Effects of ready to drink teas on AhR- and PXR-mediated expression of cytochromes P450 CYP1A1 and CYP3A4 in human cancer cell lines and primary human hepatocytes

► Dietary xenobiotics may interfere with drug metabolism in humans. ► Food-drug interactions include the induction of cytochromes P450 via xenoreceptors. ► We examined activation of PXR/AhR, and induction of P450 by ready to drink teas. ► Human hepatocytes and cell lines HepG2 and LS174T were used as in vitro models. ► Three teas induced CYP3A4 and several teas elevated CYP1A1 or activated AhR.