Keywords: RNA پلیمراز وابسته به RNA; SaV; Sapovirus; NSs; nonstructural proteins; GIII; genogroup III; RdRp; RNA-dependent RNA polymerase; ORF; open reading frame; UTR; untranslated region; nt; nucleotides; aa; amino acid; Sapovirus; Viral metagenomics; Genotype; Phylogenetic tree; Complete
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Keywords: RNA پلیمراز وابسته به RNA; 7DCMA; 7-deaza-2â²-C-methyladenosine; DENV; dengue virus; EV-A71; enterovirus A71; MTase; methyltransferase; NS5; non-structural protein 5; RAFI; rigid amphipathic fusion inhibitor; RdRp; RNA-dependent RNA polymerase; SAH; S-adenosyl-l-homocysteine; TBEV
Keywords: RNA پلیمراز وابسته به RNA; Broad-spectrum antivirals; Non-nucleoside inhibitors; Direct-acting antivirals; Norovirus; RNA-dependent RNA polymerase; Caliciviridae; BS-AV; broad-spectrum antivirals; CI; confidence intervals; FCV; feline calicivirus; IC50; half maximal inhibitory conc
Keywords: RNA پلیمراز وابسته به RNA; BYDV; Barley yellow dwarf virus; BWYV; Beet western yellows virus; CABYV; Cucurbit aphid-borne yellows virus; CYDV; Cereal yellow dwarf virus; DDA; data dependent analysis; ELISA; enzyme-linked immunosorbent assay; FDR; false discovery rate; LDV; Lactate
Keywords: RNA پلیمراز وابسته به RNA; 5â²REN; 5â²-proximal replication enhancer element; AS; activator sequence; cPR; complementary promoter; Ct; C-terminal; CNV; cucumber necrosis virus; DI; defective interfering; DL; downstream linker; eEF1A; elongation factor 1A; ESCRT; endosomal sorting
Keywords: RNA پلیمراز وابسته به RNA; NMR spectroscopy; Porcine sapovirus; RNA-dependent RNA polymerase; Viral protein genome-linked
Keywords: RNA پلیمراز وابسته به RNA; Microbial forensic methods; 454 sequencing; RT-qPCR; SYBR green; TSV; tobacco streak virus; SMV; soybean mosaic virus; BPMV; bean pod mottle virus; DIBA; dot-immunobinding assay; TRSV; tobacco ringspot virus; TomRSV; tomato ringspot virus; MP; movement pr
Keywords: RNA پلیمراز وابسته به RNA; CHIKV; chikungunya virus; SINV; Sindbis virus; SFV; Semliki Forest virus; Sur; suramin; nsP; nonstructural protein; RdRp; RNA-dependent RNA polymerase; RTCs; replication and transcription complexes; CPE; cytopathic effect; CC50; half maximal cytotoxic con
Keywords: RNA پلیمراز وابسته به RNA; DAA; NS3/4A Protease Inhibitor; Nucleoside/Nucleotide; Non-nucleoside; DAA; direct-acting antiviral agent; DCV; daclatasvir; HCV; hepatitis C virus; HTA; host-targeted antiviral agent; IFN; interferon; ISG; interferon-stimulated gene; NI; nucleoside inhib
Keywords: RNA پلیمراز وابسته به RNA; DENV; dengue virus; WNV; West Nile virus; YFV; yellow fever virus; TBEV; tick-borne encephalitis virus; HCV; hepatitis C virus; WEEV; Western equine encephalitis virus; VSV; vesicular stomatitis virus; HBV; hepatitis B virus; HIV; human immunodeficiency v
Keywords: RNA پلیمراز وابسته به RNA; Dengue virus; RNA-dependent RNA polymerase; Expression; Purification; Polymerase activity
Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase
Keywords: RNA پلیمراز وابسته به RNA; Dengue virus; Nucleoside; RNA-dependent RNA polymerase; Phosphoramidate prodrug; Mitochondrial RNA polymerase;
HSP70 Copurifies with Zika Virus Particles
Keywords: RNA پلیمراز وابسته به RNA; AHI; allosteric HSP70 inhibitor; DAA; direct acting antiviral; DGC; density-gradient centrifugation; HCV; hepatitis C virus; HSP; heat shock protein; MOI; multiplicity of infection; MTase; methyltransferase; NBD; nucleotide binding domain; NCR; non-coding
