Keywords: KME; aqueous extract of Korean mistletoe; EMG; electromyography; FoxO1; forkhead box protein O1; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GSK3; glycogen synthase kinase 3; IGF; insulin growth factor; IR; insulin receptor; IRS1; insulin receptor su
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HBP1 phosphorylation by AKT regulates its transcriptional activity and glioblastoma cell proliferation
Keywords: DNMT1; DNA-methyltransferase 1; FOXO; Forkhead box O transcription factors; GST; glutathione S-transferase; HBP1; HMG-box protein 1; HEK; human embryonic kidney; HMG; high mobility group; HPLC; high performance liquid chromatography; KD; kinase dead; MS;
Endothelial replicative senescence delayed by the inhibition of MTORC1 signaling involves MicroRNA-107
Keywords: SA-β gal; senescence-associated beta galactosidase; MTOR; mammalian target of rapamycin; 4EBP1; eIF4E binding protein 1; S6K1; S6 kinase 1; miRNA; microRNA; RISC; RNA-induced silencing complex; UTR; un-translated region; HUVEC; human umbilical vein endot
Identification and evaluation of reference genes for expression studies by RT-qPCR during embryonic development of the emerging model organism, Macrobrachium olfersii
Keywords: RT-qPCR; real-time reverse transcription quantitative polymerase chain reaction; cDNA; complementary DNA; MIQE; Minimum Information for Publication of Quantitative Real-Time PCR Experiments; β-act; β-actin; GAPDH; glyceraldehyde-3-phosphate dehydrogenas
Activation of mTOR/IκB-α/NF-κB pathway contributes to LPS-induced hypotension and inflammation in rats
Keywords: Lipopolysaccharide; mTOR; rpS6; Hypotension; Inflammation; Rat;
p90RSK Blockade Inhibits Dual BRAF and MEK Inhibitor-Resistant Melanoma by Targeting Protein Synthesis
Keywords: eIF; elongation initiation factor; ERK; extracellular signal-regulated kinase; MAPK; mitogen-activated protein kinase; MEK; MAPK/ERK kinase; m7-GTP; 7-methyl-guanosine triphosphate; p90RSK; p90 subfamily of ribosomal S6 kinase; RPPA; reverse phase protein
Role of Akt/PKB and PFKFB isoenzymes in the control of glycolysis, cell proliferation and protein synthesis in mitogen-stimulated thymocytes
Keywords: 4E-BP1; eukaryotic initiation factor 4E-binding protein 1; AMPK; AMP-activated protein kinase; BSA; bovine serum albumin; ConA; concanavalin A; eEF2; eukaryotic elongation factor 2; eIF; eukaryotic initiation factor; ERK; extracellular-signal-regulated
Data on intracellular localization of RPSA upon alteration of its redox state
Keywords: RPSA; RPS6; Redox signaling; Hydrogen peroxide; Ribosomes; Translation
Epigallocatechin-3-gallate enhances key enzymatic activities of hepatic thioredoxin and glutathione systems in selenium-optimal mice but activates hepatic Nrf2 responses in selenium-deficient mice
Keywords: ALT; alanine aminotransferase; AST; aspartate aminotransferase; BSO; buthionine sulfoximine; CDNB; 1-chloro-2, 4-dinitrobenzene; ECL; enhanced chemiluminescense; EDTA; ethylene diamine tetraacetic acid; EGCG; epigallocatechin-3-gallate; FoxO; Forkhead box
Nucleoprotein supplementation enhances the recovery of rat soleus mass with reloading after hindlimb unloading-induced atrophy via myonuclei accretion and increased protein synthesis
Keywords: Nucleoproteins; rpS6; Cell differentiation; Hindlimb suspension; Rat; Akt; protein kinase B; CSAs; cross-sectional areas; mTOR; mammalian target of rapamycin; MyoD; myoblast determination protein; Pax7; transcription factors paired-box 7; PBS; phosphate-b
Identification of nucleosome assembly protein 1 (NAP1) as an interacting partner of plant ribosomal protein S6 (RPS6) and a positive regulator of rDNA transcription
Keywords: Ribosomal protein S6; Histone deacetylase 2B; Nucleosome assembly protein 1; TOR; rDNA transcription; RPS6; ribosomal protein S6; HD2B; histone deacetylase 2B; NAP1; nucleosome assembly protein 1; BiFC; bimolecular fluorescent complementation; TOR; target
Post-transcriptional regulation of autophagy in C2C12 myotubes following starvation and nutrient restoration
Keywords: ACC; acetyl-CoA carboxylase; Akt/PKB; protein kinase B; AMPK; AMP-activated protein kinase; ANOVA; analysis of variance; Atg; autophagy-related gene; Bnip3; B-cell lymphoma 2 interacting protein 3; DMEM; Dulbecco's modified Eagle medium; DPBS; Dulbecco's
Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomes
Keywords: IRSs; insulin receptor substrates; IGFs; insulin-like growth factors; PABPC1; poly(A) binding protein cytoplasmic 1; MALDI-TOF-MS; matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry; BN-PAGE; blue native-polyacrylamide gel elec
Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression
Keywords: P70S6K; ribosomal protein S6 kinase; mTOR; the mammalian target of rapamycin; SIRT; silent information regulator; Tsc; tuberous sclerosis complex; mTORC1; the mammalian target of rapamycin complex 1; POF; premature ovarian failure; PTEN; phosphatase and t
TCDD induces the expression of insulin-like growth factor binding protein 4 in 5L rat hepatoma cells: A cautionary tale of the use of this cell line in studies on dioxin toxicity
Keywords: AhR; aryl hydrocarbon receptor; AKT1S1; proline-rich AKT1 substrate 1; CYP1A1; cytochrome P450 1A1; 4E-BP1; eukaryotic translation initiation factor 4E-binding protein 1; ERK; extracellular signal-regulated protein kinase; GSK3; glycogen synthase kinase 3
Research ArticleInactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways
Keywords: AKT; v-akt murine thymoma viral oncogene homolog; ERK; extracellular-related kinase; GLUT; glucose transporter; HCC; hepatocellular carcinoma; MAPK; mitogen-activated protein kinase; mTOR; mammalian target of rapamycin; mTORC; mTOR complex; RPS6; ribosoma
IL-33 induces innate lymphoid cell-mediated airway inflammation by activating mammalian target of rapamycin
Keywords: IL-33; TH2; innate lymphoid cells; asthma; mammalian target of rapamycin; rapamycin; AHR; Airway hyperresponsiveness; APC; Allophycocyanin; BAL; Bronchoalveolar lavage; ICOS; Inducible costimulator; ILC; Innate lymphoid cell; Lin; Lineage-specific marker;
Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass
Keywords: 4E-BP1; 4E binding protein 1; 5â²UTR; 5â² untranslated region; AICAR; 5-aminoimidazole-4-carboxamide riboside; AMP; adenosine monophosphate; AMPK; 5â²-AMP-activated protein kinase; AMPK α1â/â; AMPK α1 subunit knockout; AMPKα1â/âα2â/â; A
Mechanisms involved in the enhancement of mammalian target of rapamycin signalling and hypertrophy in skeletal muscle of myostatin-deficient mice
Keywords: PKB; protein kinase B; mTOR; mammalian target of rapamycin; GDF-8; growth differentiation factor-8; TGF-β; transforming growth factor-β; 4E-BP1; eukaryotic translation initiation factor 4E-binding protein-1; rpS6; ribosomal protein S6; COX IV; cytochrom
Research ArticleIGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage
Keywords: HCC; hepatocellular carcinoma; IGF; insulin-like growth factor; IGFBP-3; IGF binding protein 3; HCV; hepatitis C virus; FBS; fetal bovine serum; RT-PCR; real time polymerase chain reaction; miR-; microRNA; GSEA; gene set enrichment analysis; RPS6; ribosom
Differential requirement of ribosomal protein S6 by plant RNA viruses with different translation initiation strategies
Keywords: Ribosomal protein; Plant virus; RPS6; RPL19; Potyvirus; Tobamovirus; Tombusvirus
Bevacizumab and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma
Keywords: HCC; Hepatocellular carcinoma; VEGF; vascular endothelial growth factor; BEV; Bevacizumab; mTOR; mammalian target-of-rapamycin; p70S6K; p70S6 kinase; RPS6; ribosomal S6 protein; 4EBP1; eukaryotic initiation factor 4E-binding protein 1; RAPA; rapamycin; IP
d-Glucosamine inhibits proliferation of human cancer cells through inhibition of p70S6K
Keywords: d-Glucosamine; p70S6K; RPS6; Cell proliferation; Prostate cancer; Breast cancer
Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span
Keywords: Yeast replicative aging; Longevity; Translational capacity; Ribosomal protein; Rpl10; Rps6; Rps18
Effect of 3â²UTR length on the translational regulation of 5â²-terminal oligopyrimidine mRNAs
Keywords: bp; base pair(s); cDNA; DNA complementary to RNA; EGFP; Enhanced Green Fluorescent Protein; mRNA; messenger RNA; mRNP; messenger ribonucleoprotein particle; nt; nucleotide(s); PCR; polymerase chain reaction; PABP; poly(A)-binding protein; RACE; rapid ampl