Keywords: AEM; area exponential model; ALM; area linear model; AMD; age-related macular degeneration; CI; confidence interval; GA; geographic atrophy; NOS; Newcastle-Ottawa Scale; PRISMA; preferred reporting items for Systematic Reviews and Meta-Analyses; RLM; radi
مقالات ISI (ترجمه نشده)
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Keywords: AIDS; acquired immunodeficiency syndrome; AUC; area under the plasma concentration versus time curve of NVP in absence of NT; AUCI; area under the plasma concentration versus time curve of NVP in presence of NT; AUCratio; ratio between AUCI and AUC (AUCI/
Keywords: AD; Alzheimer's disease; Aβ; amyloid β peptide; APP; amyloid precursor protein; BACE1; β-amyloid cleavage enzyme 1, β-secretase 1; GSM; gamma secretase modulator; LHS; left hand side; NSAID; non-steroidal anti-inflammatory drug; SAR; structure activ
Keywords: CLint; Intrinsic hepatic clearance; HLM; Human liver microsomes; LC/MS/MS; Liquid chromatography tandem mass spectrometry; LC/UV/RAD; Liquid chromatography/ultraviolet/radioactive detection; MRM; Multiple reaction monitoring; NADPH; Nicotinamide adenine d
Keywords: Medicinal plants; North Eastern region; Morocco; Toxic plants; Alkaloids; AT; acute toxicity; ATR; atractyloside; C; cultivated; CA; cutaneous application; CATR; carboxyatractyloside; CBCH; cannabichromene; CBD; cannabidiol; CBN; cannabinol; CT; chronic t
Keywords: CsA; cyclosporin A; CV; cyclic voltammetry; DOX; doxorubicin; DPV; differential pulse voltammetry; ETC; electron transport chain; GSH; reduced glutathione; H2O2; hydrogen peroxide; mPTP; mitochondrial permeability transition pore; OXPHOS; oxidative phosph
Keywords: preclinical pharmacokinetics; physiological model; simulations; clearance; absorption; distribution; ADAM; advanced dissolution absorption and metabolism; B:P; blood-to-plasma ratio; CLint; intrinsic clearance; CLiv; intravenous clearance; CLu,intH; unbou
Keywords: GSH; glutathione; LC/MS; liquid chromatography/mass spectrometry; MRM; multiple reaction monitoring; HRMS; high resolution mass spectrometry; Qtrap; triple quadrupole linear ion trap; EMS; enhanced MS; NL; neutral loss scan; PI; precursor ion scan; MIM; m
Keywords: PM; plasmepsin; SPP; signal peptide peptidase; HIV; human immunodeficiency virus; SAR; structure-activity relationships; BACE; beta-site APP cleaving enzyme 1 or beta-secretase; TCAMS; Tres Cantos Antimalarial Set; RBC; red blood cells; CatD; cathepsin
Keywords: Architectural heritage; Stone conservation; Stone surface finishing; Travertine; Titanium dioxide; RLM; SEM-EDS; VIS-RS; micro-FTIR; XRD; Rationalism
Keywords: C12-FL; fluorescein n-dodecyl ester; C8-FL; fluorescein n-octyl ester; C4-FL; fluorescein n-butyl ester; C18-FL; fluorescein n-octadecyl ester; FL; unsubstituted fluorescein; Cn-FL; fluorescein n-alkyl ester with n hydrocarbon units; DPhPC; diphytanoylpho
Keywords: CPR; Cytochrome P450 reductase;; CYP; Cytochrome P450;; DME; Drug metabolizing enzyme;; EC; Electrochemical cell;; EDES; Electrochemically-driven enzymatic system;; EMMA; Electrophoretically-mediated microanalysis;; FMO; Flavin-containing monooxygenase;;
Food-drug interactions involving multiple mechanisms: A case study with effect of Capsaicin on the pharmacokinetics of Irinotecan and its main metabolites in rat