Genomic characterization of a RdRp-recombinat nebovirus strain with a novel VP1 genotype
Keywords: RNA پلیمراز وابسته به RNA; VP1; the major capsid protein; VP2; the minor capsid protein; RdRp; RNA-dependent RNA polymerase; nt; nucleotide; aa; amino acid; ORFs; open reading frames; UTR; untranslated region; Cattle disease; Novel nebovirus; Genome; RdRp recombination; VP1;
Coronavirus infectious bronchitis virus non-structural proteins 8 and 12 form stable complex independent of the non-translated regions of viral RNA and other viral proteins
Keywords: RNA پلیمراز وابسته به RNA; Coronavirus; Infectious bronchitis virus; IBV; Non-structure protein; RNA-dependent RNA polymerase; Protein interaction; RNA synthesis; Viral genome replication;
High detection rates of picobirnaviruses in free roaming rats (Rattus spp.): Molecular characterization of complete gene segment-2
Keywords: RNA پلیمراز وابسته به RNA; Picobirnavirus; Rats (Rattus spp.); Complete gene segment-2; Caribbean region; 5â²untranslated region; 5â² UTR; Amino acid; aa; Nucleotide; nt; Picobirnaviruses; PBVs; RNA-dependent RNA polymerase; RdRp;
Pan-Genotype Hepatitis E Virus Replication in Stem Cell-Derived Hepatocellular Systems
Keywords: RNA پلیمراز وابسته به RNA; HLCs; Antiviral; Primary Isolates; Personalized Medicine; ALB; albumin; AFP; alpha-fetoprotein; bFGF; basic fibroblast growth factor; BM; basal medium; CsA; cyclosporine A; DE; definitive endoderm; DMSO; dimethyl sulfoxide; Dox; doxycycline; ESC; embryoni
Analysis of Reptarenavirus genomes indicates different selective forces acting on the S and L segments and recent expansion of common genotypes
Keywords: RNA پلیمراز وابسته به RNA; RdRp; RNA-dependent RNA polymerase; GPC; glycoprotein precursor; NP; nucleoprotein; GARD; Genetic Algorithm Recombination Detection; GTR; General Time Reversible; dN-dS; non-synonymous substitution-synonymous substitution rate; SLAC; single-likelihood anc
Tatanan A from the Acorus calamus L. root inhibited dengue virus proliferation and infections
Keywords: RNA پلیمراز وابسته به RNA; Acorus calamus l; Tatanan A; Dengue; DENV2 infection; CC; column chromatography; CC50; half maximal cytotoxicity concentration; CPE; cytopathic effect; DENV; dengue virus; DENV2; dengue virus type 2; DEPT; distortionless enhancement by polarization transf
Synthesis and biological evaluation of a library of hybrid derivatives as inhibitors of influenza virus PA-PB1 interaction
Keywords: RNA پلیمراز وابسته به RNA; Anti-Influenza; PA-PB1; RdRp; Amino acid coupling; SPPS; Diphenyl-pyridine; AcOEt; Ethyl acetate; CC50; Half maximal cytotoxic concentration; cRNA; complementar RNA; DCM; dichloromethane; DDQ; 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone; DIPEA; N,N-Diisopro
Tomato geminivirus encoded RNAi suppressor protein, AC4 interacts with host AGO4 and precludes viral DNA methylation
Keywords: RNA پلیمراز وابسته به RNA; ADK; Adenosine kinase; AGO; Argonaute; CMT; chromomethylase; DCL; Dicer-like; GFP; Green Fluorescent Protein; MET; methyltransferase; PTGS; Post-transcriptional gene silencing; RdDM; RNA-dependent DNA methylation; RDR; RNA-dependent RNA polymerase; RISC;
Flaviviridae virus nonstructural proteins 5 and 5A mediate viral immune evasion and are promising targets in drug development
