دانلود مقالات ISI درباره Rmsd + ترجمه فارسی

In silico identification of novel antagonists and binding insights by structural and functional analyses of guanylate kinase of Leishmania donovani and interaction with inhibitors

Keywords: GK; guanylate kinase; VL; visceral leishmaniasis; GMPK; guanosine monophosphate kinase; 5GP; 5′-guanylic acid; GOLD; genetic optimization for ligand docking; CHARMM; chemistry of HARvard molecular mechanics; BLAST; basic local alignment search tool; PDB

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

Inhibition of TRAF6-Ubc13 interaction in NFkB inflammatory pathway by analyzing the hotspot amino acid residues and protein-protein interactions using molecular docking simulations

Keywords: PPI; protein-protein interaction; PDTC; Pyrrolidine dithiocarbamate; NFkB; Nuclear Factor kappa B; IkB; Inhibitor of kappa; RING; Really Interesting New Gene; TRAF6; TNF receptor associated factor 6; IL1; Interleukin 1; Ubc13; Ubiquitin conjugating prot

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

Exploring putative inhibitors of Death Associated Protein Kinase 1 (DAPK1) via targeting Gly-Glu-Leu (GEL) and Pro-Glu-Asn (PEN) substrate recognition motifs

Keywords: DAPK1; Death Associated Protein Kinase 1; NMDARs; N-methyl-D-aspartate receptors; NMDAR2A or NR2A; N-methyl-D-aspartate receptor subtype 2A; NMDAR2B or NR2B; N-methyl-D-aspartate receptor subtype 2B; NSC; neuronal survival-signaling complex; NDC; neuronal

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

Insights into the molecular basis for substrate binding and specificity of the fungal cystine transporter CgCYN1

Keywords: TMD; transmembrane domain; APC; amino acid-polyamine-organocation; WT; wild type; S.D.; synthetic defined; RMSD; root mean square deviation; Cystine transporter; Yeast; xCT; Substrate binding; APC superfamily; Homology modeling;

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

Interdomain interactions rearrangements control the reaction steps of a thermostable DNA alkyltransferase

Keywords: BG-VG; SNAP-Vista Green™ substrate; Cter; C-terminal domain; DDMP; Difference Distance Matrix Plot; dsDNAm; O6-methyl-guanine-containing double-strand DNA; DSF; Differential Scanning Fluorimetry; hAGT; human AGT; MD; molecular dynamics; Nter; N-terminal

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

Identification and expression analysis of alternatively spliced new transcript isoform of Bax gene in mouse

Keywords: Bcl-2; B-cell lymphoma 2; BH; Bcl-2 homology; TM; transmembrane; MOM; mitochondrial outer membrane; ART; Apoptosis Regulating Target; qRT-PCR; quantitative real time PCR; DOPE; Discrete Optimized Protein Energy; GR; glucocorticoid receptor; Sp1; specifici

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

Kinetic and structural characterization of a cis-3-Chloroacrylic acid dehalogenase homologue in Pseudomonas sp. UW4: A potential step between subgroups in the tautomerase superfamily

Keywords: Tautomerase superfamily; 4-Oxalocrotonate tauomerase; cis-3-Chloroacrylic acid dehalogenase; 2-Oxo-3-pentynoate; Evolution; cis-CaaD; cis-3-chloroacrylic acid dehalogenase; CHES; N-Cyclohexyl-2-aminoethanesulfonic acid; DEAE; diethyl-aminoethyl; LB; Luria

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

Structural analysis and insight into Zika virus NS5 mediated interferon inhibition

Keywords: ZIKV; Zika virus; NS5; non-structural protein 5; SIAH2; seven in absentia homolog 2; STAT2; Signal Transducer and Activator of Transcription 2; MTase; methyltransferase; IFN; interferon; IRF9; Interferon Regulatory Factor 9; ISGF3; Interferon-Stimulated G

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

Classification and structural analyses of mutational landscapes in hemochromatosis factor E protein: A protein defective in the hereditary hemochromatosis

Keywords: HH; hereditary hemochromatosis; HFE; Hereditary Hemochromatosis Factor E; MHC; major histocompatibility complex; RMSD; Root Mean Square Deviations; Rg; Radius of Gyration; RMSF; Root Mean Square Fluctuations; SASA; Solvent Accessible Surface Area; SVM; Su

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

RElative QUantitation Inferred by Evaluating Mixtures (REQUIEM)

