دانلود مقالات ISI درباره Pxr + ترجمه فارسی

Transcription regulation of nuclear receptor PXR: Role of SUMO-1 modification and NDSM in receptor function

Keywords: Nuclear receptor; SUMOylation; PXR; Transcription factor; Xenobiotic metabolism;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Cross-talk between EPAS-1/HIF-2α and PXR signaling pathway regulates multi-drug resistance of stomach cancer cell

Keywords: EPAS-1; Endothelial PAS domain-containing protein 1; PXR; Pregnane X Receptor (PXR); MDR; multi-drugs resistance; CYP3A4; cytochromes P450 3A4; HIF-2α; hypoxia-inducible transcription factors; ARNT; aryl hydrocarbon receptor nuclear translocator; HRE; hy

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2016 سفارش ترجمه

Investigation of the dominant positive effect of porcine farnesoid X receptor (FXR) splice variant 1

Keywords: CAR; constitutive androstane receptor; PXR; pregnane X receptor; FXR; farnesoid X receptor; CYP3A4; cytochrome P450 3A4; SULT2A1; hydroxysteroid sulfotransferase; UGT2B4; UDP-glucuronosyltransferase 2B4; GRβ; glucocorticoid receptor β; ERE; estrogen res

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

In vivo induction of CYP in mice by carbamazepine is independent on PXR

Keywords: CBZ; carbamazepine; CYP; cytochrome P450; PXR; pregnane X receptor; CBZ-E; CBZ 10,11-epoxide; CAR; constitutive androstane receptor; Wt; wild-type; ALT; alanine aminotransferase; AST; aspartate aminotransferase; q-PCR; quantitative real-time PCR; Inductio

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

A food contaminant ochratoxin A suppresses pregnane X receptor (PXR)-mediated CYP3A4 induction in primary cultures of human hepatocytes

Keywords: Ochratoxin A; CYP3A4; PXR; miR-148a;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Research ArticleThyroid-stimulating hormone regulates hepatic bile acid homeostasis via SREBP-2/HNF-4α/CYP7A1 axis

Keywords: BA; bile acid; TSH; thyroid-stimulating hormone; TSHR; thyroid-stimulating hormone receptor; TH; thyroid hormone; TR; thyroid hormone receptor; FXR; farnesoid X receptor; SHP; small heterodimer partner; LRH-1; liver receptor homologue-1; PXR; pregnane X r

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Arylhydrocarbon receptor-dependent mIndy (Slc13a5) induction as possible contributor to benzo[a]pyrene-induced lipid accumulation in hepatocytes

Keywords: AhR; arylhydrocarbon receptor; BaP; benzo[a]pyrene; NAFLD; non-alcoholic fatty liver disease; TCDD; 2,3,7,8-tetrachlorodibenzodioxin; SDS; sodiumdodecyl-sulfate; CAR; constitutive androstane receptor; PXR; pregnane X receptor; ARNT; aryl hydrocarbon recep

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease

Keywords: 3-Hydroxyflavone (PubChem CID: 11349); Galangin (PubChem CID: 5281616); Datiscetin (PubChem CID: 5281610); Kaempferol (PubChem CID: 5280863); Morin (PubChem CID: 5281670); Quercetin dihydrate (PubChem CID: 5284452); Isorhamnetin (PubChem CID: 5281654); Ta

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Tunicate pregnane X receptor (PXR) orthologs: Transcript characterization and natural variation

Keywords: AF-1; transcription activation function 1; AR; androgen receptor; BsVDR/PXRα; Botryllus schlosseri VDR/PXR ortholog α; BSA; bovine serum albumin; bp; base pair; CAR; constitutive androstane receptor; CiVDR/PXRα; Ciona intestinalis VDR/PXR ortholog α;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently

Keywords: CMV; cytomegalovirus; DBD; DNA-binding domain; GAL4; yeast regulatory protein GAL4; hPXR; human PXR; LBD; ligand-binding domain; NR1I2; nuclear receptor subfamily 1 group I member 2, a. k. a pregnane X receptor; pbPXR; polar bear PXR; PXR; pregnane X rece

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Tanshinone IIA exerts protective effects in a LCA-induced cholestatic liver model associated with participation of pregnane X receptor

Keywords: BAs; Bile acids; LCA; lithocholic acid; Tan IIA; Tanshinone IIA; siRNA; Small interfering RNA; RIF; Rifampicin; PCN; pregnenolone 16a-carbonitrile; PXR; pregnane X receptor; CAR; constitutive androstane receptor; VDR; vitamin D receptor; Tanshinone IIA (P

