دانلود مقالات ISI درباره Pxr + ترجمه فارسی

Anti-inflammatory and metabolic actions of FXR: Insights into molecular mechanisms

Keywords: AF1; activation function 1; ANIT; α-naphthylisothiocyanate; AR; androgen receptor; BA; bile acids; BDL; bile duct ligation; ChIP-seq; chromatin immunoprecipitation-sequencing; DBD; DNA binding domain; DR; direct repeat; ER; estrogen receptor; FXR; farnes

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Ligand dependent hepatic gene expression profiles of nuclear receptors CAR and PXR

Keywords: CAR; constitutive androstane receptor; PXR; pregnane X receptor; RXR; retinoid X receptor; PPAR; peroxisome proliferator-activated receptor; CYP; cytochrome P450; UGT; UDP-glucuronyltransferase; GST; glutathione S-transferase; SULT; sulfotransferase; ABC;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Evaluation of hepatic and thyroid responses in male Sprague Dawley rats for up to eighty-four days following seven days of dietary exposure to potassium perfluorooctanesulfonate

Keywords: Potassium perfluorooctanesulfonate; PPARα; CAR; PXR; PFOS; Hepatomegaly; Thyroid

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Reduced Expression of UGT1A1 in Intestines of Humanized UGT1 Mice via Inactivation of NF-κB Leads to Hyperbilirubinemia

Keywords: Nursing; Mouse Model; Neonatal Jaundice; Gene Regulation; AhR; aryl hydrocarbon receptor; BIND; bilirubin-induced neurological dysfunction; CAR; constitutive androstane receptor; Cyp; cytochrome P450; GI; gastrointestinal; IKK; IκB kinase; LPS; lipopolys

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Hepatocellular hypertrophy and cell proliferation in Sprague–Dawley rats from dietary exposure to potassium perfluorooctanesulfonate results from increased expression of xenosensor nuclear receptors PPARα and CAR/PXR

Keywords: Potassium perfluorooctanesulfonate; PPARα; CAR; PXR; PFOS; Hepatomegaly

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

DEHP: Genotoxicity and potential carcinogenic mechanisms-A review

Keywords: ADME; absorption, distribution, metabolism and elimination; CAR; constitutive androstane receptor; CERHR; NTP Center for the Evaluation of Risks to Human Reproduction; CHO; Chinese hamster ovary; CYP; cytochrome p450; CpG; cytosine guanine dinucleotide; D

دانلود رایگان متن کامل مقاله ISI 76 صفحه سال انتشار : 2012 سفارش ترجمه

Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1)

Keywords: Type 2 diabetes; 11β-HSD-1 inhibitors; Triazolopyridine; PXR

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Influence of gender, feeding regimen, and exposure duration on gene expression associated with xenobiotic metabolism in fathead minnows (Pimephales promelas)

Keywords: FHM; fathead minnow; PXR; pregnene x-receptor; CYP3A4; cytochrome P450 3A4; G6P; glucose 6-phosphatase; PEPCK; phosphoenolpyruvate carboxykinase; SCD1; stearoyl-Coenzyme A desaturase 1; CTZ; clotrimazole; PCN; pregnenolone 16α-carbonitrile; Fathead minno

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Post-translational modification of pregnane x receptor

Keywords: PXR; pregnane x receptor; NR; nuclear receptor; PCN; pregnenalone 16α-carbonitrile; Rif; rifampicin; G6Pase; glucose-6-phosphatase; PEPCK; phosphoenolpyruvate carboxykinase; CYP3A; cytochrome P450 3A; CREs; cyclic AMP response elements; PKA; cyclic AMP-d

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Calcitriol stimulates prolactin expression in non-activated human peripheral blood mononuclear cells: Breaking paradigms

Keywords: Calcitriol; 1,25-dihydroxyvitamin D3; EC50; half maximal effective concentration; PBMNC; peripheral blood mononuclear cells; PHA; phytohemagglutinin; PXR; pregnane X receptor; PRL; prolactin; qPCR; real time polymerase chain reaction; RXR; retinoid X rece