Keywords: RNA پلیمراز وابسته به RNA; AAF; IFN-α-activated factor; ATA; Aurintricarboxylic acid; BDV; border disease virus; BPgV; GBV-D; BVDV-1; bovine viral diarrhea virus-1; C; capsid protein; CLRs; C-type lectin receptors; Core; core protein; CSFV; classical swine fever virus; DENV; dengu
Anti-TMV activity and functional mechanisms of two sesquiterpenoids isolated from Tithonia diversifolia
Keywords: RNA پلیمراز وابسته به RNA; TMV; Tobacco mosaic virus; ID-ELISA; Indirect enzyme-linked immunosorbent assay; CP; coat protein; RdRp; RNA-dependent RNA polymerase; qRT-PCR; Real-time fluorescence quantification; Curative activities; Sesquiterpene; Half-leaf method; Bio-pesticides;
Flaviviridae viruses use a common molecular mechanism to escape nucleoside analogue inhibitors
Keywords: RNA پلیمراز وابسته به RNA; Flaviviridae; Virus; Polymerase; Analogue; Interrogating; Water; CMA; 2'-C-methyladenosine; CMA-TP; 2'-C-methyladenosine Triphosphate; CPUs; Computer-Processing Units; HCV; Hepatitis C Virus; JEV; Japanese Encephalitis Virus; NTP; Nucleoside Triphosphate;
Simple and effective generation of transgene-free induced pluripotent stem cells using an auto-erasable Sendai virus vector responding to microRNA-302
Keywords: RNA پلیمراز وابسته به RNA; SeV; Sendai virus; SeVdp; replication-defective and persistent Sendai virus; PSC; pluripotent stem cell; RdRp; RNA-dependent RNA polymerase; MEF; mouse embryonic fibroblast; UTR; untranslated region; Cluc; Cypridina noctiluca luciferase; LNA; locked nucle
Near-Atomic Resolution Structure Determination of a Cypovirus Capsid and Polymerase Complex Using Cryo-EM at 200Â kV
Keywords: RNA پلیمراز وابسته به RNA; cryo-EM; cryo-electron microscopy; DED; direct electron detection; CCD; charge-coupled device; EM; electron microscopy; TEM; transmission electron microscope; dsRNA; double-stranded RNA; RdRp; RNA-dependent RNA polymerase; DQE; detective quantum efficienc
Molecular characterization and expression analysis of interferon-gamma in black seabream Acanthopagrus schlegelii
Keywords: RNA پلیمراز وابسته به RNA; Black seabream; IFN-gamma; Red spotted grouper nervous necrosis virus; JAK-STAT; ISG; AP-1; activator protein 1; bp; base pair; CaMKII; calcium/calmodulin kinase II; GAS; gamma IFN-activated sequences; ORF; open reading frame; GATA3; GATA-binding protein
Silencing the tobacco gene for RNA-dependent RNA polymerase 1 and infection by potato virus Y cause remodeling of cellular organelles
Keywords: RNA پلیمراز وابسته به RNA; RNA-dependent RNA polymerase; Potato virus Y; Heterochromatin; Euchromatin; Nuclear remodeling; Chromosomal remodeling; Organelle remodeling;
Substrate selectivity of Dengue and Zika virus NS5 polymerase towards 2â²-modified nucleotide analogues
Keywords: RNA پلیمراز وابسته به RNA; Dengue virus; Zika virus; NS5; RNA-dependent RNA polymerase; Elongation complex; 2â²-modified NTP analogue;
Picornaviral polymerase structure, function, and fidelity modulation
Keywords: RNA پلیمراز وابسته به RNA; 3Dpol; picornavirus RNA-dependent RNA polymerase; CTP; cytosine triphosphate; CV; coxsackievirus B3; EC; polymerase-RNA elongation complex; EMCV; encephalomyocarditis virus; EV71; enterovirus 71; FMDV; foot-and-mouth disease virus; HCV; hepatitis C virus;
A structural view of the RNA-dependent RNA polymerases from the Flavivirus genus
Keywords: RNA پلیمراز وابسته به RNA; BVDV; Bovine viral diarrhea virus; C; capsid; cHP; capsid region hairpin; DENV; Dengue virus; DB; dumbbell; E; envelope; EC; elongation complex; EV71; Enterovirus 71; HCV; Hepatitis C virus; HIV-1; Human immunodeficiency virus 1; IC; initiation complex; I
Synthesis, antiviral evaluation and molecular docking studies of N4-aryl substituted/unsubstituted thiosemicarbazones derived from 1-indanones as potent anti-bovine viral diarrhea virus agents
Keywords: RNA پلیمراز وابسته به RNA; Thiosemicarbazones; Bovine viral diarrhea virus (BVDV); RNA-dependent RNA polymerase; Molecular docking; Antiviral activity; Antiviral resistance;
Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design
Keywords: RNA پلیمراز وابسته به RNA; Phenyl [(phenylcarbamoyl)amino]benzene-1-sulfonate derivatives; N-Phenyl-[(phenylcarbamoyl)amino]benzene-1-sulfonamide derivatives; Fragment-linking strategy; Dengue virus; NS5 methyltransferase inhibitors; Antiviral activity; DENV; dengue virus; NS; non-
3-(imidazo[1,2-a:5,4-bâ²]dipyridin-2-yl)aniline inhibits pestivirus replication by targeting a hot spot drug binding pocket in the RNA-dependent RNA polymerase
Keywords: RNA پلیمراز وابسته به RNA; Bovine viral diarrhea virus; RNA-dependent RNA polymerase; 3-(imidazo[1,2-a:5,4-bâ²]dipyridin-2-yl)aniline;
Research ArticleHepatitis E virus mutations associated with ribavirin treatment failure result in altered viral fitness and ribavirin sensitivity
Keywords: RNA پلیمراز وابسته به RNA; HEV; hepatitis E virus; RBV; ribavirin; ALT; alanine aminotransferase; IU; international units; γGT; γ-glutamyltransferase; CLL; chronic lymphoid leukemia; NGS; next-generation sequencing; RdRp; RNA-dependent RNA polymerase; HVR; hypervariable region; O
Hepatitis E Virus Mutations: Functional and Clinical Relevance
Keywords: RNA پلیمراز وابسته به RNA; HEV; hepatitis E virus; ORF; open reading frame; MeT; methyltransferase; Y; Y-domain; PCP; papain-like cysteine protease; HVR; hypervariable region; X-domain; macro-domain; Hel; RNA helicase; RdRp; RNA-dependent RNA polymerase; PPR; polyproline region; CP
New pseudodimeric aurones as palm pocket inhibitors of Hepatitis C virus RNA-dependent RNA polymerase
Keywords: RNA پلیمراز وابسته به RNA; Aurones; Hepatitis C virus; RNA-dependent RNA polymerase;
Rupestonic acid derivative YZH-106 suppresses influenza virus replication by activation of heme oxygenase-1-mediated interferon response
Keywords: RNA پلیمراز وابسته به RNA; IAV; influenza A virus; HO-1; heme oxygenase-1; Nrf2; erythroid 2-related factor 2; ISGs; IFN-stimulated genes; RdRp; RNA-dependent RNA polymerase; TLRs; toll-like receptors; RLR; RIG-I-like receptors; MKP5; MAPK phosphatase 5; IRF3; interferon regulatory
Phosphorylation at the N-terminal finger subdomain of a viral RNA-dependent RNA polymerase
Keywords: RNA پلیمراز وابسته به RNA; Hepatitis C virus; Phosphorylation; RNA-dependent RNA polymerase; Fingers; NS5B;
Synthesis and inhibitory effects of novel pyrimido-pyrrolo-quinoxalinedione analogues targeting nucleoproteins of influenza AÂ virus H1N1
Keywords: RNA پلیمراز وابسته به RNA; RNA-dependent RNA polymerase; Influenza nucleoprotein; Anti-influenza; Pyrimido-pyrrolo-quinoxalinedione (PPQ); RNP-Rab11; ribonucleoprotein Rab-11; MDCK; Madin-Darby canine kidney; RNP; ribonucleoprotein; MOI; multiplicity of infection; RdRP; RNA-depen
