Poly(ADP-ribose) polymerase-1 is involved in the neuronal death induced by quinolinic acid in rats
Keywords: اسید کینولینیک; PJ-34; Quinolinic acid; Poly(ADP-ribose) polymerase
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Adenosine A2A receptor blockade before striatal excitotoxic lesions prevents long term behavioural disturbances in the quinolinic rat model of Huntington's disease
Keywords: اسید کینولینیک; Adenosine receptor; Quinolinic acid; Huntington's disease; Open-field; Plus-maze; Striatum; Excitotoxicity;
Cognitive neuroscienceOrbitofrontal cortex lesions disrupt risk assessment in a novel serial decision-making task for rats
Keywords: اسید کینولینیک; uncertainty; gambling; reward; persistence; quinolinic acid; OFC; orbitofrontal cortex/cortical; PBS; phosphate buffer saline;
Mechanisms by which acyclovir reduces the oxidative neurotoxicity and biosynthesis of quinolinic acid
Keywords: اسید کینولینیک; Acyclovir; 3-Hydroxyanthranilate-3,4-oxygenase; Indoleamine-2,3-dioxygenase; Iron; Lipid peroxidation; Neuroprotection; Quinolinic acid; Superoxide anion
Clinical aspects of indoleamine 2,3-dioxygenase (IDO)-initiated tryptophan metabolism: IDO is a target of drug discovery for various diseases
Keywords: اسید کینولینیک; IDO; Immunosuppression; Quinolinic acid; Alzheimer's disease; Age-related cataract
Phthalate esters enhance quinolinate production by inhibiting amino-carboxymuconate-semialdehyde decarboxylase (ACMSD), a key enzyme of the tryptophan-niacin pathway
Keywords: اسید کینولینیک; Quinolinic acid; ACMSD; Phthalic acid esters; QPRT; Tryptophan; Niacin
Chronic HIV infection leads to an Alzheimer's disease like illness. Involvement of the kynurenine pathway
Keywords: اسید کینولینیک; Kynurenine pathway; Neurodegeneration; Neuroinflammation; Quinolinic acid; Human brain cell; HIV;
In vitro effect of quinolinic acid on energy metabolism in brain of young rats
Keywords: اسید کینولینیک; Energy metabolism; Quinolinic acid; Respiratory chain; Citric acid cycle; Cerebral cortex;
Functions, dysfunctions and possible therapeutic relevance of adenosine A2A receptors in Huntington's disease
Keywords: اسید کینولینیک; A2AR(s); adenosine A2A receptor(s); BDNF; brain-derived neurotrophic factor; CNS; central nervous system; DMPX; 3,7-dimethyl-1-propargylxanthine; HD; Huntington's disease; KO; knock-out; 3NP; 3-nitropropionic acid; PLC; phospholipase C; PND; postnatal day
N-Methyl-d-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease
Keywords: اسید کینولینیک; 3-NP; 3-nitropropionic acid; ADP; adenosine 5â²-diphosphate; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid; AMPAR; AMPA receptor; AP-2; adaptor protein-2; ATP; adenosine 5â²-triphosphate; cAMP; cyclic adenosine 5â²-monophosphate; CNS; ce
Time course of oxidative events in the hippocampus following intracerebroventricular infusion of quinolinic acid in mice
Keywords: اسید کینولینیک; Quinolinic acid; Neurotoxicity; Oxidative stress; ROS formation; Antioxidant response; Cellular damage;
Quercitrin, a glycoside form of quercetin, prevents lipid peroxidation in vitro
Keywords: اسید کینولینیک; Quercitrin; Oxidative stress; Quinolinic acid; TBARS; Deoxyribose degradation; Flavonoids; Sodium nitroprusside; Fenton reaction;
Kynurenic acid attenuates NMDA-induced pial arteriolar dilation in newborn pigs
Keywords: اسید کینولینیک; Global cerebral ischemia; Hypercapnia; Kainate; Quinolinic acid; Cranial window
The cannabinoid receptor agonist WIN 55,212-2 attenuates the effects induced by quinolinic acid in the rat striatum
Keywords: اسید کینولینیک; Cannabinoids; WIN 55,212-2; Quinolinic acid; Excitotoxicity; Striatum
Neural progenitor implantation restores metabolic deficits in the brain following striatal quinolinic acid lesion
Keywords: اسید کینولینیک; Neural stem cell; Neural progenitor; Excitotoxic lesion; Quinolinic acid; Fluordeoxyglucose; Positron emission tomography; Glucose metabolism; Neurosphere; Transplantation; Rotational behavior
Combined minocycline plus pyruvate treatment enhances effects of each agent to inhibit inflammation, oxidative damage, and neuronal loss in an excitotoxic animal model of Huntington’s disease
Keywords: اسید کینولینیک; minocycline; pyruvate; quinolinic acid; oxidative stress; microglia; Huntington’s diseaseAP, anteroposterior; COX-2, cyclooxygenase-2; GFAP, glial fibrillary acidic protein; HD, Huntington’s disease; HEt, hydroethidine; IL-1β, interleukin-1β; IL-6, interl