Keywords: Relative quantitation; Precision; Accuracy; Mass spectrometry; RNA-Seq; ES; embryonic stem (cells); GC-FID; gas chromatography with flame ionization detection; HPAEC-PAD; high performance anion exchange chromatography with pulsed amperometric detection; R

دانلود رایگان متن کامل مقاله ISI 54 صفحه سال انتشار : 2017 سفارش ترجمه

Anti-proliferative effects of copper(II) complexes with hydroxyquinoline-thiosemicarbazone ligands

Keywords: Thiosemicarbazone; Copper(II) complex; 8-Hydroxyquinoline; Proliferation; ROS; Anticancer; ATCUN; amino-terminal copper and nickel binding; CD; circular dichroism; DMF; dimethylformamide; DMSO; dimethyl sulfoxide; Dien; diethylenetriamine; EDTA; ethylened

دانلود رایگان متن کامل مقاله ISI 59 صفحه سال انتشار : 2017 سفارش ترجمه

Exploring the membrane fusion mechanism through force-induced disassembly of HIV-1 six-helix bundle

Keywords: Six-helix bundle; Protein unfolding; Molecular dynamics simulations; Interfacial interaction; Membrane fusion; MD; molecular dynamics; SMD; steered molecular dynamics; 6HB; six-helix bundle; NHR/CHR; N/C-terminal heptad repeat; RMSD; root-mean-square devi

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Conformation switching of AIM2 PYD domain revealed by NMR relaxation and MD simulation

Keywords: AIM2; PYD; NMR; MD; Conformation exchange; AIM2; absent in melanoma 2; PYD; pyrin domain; NMR; nuclear magnetic resonance; ASC; apoptosis-associated speck-like protein containing a caspase-activation and recruitment domain (CARD); CARD; caspase-activation

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Herbalog: A tool for target-based identification of herbal drug efficacy through molecular docking

Keywords: Herbalog; Natural product; Virtual screening; Molecular docking; FABP4 inhibitor; Andrographis paniculata; CXCR4; C-X-C chemokine receptor type 4; RMSD; Root-mean square deviation; FABP4; Fatty acid binding protein 4; 1; 8-ANS, 1-Anilinonaphthalene-8-sulf

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Structural basis for recognition of a kink-turn motif by an archaeal homologue of human RNase P protein Rpp38

Keywords: Crystal structure; Kink-turn; Pyrococcus horikoshii; Ribonuclease P; Ribosomal protein L7Ae; ITC; isothermal temperature calorimetry; K-turn; kink-turn; PfupRNA; ribonuclease P RNA from Pyrococcus furiosus; PhopRNA; ribonuclease P RNA from P. horikoshii;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Six independent fucose-binding sites in the crystal structure of Aspergillus oryzae lectin

Keywords: Lectin; Seleno-sugar; Fucose; Affinity; Phase determination; Crystal structure; AOL; fucose-specific lectin from Aspergillus oryzae; AAL; fucose-specific lectin from Aleuria aurantia; AFL; fucose-specific lectin from Aspergillus Fumigatus; α-Se-Fuc; α-s

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Production of a soluble single-chain variable fragment antibody against okadaic acid and exploration of its specific binding

Keywords: Okadaic acid; CLEIA; Single-chain variable fragment; Binding complex; OA; okadaic acid; DSP; diarrhetic shellfish poisoning; ELISA; enzyme-linked immunosorbent assay; scFv; single-chain variable fragment; CDR; complementarity-determining region; PDB; Prot

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

The MPN domain of Caenorhabditis elegans UfSP modulates both substrate recognition and deufmylation activity

Keywords: UfSP; Ufm1; MPN domain; Deufmylation; Crystal structure; Ufm1; Ubiquitin-fold modifier 1; UfSP; Ufm1 specific protease; cUfSP; UfSP from C. elegans; UBL; ubiquitin-like protein; ER; endoplasmic reticulum; MPN; Mpr1p and PAD1p N-terminal; UfBP1; Ufm1 bindi

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Human 15-LOX-1 active site mutations alter inhibitor binding and decrease potency

Keywords: LOX; lipoxygenase; h15-LOX-1; human reticulocyte 15-lipoxygenase-1; tPA; tissue plasminogen activator; FDA; Food and Drug Administration; s15-LOX-1; soybean 15-lipoxygenase-1; r15-LOX; rabbit reticulocyte 15-LOX; AA; arachidonic acid; 12-HpETE; 12-hydrope

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Crystal structure of the enzyme-product complex reveals sugar ring distortion during catalysis by family 63 inverting α-glycosidase