The dengue virus NS5 protein as a target for drug discovery
Keywords: RNA پلیمراز وابسته به RNA; DENV; dengue virus; DHF; dengue hemorrhagic fever; NS5; non-structural protein 5; MTase; methyltransferase; GTase; guanylyltransferase; RdRp; RNA-dependent RNA polymerase; NS3; non-structural protein 3; nt; nucleotide; ss; single strand; ds; double strand
The RNA synthesis machinery of negative-stranded RNA viruses
Keywords: RNA پلیمراز وابسته به RNA; Negative-stranded RNA virus; Ribonucleoprotein; Nucleocapsid; RNA-dependent RNA polymerase; Transcription; RNA replication;
Computational study on the drug resistance mechanism of HCV NS5B RNA-dependent RNA polymerase mutants V494I, V494A, M426A, and M423T to Filibuvir
Keywords: RNA پلیمراز وابسته به RNA; Filibuvir; Molecular dynamics (MD); RNA-dependent RNA polymerase; Mutation; Drug resistance mechanism
Picornavirus RNA polyadenylation by 3Dpol, the viral RNA-dependent RNA polymerase
Keywords: RNA پلیمراز وابسته به RNA; Picornavirales; Picornaviridae; RNA-dependent RNA polymerase; 3Dpol; Reiterative transcription; Polyadenylation;
Identification and molecular characterization of human antibody fragments specific for dengue NS5 protein
Keywords: RNA پلیمراز وابسته به RNA; DENV; dengue virus; NS; non-structural protein; NS5FL; full-length NS5 protein; MTase; methyltrasferase; RdRp; RNA-dependent RNA polymerase; Fab; antigen-binding fragment; Dengue; NS5; Phage display; Antibody; Cross-reactivity;
RacGTPase-activating protein 1 interacts with hepatitis C virus polymerase NS5B to regulate viral replication
Keywords: RNA پلیمراز وابسته به RNA; CE; cell extract; co-IP; coimmunoprecipitation; DMEM; Dulbecco's modified Eagle's medium; dsRNA; double-stranded RNA; FBS; fetal bovine serum; FFU; focus-forming units; GAP; GTPase activating protein; GFP; green fluorescent protein; HEK; human embryo
Biophysical characterization of sites of host adaptive mutation in the influenza A virus RNA polymerase PB2 RNA-binding domain
Keywords: RNA پلیمراز وابسته به RNA; ATCC; American Type Culture Collection; EMSA; electrophoretic mobility shift assays; FAM; fluorescein amidite; FLuc; firefly luciferase; HEK; human embryonic kidney; NMR; nuclear magnetic resonance; RdRp; RNA-dependent RNA polymerase; RLuc; Renilla lucife
Polymerases of hepatitis C viruses and flaviviruses: Structural and mechanistic insights and drug development
Keywords: RNA پلیمراز وابسته به RNA; Flaviviridae; RNA-dependent RNA polymerase; RNA synthesis; RdRp regulation; Nucleoside inhibitors; Non-nucleoside inhibitors;
Amodiaquine, an antimalarial drug, inhibits dengue virus type 2 replication and infectivity
Keywords: RNA پلیمراز وابسته به RNA; DENV; dengue virus; AQ; amodiaquine; CQ; chloroquine; AQD; amodiaquine derivative; NS; nonstructural protein; WNV; West Nile virus; RdRP; RNA-dependent RNA polymerase; Repurposing antimalarials as dengue antivirals; Chloroquine; Primaquine; Stable replico
The intracellular inhibition of HCV replication represents a novel mechanism of action by the innate immune Lactoferrin protein
Keywords: RNA پلیمراز وابسته به RNA; HCV; Hepatitis C virus; hLF; human Lactoferrin; LF; Lactoferrin; HIV; human immunodeficiency virus; HSV1; herpes simplex virus type 1; CMV; cytomegalovirus; RDRP; RNA-dependent RNA polymerase; NGS; normal goat serum; WGA; wheat germ agglutinin; IPTG; isop