Keywords: تنش تکراری; Hematopoietic stem cells; Genome integrity; Replication stress; Blood system; Aging; Transformation;
مقالات ISI تنش تکراری (ترجمه نشده)
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Keywords: تنش تکراری; human pluripotent stem cells; aneuploidy; replication stress; condensation perturbations; chromosomal aberrations; genomic instability; SRF
Keywords: تنش تکراری; Cdc6; Cdt1; Replication licensing factors; Replication stress; CancerRS, replication stress; DDR, DNA damage response; RLM, replication licensing machinery; pre-RC, pre-replication complex; CDK, cyclin-dependent kinase; ORC, origin recognition complex; Cd
Keywords: تنش تکراری; 3-AP; 3-aminopyridine-2-carboxaldehyde thiosemicarbazone; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related protein; AMP/ADP/ATP; adenosine mono-, di-, and tri-phosphate; BLM; Bloom syndrome RecQ helicase-like; BRAF; V-raf mu
Keywords: تنش تکراری; DNA damage; Replication stress; DNA translesion synthesis; Rev1; Rev3; Rev7; mutagenesis; Genome stability; Mouse models;
Keywords: تنش تکراری; Replication Stress; ATR; CHK1; Cancer;
Keywords: تنش تکراری; Replication stress; Cancer; Senescence; Genome instability; Catastrophic mitosis;
Keywords: تنش تکراری; Cellular reprogramming; Genomic instability; iPSCs; DNA damage and repair; Replication stress
DNA replication stress drives fragile site instability
Keywords: تنش تکراری; Replication stress; Common fragile sites; Chromosomal instability;
Collaboration in the actions of Brh2 with resolving functions during DNA repair and replication stress in Ustilago maydis
Keywords: تنش تکراری; HR; homologous recombination; HU; hydroxyurea; MMS; methyl methanesulfonate; UV; ultraviolet light; BRCA2; Blm; Mus81; Gen1; DNA repair; Replication stress;
Role of specialized DNA polymerases in the limitation of replicative stress and DNA damage transmission
Keywords: تنش تکراری; Replication stress; Specialized DNA polymerases; DNA damage transmission; Non-B DNA; Repetitive sequences; Common fragile sites;
NASP antagonize chromatin accessibility through maintaining histone H3K9me1 in hepatocellular carcinoma
Keywords: تنش تکراری; NASP; Liver cancer; Replication stress; Transcription; H3K9me1;
Mutant analysis of Cdt1's function in suppressing nascent strand elongation during DNA replication in Xenopus egg extracts
Keywords: تنش تکراری; DNA replication; Cdt1; Replication stress; Genome instability; Xenopus egg extracts;
Distinct functions of human RecQ helicases during DNA replication
Keywords: تنش تکراری; DNA replication; Replication stress; RecQ helicases; Genomic instability; Cancer;
ReviewTargeted inhibition of WRN helicase, replication stress and cancer
Keywords: تنش تکراری; WRN helicase; RNase P; EGS; Selective cancer therapy; Replication stress; DNA repair;
hSSB1 phosphorylation is dynamically regulated by DNA-PK and PPP-family protein phosphatases
Keywords: تنش تکراری; hSSB1; DNA-PK; PPP-family phosphatase; Replication fork; Replication stress;
MDM2 Antagonists Counteract Drug-Induced DNA Damage
Keywords: تنش تکراری; DNA damage; Replication stress; Mitotic inhibitor; MDM2 antagonist; Melanoma; Polyploidy; p21; p53;
DNA damage tolerance by recombination: Molecular pathways and DNA structures
Keywords: تنش تکراری; DDT; DNA damage tolerance; DDR; DNA damage response; ss; single stranded; DSBs; Double strand breaks; TLS; Translesion Synthesis; PRR; Postreplication repair; HR; Homologous recombination; PCNA; proliferating cell nuclear antigen; SLDs; SUMO-like domains;
Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities
Keywords: تنش تکراری; ATR; CHK1; synthetic lethality; cancer; DNA damage; replication stress
Original ArticleInhibition of ATR-dependent feedback activation of Chk1 sensitises cancer cells to Chk1 inhibitor monotherapy
Keywords: تنش تکراری; Chk1; ATR; ATM; DNA-PK; Kinase inhibitor; Replication stress;
ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA
Keywords: تنش تکراری; sirtuin; metabolism; SIRT2; ATR; ATRIP; replication stress; DNA replication; DNA damage response; DNA repair; acetylome; cell cycle; checkpoint
Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis
Keywords: تنش تکراری; POT1; telomere; ATR; replication stress; thymic lymphoma; cutaneous T cell lymphoma
Human CST Facilitates Genome-wide RAD51 Recruitment to GC-Rich Repetitive Sequences in Response to Replication Stress
Keywords: تنش تکراری; CTC1/STN1/TEN1; replication stress; RAD51; genome stability
A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN
Keywords: تنش تکراری; replication stress; phosphoproteomics; gene regulation; ATM; ATMIN; γH2AX; CRMP2