Keywords: EcYgjK; Escherichia coli YgjK; GH63; glycoside hydrolase family 63; Glc1,2Gal; 2-O-α-d-glucopyranosyl-d-galactose; β-GlcF; β-glucopyranosyl fluoride; PDB; Protein Data Bank; RMSD; root mean squared deviation; Glycoside hydrolase family 63; Inverting me

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Identification of novel mutations in CD2BP1 gene in clinically proven rheumatoid arthritis patients of south India

Keywords: CD2BP1; PAPA syndrome; Rheumatoid arthritis; RMSD; SH3 domain

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Crystal structure of a polypeptide's C-terminus in complex with the regulatory domain of ER aminopeptidase 1

Keywords: ER; endoplasmic reticulum; ERAP1; endoplasmic reticulum aminopeptidase 1; ERAP1_R; ERAP1 regulatory domain; MHC-I; major histocompatibility complex class I; TAP; transporter associated with antigen processing; rmsd; root mean square deviation/displacement

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Sensitivity of embedded active PZT sensor for concrete structural impact damage detection

Keywords: Embedded PZT sensor; Concrete structure; Impact damage; Sensitivity; RMSD;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Bupropion and its photoreactive analog (±)-SADU-3-72 interact with luminal and non-luminal sites at human α4β2 nicotinic acetylcholine receptors

Keywords: Human α4β2 nicotinic acetylcholine receptor; Bupropion; (±)-SADU-3-72; Molecular docking; Luminal and non-luminal sites; Ca2+ influx; AChR; nicotinic acetylcholine receptor; NCA; noncompetitive antagonist; (±)-BP; (±)-bupropion [(±)-2-(tert-butylami

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Gypsy moth pheromone-binding protein-ligand interactions: pH profiles and simulations as tools for detecting polar interactions

Keywords: Gypsy moth; Olfaction; Ligand interactions; Pheromone-binding protein; Homology modeling; pH profile of ligand binding; (−)-Dis; (−)-disparlure = (7S, 8R)-epoxy-2-methyloctadecane; (+)-Dis; (+)-disparlure = (7R, 8S)-epoxy-2-methyloctadecane; ANOVA

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Effects of interface mutations on the dimerization of alanine glyoxylate aminotransferase and implications in the mistargeting of the pathogenic variants F152I and I244T

Keywords: Primary hyperoxaluria type I; Human alanine glyoxylate aminotransferase; Interface hot spots; Protein dimerization; Molecular dynamics; Protein mistargeting; AGT-Mi; minor allele of human alanine glyoxylate aminotransferase; PH1; Primary Hyperoxaluria typ

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Molecular principles behind pyrazinamide resistance due to mutations in panD gene in Mycobacterium tuberculosis

Keywords: MD, molecular dynamics; DM, double mutant; RMSD, root mean square deviation; RMSF, root mean square fluctuationDocking; Simulation; Pyrazinamide; RMSD; RMSF

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Structural and functional characterisation of the cyanobacterial PetC3 Rieske protein family

Keywords:  ∆ petC3; petC3 deletion strain (of Synechocystis PCC 6803); b6f; cytochrome b6f complex; C; inorganic carbon (in the form of CO2 and HCO3−); Em; midpoint redox potential; N; inorganic nitrogen; NDH-1; NADH dehydrogenase-like complex; NSAF; normalis

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Molecular docking studies in factor XIa binding site

Keywords: Factor XIa; Docking; XP; SP; Binding site; RMSD; Catalytic aspartate; Anionic; GlideScore

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2016 سفارش ترجمه

Establishment of correlation between in-silico and in-vitro test analysis against Leishmania HGPRT to inhibitors

Keywords: HGPRT; hypoxanthine-guanine phosphoribosyltransferase; HPRT; hypoxanthine phosphoribosyltransferase; APRT; adenosine phosphoribosyltransferase; XPRT; xanthine phosphoribosyltransferase; CL; cutaneous leishmaniasis; MCL; muco-cutaneous leishmaniasis; VL; v

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2016 سفارش ترجمه

Spatial patterns and cell surface clusters in perineuronal nets

Keywords: PNN; perineuronal nets; CNS; central nervous system; CSPG; chondroitin sulfate proteoglycans; AMPA receptor; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; WFA; Wisteria floribunda agglutinin; GalNAc; N-acetyl-galactosamine; CS; chondroit

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2016 سفارش ترجمه

Molecular dynamics simulation and free energy landscape methods in probing L215H, L217R and L225M βI-tubulin mutations causing paclitaxel resistance in cancer cells