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Molecular and Cellular PharmacologyEffect of pregnane X receptor (PXR) prototype agonists on chemoprotective and drug metabolizing enzymes in mice

Keywords: PXR; Dexamethasone; Spironolactone; Pregnenolone-16alpha-carbonitrile; Drug metabolizing enzymes;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Lack of association of ABCB1 and PXR polymorphisms with response to treatment in epilepsy

Keywords: Epilepsy; ABCB1; PXR; Polymorphism; P-glycoprotein; Antiepileptic drug

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor

Keywords: PXR; pregnane X receptor; NHR; nuclear hormone receptor; DEX; dexamethasone; VD3; cholecalciferol; DCA; deoxycholic acid; TBHP; tert-butylhydroperoxide; CHX; cycloheximide; CYP3A4; Aflatoxins; PXR; Gene expression;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Lipopolysaccharide down-regulates carbolesterases 1 and 2 and reduces hydrolysis activity in vitro and in vivo via p38MAPK-NF-κB pathway

Keywords: LPS; lipopolysaccharide; NS; normal saline; HCE1; human carboxylesterases 1; HCE2; human carboxylesterases 2; mCE1; mouse carboxylesterases 1; mCE2; mouse carboxylesterases 2; CYP450; cytochrome P450; DMEs; drug metabolism enzymes; PXR; pregnane X recepto

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Nonylphenol-mediated CYP induction is PXR-dependent: The use of humanized mice and human hepatocytes suggests that hPXR is less sensitive than mouse PXR to nonylphenol treatment

Keywords: PXR; P450s; Nonylphenol; CAR

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes

Keywords: Perfluoroalkyl acids; PPARA; Metabolic regulation; Species specificity; CAR; PXR; LXR;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene

Keywords: Metformin; Cytochrome P450; Induction; PXR; AMPK

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

The role of lithocholic acid in the regulation of bile acid detoxication, synthesis, and transport proteins in rat and human intestine and liver slices

Keywords: Lithocholic acid; VDR; FXR; PXR; GR; Intestinal slices; Liver slices; Cytochrome P450; Transporters; Bile acid; Induction

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Induction of a mature hepatocyte phenotype in adult liver derived progenitor cells by ectopic expression of transcription factors

Keywords: ALDPC; adult liver-derived progenitor cells; iPS; induced pluripotent stem cells; LETF; liver enriched transcription factors; LD; liver differentiation medium; HBM; hepatocyte basal medium; MM; maintenance medium; ESC; embryonic stem cells; Foxa2; forkhea

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors

Keywords: PXR; Pregnane X receptor; SAR; PXR transactivation; Insulin-like Growth Factor 1 Receptor kinase; IGF-1R; CYP3A expression; Cytochrome P450

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Lack of P-glycoprotein induction by rifampicin and phenobarbital in human lymphocytes

Keywords: P-glycoprotein; Lymphocyte; Rifampicin; Phenobarbital; PXR; CAR

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Overcoming drug resistance by regulating nuclear receptors

Keywords: Drug resistance; MDR1; PXR; CYP3A4; ABC transporters; Drug-metabolizing enzymes

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor

Keywords: Pesticide; Endosulfan; PXR; CAR; CYP3A4; CYP2B6; Human hepatocytes; HepG2 cell line

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Research ArticleRegulation of the human bile acid UDP-glucuronosyltransferase 1A3 by the farnesoid X receptor and bile acids

Keywords: BA; bile acid; CDCA; chenodeoxycholic acid; CA; cholic acid; DCA; deoxycholic acid; LCA; lithocholic acid; CYP; cytocrome P450; PXR; pregnane X receptor; CAR; constitutive androstane receptor; FXR; farnesoid X receptor; JNK; c-Jun N-terminal kinase; UGT;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors

Keywords: Cytochrome P450; Drug metabolism; Nuclear receptor; CAR; PXR; CYP3A4

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Interactions of pharmaceuticals and other xenobiotics on hepatic pregnane X receptor and cytochrome P450 3A signaling pathway in rainbow trout (Oncorhynchus mykiss)

Keywords: Nuclear receptors; PXR; CYP3A; P-glycoprotein; Pharmaceuticals; Fish

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Possible protective role of pregnenolone-16α-carbonitrile in lithocholic acid-induced hepatotoxicity through enhanced hepatic lipogenesis

Keywords: Lithocholic acid; PCN; Hepatotoxicity; PXR; Lipogenesis; Phospholipid

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Exposure to antiepileptic drugs does not alter the functionality of P-glycoprotein in brain capillary endothelial and kidney cell lines

Keywords: Phenobarbital; Nuclear receptor; PXR; CAR; Pharmacoresistance; Epilepsy

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11β-HSD1 inhibitors

Keywords: 11β-HSD1; Type II diabetes; Insulin sensitivity; Cyclohexyl benzamide; Piperidyl benzamide; PXR; Microsomal stability; Hepatocyte stability

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Perfluorinated chemicals 2008: PFAA Days II meeting report and highlights

Keywords: PFAA; perfluoroalkyl acid; PFBA; perfluorobutyric acid; PFBS; perfluorobutane sulfonate; PFHA; perfluorohexanoic acid; PFHS; perfluorohexane sulfonate; PFOA; perfluorooctanoic acid; PFOS; perfluorooctane sulfonate; PFOSA; perfluorooctane sulfonamide; PFNA

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

PXR-mediated induction of human CYP3A4 and mouse Cyp3a11 by the glucocorticoid budesonide

Keywords: Budesonide; Dexamethasone; Cytochrome P450; CYP3A4; Cyp3a11; PXR

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA

Keywords: PXR, pregnane X receptor; CAR, constitutive androstane receptor; GR, glucocorticoid receptor; PXRE, PXR response element; hPXR, human PXR; PCR, polymerase chain reaction; wt, wild-typeCryptotanshinone; Tanshinone IIA; PXR; CYP3A4; Induction

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Arsenite and its metabolites, MMAIII and DMAIII, modify CYP3A4, PXR and RXR alpha expression in the small intestine of CYP3A4 transgenic mice

Keywords: Sodium arsenite; CYP3A4; PXR; RXR alpha; Ubiquitin-proteasome pathway; Transgenic mice;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Toxicogenomic effects common to triazole antifungals and conserved between rats and humans

Keywords: Myclobutanil; Propiconazole; Triadimefon; Toxicogenomics; CAR; PXR

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Targeted Metabolomics Identifies Glucuronides of Dietary Phytoestrogens as a Major Class of MRP3 Substrates In Vivo

Keywords: ABC; ATP-binding cassette; ATP; adenosine triphosphate; BSA; bovine serum albumin; cDNA; complementary DNA; CID; collision-induced dissociation; HEK; Human Embryonic Kidney cells; LC; liquid chromatography; MRM; multiple reaction monitoring; MRP3; Multidr

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Synthesis of novel ketoconazole derivatives as inhibitors of the human Pregnane X Receptor (PXR; NR1I2; also termed SXR, PAR)

Keywords: Pregnane X receptor; PXR; Ketoconazole; Azole; Analogs; Nuclear receptors

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

PPARα gene expression is up-regulated by LXR and PXR activators in the small intestine

Keywords: GW3965; LXR; PCN; PPARα; PXR; T0901317; Transcriptional regulation; Lipid metabolism

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

A mechanism for the anti-fibrogenic effects of the pregnane X receptor (PXR) in the liver: Inhibition of NF-κB?

Keywords: PXR; NF-κB; Fibrosis; Myofibroblast; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Expression of nuclear receptor mRNA and liver X receptor-mediated regulation of ABC transporter A1 at rat blood–brain barrier

Keywords: ABC transporter; Blood–brain barrier; Brain capillary endothelial cell; Nuclear receptor; LXR; PPAR; PXR

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

A new class of bradykinin B1 receptor antagonists with high oral bioavailability and minimal PXR activity

Keywords: Bradykinin; GPCR; Pain; PXR; P-glycoprotein

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Coactivator PGC-1α regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes

Keywords: CYP; cytochrome P450; PGC-1α; peroxisome proliferator-activated receptor γ coactivator 1α; cAMP; cyclic adenosine monophosphate; HNF-4α; hepatocyte nuclear factor 4α; PPAR; peroxisome proliferator-activated receptor; COH; coumarin 7-hydroxylase; Q-PC

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Activation of the farnesoid X receptor represses PCSK9 expression in human hepatocytes

Keywords: BA; bile acid; CA; cholic acid; CDCA; chenodeoxycholic acid; DCA; deoxycholic acid; FXR; farnesoid X receptor; IHH; immortalized human hepatocytes; LA; lithocholic acid; LDL-c; low density lipoprotein cholesterol; LDLr; low density lipoprotein receptor; P

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Genetic factors of susceptibility and of severity in primary biliary cirrhosis

Keywords: PBC; primary biliary cirrhosis; CTLA-4; cytotoxic T-lymphocyte antigen 4; TNFα; tumor necrosis factor α; SNP; single nucleotide polymorphism; Ht SNP; haplotype-tagging single nucleotide polymorphism; MDR1; multidrug resistance 1; UDCA; ursodeoxycholic a

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Receptor interactions by polybrominated diphenyl ethers versus polychlorinated biphenyls: A theoretical structure–activity assessment

Keywords: Polybrominated diphenyl ethers; PBDEs; Polychlorinated biphenyls; PCBs; AhR; CAR; PXR; ER; AR; PR; DHT; TH; T3; T4; IGF; PPAR; RyR; GR; GABA; Conformation; Constitution; Binding affinity; Polarizability; Hydrophilicity; Gibbs free solvation energy; Induct

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis

Keywords: Acc-1; acetyl CoA carboxylase 1; DTg; double transgenic; Fae; long-chain free fatty acid elongase; Fas; fatty acid synthase; FFA; free fatty acid; HA; hemagglutinin; LXR; liver X receptor; PCN; pregnenolone-16α-carbonitrile; PPAR; peroxisome proliferator

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2008 سفارش ترجمه

Bile acids and signal transduction: Role in glucose homeostasis

Keywords: CDCA; chenodeoxycholic acid (3α,7α-dihydroxy-5β cholan-24-oic acid); CA; cholic acid (3α,7α,12α-trihydroxy-5β cholan-24-oic acid); DCA; deoxycholic acid (3α,12α-dihydroxy-5β cholan-24-oic acid); LCA; lithocholic acid (3α-monohydroxy-5β cholan-

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2008 سفارش ترجمه

Production and application of a novel energy-tunable X-ray source at the RPI LINAC

Keywords: 41.60.−m; 87.59.−e; 41.75.FrParametric X-rays; PXR; Crystal; Copper; Tungsten; Imaging; LINAC

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2007 سفارش ترجمه

Nuclear receptors and susceptibility to chemical exposure in aquatic organisms

Keywords: Nuclear receptors; Cytochrome P450; Aquatic organisms; Biomarkers; Susceptibility; PXR; PPAR

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Regulation and induction of CYP3A11, CYP3A13 and CYP3A25 in C57BL/6J mouse liver

Keywords: CYP3A11; CYP3A13; CYP3A25; PXR; RXRα; CAR; DEX; Mouse; Expression; Induction

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Constitutive androstane receptor–vitamin D receptor crosstalk: Consequence on CYP24 gene expression

Keywords: CAR; VDR; PXR; Crosstalk; Vitamin D3; CYP24; Osteomalacia

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه