کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8949253 1645702 2018 40 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Control of the NADPH supply and GSH recycling for oxidative stress management in hepatoma and liver mitochondria
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Control of the NADPH supply and GSH recycling for oxidative stress management in hepatoma and liver mitochondria
چکیده انگلیسی
Kinetic modeling revealed that the oxidative stress management was mainly controlled by GR, GPx and IDH. Modeling and experimentation also revealed that, due to their higher IDH-2 activity and lower GPx activity presumably by acetylation, HepM (i) showed higher steady-state NADPH levels; (ii) required greater peroxide concentrations to achieve reliable steady-state fluxes and metabolite concentration; and (iii) endured higher peroxide concentrations without collapsing their GSH/GSSG ratios. Then, to specifically prompt lower GSH/GSSG ratios under oxidative stress thus compromising cancer mitochondria functioning, GPx should be re-activated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Bioenergetics - Volume 1859, Issue 10, October 2018, Pages 1138-1150
نویسندگان
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