Depletion of Werner helicase results in mitotic hyperrecombination and pleiotropic homologous and nonhomologous recombination phenotypes

▶ WRN deficiency results in hyperrecombinogenic mitotic homologous recombination. ▶ WRN may cooperate mechanistically with ERCC1-XPF in resolving intermediates. ▶ WRN is important for efficient nonhomologous recombination.