Keywords: APC; 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxy-camptothecin; AUC; Area under the plasma concentration-time curve; CAP; Capsaicin; CES; Carboxylesterase; CPT; Camptothecin; CPT-11; Irinotecan; CYP; cytochrome P450; DMEs; Drug-meta
Sulfotransferase-catalyzed biotransformation of liguzinediol and comparison of its metabolism in different species using UFLC-QTOF-MS
Keywords: LZDO; liguzinediol; Cys; cysteine; NAC; N-acetylcysteine; GSH; glutathione; 2-NAC-LZDO; 2-N-acetylcysteine-LZDO; 2-Cys-LZDO; 2-cysteine-LZDO; 2-GSH-LZDO; 2-glutathione-LZDO; HLC; human liver cytosol; HLM; human liver microsomes; RLC; rat liver cytosol; RL
Respiratory complex II in mitochondrial dysfunction-mediated cytotoxicity: Insight from cadmium
Keywords: CI; CII, CIII, CIV, CV, complexes I, II, III, IV, V of mitochondrial respiratory chain; TTFA; thenoyltrifluoroacetone; RLM; rat liver mitochondria; ROS; reactive oxygen species; dUb; decylubiquinone; mtETC; mitochondrial electron transport chain; MPT; mit
Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of Glibenclamide in rat: An herb-drug interaction study
Keywords: TC; Tinospora cordifolia; TCE; Tinospora cordifolia extract; CYP; Cytochrome P450; CAM; complementary and alternative medicine; IS; internal standard; LLOQ-QC; quality control sample at lowest limit of quantification level; LQC; low quality control sample
Evaluation of the inhibition effects of apatinib on human and rat cytochrome P450
Keywords: NADPH; nicotinamide adenine dinucleotide phosphate; Tris-HCl; tris (hydroxymethyl) aminomethane hydrochloride; HLM; pooled human liver microsomes; RLM; pooled rat liver microsomes; Apatinib; Cytochrome P450; Drug-drug interactions; Inhibition mechanism;
Identification of metabolites of MDR-1339, an inhibitor of β-amyloid protein aggregation, and kinetic characterization of the major metabolites in rats
Keywords: AD; alzheimer's disease; AUCINF; area under the concentration time curve from time zero to the last sampling time plus the extrapolated area (i.e., the last concentration divided by the elimination rate constant); AUClast; area under the concentration t
Design and optimization of the cocktail assay for rapid assessment of the activity of UGT enzymes in human and rat liver microsomes
Keywords: Estradiol (PubChem CID: 5757); Chenodeoxycholic acid (PubChem CID: 10133); Serotonin (PubChem CID: 5202); Propofol (PubChem CID: 4943); Zidovudine (PubChem CID: 35370); CYP; cytochrome P450; UGT; UDP-glucuronosyltransferases; DDI; drug-drug interactions;
Control of the NADPH supply and GSH recycling for oxidative stress management in hepatoma and liver mitochondria
Keywords: 2-OG; 2-oxoglutarate; CHP; cumene hydroperoxide; Glu; glutamate; GDH; glutamate dehydrogenase; GPx-1; glutathione peroxidase 1; GPx-4; glutathione peroxidase 4; GR; glutathione reductase; GSH; reduced glutathione; GSSG; oxidized glutathione; GST; GSH-S-tr
Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes
Keywords: ADME; absorption, distribution, metabolism and excretion; Clint; intrinsic clearance; Clp; plasma clearance; Clu; unbound clearance; DCM; dichloromethane; DHEP; dog hepatocytes; DLM; dog liver microsomes; DMAc; dimethylacetamide; DMF; dimethylformamide; D
Herb-drug interaction potential of Berberis aristata through cytochrome P450 inhibition assay
Keywords: CYP450; cytochrome P450; HTS; high-throughput screening; IC50; the 50% inhibitory concentration; RP-HPLC; reverse phase high-performance liquid chromatography; CYP450-CO; cytochrome P450- carbon monoxide; RLM; rat liver microsome; CI; combination index; H
