Keywords: سندرم ورنر; Werner syndrome; Musculoskeletal system; Soft-tissue calcification; Adult progeria; X-ray;
مقالات ISI سندرم ورنر (ترجمه نشده)
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Keywords: سندرم ورنر; Werner syndrome; Aging; Behavior; Memory; Mouse;
Keywords: سندرم ورنر; Werner syndrome; Progeroid syndrome; Genomic instability; Human;
Keywords: سندرم ورنر; Bloom syndrome; dyskeratosis congenita; genetic testing; Gorlin syndrome; Muir-Torre syndrome; nonmelanoma skin cancer; oculocutaneous albinism; Rothmund-Thomson syndrome; Werner syndrome; 5-FU; 5-fluorouracil; ADA1; adenosine deaminase 1; ADA-SCID; a
Keywords: سندرم ورنر; Werner syndrome; Stem cells; Aging; WRN;
Keywords: سندرم ورنر; Chip-qPCR; chromatin immunoprecipitation quantitative polymerase chain reaction; COL1A1; collagen alpha-1(I) chain; DDR; DNA damage response; DEM; diethylmaleate; EJC; exon junction complex; ETP; etoposide; H3K4me3; trimethylation of histone H3 at Lys4; H
Keywords: سندرم ورنر; Crystalline lens; Ionizing radiation; DNA repair factors; Nontargeted effects; Inflammation; Tumor suppressors; A-bomb; atomic-bomb; Acvr1; activin A type 1 receptor; AP; apurinic/apyrimidinic; APE1; apurinic/apyrimidinic endonuclease 1; AQP; aquaporin; A
Keywords: سندرم ورنر; ATG; Autophagy-related gene; EBSS; Earle's balanced salt solution; EGFP-LC3; Enhanced green fluorescent protein-microtubule-associated protein-1 light chain 3; MDC; Monodansylcadaverine; mTOR; Mammalian target of rapamycin; WS; Werner syndrome; WRNp; Wern
Folate modulates guanine-quadruplex frequency and DNA damage in Werner syndrome
Keywords: سندرم ورنر; G-quadruplex; DNA damage; Werner syndrome; Folate; Methylation; DNA helicase;
Nonfunctional mutant Wrn protein leads to neurological deficits, neuronal stress, microglial alteration, and immune imbalance in a mouse model of Werner syndrome
Keywords: سندرم ورنر; Werner syndrome; Mouse aging; Behavior; Brain; Microglia; Neuron; Oxidative stress; Cytokines;
Werner syndrome (WRN) gene variants and their association with altered function and age-associated diseases
Keywords: سندرم ورنر; Werner syndrome; Single nucleotide polymorphisms; Age-related phenotypes; Longevity; Cancer;
Exome sequencing reveals a de novo POLD1 mutation causing phenotypic variability in mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome (MDPL)
Keywords: سندرم ورنر; Lipodystrophy; POLD1 gene; Whole-exome sequencing; MDPL syndrome; ZnF2; MDPL; Mandibular hypoplasia, deafness, progeroid features and lipodystrophy syndrome; POLD1; Polymerase (DNA directed), delta 1, catalytic subunit; MAD; Mandibuloacral dysplasia; ZMPS
Biochemical and cell biological assays to identify and characterize DNA helicase inhibitors
Keywords: سندرم ورنر; Helicase; Replication; DNA repair; Small molecule; Inhibitor; Werner syndrome; Cancer therapy;
Targeted inhibition of WRN helicase by external guide sequence and RNase P RNA
Keywords: سندرم ورنر; External guide sequence; RNase P RNA; WRN helicase, selective cancer therapy; Werner syndrome;
MARK-AGE population: From the human model to new insights
Keywords: سندرم ورنر; CS; Cockayne syndrome; DS; Down syndrome; GO; GEHA offspring; RASIG; randomly recruited age-stratified individuals from the general population; SGO; spouses of GO; WS; Werner syndrome; Human ageing; Biomarkers; Recruitment; MARK-AGE population;
G-quadruplexes: A possible epigenetic target for nutrition
Keywords: سندرم ورنر; G-quadruplex; Werner Syndrome; Nutrition; Methylation; Oxidation; Ageing;
Impact of vitamin C on the cardiometabolic and inflammatory profiles of mice lacking a functional Werner syndrome protein helicase
Keywords: سندرم ورنر; Vitamin C; Metabolomic; Transcriptome; Werner syndrome; Mouse aging; Endoplasmic reticulum;
Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights
Keywords: سندرم ورنر; HDAC inhibitor; DNA damage response; DNA repair; Cell cycle checkpoints; Apoptosis; Rational combinations; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; APAF-1; apoptotic protease activating factor 1; ASK1; apoptosis signal-regulating ki
The non-synonymous polymorphism at position 114 of the WRN protein affects cholesterol efflux in vitro and correlates with cholesterol levels in vivo
Keywords: سندرم ورنر; Werner syndrome; Polymorphisms; Total cholesterol; Cholesterol efflux; Ageing
Distinct functions of human RECQ helicases WRN and BLM in replication fork recovery and progression after hydroxyurea-induced stalling
Keywords: سندرم ورنر; DNA replication/human; Hydroxyurea; RECQ helicase; Werner syndrome; Bloom syndrome; Mitosis;
Quantitative analysis of WRN exonuclease activity by isotope dilution mass spectrometry
Keywords: سندرم ورنر; Werner syndrome; WRN; Exonuclease; Mass spectrometry; Aging; PARP1
Two mechanisms underlying the loss of p16Ink4a function are associated with distinct tumorigenic consequences for WS MEFs escaping from senescence
Keywords: سندرم ورنر; Genomic DNA deletion; p53 mutation; p16Ink4a methylation; Senescence; Werner syndrome;
RecQ helicases in DNA double strand break repair and telomere maintenance
Keywords: سندرم ورنر; RecQ helicases; DNA double strand break repair; Werner syndrome; Bloom syndrome; Rothmund Thomson syndrome; Telomere maintenance
Recruitment and retention dynamics of RECQL5 at DNA double strand break sites
Keywords: سندرم ورنر; DSBs; Double strand breaks; SSBs; Single strand breaks; BLM; Bloom syndrome protein; WRN; Werner syndrome protein; HR; Homologous recombination; BS; Bloom syndrome; WS; Werner syndrome; RTS; Rothmund-Thomson syndrome; RECQL5; Micro-irradiation; Confocal
DNA secondary structure of the released strand stimulates WRN helicase action on forked duplexes without coordinate action of WRN exonuclease
Keywords: سندرم ورنر; RPA; replication protein A; WRN; Werner syndrome protein; WS; Werner syndrome; dsDNA; double-stranded DNA; WRN helicases; DNA secondary structure; DNA unwinding;
SÃndrome de Werner atÃpico: sÃndrome progeroide atÃpico
Keywords: سندرم ورنر; SÃndrome de Werner; AtÃpico; Progeria; SÃndrome progeroide; Esclerodermia; Werner syndrome; Atypical; Progeria; Progeroid syndrome; Scleroderma;
Molecular analyses of DNA helicases involved in the replicational stress response
Keywords: سندرم ورنر; Helicase; DNA repair; Replication; Fluorescence; ATPase; Quadruplex; Triplex; Streptavidin; FANCJ; Werner syndrome
Human RECQ helicases: Roles in DNA metabolism, mutagenesis and cancer biology
Keywords: سندرم ورنر; RECQ helicases; Bloom syndrome; Werner syndrome; Rothmund–Thomson syndrome; DNA replication; DNA repair; Telomeres; Homologous recombination; Genetic instability; Cancer predisposition syndrome; Cancer chemotherapy; Premature aging syndrome
Depletion of Werner helicase results in mitotic hyperrecombination and pleiotropic homologous and nonhomologous recombination phenotypes
Keywords: سندرم ورنر; Werner syndrome; Homologous and nonhomologous recombination; ERCC1;
Delineation of WRN helicase function with EXO1 in the replicational stress response
Keywords: سندرم ورنر; Werner syndrome; Helicase; RecQ; rad50; Replicational stress; Genomic instability;
Roles of Werner syndrome protein in protection of genome integrity
Keywords: سندرم ورنر; γ-H2AX; phosphorylated histone H2AX; 4-NQO; 4-nitroquinoline 1-oxide; 5-OHdC; 5-hydroxycytidine; 5-OHU; 5-hydroxyuracil; 8-oxodA; 8-oxoadenine; 8-oxodG; 8-oxoguanine; ALT; alternative lengthening of telomeres; APE1; apurinic/apyrimidinic endonuclease 1;
Microwave-assisted synthesis of 5-aminopyrazol-4-yl ketones and the p38MAPK inhibitor RO3201195 for study in Werner syndrome cells
Keywords: سندرم ورنر; p38 MAPK; Werner syndrome; RO3201195; Microwaves; Heterocycles
NEMO shuttle: A link between DNA damage and NF-κB activation in progeroid syndromes?
