کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485301 | 1114351 | 2011 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Toward an integrated human clearance prediction strategy that minimizes animal use
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
Prediction of human clearance plays a critical role in early drug discovery and development. However, there is no consensus on the most appropriate method to gather such data. A variety of in vivo and in vitro methods exist and a comparison of in vitro data from a standard set of compounds has been called for. This paper compares the predictive capacity of human liver microsomes and singleâspecies scaling (SSS) from rat and nonâhuman primate for a standard set of compounds representing marketed drugs. The results enable a framework to be proposed wherein compounds are selected using in vitro methods alone or in vitro methods combined with SSS in the rat. Further investigation of this framework has the potential to increase the efficiency of drug discovery and reduce animal use. © 2011 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 100:4518-4535, 2011
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 10, October 2011, Pages 4518-4535
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 10, October 2011, Pages 4518-4535
نویسندگان
Kevin Beaumont, Iain Gardner, Kathryn Chapman, Michael Hall, Malcolm Rowland,