کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1981045 1061897 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Roles of the Werner syndrome RecQ helicase in DNA replication
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Roles of the Werner syndrome RecQ helicase in DNA replication
چکیده انگلیسی

Congenital deficiency in the WRN protein, a member of the human RecQ helicase family, gives rise to Werner syndrome, a genetic instability and cancer predisposition disorder with features of premature aging. Cellular roles of WRN are not fully elucidated. WRN has been implicated in telomere maintenance, homologous recombination, DNA repair, and other processes. Here I review the available data that directly address the role of WRN in preserving DNA integrity during replication and propose that WRN can function in coordinating replication fork progression with replication stress-induced fork remodeling. I further discuss this role of WRN within the contexts of damage tolerance group of regulatory pathways, and redundancy and cooperation with other RecQ helicases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 7, Issue 11, 1 November 2008, Pages 1776–1786
نویسندگان
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