 2,2'-azinobis (3-ethylbenzothiazoline-6- sulfonic acid); AChE; acetylcholinesterase; AD; Alzheimer's disease; AGEs; advanced glycation endproducts; B16F10; mouse skin melanoma; BACE1; β-site amyloid precursor cleavin
Causes and solutions to “globesity”: The new fa(s)t alarming global epidemic
Keywords: Obesity; Chronic low-grade inflammation; Pharmacotherapy; Novel targets; Medicinal plants; Clinical studies; Contents; 5HT2CR; Serotonin receptors subtype 2C; ACC; Acetyl-CoA carboxylase (EC 6.4.1.2); ACTH; Adrenocorticotropic hormone; AgRP; Agouti-relate
Varic acid analogues from fungus as PTP1B inhibitors: Biological evaluation and structure-activity relationships
Keywords: PTP1B; Varic acid; Structure-activity relationships; Insulin-sensitizing effect; Type 2 diabetes mellitus;
Benzo[c][1,2,5]thiadiazole derivatives: A new class of potent Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors
Keywords: Benzo[c][1,2,5]thiadiazole derivatives; PTP1B; SHP2; Inhibitors; Structure-activity relationships (SAR);
Two new γ-lactones from the cultures of basidiomycete Lenzites betulinus
Keywords: Lenzites betulinus; Betulactone A; PTP1B;
Xanthones from the twigs of Garcinia oblongifolia and their antidiabetic activity
Keywords: Type 2 diabetes; α-Glucosidase; PTP1B; Garcinia oblongifolia; Xanthones; Oblongixanthone C (PubChem CID: 25209204); Cowanin (PubChem CID: 11754819); Cowanol (PubChem CID: 101671063); Rubraxanthone (PubChem CID: 9953366); Cowagarcinone E (PubChem CID: 114
Four new neolignans isolated from Eleutherococcus senticosus and their protein tyrosine phosphatase 1B inhibitory activity (PTP1B)
Keywords: Eleutherococcus senticosus; PTP1B; Obesity; Neo-lignans;
PTP1B inhibitors from the seeds of Iris sanguinea and their insulin mimetic activities via AMPK and ACC phosphorylation
Keywords: Iris sanguinea; Triterpene; PTP1B; AMPK; Glucose uptake;
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata
Keywords: Glycyrrhiza inflata; Prenylated phenolics; Anti-inflammatory; Cytotoxicity; PTP1B; Tyrosinase;
In vitro anti-diabetic activity of flavonoids and pheophytins from Allophylus cominia Sw . on PTP1B, DPPIV, alpha-glucosidase and alpha-amylase enzymes
Keywords: PTP1B; (Protein Tyrosine Phosphatase 1B); DPPIV; (Dipeptidyl peptidase-4); Ki; (inhibitory constant); TFMS (; [Bis(4-trifluoromethylsulfonamidophenyl)â1,4-diisopropylbenzine), P32/98 ({(3N-[(2S, 3S)â2-amino-3-methyl-pentanoyl]â1,3-thiazolidine) hemi
Cucurbitane triterpenoids from Momordica charantia L. and their inhibitory activity against α-glucosidase, α-amylase and protein tyrosine phosphatase 1B (PTP1B)
Keywords: Momordica charantia L.; Cucurbitane; PTP1B; α-glucosidase; α-amylase; Hypoglycaemic activity;
Leptin receptor knockout-induced depression-like behaviors and attenuated antidepressant effects of exercise are associated with STAT3/SOCS3 signaling
Keywords: FST; forced swim test; GSK-3β; glycogen synthase kinase-3β; HDL; high density lipoprotein; IKKβ; inhibitor of κB kinase β; IL; interleukin; LepRb; leptin receptor; NFκB; nuclear factor kappaB; OFT; open field test; PTP1B; protein tyrosine phosphatas
Characterization of the inhibitory activity of natural tanshinones from Salvia miltiorrhiza roots on protein tyrosine phosphatase 1B
Keywords: Salvia miltiorrhiza; Lamiaceae; Tanshinone; Anti-diabetes; PTP1B; Molecular docking; AD; Alzheimer's disease; ADT; AutoDock Tools; CIDs; compound identifiers; DM; diabetes mellitus; DTT; dithiothreitol; EDTA; ethylenediaminetetraacetic acid; GAs; genetic
Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoEâ/â mouse model of atherosclerosis with alterations in IL10/AMPKα pathway
Keywords: PTP1B; Insulin resistance; Interleukin-10; AMPK; Atherosclerosis;
Knocking down amygdalar PTP1B in diet-induced obese rats improves insulin signaling/action, decreases adiposity and may alter anxiety behavior
Keywords: Amygdala; PTP1B; Insulin; Anxiety; Obesity; Akt; protein kinase B; ASO; antisense oligonucleotide; BAT; brown adipose tissue; CeA; central nucleus of the amygdala; CNS; central nervous system; EPM; elevated plus maze; ER; endoplasmatic reticulum; FI; food
Punicalagin, a PTP1B inhibitor, induces M2c phenotype polarization via up-regulation of HO-1 in murine macrophages
Keywords: Punicalagin; M2 polarization; PTP1B; HO-1; Murine;
Baicalein improves insulin resistance via regulating SOCS3 and enhances the effect of acarbose on diabetes prevention
Keywords: 2h-PG; 2-hour postprandial glucose; ALT; alanine transaminase; AUC; area under the curve; AST; aspartate transaminase; JNK; C-Jun N-terminal kinase; DMEM; Dulbecco's modified Eagle's medium; FBG; fasting blood glucose; GPx; glutathione peroxidase; HDL
Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors