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Environmental pollutants parathion, paraquat and bisphenol A show distinct effects towards nuclear receptors-mediated induction of xenobiotics-metabolizing cytochromes P450 in human hepatocytes

Keywords: Human hepatocytes; CYP3A4; TAT; PXR; AhR

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

A proposed mechanism for the adverse effects of acebutolol: CES2 and CYP2C19-mediated metabolism and antinuclear antibody production

Keywords: AO; aldehyde oxidase; ANA; antinuclear antibody; AADAC; arylacetamide deacetylase; BNPP; bis(4-nitrophenyl)phosphate; CES; carboxylesterase; CYP; cytochrome P450; DTNB; 5,5′-dithiobis(2-nitrobenzoic acid); EDTA; ethylenediamine-N,N,N′N′-tetraacetic

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Memory recuperative potential of rifampicin in aluminum chloride-induced dementia: Role of pregnane X receptors

Keywords: Aβ; amyloid beta; AChE; acetylcholinesterase; AlCl3; aluminum chloride; BBB; blood-brain barrier; DMSO; dimethyl sulfoxide; ELT; escape latency time; GSH; glutathione; H&E; hematoxylin and eosin; MPO; myeloperoxidase; MWM; Morris water maze; P-gp; P-gl

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Utility of an appropriate reporter assay: Heliotrine interferes with GAL4/upstream activation sequence-driven reporter gene systems

Keywords: Firefly luciferase inhibition; Nuclear receptor; Transactivation assay; LBD; ligand-binding domain; DBD; DNA-binding domain; UAS; upstream activating sequence; PXR; pregnane X receptor; mRNA; messenger RNA;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Regulation of pregnane-X-receptor, CYP3A and P-glycoprotein genes in the PCB-resistant killifish (Fundulus heteroclitus) population from New Bedford Harbor

Keywords: AhR; arylhydrocarbon receptor; CAR; constitutive androstane receptor; CYP; cytochrome P450; DMSO; dimethylsulphoxide; DBD; DNA binding domain; LBD; ligand binding domain; NBH; New Bedford Harbor; PCR; polymerase chain reaction; PXR; pregnane-X-receptor; P

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2015 سفارش ترجمه

Telaprevir is a substrate and moderate inhibitor of P-glycoprotein, a strong inductor of ABCG2, but not an activator of PXR in vitro

Keywords: Telaprevir; Drug transporters; CYPs; PXR; Interaction

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Design and synthesis of lactam-thiophene carboxylic acids as potent hepatitis C virus polymerase inhibitors

Keywords: HCV; NS5B polymerase; PXR; CYP induction; Lactam; Thiophene;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Research ArticleCharacterization of a novel PXR isoform with potential dominant-negative properties

Keywords: PXR; Pregnane X Receptor; TSS; transcription start site; DBD; DNA-binding domain; LBD; ligand-binding domain; CGI; CpG island; MSP PCR; Methylation-specific PCR; EMAS; Electrophoretic mobility shift assay; Hepatocyte; Nuclear receptor; Epigenetic regulati

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Effect on metabolic enzymes and thyroid receptors induced by BDE-47 by activation the pregnane X receptor in HepG2, a human hepatoma cell line

Keywords: PXR; pregnane X receptor; hPXR; human pregnane X receptor; PBDE; polybrominated diphenyl ethers; BDE-47; 2,2′,4,4′-tetra-bromodiphenyl ether; CYP3A4; cytochrome P450 3A4; TRs; thyroid receptors; TREs; thyroid hormone response elements; UGTs; uridine d

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Identification and characterization of phosphorylation sites within the pregnane X receptor protein

Keywords: PXR; Drug metabolism; Phosphorylation; Phosphomimetic Mutations.;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Hepatic expression patterns of aryl hydrocarbon receptor, pregnane X receptor, two cytochrome P450s and five phase II metabolism genes responsive to 17alpha-methyltestosterone in rare minnow Gobiocypris rarus

Keywords: AHR; aryl hydrocarbon receptor; PXR; pregnane X receptor; CYP; cytochrome P450; SULT; sulfotransferase; UGT; UDP-glucuronosyltransferases; AHR2; PXR; Cytochrome P450; Sulfotransferase; UDP-glucuronosyltransferases; 17Alpha-methyltestosterone;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Apoptotic and neurotoxic actions of 4-para-nonylphenol are accompanied by activation of retinoid X receptor and impairment of classical estrogen receptor signaling

Keywords: ATP; adenosine triphosphate; AhR; aryl hydrocarbon receptor; CAR; constitutive and rostane receptor; DMSO; dimethyl sulfoxide; DPN; highly potent estrogen receptor β agonist; EDCs; endocrine disrupting chemicals; ER; estrogen receptor; GPR30; G-protein-c

