Sphingosine 1-phosphate regulates inflammation-related genes in human endothelial cells through S1P1 and S1P3
Keywords: S1P; S1P1; S1P3; Endothelial cells
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A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC)
Keywords: HPLC; high-performance liquid chromatography; HUVEC; human umbilical vein endothelial cells; IMAC; immobilized metal affinity chromatography; MEEC; mouse embryonic endothelial cells; MEF; mouse embryonic fibroblast; S1P; sphingosine 1-phosphate; S1Px; sph
A sphingosine-1-phosphate type 1 receptor agonist inhibits the early T-cell transient following renal ischemia–reperfusion injury
Keywords: S1P; EDG1; chemokine; ischemic renal injury; lymphocyte; renal lymphatics
Sphingosine-1-phosphate initiates rapid retraction of pseudopodia by localized RhoA activation
Keywords: DB; DMEM containing 0.1% fatty-acid-free bovine serum albumin; DMEM; Dulbecco's Modified Eagle's Medium; EDG; endothelial differentiation gene; LPA; Lysophosphatidic acid; PDGF; platelet-derived growth factor; S1P; sphingosine-1-phosphate.; mDia; ROCK; Rh
S1P and LPA have an attachment-dependent regulatory effect on invasion of epithelial ovarian cancer cells
Keywords: S1P; LPA; Invasion; Cellular attachment; N-cadherin; Ovarian cancer
Disruption of sphingolipid metabolism elicits apoptosis-associated reproductive defects in Drosophila
Keywords: S1P, sphingosine-1-phosphateSphingolipid; Ceramide; S1P; Apoptosis; Cell death; Drosophila; Oogenesis; Spermatogenesis; Reproduction; Germ cells
Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P1) receptor
Keywords: Sphingosine-1-phosphate; S1P; Immunosuppressant; Lymphocyte-lowering; Agonist; Heteropentalene
Hypothesis: VPAC G protein-coupled receptors for vasoactive intestinal peptide constitute a dynamic system for signaling T cells from plasma membrane and nuclear membrane complexes
Keywords: VIP; vasoactive intestinal peptide; GPCR; G protein-coupled receptor; VPAC1; type 1 VIP receptor; VPAC2; type 2 VIP receptor; T cell; T lymphocyte; LPA; lysophosphatidic acid; S1P; sphingosine 1-phosphate; LPA1; type 1 LPA receptor; iNOS; inducible nitric
S1P regulation of ovarian carcinoma invasiveness
Keywords: S1P; LPA; Ovarian cancer; Invasion; S1P receptors; LPA receptors
S1P1-selective agonist, SEW2871, ameliorates ischemic acute renal failure
Keywords: S1P; EDG1; TNF-α; ICAM-1; ischemic renal injury; lymphocytopenia
Mechanisms of pericyte recruitment in tumour angiogenesis: A new role for metalloproteinases
Keywords: Pericyte; Metalloproteinase; Tumour; Angiogenesis; PDGF; HB-EGF; S1P; TGF-β1; Angiopoietin 1α-SMA, α-smooth muscle actin; ALK, activin-like kinase; Ang1, angiopoietin 1; AngII, angiotensin II; bFGF, basic fibroblast growth factor; EC, endothelial cell; EC
Sphingosine-1-phosphate inhibits cell migration and endothelial to mesenchymal cell transformation during cardiac development
Keywords: Sphingosine-1-phosphate; S1P; Heart; Endocardial cushion; Cardiac; Atrioventricular canal; Embryo; Mouse
Downregulation of the angiogenesis inhibitor thrombospondin 1 in fibroblasts exposed to platelets and their related phospholipids
Keywords: Thrombospondin 1; Sphingosine; S1P; Platelets; Angiogenesis; Hemostasis; Cancer;
Lysophospholipids in the nervous system
Keywords: Lysophosphatidic acid; Lysophosphatidylcholine; Sphingosine 1-phosphate; Neuroscience; G protein-coupled receptor; LPA; S1P;
Serine palmitoyl-CoA transferase (SPT) deficiency and sphingolipid levels in mice
Keywords: SPT; serine palmitoyl-CoA transferase; LCB; long chain base; Cer; ceramide; Sph; sphingosine; S1P; sphingosine-1-phosphate; SM; sphingomyelin; PL; choline-containing phospholipids; TG; triglyceride; FPLC; fast protein liquid chromatography;
Multiple Anti-apoptotic Pathways Stimulated by EGF in Cytotrophoblasts
Keywords: Trophoblasts; Signal transduction; ERK; p38; PI-3 kinase; JNK; SPHK-1; S1P; EGF;
Involvement of p38 MAP kinase-mediated cytochrome c release on sphingosine-1-phosphate (S1P)- and N-monomethyl-S1P-induced cell death of PC12 cells