Keywords: PTP1B; Bromophenol; Saccharide; Selectivity; Permeability;
Synthesis, biological evaluation and in silico studies of 5-(3-methoxybenzylidene)thiazolidine-2,4-dione analogues as PTP1B inhibitors
Keywords: PTP1B; Diabetes; 5-(3-Methoxybenzylidene)-thiazolidine-2,4-dione; Docking;
Insulin-dependent metabolic and inotropic responses in the heart are modulated by hydrogen peroxide from NADPH-oxidase isoforms NOX2 and NOX4
Keywords: ROS; Reactive oxygen species; PKA; Protein kinase A; NOX; NADPH oxidase; PTP1B; Protein tyrosine phosphatase 1B; CaMK; Calmodulin Kinase; mTOR; Mammalian target of rapamycin; AAV; Adeno-associated virus; CIRKO; Cardiac insulin receptor knockout; IGF-1; In
Competitive protein tyrosine phosphatase 1B (PTP1B) inhibitors, prenylated caged xanthones from Garcinia hanburyi and their inhibitory mechanism
Keywords: PTP1B; protein tyrosine phosphatase 1B; IC50; the inhibitor concentration leading 50% activity loss; Ki; inhibition constant; Kiapp; apparent Ki; Vmax; maximum velocity; Km; Michaelis-Menten constant; Kobs; apparent first-order rate constant for the trans
Synthesis and characterization of oxidovanadium complexes as enzyme inhibitors targeting dipeptidyl peptidase IV
Keywords: DPP-IV; dipeptidyl peptidase IV; mg V·kgâ 1; mg Vanadium injected/weight of mice in kg; GLP-1; glucagon-like peptide-1; GIP; glucose-dependent insulinotropic peptide; BEOV; bis(ethylmaltolato)oxovanadium(IV); PTP1B; protein tyrosine phosphatase 1B; P
Vitamin D supplementation inhibits oxidative stress and upregulate SIRT1/AMPK/GLUT4 cascade in high glucose-treated 3T3L1 adipocytes and in adipose tissue of high fat diet-fed diabetic mice
Keywords: High glucose; Oxidative stress; Vitamin D; SIRT1/AMPK/IRS1/GLUT4; Glucose metabolism; 1,25(OH)2D3; 1,25-dihydroxyvitamin D3; AKT; serine/threonine protein kinase; AMPK; AMP activated protein kinase; GLUT1; glucose transporter 1; GLUT4; glucose transporter
Effects of vitamin D and resveratrol on metabolic associated markers in liver and adipose tissue from SAMP8 mice
Keywords: AD; Alzheimer's disease; AMPK; AMP-activated protein kinase; APP; amyloid precursor protein; AUC; area under the curve; ER; endoplasmic reticulum; EPI; epididymal; FFAs; free fatty acids; GRP78; 78Â kDa glucose-regulated protein; GTT; glucose tolerance te
Redox regulation of the tumor suppressor PTEN by the thioredoxin system and cumene hydroperoxide
Keywords: AP-1; activator protein-1; DMEM; Dulbecco's modified Eagle's medium; DTT; dithiothreitol; FBS; fetal bovine serum; Grx; glutaredoxin; GSH; glutathione; HPLC; high- performance liquid chromatography; HRP; horseradish peroxidase; MEFs; mouse embryonic fibro
Deletion of protein tyrosine phosphatase 1B obliterates endoplasmic reticulum stress-induced myocardial dysfunction through regulation of autophagy
Keywords: ER stress; PTP1B; Tunicamycin; Cardiac function; Autophagy;
Prediction and verification of novel peptide targets of protein tyrosine phosphatase 1B
Keywords: Protein tyrosine phosphatases; Computational prediction; Peptide substrates; PTP1B;
Novel PTP1B inhibitors identified by DNA display of fragment pairs
Keywords: DNA-encoded library; Peptide nucleic acid (PNA); Fragment based drug discovery; PTP1B
Blockade of the interaction between Bcr-Abl and PTB1B by small molecule SBF-1 to overcome imatinib-resistance of chronic myeloid leukemia cells
Keywords: SBF-1; Chronic myeloid leukemia; Imatinib; Bcr-Abl; PTP1B;
New sesquiterpenoids from the edible mushroom Pleurotus cystidiosus and their inhibitory activity against α-glucosidase and PTP1B
Keywords: Pleurotus cystidiosus; Sesquiterpenoids; Clitocybulol derivatives; Structure elucidation; PTP1B
Secondary metabolites from the flower buds of Lonicera japonica and their in vitro anti-diabetic activities
Keywords: Lonicera japonica; ECD; α-Glucosidase; PTP1B; Molecular docking;
A-type lamin-dependent homo-oligomerization for pY19-Caveolin-2 to function as an insulin-response epigenetic regulator
Keywords: ER; endoplasmic reticulum; PM; plasma membrane; Cav-2; Caveolin-2; INM; inner nuclear membrane; STAT3; signal transducer and activator of transcription 3; PTP1B; protein tyrosine phosphatase 1B; H3K9me3; histone H3 lysine 9 trimethylation; H3K9ac; histone
Coumarins from Angelica decursiva inhibit α-glucosidase activity and protein tyrosine phosphatase 1B
Keywords: Angelica decursiva; Coumarin; PTP1B; α-glucosidase; Molecular docking simulation; Enzyme kinetic studyDMSO, dimethyl sulfoxide; IC50, inhibitory concentrations 50%; (PTP1B), protein tyrosine phosphatase 1B; DM, diabetes mellitus; ONOO−, nitrotyrosine; CDC
PTP1B, α-glucosidase, and DPP-IV inhibitory effects for chromene derivatives from the leaves of Smilax china L.