Identification of cytochrome P450 isoforms involved in the metabolism of Syl930, a selective S1PR1 agonist acting as a potential therapeutic agent for autoimmune encephalitis
Keywords: Syl930; Hydroxylated metabolites; CYP450 isoforms; Metabolism; LC-MS/MS; CYPs; cytochrome P450 isoforms; LM; liver microsome; HLM; human liver microsome; RLM; rat liver microsome; MS; multiple sclerosis; S1PRs; sphingosine-1-phosphate receptors; S1PR1; sp
Biotransformation of bromhexine by Cunninghamella elegans, C. echinulata and C. blakesleeana
Keywords: Cunninghamella sp.; Bromhexine; RLM; CYP3A4; Inhibitor; Metabolism;
In silico and in vitro inhibition of cytochrome P450 3A by synthetic stilbenoids
Keywords: CYP; cytochrome P450; P450s; cytochrome P450 enzymes; RLM; rat liver microsomes; CYP3A4; Resveratrol; Nitrostilbene; Di-methoxy-nitrostilbene; Microsomes; Docking;
The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement
Keywords: NaV1.7; voltage gated sodium channel 1.7; SCN9A; sodium voltage-gated channel alpha subunit 9; TM; transmembrane; VSD; voltage sensing domain; CLu; unbound clearance; HLM; human liver microsome; RLM; rat liver microsome; PX; patch express; LLE; ligand lip
Pharmacokinetics, pharmacodynamics and safety profiling of IS01957, a preclinical candidate possessing dual activity against inflammation and nociception
Keywords: Pharmacokinetics; Inflammation; Nociception; Safety pharmacology; IS01957; Para-coumaric acid derivative; p-CA; Para coumaric acid; ADME; Absorption, distribution, metabolism and excretion; CH; Chlorpromazine hydrochloride; PS; Pentobarbital sodium; PBS;
nmsBuilder: Freeware to create subject-specific musculoskeletal models for OpenSim
Keywords: Musculoskeletal model; Subject-specific model; Image-based model; Imaging data processing; Freeware; OpenSim; API; application programming interface; GUI; graphical user interface; ALBA; agile library for biomedical applications; MAF; multimod application
CYP2C8-mediated interaction between repaglinide and steviol acyl glucuronide: In vitro investigations using rat and human matrices and in vivo pharmacokinetic evaluation in rats
Keywords: CYP2C8; Steviol acyl glucuronide; Repaglinide; Reversible inhibition; Food-drug interaction; AUC; area under the plasma time-concentration curve; Cmax; plasma maximum concentration; CYP; cytochrome P450; HLM; human liver microsomes; RLM; rat liver microso
Contribution of bacteriochlorophyll conformation to the distribution of site-energies in the FMO protein
Keywords: AHC; agglomerative hierarchical clustering; BChl; bacteriochlorophyll; Chl; chlorophyll; E(BChl)cryst; in vacuo SPE of BChl in protein bound conformation; ÎQy[Mac]; site-energy perturbation due to macrocycle distortion; dip; mean absolute deviation of NS
Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groups
Keywords: S1P1 receptor agonist; Immunomodulator; Lymphocyte count; Aminomethyl pyridine; Aminomethyl benzene; Aminomethyl thiophene; Phototoxicity; BuLi; n-butyl lithium; CC; column chromatography; DCM; dichloromethane; DIPEA; diisopropylethylamine; DEAD; diethyl
In vitro metabolism of l-corydalmine, a potent analgesic drug, in human, cynomolgus monkey, beagle dog, rat and mouse liver microsomes
Keywords: l-Corydalmine; Metabolism; Hepatic microsomes; Cytochrome P450s; Interspecies difference; CyLM; cynomolgus monkey liver microsomes; CYP450; cytochrome P450; DLM; dog liver microsomes; HLM; human liver microsomes; HPLC; high-performance liquid chromatograp