Keywords: Microtubule; βI-tubulin; Paclitaxel; Drug resistance; Molecular dynamics simulation; Free energy landscape; WT; wild type; MT; mutant type; Ptxl; paclitaxel; MD; molecular dynamics; PCA; principle component analysis; FEL; free energy landscape; RMSD; roo

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2016 سفارش ترجمه

β-N-oxalyl-L-α, β- diaminopropionic acid induces HRE expression by inhibiting HIF-prolyl hydroxylase-2 in normoxic conditions

Keywords: ATP; adenosine triphosphate; β-ODAP; β-N-oxalyl-L-α,β-diaminopropionic acid; DMOG; dimethyloxalylglycine; 1,4 DPCA; 1,4-dihydrophenonthrolin-4-one-3-carboxylic acid; D-ODAP; β-N-oxalyl-D-α,β-diaminopropionic acid; DTT; dithiothreitol; EDTA; ethylen

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2016 سفارش ترجمه

The C-terminal region of the transcriptional regulator THAP11 forms a parallel coiled-coil domain involved in protein dimerization

Keywords: THAP; Thanatos-associated protein; HCF-1; host cell factor 1; HBM; HCF-1 binding motif; TEV; tobacco etch virus; LB; Luria-Bertani; IPTG; isopropyl-β-d-1-thiogalactopyranoside; IMAC; immobilized metal affinity chromatography; SEC; size exclusion chroma

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2016 سفارش ترجمه

Smyd3 open & closed lock mechanism for substrate recruitment: The hinge motion of C-terminal domain inferred from μ-second molecular dynamics simulations

Keywords: SET; Suppressor of variegation, Enhancer of Zeste, Trithorax; MYND; Myeloid-Nervy-DEAF1; siRNA; small interfering RNA; VEGFR1; vascular endothelial growth factor receptor-1; MD; molecular dynamics; HKMT; histone lysine methyltranferase; RMSD; root-mean sq

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2016 سفارش ترجمه

Pterostilbene-mediated Nrf2 activation: Mechanistic insights on Keap1:Nrf2 interface

Keywords: PTS; pterostilbene; ARE; antioxidant responsive element; Keap1; Kelch-like ECH-associated protein-1; Nrf2; nuclear factor erythroid 2-related factor 2; MIN6 cells; mouse insulinoma-6 cells; MD; molecular dynamics; RMSD; root-mean square deviation; MM-GBSA

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2016 سفارش ترجمه

A promiscuous recognition mechanism between GPR17 and SDF-1: Molecular insights

Keywords: SDF-1; stromal cell-derived factor 1; GPCR; G protein-coupled receptor; CNS; central nervous system; NS; nervous system; DRG; dorsal root ganglion; OPC; oligodendrocyte precursor cell; MS; multiple sclerosis; PDB; Protein Data Bank; TM; transmembrane; EL;

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2016 سفارش ترجمه

Inherent conformational flexibility of F1-ATPase α-subunit

Keywords: Mg(II); free magnesium ion; ATP; adenosine 5′-triphosphate; ADP; adenosine 5′-diphosphate; EDTA; ethylenediaminetetraacetic acid; Tris; 2-amino-2-(hydroxymethyl)propane-1,3-diol; MgCl2; magnesium chloride; ATPase; adenosine 5′-triphosphatase; MF1, T

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2016 سفارش ترجمه

A multi-subunit based, thermodynamically stable model vaccine using combined immunoinformatics and protein structure based approach

Keywords: APC; antigen presenting cells; CTL; cytolytic T-lymphocytes; FASTA; FAST-ALL; HBHA; heparin-binding hemagglutinin; HTL; helper T-lymphocytes; IC50; inhibitory concentration; IEDB-AR; immune epitope database analysis resource; JCAT; Java Codon Adaptation T

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis and evaluation of xanthine oxidase inhibitory and antioxidant activities of 2-arylbenzo[b]furan derivatives based on salvianolic acid C

Keywords: Salvianolic acid C; 2-arylbenzo[b]furan derivatives; Xanthine oxidase inhibitor; Antioxidant; Molecular docking; XOR; xanthine oxidoreductase; ROS; reactive oxygen species; XO; xanthine oxidase; XDH; xanthine dehydrogenase; SARs; structure-activity relati

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2016 سفارش ترجمه

Structural and biochemical characterization of bacterial YpgQ protein reveals a metal-dependent nucleotide pyrophosphohydrolase