G-quadruplex ligand-induced DNA damage response coupled with telomere dysfunction and replication stress in glioma stem cells
Keywords: تنش تکراری; DNA damage response; Glioma stem cells; G-quadruplex; Replication stress; Telomere;
The Mechanism by Which MYCN Amplification Confers an Enhanced Sensitivity to a PCNA-Derived Cell Permeable Peptide in Neuroblastoma Cells
Keywords: تنش تکراری; Proliferating Cell Nuclear Antigen (PCNA); MYC; MYCN; Replication stress; Neuroblastoma; DNA damage response; Chk1
Nucleotide Pool Depletion Induces G-Quadruplex-Dependent Perturbation of Gene Expression
Keywords: تنش تکراری; G quadruplexes; replication stress; epigenetic instability; transcriptional memory
Myc and Ras oncogenes engage different energy metabolism programs and evoke distinct patterns of oxidative and DNA replication stress
Keywords: تنش تکراری; Myc; Ras; Replication stress; DNA fork progression; Energy metabolism; DNA damage response; DDR; DNA damage response; ROS; reactive oxygen species; CIN; chromosome instability; RS; replication stress; FBS; fetal bovine serum; 4-OHT; 4-hydroxytamoxifen; Do
A whole genome RNAi screen identifies replication stress response genes
Keywords: تنش تکراری; Replication stress; ATR; Checkpoint; RNAi screen; DNA damage; Hydroxyurea; Gemcitabine; Camptothecin; PARP inhibitor;
Oxidative stress preferentially induces a subtype of micronuclei and mediates the genomic instability caused by p53 dysfunction
Keywords: تنش تکراری; ROS; reactive oxygen species; H2O2; hydrogen peroxide; NAC; N-acetylcysteine; MN; micronuclei; DSBs; double-strand breaks; MSF; primary mouse skin fibroblasts; Micronuclei; Genomic instability; p53; Oxidative stress; Replication stress;
ATMIN is required for the ATM-mediated signaling and recruitment of 53BP1 to DNA damage sites upon replication stress
Keywords: تنش تکراری; Replication stress; 53BP1; ATM; ATMIN; MEFs; mouse embryonic fibroblasts; Aph; aphidicolin; IR; ionizing radiation; Gy; Gray; MMS; methyl methanesulfonate; HU; hydroxyurea; NCS; neocarzinostatin; DAPI; diamidino-2-phenylindole; HR; homologous recombinatio
Targeting ATR in DNA damage response and cancer therapeutics
Keywords: تنش تکراری; ATR; Cancer; Replication stress; DNA damage; Radiation; Chemotherapy; Therapeutics;
DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe
Keywords: تنش تکراری; DNA repair; Replication stress; Checkpoint regulation; Homologous recombination
DNA replication stress: Causes, resolution and disease
Keywords: تنش تکراری; pre-RC; pre-replicative complex; CFS; common fragile site; DSB; DNA double strand break; CMG complex; Cdc45.Mcm2-7.GINS; ERFS; early-replicating fragile site; DDR; DNA damage response; ssDNA; single-stranded DNA; IR; ionizing radiation; HGPS; Hutchinson
Differential binding kinetics of replication protein A during replication and the pre- and post-incision steps of nucleotide excision repair
Keywords: تنش تکراری; ssDNA; single stranded DNA; DDR; DNA damage response; NER; nucleotide excision repair; UV; ultraviolet light; CPDs; cyclobutane pyrimidine dimers; 6-4PPs; 6-4 photoproducts; LUD; local UV-induced DNA damage; FRAP; fluorescence recovery after photobleachin
Swi2/Snf2-like protein Uls1 functions in the Sgs1-dependent pathway of maintenance of rDNA stability and alleviation of replication stress
Keywords: تنش تکراری; Replication stress; STUbL; Helicase; Endonuclease; rDNA
Implication of RPA32 phosphorylation in S-phase checkpoint signalling at replication forks stalled with aphidicolin in Xenopus egg extracts
Keywords: تنش تکراری; ATR; Replication stress; Chk1; Replication protein A;
Aberrant expression of alternative DNA polymerases: A source of mutator phenotype as well as replicative stress in cancer
Keywords: تنش تکراری; Mutator phenotype; Replication stress; Alternative DNA polymerases; Genetic instability
Inhibition of topoisomerase I prevents chromosome breakage at common fragile sites
Keywords: تنش تکراری; Common fragile sites; Topoisomerase I; Camptothecin; Replication stress
Fanconi anemia proteins and endogenous stresses
Keywords: تنش تکراری; DNA interstrand crosslinks; Endogenous stress; Oxidative stress; Lipid peroxidation; Critically short telomeres; Replication stress
Roles of the Werner syndrome RecQ helicase in DNA replication
Keywords: تنش تکراری; Werner syndrome; RecQ helicase; Human cell culture; Replication stress; Damage tolerance
Common fragile sites as targets for chromosome rearrangements
Keywords: تنش تکراری; Common fragile site; Replication stress; Translocations; Cancer
The molecular basis of common and rare fragile sites
Keywords: تنش تکراری; Rare fragile sites; Common fragile sites; Genomic instability; Replication stress