Keywords: Smilax china L.; DPP-IV; PTP1B; α-Glucosidase inhibitor; Molecular docking
PTP1B confers liver fibrosis by regulating the activation of hepatic stellate cells
Keywords: HSCs; Hepatic stellate cells; PTP1B; Protein tyrosine phosphatase 1B; TGF-β1; Transforming growth factor-β1; MDI; Adipogenic differentiation mixture; ECM; Extracellular matrix; qHSCs; Quiescent HSCs; α-SMA; α-smooth muscle actin; col1α1; Type I colla
Design and synthesis of new potent PTP1B inhibitors with the skeleton of 2-substituted imino-3-substituted-5-heteroarylidene-1,3-thiazolidine-4-one: Part I
Keywords: 1,3-Thiazolidine-4-one; PTP1B; Pyrrole; Pyridine; Dock; SAR
S-nitrosylation of endogenous protein tyrosine phosphatases in endothelial insulin signaling
Keywords: ACN; acetonitrile; APIAM; N-(4-acetylphenyl)-2-iodoacetamide; BiFC; Bimolecular Fluorescence Complementation; BSA; bovine serum albumin; Cys; cysteine; DAPI; (4â²,6-diamidino-2-phenylindole); DPIAM; N-(2,3-dimethylphenyl)-2-iodoacetamide; DMEM; Dulbecco'
High-resolution PTP1B inhibition profiling combined with high-performance liquid chromatography-high-resolution mass spectrometry-solid-phase extraction-nuclear magnetic resonance spectroscopy: Proof-of-concept and antidiabetic constituents in crude extra
Keywords: Gallic acid (PubChem CID: 370); Gramine (PubChem CID: 6890); Caffeine (PubChem CID: 2519); Quercetin (PubChem CID: 5280343); Shikonin (PubChem CID: 479503); Luteolin (PubChem CID: 5280445); Dinatin (PubChem CID: 5281628); Tricin (PubChem CID: 5281702); 3,
Reversible oxidation controls the activity and oligomeric state of the mammalian phosphoglycolate phosphatase AUM
Keywords: CD; circular dichroism; DTT; dithiothreitol; EGF; epidermal growth factor; G3P; glycerol-3-phosphate; HAD; haloacid dehalogenase; IAA; iodoacetic acid; IAP; iodoacetyl polyethylene glycol; LDH; lactate dehydrogenase; MALS; multi angle light scattering; PD
Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction
Keywords: AMPK; AMP-activated protein kinase; ATM; adipose tissue macrophages; CCL; chemokine (C-C motif) ligand; CCR2; chemokine (C-C motif) receptor 2; CX3CL1; chemokine (C-X3-C motif) ligand 1; CX3CR1; chemokine (C-X3-C motif) receptor; CXCL; CXC chemokine ligan
A pair of new tetrahydro-naphthalenone enantiomers from Eremurus altaicus (Pall.) Stev.
Keywords: Eremurus altaicus (Pall.) Stev.; 4-Hydroxytetralone derivative; Absolute configuration; ECD calculations; PTP1B;
Two new diphenyl ethers from Acanthopanax senticosus (Rupr. & Maxim.) Harms with PTP1B inhibitory activity
Keywords: Acanthopanax senticosus (Rupr. &; Maxim.) Harms; Araliaceae; Diphenyl ethers; PTP1B;
Strategies to make protein serine/threonine (PP1, calcineurin) and tyrosine phosphatases (PTP1B) druggable: Achieving specificity by targeting substrate and regulatory protein interaction sites
Keywords: Protein phosphatase 1; Serine/threonine phosphatases; Calcineurin; Drug design; PTP1B;
Absolute structures and bioactivities of euryspongins and eurydiene obtained from the marine sponge Euryspongia sp. collected at Iriomote Island
Keywords: Euryspongin; Eurydiene; Marine sponge; Euryspongia sp.; PTP1B;