Diethylstilbestrol can effectively accelerate estradiol-17-O-glucuronidation, while potently inhibiting estradiol-3-O-glucuronidation
Keywords: DES; diethylstilbestrol; UGT; UDP-glucuronosyltransferases; HLM; human liver microsomes; DLM; liver microsomes from beagle dog; RbtLM; liver microsomes from New Zealand rabbits; RLM; liver microsomes from Sprague-Dawley rats; MLM; liver microsomes from
A mitochondria-targeted derivative of ascorbate: MitoC
Keywords: ACR; accumulation ratio; AO; ascorbate oxidase; AFR; ascorbyl free radical; DHA; dehydroascorbic acid; DTPA; diethylenetriaminepenta-acetic acid; FCCP; carbonylcyanide p-(trifluoromethoxy)phenylhydrazone; FCS; foetal calf serum; GSH; glutathione; LAH; lin
Synthesis-based design and implementation methodology of high-speed, high-performing unit: L2 cache unit design
Keywords: LBS; RLM; Physical design; Soft hierarchy; Interior pin
Calendar-dated glacier variations in the western European Alps during the Neoglacial: the Mer de Glace record, Mont Blanc massif
Keywords: Holocene; Neoglacial; Glacier chronology; Tree-rings; Dendrochronology; Subfossil wood; Pinus cembra; Mont Blanc; Western Alps; BWP; Bronze Age Warm Period; EACC; Eastern Alpine Conifer Chronology; ELA; Equilibrium Line Altitude; FMA; First Millennium Adv
Absolute quantification of UGT1A1 in various tissues and cell lines using isotope label-free UPLC-MS/MS method determines its turnover number and correlates with its glucuronidation activities
Keywords: UGT; uridine 5â²-diphospho-glucuronosyltransferase (UDP-glucuronosyltransferase); CYP; cytochrome P450; UPLC; ultra performance liquid chromatography; MRM; multiple reaction monitoring; DP; declustering potential; CE; collision energy; CXP; collision cel
Role of CYP3A in regulating hepatic clearance and hepatotoxicity of triptolide in rat liver microsomes and sandwich-cultured hepatocytes
Keywords: TP; triptolide; TWHF; Tripterygium wilfordii Hook. F.; CYP; cytochrome P450; RLM; rat liver microsomes; SCRH; sandwich-cultured rat hepatocytes; LDH; lactate dehydrogenase; AST; aspartate transaminase; ALT; alanine aminotransferase; MDA; malondialdehyde;
In vitro metabolism, permeation, and brain availability of six major boswellic acids from Boswellia serrata gum resins
Keywords: AαBA; 3-acetyl-α-boswellic acid; AβBA; 3-acetyl-β-boswellic acid; AKBA; 3-acetyl-11-keto-β-boswellic acid; BA; boswellic acid; αBA; α-boswellic acid; βBA; β-boswellic acid; BSE; Boswellia serrata gum resin extract; HLM; human liver microsomes; KB
Validated liquid chromatography-tandem mass spectrometry method for determination of totally nine probe metabolites of cytochrome P450 enzymes and UDP-glucuronosyltransferases
Keywords: CD; Choline-deficient; CYP; Cytochrome P450; ESI; Electrospray ionization; FDA; Food and Drug Administration; IACUC; Institutional Animal Care and Use Committee; IS; Internal standard; HPLC; High-performance liquid chromatography; LC-MS/MS; Liquid chromat
Metabolic fate of combretastatin A-1: LC-DAD-MS/MS investigation and biological evaluation of its reactive metabolites
Keywords: DTNB; 5,5â²-dithiobis(2-nitrobenzoic acid); GSH; reduced glutathione; GTP; guanosine-5â²-triphosphate; HLM; human liver microsomes; NAC; N-acetyl-L-cysteine; NEM; N-ethyl-maleimide; MEM; minimal essential medium; MTT; (3-(4,5-dimethylthiazol-2-yl)-2,5-d