Keywords: HD; histidine-aspartate; (d)NTP; (deoxy)ribonucleoside triphosphate; bsYpgQ; Bacillus subtilis YpgQ; dNTP; deoxyribonucleoside triphosphate; NTP; ribonucleoside triphosphate; dNMP; deoxyribonucleoside monophosphate; Pi; inorganic monophosphate; PPi; inorg

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2016 سفارش ترجمه

Functional analysis and crystallographic structure of clotrimazole bound OleP, a cytochrome P450 epoxidase from Streptomyces antibioticus involved in oleandomycin biosynthesis

Keywords: OleP; 8.8a-deoxyoleandolide epoxigenase; P450; cytochrome P450; EpoK; Epothilone C-D monooxygenase; PimD; Pimaricin monooxygenase; MycG; Mycinamicin monooxygenase; CLT; clotrimazole; KC; ketoconazole; DMSO; dimethyl sulfoxide; DEO; 8.8a-deoxyoleandolide

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2016 سفارش ترجمه

Molecular basis of the recognition of FMN by a HAD phosphatase TON_0338

Keywords: HAD; haloalkaloic acid dehalogenase; FMN; flavin mono-nucleotide; MD; molecular dynamics; RMSD; root-mean-square deviation; MM-GB/SA; molecular mechanics generalized Born surface area; RMSF; root-mean-square fluctuation; HAD phosphatase; TON_0338; FMN; Do

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2016 سفارش ترجمه

Novel non-peptide small molecules preventing IKKβ/NEMO association inhibit NF-κB activation in LPS-stimulated J774 macrophages

Keywords: ADME; absorption, distribution, metabolism, and excretion; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; EMSA; Electrophoretic Mobility Shift Assay; Erk; extracellular-signal-related kinase; FBS; foetal bovine serum; GAPDH; glyce

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2016 سفارش ترجمه

Structural insight into activation of homoserine dehydrogenase from the archaeon Sulfolobus tokodaii via reduction

Keywords: HSD; homoserine dehydrogenase; Tris; tris(hydroxymethyl)aminomethane; PDB; Protein Data Bank; Tricine; N-[tris(hydroxymethyl)methyl]glycine; Bis-tris; 2,2-bis(hydroxymethyl)-2,2′,2″-nitrilotriethanol; HEPES; [4-(2-hydroxyethyl)-1-piperazinyl] ethanesu

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Evaluation of the reliability of the maximum entropy method for reconstructing 3D and 4D NOESY-type NMR spectra of proteins

Keywords: CS; compressed sensing; FT; Fourier transform; IRLS; iteratively reweighted least-squares; IST; iterative soft thresholding; MaxEnt; maximum entropy; MDD; multi-dimensional decomposition; QME; quantitative maximum entropy; RMSE; root mean square error; RM

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Structural impact of complete CpG methylation within target DNA on specific complex formation of the inducible transcription factor Egr-1

Keywords: 5mC; 5-methylcytosine; MBD; methyl-CpG-binding domain; RMSD; root-mean-square deviation; TAMRA; tetramethylrhodamine; Protein-DNA interaction; CpG methylation; Egr-1; Crystallography; Fluorescence;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Research paperMolecular principles behind Boceprevir resistance due to mutations in hepatitis C NS3/4A protease

Keywords: HCV; hepatitis C virus; MD; molecular dynamics; RMSD; root mean square deviation; RMSF; root mean square fluctuation; Rg; radius of gyration; VMD; visual molecular dynamics; HCV; Molecular dynamics; Simulations; Boceprevir; Resistance; Mutants;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

High-resolution structures of the d-alanyl carrier protein (Dcp) DltC from Bacillus subtilis reveal equivalent conformations of apo- and holo-forms

Keywords: CP; carrier protein; Dcp; d-alanyl CP; ACP; acyl CP; PCP; peptidyl CP; ArCP; aryl CP; ppant; 4′-phosphopantetheine; FA; fatty acid; PK; polyketide; NRP; non-ribosomal peptide; SeMet; selenomethionine; rmsd; root mean square deviation; Carrier protein; P

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Structural alterations by five disease-causing mutations in the low-pH conformation of human dihydrolipoamide dehydrogenase (hLADH) analyzed by molecular dynamics - Implications in functional loss and modulation of reactive oxygen species generation by pa

Keywords: LADH; (dihydro)lipoamide dehydrogenase; PDHc; pyruvate dehydrogenase complex; α-KGDHc; alpha-ketoglutarate dehydrogenase complex; ROS; reactive oxygen species; RMSD; root mean square deviation; FAD; flavin adenine dinucleotide; NAD+/NADH; nicotinamide ad

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه