کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870883 1074025 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomes
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomes
چکیده انگلیسی
Insulin receptor substrates (IRSs) are known to play important roles in mediating intracellular insulin-like growth factors (IGFs)/insulin signaling. In this study, we identified components of messenger ribonucleoprotein (mRNP) as IRS-1-associated proteins. IRS-1 complex formation analysis revealed that IRS-1 is incorporated into the complexes of molecular mass more than 1000 kDa, which were disrupted by treatment with RNase. Furthermore, oligo(dT) beads precipitated IRS-1 from cell lysates, showing that the IRS-1 complexes contained messenger RNA. Taken together with the data that IRS-1 was fractionated into the polysome-containing high-density fractions, we concluded that IRS-1 forms the novel complexes with mRNPs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 587, Issue 15, 2 August 2013, Pages 2319-2324
نویسندگان
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