Keywords: سندرم ورنر; Aging; ATM; Genotoxic stress; Inflamm-aging; Progeria; Werner syndrome
Sirtuin-mediated deacetylation pathway stabilizes Werner syndrome protein
Keywords: سندرم ورنر; SIRT; Werner syndrome; Longevity; Caloric restriction;
The transcriptional response to distinct growth factors is impaired in Werner syndrome cells
Keywords: سندرم ورنر; Werner syndrome; Growth factors; Transcription; RNA polymerase I; rDNA methylation
Roles of the Werner syndrome RecQ helicase in DNA replication
Keywords: سندرم ورنر; Werner syndrome; RecQ helicase; Human cell culture; Replication stress; Damage tolerance
Telomere ResQue and preservation—Roles for the Werner syndrome protein and other RecQ helicases
Keywords: سندرم ورنر; Werner syndrome; RecQ helicase; Telomere; DNA replication and repair
Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging
Keywords: سندرم ورنر; Aging; Caloric restriction; FoxO; Inflammation; Klotho; Life span; NF-kB; Sirtuins; Werner syndrome
Synthesis and in vivo activity of MK2 and MK2 substrate-selective p38αMAPK inhibitors in Werner syndrome cells
Keywords: سندرم ورنر; Werner syndrome; Inhibitors; Heterocycles; Microwaves; Inflammation; p38 MAP kinases; Senescence
Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells
Keywords: سندرم ورنر; p38 MAPK; Werner syndrome; VX-745; Microwaves; Heterocycles; Ullmann coupling; Palladium
New areas of focus at workshop on human diseases involving DNA repair deficiency and premature aging
Keywords: سندرم ورنر; Cockayne syndrome; Werner syndrome; Trichothiodystrophy; Xeroderma pigmentosum; Mitochondria; DNA repair; Oxidative stress;
WRN exonuclease activity is blocked by DNA termini harboring 3′ obstructive groups
Keywords: سندرم ورنر; Exonuclease; WRN; Werner syndrome; 3′ Damage repair
Werner syndrome protein: Functions in the response to DNA damage and replication stress in S-phase
Keywords: سندرم ورنر; Aging; Werner syndrome; DNA repair; Replication; Telomere; Base excision repair; Recombination
Structural alterations in outer arms of IgG oligosaccharides in patients with Werner syndrome
Keywords: سندرم ورنر; Oligosaccharides; Structural alteration; IgG; Werner syndrome; Aging
Role for the Werner syndrome protein in the promotion of tumor cell growth
Keywords: سندرم ورنر; Werner syndrome; Genomic instability; Senescence; Oncogenic growth
Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair
Keywords: سندرم ورنر; amyotrophic lateral sclerosis; ataxia-telangiectasia-like disorder; Werner syndrome; xeroderma pigmentosum; nitric oxide synthase; superoxide dismutase; AfXPB; Archaeoglobus fulgidus XPB; AH; autoinhibitory helix; ALS; amyotrophic lateral sclerosis; ATL
Increased insulin, triglycerides, reactive oxygen species, and cardiac fibrosis in mice with a mutation in the helicase domain of the Werner syndrome gene homologue
Keywords: سندرم ورنر; Werner syndrome; Mouse DNA helicase; Cardiovascular disease; Oxidative stress; Hyperinsulinemia; Hyperglycemia; Hypertriglyceridemia; Hypercholesterolemia
Meningioma arising in Werner syndrome confirmed by mutation analysis
Keywords: سندرم ورنر; meningioma; mutation analysis; mutation 4/4; Werner syndrome;
Pathways and functions of the Werner syndrome protein
Keywords: سندرم ورنر; Base excision repair; Telomere; WRN; RecQ conserved; RQC; Werner syndrome;
Deficient DNA repair in the human progeroid disorder, Werner syndrome
Keywords: سندرم ورنر; Werner syndrome; RecQ helicases; DNA repair;