Keywords: کلیه; Baclofen; drug toxicity; decreased kidney function; end-stage kidney disease (ESKD); hemodialysis; pharmacokinetics; renal clearance; muscle relaxant; drug dosing; creatinine clearance;
مقالات ISI کلیه (ترجمه نشده)
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Keywords: کلیه; Molecule probe; NIR II bioimaging; Renal clearance; Tiny tumor diagnosis; X-ray bioimaging;
Keywords: کلیه; Cystic fibrosis; Population pharmacokinetics; Metabolite formation; Renal clearance; Nonrenal clearance; Allometric scaling; Parametric and nonparametric bootstrap;
Keywords: کلیه; ADAM; advanced dissolution, absorption, and metabolism; AED; antiepileptic drug; AUC; area-under-the-curve; B/P; blood to plasma ratio; BID; twice daily; BMI; body mass index; CBZ; carbamazepine; CLint; intrinsic clearance; CLR; renal clearance; CL; clear
Keywords: کلیه; Renal clearance; Enoxaparin; Critically ill; ICU;
Keywords: کلیه; organic cation transporters (OCTs); renal clearance; hepatic transport; hepatocytes; elderly; AUC; area under the curve; CKD; chronic kidney disease; CVD; cardiovascular disease; FMO3; flavin-containing monooxigenase 3; HEK; human embryonic kidney; HK; h
Keywords: کلیه; valproic acid; carnitine; renal clearance; β-oxidation; pharmacokinetics; metabolism; metabolite kinetics; renal excretion; drug interaction; glucuronide;
Keywords: کلیه; ABC; ATP-binding cassette; ATP; adenosine triphosphate; AUC; area under the plasma concentration curve; BBB; blood-brain barrier; Cmax; maximum plasma concentration; CHO; Chinese hamster ovary; CL; plasma clearance; CLR; renal clearance; DDIs; drug-dr
Keywords: کلیه; AUClast; area under the plasma concentration-versus-time curve from time 0 until the last detectable concentration; BMI; body mass index; BW; body weight; CAD; collision-activated dissociation; CE; collision energy; DP; declustering potential; EP; entranc
Dabigatran Reversal in a Patient With End-Stage Liver Disease and Acute Kidney Injury
Keywords: کلیه; Dabigatran; end-stage liver disease (ESLD); acute kidney injury (AKI); thrombin inhibitor; oral anticoagulant; renal clearance; hemorrhage; bleeding; dose adjustment; drug safety; decreased kidney function; idarucizumab;
Toxicokinetics of the neonicotinoid insecticide imidacloprid in rainbow trout (Oncorhynchus mykiss)
Keywords: کلیه; Imidacloprid; Neonicotinoids; Rainbow trout; Fish; Toxicokinetics; Renal clearance; Biotransformation; Bioaccumulation;
Synthesis and characterization of small-sized gold nanoparticles coated by bovine serum albumin (BSA) for cancer photothermal therapy
Keywords: کلیه; Small-sized gold nanoparticles; Photothermal therapy (PPT); BSA; Renal clearance; Cytotoxicity;
Nanotechnological foundations of a “new” Nephrology
Keywords: کلیه; Nanotechnology; Nanomedicine; Nephrology; Renal clearance; Renal nanodiagnostics; Renal nanodrugs; Renal replacement nanotechnologies; Renal tissue nanoregeneration; NanotecnologÃa; Nanomedicina; NefrologÃa; Aclaramiento renal; Nanodiagnósticos renales
Bases nanotecnológicas de una «nueva» NefrologÃa
Keywords: کلیه; NanotecnologÃa; Nanomedicina; NefrologÃa; Aclaramiento renal; Nanodiagnósticos renales; Nanofármacos renales; NanotecnologÃas de reemplazo renal; Nanorregeneración de tejido renal; Nanotechnology; Nanomedicine; Nephrology; Renal clearance; Renal nan
Evaluation of Renal Transporter Inhibition Using Creatinine as a Substrate In Vitro to Assess the Clinical Risk of Elevated Serum Creatinine
Keywords: کلیه; renal transporter; drug interactions; in vitro-in vivo correlation; renal clearance; inhibition; AUC; area under the concentration curve; CLcr; creatinine renal clearance; Cmax; maximal total plasma concentration; Cmax,u; maximal unbound plasma concen
Quantitative Analyses of the Influence of Parameters Governing Rate-Determining Process of Hepatic Elimination of Drugs on the Magnitudes of Drug-Drug Interactions via Hepatic OATPs and CYP3A Using Physiologically Based Pharmacokinetic Models
Keywords: کلیه; cytochrome P450; drug interaction; hepatic clearance; mathematical model; organic anion-transporting polypeptide transporters; pharmacokinetics; AUC; area under the plasma concentration-time curve; CL; clearance; CLint,all; overall hepatic intrinsic cle
Determinants of Intestinal Availability for P-glycoprotein Substrate Drugs Estimated by Extensive Simulation With Mathematical Absorption Models
Keywords: کلیه; drug-drug interaction; P-glycoprotein; physiologically based pharmacokinetic model; modeling and simulation; intestinal absorption; substrate drug; CLh; hepatic clearance; CLr; renal clearance; CYP3A; cytochrome P450 3A; DDI; drug-drug interaction; EQ
Discordance Between Iothalamate and Iohexol Urinary Clearances
Keywords: کلیه; Glomerular filtration rate (GFR); measured GFR (mGFR); iothalamate; iohexol; exogenous filtration marker; renal clearance; kidney function; liquid chromatography tandem mass spectrometry (LC-MS/MS); urine; plasma;
Detection of ECG effects of (2R,4R)-monatin, a sweet flavored isomer of a component first identified in the root bark of the Sclerochitin ilicifolius plant
Keywords: کلیه; (2R,4R)-Monatin; QT prolongation; QTc; TQT study; Food ingredient; ADME; absorption, distribution, metabolism, and elimination; AE; adverse event; Ae; amounts excreted; AUC0-inf; area under the plasma concentration-time curve to infinite time; AUC0-t; a
A porphyrin-PEG polymer with rapid renal clearance
Keywords: کلیه; Porphyrin; Polyamide; Fluorescence imaging; Positron emission tomography; Renal clearance; Acute renal failure;
Pre-clinical toxicity evaluation of MB-102, a novel fluorescent tracer agent for real-time measurement of glomerular filtration rate
Keywords: کلیه; GFR; Renal function; Pyrazine; Fluorescence; Optical monitoring; Renal clearance; Single-dose toxicity; Preclinical evaluation;
Regular ArticleThe kidneys play an important role in the clearance of rFVIIa in rats
Keywords: کلیه; AT; anti-thrombin; BSA; bovine serum albumin; C0; concentration at time 0 after iv administration; CL; clearance; CLNR; non-renal clearance; CLR; renal clearance; CMax; maximum concentration measured; EDTA; Ethylenediaminetetraacetic acid; ELISA; enzyme-l
In Vitro-In Vivo Extrapolation Method to Predict Human Renal Clearance of Drugs
Keywords: کلیه; in vitro-in vivo correlations (IVIVC); renal clearance; renal reabsorption; permeability; drug transport; in vitro models; membrane transport; pharmacokinetics; LLC-PK1 cell line; clearance prediction;
Inhibitory effects of p-aminohippurate and probenecid on the renal clearance of adefovir and benzylpenicillin as probe drugs for organic anion transporter (OAT) 1 and OAT3 in humans
Keywords: کلیه; Organic anion transporter (OAT); Probe drug; Renal clearance; Adefovir; Benzylpenicillin
Prediction of Clinical Drug-Drug Interactions of Veliparib (ABT-888) with Human Renal Transporters (OAT1, OAT3, OCT2, MATE1, and MATE2K)
Keywords: کلیه; drug transport; drug interaction; membrane transporters; organic anion transporters; organic cation transporters; renal clearance; renal transport; veliparib;
Reduced Renal Clearance of Cefotaxime in Asians with a Low-Frequency Polymorphism of OAT3 (SLC22A8)
Keywords: کلیه; organic anion transporter; cefotaxime; tubular secretion; OAT3; polymorphisms; pharmacogenomic; pharmacokinetics; renal clearance
Precise comparison of protein localization among OCT, OAT, and MATE in human kidney
Keywords: کلیه; active transport; renal excretion; membrane transporter; drug transport; organic anion transporter; organic cation transporter; elimination; renal clearance; multidrug and toxin extrusion
Relationship Between the Urinary Excretion Mechanisms of Drugs and Their Physicochemical Properties
Keywords: کلیه; renal clearance; renal transport; renal reabsorption; transporters; physicochemical
A Pharmacokinetic Standard for Babies and Adults
Keywords: کلیه; clinical pharmacokinetics; clearance; renal clearance; glomerular filtration; pediatric; allometric scaling; maturation; premature babies; adults; standard
The role of the kidney in the systemic elimination of interleukin 6, platelet-derived growth factor and transforming growth factor beta
Keywords: کلیه; Cytokines; Growth factors; Renal clearance; Elimination ratio;
Bayesian estimation of pharmacokinetic parameters of vancomycin in patients with decreasing renal function
Keywords: کلیه; therapeutic drug monitoring; dosage adjustment; Bayesian estimation; mutable covariates model; disease state; clinical pharmacokinetics; renal clearance; renal failure; mathematical modeling; vancomycin;
In vivo renal clearance, biodistribution, toxicity of gold nanoclusters
Keywords: کلیه; Gold nanoclusters; Renal clearance; Biodistribution; In vivo toxicity
Part 2: Design, synthesis and evaluation of hydroxyproline-derived α2δ ligands