Molecular mechanism for the selective impairment of cancer mitochondrial function by a mitochondrially targeted vitamin E analogue
Keywords: CII; respiratory complex II; MitoVES; triphenylphosphonium tagged vitamin E succinate; mtDNA; mitochondrial DNA; 2-OG; 2-oxoglutarate; OxPhos; oxidative phosphorylation; Pyr/Mal; pyruvate + malate; RLM; rat liver mitochondria; SDH; succinate dehydrogena
Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
Keywords: DTT; dithiothreitol; HLM; human liver microsomes; HRN; Hepatic Reductase Null mouse; POR; NADPH-P450 oxidoreductase; RLM; rat liver microsomes; WT; wild type; Antitumour agents; Capridine β; C-1748; Hypoxia; Metabolism; 1-Nitroacridines;
In vitro metabolism in Sprague-Dawley rat liver microsomes of forsythoside A in different compositions of Shuang-Huang-Lian
Keywords: SHL; Shuang-Huang-Lian, a traditional Chinese formula; LJF; Lonicerae japonicae flos; SR; Scutellariae radix; FF; Forsythiae fructus; FTA; Forsythoside A; CHA; Chlorogenic acid; BC; Baicalin; BAI; Baicalein; Cmax; The maximum plasma concentration; RLM
Analysis of expression and structure of the rat GH-secretagogue/ghrelin receptor (Ghsr) gene: Roles of epigenetic modifications in transcriptional regulation
Keywords: 5-aza-dC; 5-aza-2-deoxycytidine; ChIP; chromatin immunoprecipitation; ERK1/2; extracellular signal-regulated kinase 1/2; DMEM; Dulbecco's modified Eagle's medium; DNMT; DNA methyltransferase; EST; expressed sequence tag; FBS; fetal bovine serum; GH; g
An investigation of the occurrence and properties of the mitochondrial intermediate-conductance Ca2+-activated K+ channel mtKCa3.1
Keywords: BKCa; big conductance Ca2+-activated K+-channel (KCa1.1); Clotrimazole; 1-[(2-chlorophenyl)-diphenyl-methyl]imidazole; CsA; Cyclosporin A; DC-EBIO; 5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one; DMEM; Dulbecco's modified Eagle medium; ER; endopla
Mitochondrial respiratory chain super-complex I-III in physiology and pathology
Keywords: BHM; Beef Heart Mitochondria; BN-PAGE; Blue Native Polyacrylamide Gel Electrophoresis; CL; Cardiolipin; Cn; Metabolic Flux Coefficient; CoQ; Coenzyme Q, Ubiquinone; mtDNA; mitochondrial DNA; OXPHOS; Oxidative Phosphorylation System; POM; Potato Tuber Mito
Impact of mitochondriotropic quercetin derivatives on mitochondria
Keywords: BC; Bathocuproinedisulfonic acid; BF; Bathofenanthrolinedisulfonic acid; BHT; 2,5-di-t-Butyl-p-HydroxyToluene; CsA; Cyclosporine A; DTT; Dithiothreitol (1,4-Dimercapto-2,3-butanediol); εÌH; transmembrane electrochemical proton gradient; ÎΨ; mitochon
Cobalt induces oxidative stress in isolated liver mitochondria responsible for permeability transition and intrinsic apoptosis in hepatocyte primary cultures
Keywords: AdNT; adenine nucleotide translocase; AIF; apoptosis inducing factor; APF; 2-[6-(4â²-amino)phenoxy-3H-xanthen-3-on-9-yl]benzoic acid; BHT; butylhydroxytoluene; BKA; bongkrekic acid; DMF; dimethyl formamide; CsA; cyclosporin A; cyt c; cytochrome c; DTE; d
Differential effect of Shenmai injection, a herbal preparation, on the cytochrome P450 3A-mediated 1â²-hydroxylation and 4-hydroxylation of midazolam
Keywords: SMI; Shenmai injection; MDZ; midazolam; 1â²-OH MDZ; 1â²-hydroxymidazolam; 4-OH MDZ; 4-hydroxymidazolam; TG; total ginsenoside; OTS; ophiopogon total saponins; OTF; ophiopogon total flavone; KTZ; ketoconazole; RLM; rat liver microsomes; HLM; human liver