Keywords: S1P; d-erythro-Sphingosine-1-phosphate; MM-S1P; d-erythro-N-Monomethyl-S1P; MAPK; mitogen-activated protein kinase; ERK1/2; extracellular regulated protein kinase 1/2; NGF; nerve growth factor; PTX; pertussis toxin; SB203580; 4-(4-fluorophenyl)-2-(4-methy
The epidermal growth factor stimulates sphingosine kinase-1 expression and activity in the human mammary carcinoma cell line MCF7
Keywords: BSA; bovine serum albumin; DAPI; 4,6-diamino-2-phenylindole; DMEM; Dulbecco's modified Eagle medium; DMS; N,N-dimethyl sphingosine; EGF; epidermal growth factor; GRE; glucocorticoid responsive element; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; IκB
Sphingosine kinase 1 is involved in dibutyryl cyclic AMP-induced granulocytic differentiation through the upregulation of extracellular signal-regulated kinase, but not p38 MAP kinase, in HL60 cells
Keywords: SPHK; sphingosine kinase; S1P; sphingosine-1-phosphate; DMS; N,N-dimethylsphingosine; dbcAMP; dibutyryl cyclic AMP; NBT; nitroblue tetrazolium; fMLP; N-formyl-methionyl-leucyl-phenylalanine; ERK; extracellular regulating protein kinase; MAPK; mitogen acti
Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells
Keywords: P-Rex2b; GEF; Cell migration; Endothelial cell; HEK293T cell; Rac1; P-Rex2; PtdIns(3,4,5)P3-dependent Rac exchange factor 2; SRE.L; SRE-Luciferase reporter gene; S1P; spingosine-1 phosphate; GEF; guanine nucleotide exchange factor; PIP3; phosphatidylinosi
Enhancement of intracellular sphingosine-1-phosphate production by inositol 1,4,5-trisphosphate-evoked calcium mobilisation in HEK-293 cells: endogenous sphingosine-1-phosphate as a modulator of the calcium response
Keywords: S1P; sphingosine-1-phosphate; SK; sphingosine kinase; PKC; protein kinase C; IP3; inositol 1,4,5-trisphosphate; 2-APB; 2-aminoethyl diphenyl borate; IPx; inositol phosphates; HBSS; HEPES buffered salt solution; cS1P; caged sphingosine-1-phosphate; PLC; ph
The role of sphingosine-1-phosphate in smooth muscle contraction
Keywords: ASM; airway smooth muscle; [Ca2+]i; intracellular calcium concentration; CNP; C-type natriuretic peptide; CHO; Chinese hamster ovary; DAG; diacylglycerol; dihydro-S1P; sphinganine-1-phosphate; eNOS; endothelial nitric oxide synthase; ER; endoplasmic retic
Sphingosylphosphorylcholine generates reactive oxygen species through calcium-, protein kinase Cδ- and phospholipase D-dependent pathways
Keywords: SPC; sphingosylphosphorylcholine; GPCRs; G protein-coupled receptors; PLC; phospholipase C; PIP2; phosphatidylinositol 4, 5-bisphosphate; [Ca2+]i; intracellular Ca2+; PLD; phospholipase D; LPA; lysophosphatidic acid; PKC; protein kinase C; ARF; ADP-ribosy
FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors
Keywords: AZ; azathioprine; CI; combination index; CsA; cyclosporin A; EAE; experimental autoimmune encephalomyelitis; FK506; tacrolimus; FTY720; 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride; FTY720-P; FTY720-phosphate; GvHR; graft versus host r
Phosphorylation-independent internalisation and desensitisation of the human sphingosine-1-phosphate receptor S1P3
Keywords: S1P; d-erythro-sphingosine-1-phosphate; G-protein; guanine nucleotide-binding regulatory protein; ERK; extracellular signal-regulated kinase; GPCR; G-protein-coupled receptor; GRK; G-protein-coupled receptor kinase; PKC; protein kinase C; GFP; green fluor
p85 β-PIX is required for cell motility through phosphorylations of focal adhesion kinase and p38 MAP kinase
Keywords: LPA; lysophosphatidic acid; PAK; p21 activated kinase; PID; PAK inhibitory domain; PIX; PAK-interacting exchange factor; GIT1; G-protein-coupled receptor kinase interacting targets; bFGF; basic fibroblast growth factor; FAK; focal adhesion kinase; LysoPLD
RNA interference: From gene silencing to gene-specific therapeutics
Keywords: RNAi; siRNA; shRNA; Disease; Validation; Therapy; AAV; adeno-associated virus; ABCA1; ATP-binding cassette, subfamily A, member 1; Bcl-2; B-cell chronic lymphocytic leukemia/lymphoma 2; BCR-ABL; breakpoint cluster region-protooncogene tyrosine-protein kin