Keywords: کلیه; Gabapentin; α2δ; Renal clearance; Glomerular filtration
Multifunctional and degradable zwitterionic nanogels for targeted delivery, enhanced MR imaging, reduction-sensitive drug release, and renal clearance
Keywords: کلیه; Zwitterionic; Degradable; Reduction-sensitive; Renal clearance; Targeting; MRI (magnetic resonance imaging)
Lamotrigine and its N2-glucuronide during pregnancy: The significance of renal clearance and estradiol
Keywords: کلیه; Lamotrigine; Pregnancy; Glucuronide; UGT1A4; Renal clearance; Estradiol
Investigation into modification of mass transfer kinetics by acrolein in a renal biochip
Keywords: کلیه; Bioartificial kidney; PDMS; Blood-tissue barrier model; Drug permeability; Ifosfamide; Acrolein toxicity; Renal clearance
Validation of 96-well Equilibrium Dialysis with Non-radiolabeled Drug for Definitive Measurement of Protein Binding and Application to Clinical Development of Highly-Bound Drugs
Keywords: کلیه; protein binding; drug interactions; renal clearance; hepatic clearance;
Toward an integrated human clearance prediction strategy that minimizes animal use
Keywords: کلیه; clearance; cytochrome P450; clinical pharmacokinetics; In vitro/in vivo correlations (IVIVC); renal clearance;
Glomerular filtration rate is increased in burn patients
Keywords: کلیه; Burns; Iohexol clearance; Kidney function; Glomerular filtration rate; Organ dysfunction; Renal clearance; Resuscitation
Therapeutic implications of renal anionic drug transporters
Keywords: کلیه; Renal clearance; Drug transporters; Drug interactions; Transporter polymorphism; Nephrotoxicity; Renal failureABC, ATP-binding cassette; BCRP, breast cancer resistance protein; CMPF, 3-carboxy-4-methyl-5-propyl-2-furanpropionate; CsA, cyclosporine A; DHEA
Changes in renal clearance and renal tubular function in albino mice under the influence of Dichlorvos
Keywords: کلیه; Renal clearance; Renal tubular function; Dichlorvos; Organophosphate; Kidney; Albino mice;
Dosimetry considerations in the enhanced sensitivity of male Wistar rats to chronic ethylene glycol-induced nephrotoxicity
Keywords: کلیه; Ethylene glycol; Oxalic acid; Renal clearance; Chronic toxicity; Nephrotoxicity;
The Pharmacology of PEGylation: Balancing PD with PK to Generate Novel Therapeutics
Keywords: کلیه; biotechnology; conjugation; drug delivery; macromolecular drug delivery; PEGylation; pharmacokinetics/pharmacodynamics; renal clearance;
Renal clearance parameters for PBPK model analysis of early lifestage differences in the disposition of environmental toxicants
Keywords: کلیه; Renal clearance; PBPK models; Glomerular filtration rate; Tubular secretion; Tubular reabsorption; Toxicokinetics; Pharmacokinetics; Early life stage; Infants/neonates susceptibility; Risk assessment
P-glycoprotein and cytochrome P450 3A4 involvement in risperidone transport using an in vitro Caco-2/TC7 model and an in vivo model
Keywords: کلیه; ab; apical to basolateral; AQ; absorptive quotient; AUCT; area under the curve; ba; basolateral to apical; ClR; renal clearance; Cmax; maximum plasma concentration; CYP; cytochrome P450; ER; efflux ratio; F; fraction not metabolised; FA; fraction absorbed
Thiol exchange: An in vitro assay that predicts the efficacy of novel homocysteine lowering therapies
Keywords: کلیه; homocysteine; atherosclerosis; thiol exchange; HPLC; protein binding; renal clearance; clinical pharmacokinetics; dose response;
Prediction of human drug clearance from animal data: Application of the rule of exponents and 'fu corrected intercept method' (FCIM)
Keywords: کلیه; allometric scaling; preclinical pharmacokinetics; clearance; protein binding; biliary excretion; renal clearance; vertical allometry;
Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin
Keywords: کلیه; cyclodextrins; distribution; pharmacokinetics; renal clearance; complexation;
Renal clearance of perfluorooctane sulfonate and perfluorooctanoate in humans and their species-specific excretion
Keywords: کلیه; Perfluorooctane sulfonate; Perfluorooctanoate; Serum; Urine; Renal clearance;
UDP-glucuronosyltransferases and clinical drug-drug interactions
Keywords: کلیه; UDP-glucuronosyltransferase; UGT1A; UGT2A; UGT2B; Glucuronidation; Drug interaction; Aet-ss; the amount of total drug excreted in urine during one dosage interval; AUCi; area under the plasma concentration-time curve in the presence of an inhibitor; AUC;