Quinolinic acid reduces the antioxidant defenses in cerebral cortex of young rats
Keywords: اسید کینولینیک; Oxidative stress; Quinolinic acid; Antioxidant defenses; Lipid peroxidation;
Intravenous administration of human neural stem cells induces functional recovery in Huntington's disease rat model
Keywords: اسید کینولینیک; Huntington's disease; Neural stem cell; Quinolinic acid; ERV-3;
De novo and salvage biosynthetic pathways of pyridine nucleotides and nicotinic acid conjugates in cultured plant cells
Keywords: اسید کینولینیک; SAM; S-adenosyl-l-methionine; Nicotinamide; Nicotinic acid; Nicotinic acid glucoside; Quinolinic acid; Trigonelline;
Biochemical and medical aspects of the indoleamine 2,3-dioxygenase-initiated l-tryptophan metabolism
Keywords: اسید کینولینیک; Heme-containing dioxygenase; Tryptophan; Interferon-γ; Immunosuppression; Dendritic cells; Quinolinic acid; Alzheimer's disease; Age-related cataract; Kynurenilation; Neurotoxin; Metabolism; Indoleamine dioxygenase;
The effect of orbital prefrontal cortex lesions on performance on a progressive ratio schedule: implications for models of inter-temporal choice
Keywords: اسید کینولینیک; Orbital prefrontal cortex; Lesion; Quinolinic acid; Progressive ratio schedule; Reinforcer efficacy; Inter-temporal choice; Rat;
Gestational and postnatal malnutrition affects sensitivity of young rats to picrotoxin and quinolinic acid and uptake of GABA by cortical and hippocampal slices
Keywords: اسید کینولینیک; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate; GAD; Glutamate descarboxilase; GAT; GABA transporter; mIPSCs; Miniature inhibitory postsynaptic currents; NMDA; N-methyl-d-aspartate; PCT; Picrotoxin; QA; Quinolinic acid; Development and regenerati
Identification of kynurenine pathway enzyme mRNAs and metabolites in human placenta: Up-regulation by inflammatory stimuli and with clinical infection
Keywords: اسید کینولینیک; Intrauterine infection; Placenta; Kynurenine; Quinolinic acid;
Deprenyl enhances the striatal neuronal damage produced by quinolinic acid
Keywords: اسید کینولینیک; Disorders of the nervous system; Neurotoxicity; Quinolinic acid; Huntington's disease; Deprenyl; Dopamine; Neurodegeneration;
Quantitative analysis of the generation of different striatal neuronal subtypes in the adult brain following excitotoxic injury
Keywords: اسید کینولینیک; ANOVA; analysis of variance; BDNF; brain-derived neurotrophic factor; BrdU; 5-bromo-2â²-deoxyuridine; ChAT; choline acetyltransferase; DARPP-32; dopamine- and adenosine 3â²:5â²-monophosphate-regulated phosphoprotein with a molecular weight of 32 kDa; D
Excitotoxic brain damage involves early peroxynitrite formation in a model of Huntington's disease in rats: Protective role of iron porphyrinate 5,10,15,20-tetrakis (4-sulfonatophenyl)porphyrinate iron (III)
Keywords: اسید کینولینیک; excitotoxic damage; peroxynitrite; oxidative/nitrosative stress; NMDA receptor; iron porphyrinate; neuroprotection; ANOVA; analysis of variance; APM; apomorphine; Fe(TPPS); 5,10,15,20-tetrakis (4-sulfonatophenyl)porphyrinate iron (III); F.U.; fluorescent
Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum
Keywords: اسید کینولینیک; PK11195; Peripheral benzodiazepine receptors; Neuroprotection; Quinolinic acid; Microglia; Inflammation; Oxidative damage;
Minocycline in phenotypic models of Huntington's disease
Keywords: اسید کینولینیک; Huntington's disease; 3-Nitropropionic acid; Quinolinic acid; Minocycline; Striatum; Cell death;
HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations
Keywords: اسید کینولینیک; Disorders of the nervous system; Infectious diseases; HIV; human immunodeficiency virus; HIVD; human immunodeficiency virus-dementia; AD; Alzheimer's disease; CSF; cerebrospinal fluid; ROS; reactive oxygen species; HNE; 4-hydroxy-2-nonenal; GSH; glutathio
Divergent regulatory mechanisms governing BDNF mRNA expression in cerebral cortex and substantia nigra in response to striatal target ablation
Keywords: اسید کینولینیک; Neurotrophins; Striatum; Subthalamic nucleus; Quinolinic acid; Nigrostriatal system; Corticostriatal system; Neuronal activity; DCG-IV;
Cytokines and major depression
Keywords: اسید کینولینیک; ACh; acetylcholine; ACTH; adrenocorticotropic hormone; ANS; autonomous nervous system; APP; acute-phase protein; BBB; blood-brain barrier; CAA; competing amino acid; CMS; chronic mild stress; CNS; central nervous system; CRH; corticotropin-releasing hor