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Thiazide-like diuretic drug metolazone activates human pregnane X receptor to induce cytochrome 3A4 and multidrug-resistance protein 1

Keywords: PXR; Metolazone; Drug metabolism; CYP3A4; MDR1

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Human cytochrome P450 epoxygenases: Variability in expression and role in inflammation-related disorders

Keywords: Inflammation; Cytochrome P450; Epoxygenase; Epoxyeicosatrienoic acids; Variability; AA; arachidonic acid; AhR; aryl hydrocarbon receptor; AP-1; activator protein-1; bZIP; basic leucine zipper; CAR; constitutive androstane receptor; CCRP; cytoplasmic CAR r

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2014 سفارش ترجمه

Pregnane X receptor-mediated transcriptional activation of UDP-glucuronosyltransferase 1A1 by natural constituents from foods and herbs

Keywords: Natural constituents; PXR; Induction; UGT1A1;

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2014 سفارش ترجمه

Med25 is required for estrogen receptor alpha (ERα)-mediated regulation of human CYP2C9 expression

Keywords: CYP; cytochrome P450; Med; Mediator; CAR; constitutive androstane receptor; PXR; pregnane X receptor; GR; glucocorticoid receptor; HNF4α; hepatic nuclear factor 4α; ERα/β; estrogen receptor α/β; E2; 17β-estradiol; RE; responsive element; ERE; estro

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2014 سفارش ترجمه

Expression alterations of cytochromes P4501A1, 2E1, and 3A, and their receptors AhR and PXR caused by 1-octyl-3-methylimidazolium chloride in mouse mammary carcinoma cells

Keywords: Ionic liquids; EMT6; Cytochrome P450; AhR; PXR; Expression;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Liver, Pancreas and Biliary TractHepatitis B virus X protein co-activates pregnane X receptor to induce the cytochrome P450 3A4 enzyme, a potential implication in hepatocarcinogenesis

Keywords: ChIP; chromatin immunoprecipitation; CYP3A4; cytochrome P450 3A4; DMSO; dimethyl sulfoxide; GST; glutathione S-transferase; HBV; hepatitis B virus; HBx; hepatitis B virus X protein; HCC; hepatocellular carcinoma; PCN; pregnenolone 16α carbonitrile; PXR;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR

Keywords: AhR; aryl hydrocarbon receptor; BaP; benzo[a]pyrene; BaPD; (±)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene; BaPDE; (±)-anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; BcP; benzo[c]phenanthrene; BcPD; (±)-trans-3,4-dihydroxy-3,4-dihyd

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Interrelationship between ATP-binding cassette transporters and oxysterols

Keywords: ABC; ATP-binding cassette; apo; apolipoprotein; BCRP; breast cancer resistance protein; CYP; cytochrome P450; EC; epoxycholesterol; ER; endoplasmic reticulum; GS-X; glutathione-conjugate; HDL; high-density lipoprotein; INSIG; insulin-inducible genes; 7-KC

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2013 سفارش ترجمه

Coherent X-ray radiation produced by microbunched beams in amorphous and crystalline radiators

Keywords: X-ray transition radiation; Undulator radiation; Channeling radiation; PXR;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response

Keywords: PXR; Cancer; Drug resistance; Endocrine disruption; Dog

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

A vinblastine fluorescent probe for pregnane X receptor in a time-resolved fluorescence resonance energy transfer assay

Keywords: PXR; Drug metabolism; Xenobiotics; High-throughput screening; BODIPY FL vinblastine; Time-resolved fluorescence resonance energy transfer assay

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Disturbance of Hepatic and Intestinal UDP-glucuronosyltransferase in Rats with Trinitrobenzene Sulfonic Acid-induced Colitis

Keywords: AhR; PPAR; PXR; FXR; nuclear receptors; phase II drug metabolism; UDP-glucuronosyl-transferases; cytokines; inflammation; membrane barriers

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Preparation of archival formalin-fixed paraffin-embedded mouse liver samples for use with the Agilent gene expression microarray platform

Keywords: cDNA; complementary deoxyribonucleic acid; CAR; constitutive androstane receptor; Cy; cyanine; Cyp; cytochrome P450; dT; deoxy-thymine; DEG; differentially expressed gene; FFPE; formalin-fixed paraffin-embedded; FF; fresh-frozen; IPA; Ingenuity Pathway An

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

The human constitutive androstane receptor promotes the differentiation and maturation of hepatic-like cells

Keywords: CAR; PXR; Hepatic differentiation; Lentivirus; siRNA; hESCs; Drug metabolism

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor

Keywords: PXR; Drug metabolism; Molecular docking; Natural product derivative

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Constitutive androstane receptor upregulates Abcb1 and Abcg2 at the blood-brain barrier after CITCO activation

Keywords: ABC-transporter; ATP-binding cassette transporter; BBB; blood-brain barrier; BCRP; breast cancer resistance protein; BMDP; brain multidrug resistance protein; CAR; constitutive androstane receptor; CYP; cytochrome P450; pgCAR; porcine CAR; CITCO; 6-(4-c

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Improvac does not modify the expression and activities of the major drug metabolizing enzymes cytochrome P450 3A and 2C in pigs

Keywords: Immunocastration; Tolbutamide, 7-benzyloxy-4-trifluoromethylcoumarin; 7-benzyloxyquinoline; CAR; PXR

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Farnesoid X Receptor Targeting for Hepatitis C: Study Protocol for a Proof-of-concept Trial

Keywords: clinical trial; farnesoid X receptor; hepatitis C; proof of concept; essai clinique; récepteur nucléaire des acides biliaires; hépatite C; preuve de concept; Afssaps; french Agency for the Safety of Health Products (currently ANSM); BA; bile acid; CBC;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Effects of ready to drink teas on AhR- and PXR-mediated expression of cytochromes P450 CYP1A1 and CYP3A4 in human cancer cell lines and primary human hepatocytes

Keywords: AhR; aryl hydrocarbon receptor; CYP; cytochrome P450; GR; glucocorticoid receptor; HepG2; human Caucasian hepatocellular carcinoma cell line; LS174T; human colon tumour cell line; PXR; pregnane X receptor; RDT; ready to drink tea; RIF; rifampicin; TCDD; 2

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

The suitability of rat hepatoma cell line H4IIE for evaluating the potentials of compounds to induce CYP3A23 expression

Keywords: CYP induction; H4IIE cells; TaqMan RT-PCR; DNA microarray; Cyp3a23/3a1; Pxr; DEX; Cloned cells

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Effects of flavored mineral waters on AhR-CYP1A1 signaling pathway in primary human hepatocytes and in human hepatic and intestinal cancer cells

Keywords: AhR; aryl hydrocarbon receptor; CAR; constitutive androstane receptor; MW; mineral water; PXR; pregnane X receptor; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; Cell lines; Cytochrome P450; Food-drug interaction; Hepatocytes; Mineral waters;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Non-coplanar polychlorinated biphenyls (PCBs) are direct agonists for the human pregnane-X receptor and constitutive androstane receptor, and activate target gene expression in a tissue-specific manner

Keywords: AhR, Aryl hydrocarbon receptor; CAR, constitutive androstane receptor; PCB, polychlorinated biphenyls; PXR, pregnane‐X receptorNuclear receptor; Gene expression; Drug metabolism; PXR; CAR

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Time dependence of the intensity of parametric X-ray radiation produced by relativistic particles passing through crystals

Keywords: X-rays; PXR; Dynamical diffraction; Femtosecond electron bunch; Photonic crystal; Terahertz

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

PXR and NF-κB correlate with the inducing effects of IL-1β and TNF-α on ABCG2 expression in breast cancer cell lines

Keywords: Proinflammatory cytokines; Multidrug resistance; ABCG2; PXR; NF-κB;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system

Keywords: ACN; acetonitrile; AhR; aryl hydrocarbon receptor; CAR; constitutive androstane receptor; CITCO; 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichloro-benzyl)oxime; CYP; cytochrome P450; DMSO; dimethyl sulfoxide; GAPDH; glyseraldehy

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Research ArticleEffect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health

Keywords: UDCA; ursodeoxycholic acid; PBC; primary biliary cirrhosis; ASBT; apical sodium-dependent bile acid transporter; FXR; farnesoid X receptor; PXR; pregnane X receptor; VDR; vitamin D receptor; CA; cholic acid; CDCA; chenodeoxycholic acid; DCA; deoxycholic a

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Dancing with the sterols: Critical roles for ABCG1, ABCA1, miRNAs, and nuclear and cell surface receptors in controlling cellular sterol homeostasis

Keywords: ABC; ATP Binding Cassette; AICAR; Aminoimidazole Carboxamide Ribonucleotide; ApoE; Apolipoprotein E; ApoER2; ApoE receptor 2 (LRP8); AR; Androgen Receptor; BAC; Bacterial Artificial Chromosome; CETP; Cholesterol Ester Transfer Protein; eNOS; endothelial N

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه