Generation of predictive pharmacophore model for SARS-coronavirus main proteinase
Keywords: SARS-CoV; Pharmacophore; Virtual screening; Drug design;
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Screening of drugs by FRET analysis identifies inhibitors of SARS-CoV 3CL protease
Keywords: SARS; SARS-CoV; 3C-like protease; SARS-CoV 3CL protease; Fluorescence resonance energy transfer; Hexachlorophene; Molecular docking; Inhibitors; HPLC; Kinetic analysis;
Concentration and detection of SARS coronavirus in sewage from Xiao Tang Shan Hospital and the 309th Hospital
Keywords: SARS-CoV; Detection; Concentration; Sewage; Hospital;
JNK and PI3k/Akt signaling pathways are required for establishing persistent SARS-CoV infection in Vero E6 cells
Keywords: SARS-CoV; Persistent infection; c-Jun N-terminal protein kinase; Phosphatidylinositol 3â²-kinase/Akt;
Synthetic peptides derived from SARS coronavirus S protein with diagnostic and therapeutic potential
Keywords: SARS-CoV; severe acute respiratory syndrome-associated coronavirus; Abs; antibodies; Severe acute respiratory syndrome coronavirus; Spike protein; Synthetic peptide; Syncytia formation and disease prevention;
Design of recombinant protein-based SARS-CoV entry inhibitors targeting the heptad-repeat regions of the spike protein S2 domain
Keywords: Design; SARS-CoV; Protein inhibitors; Heptad-repeat regions; Spike protein; Pseudotyped virus;
The interaction of the SARS coronavirus non-structural protein 10 with the cellular oxido-reductase system causes an extensive cytopathic effect
Keywords: SARS-CoV; severe acute respiratory syndrome coronavirus; BTF3; basic transcription factor-3; ATF5; activation transcription factor-5; NADH; nicotinamide adenine dinucleotide dehydrogenase; FBS; fetal bovine serum; DMEM; double minimal essential media; QDO
Study on the resistance of severe acute respiratory syndrome-associated coronavirus
Keywords: SARS-CoV; Resistance; In vitro; Disinfection;
Evaluation of a safe and sensitive Spike protein-based immunofluorescence assay for the detection of antibody responses to SARS-CoV
Keywords: SARS-CoV; Spike protein; IFA; Antibody detection;
Structural analysis of inhibition mechanisms of Aurintricarboxylic Acid on SARS-CoV polymerase and other proteins
Keywords: SARS-CoV; RNA-dependent RNA polymerase; Inhibitor; HIV;
Adenoviral expression of a truncated S1 subunit of SARS-CoV spike protein results in specific humoral immune responses against SARS-CoV in rats
Keywords: Ad-LacZ; recombinant replication-incompetent adenoviral vector containing β-galactosidase gene; Ad-SN; recombinant replication-incompetent adenoviral vector containing the SN fragment of SARS-CoV; ELISA; enzyme-linked immuno-sorbent assay; MOI; multiplic
A human SARS-CoV neutralizing antibody against epitope on S2 protein
Keywords: SARS-CoV; Neutralizing antibody; S2 protein; scFv; Phage-display library;
Induction of Th1 type response by DNA vaccinations with N, M, and E genes against SARS-CoV in mice
Keywords: SARS-CoV; Nucleocapsid protein; Membrane protein; Envelop protein; DNA vaccine; In vivo CTL; Th1 response;
Antibody responses to individual proteins of SARS coronavirus and their neutralization activities
Keywords: SARS coronavirus; Recombinant protein; Protein microarray; Antibodies; Neutralizing antibodies; E protein; envelope glycoprotein; FI; fluorescence intensity; M protein; membrane protein; N protein; nucleocapsid protein; SARS-CoV; the SARS coronavirus; S p
A novel cell-based binding assay system reconstituting interaction between SARS-CoV S protein and its cellular receptor
Keywords: SARS-CoV; Ectodomain; CHO; EGFP-tagged; ACE2; Cell-based assay;
Development of a homogeneous screening assay for automated detection of antiviral agents active against severe acute respiratory syndrome-associated coronavirus
Keywords: SARS-CoV; High-throughput screening; Antiviral activity; EGFP expression;
Identification of single-chain antibody fragments specific against SARS-associated coronavirus from phage-displayed antibody library
Keywords: SARS-CoV; Phage display; scFv; Labeling; ELISA;
Intranasal immunization with inactivated SARS-CoV (SARS-associated coronavirus) induced local and serum antibodies in mice
Keywords: SARS-CoV; Intranasal immunization; Inactivated vaccine;
Immunogenicity, safety, and protective efficacy of an inactivated SARS-associated coronavirus vaccine in rhesus monkeys
Keywords: SARS-CoV; Inactivated vaccine; Rhesus monkeys
The design and application of DNA chips for early detection of SARS-CoV from clinical samples
Keywords: SARS-CoV; severe acute respiratory syndrome-coronavirus; HEX; hexa-chloro-6-carboxyfluorescein; TAMRA; 6-carboxytetramethylrhodamine; SARS; Coronavirus; SARS-CoV; Early detection; Gene chip;
Molecular evolution and multilocus sequence typing of 145 strains of SARS-CoV
Keywords: Severe acute respiratory syndrome; SARS-CoV; Genotype; Phylogeny; Most recent common ancestor
Identification of a critical neutralization determinant of severe acute respiratory syndrome (SARS)-associated coronavirus: importance for designing SARS vaccines
Keywords: SARS-CoV; Spike protein; Receptor-binding domain; Neutralizing antibodies; Monoclonal antibodies; Vaccines;
Comparison of 9 different PCR primers for the rapid detection of severe acute respiratory syndrome coronavirus using 2 RNA extraction methods
Keywords: SARS-CoV; Real-time and conventional RT-PCR; Sensitivity and specificity;
Serum neopterin for early assessment of severity of severe acute respiratory syndrome
Keywords: Coronavirus; CoV; Fever; Inflammation; Neopterin; Severe acute respiratory syndrome; SARS; SARS-CoV; Steroid;
Coronavirus phylogeny based on a geometric approach
Keywords: Phylogenetic tree; Coronavirus; Severe acute respiratory syndrome; SARS-CoV; Z-curve;
SARS-coronavirus replication in human peripheral monocytes/macrophages
Keywords: SARS-CoV; Monocytes/macrophages; Interferon;
Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus
Keywords: SARS-CoV; Proprotein convertases; Furin; Inhibitor; Viral infection; Viral spread; Biosynthesis; Spike glycoprotein processing;
Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome
Keywords: Severe acute respiratory syndrome; Immune monitoring; Immune system; ALT; aminotransferase; ANOVA; analysis of variance; AST; aspartate aminotransferase; C; complement; CoV; coronavirus; ctr; control; ELISA; enzyme-linked immunosorbent assay; FBS; fetal b
Nucleolar localization of non-structural protein 3b, a protein specifically encoded by the severe acute respiratory syndrome coronavirus
Keywords: DMEM; Dulbecco's modified Eagel's medium; ECL; enhanced chemiluminescence; EGFP; enhanced green fluorescent protein; N; nucleocapsid; NLS; nuclear localization signal; NoLS; nucleolus localization signal; ORF; open reading frame; PBS; phosphate-buffered s
Epitope mapping and biological function analysis of antibodies produced by immunization of mice with an inactivated Chinese isolate of severe acute respiratory syndrome-associated coronavirus (SARS-CoV)
Keywords: SARS-CoV; Monoclonal antibody; Epitope mapping; Inactivated vaccine;
Sumoylation of the nucleocapsid protein of severe acute respiratory syndrome coronavirus
Keywords: SARS-CoV; Nucleocapsid protein; Sumoylation; Oligomerization; Multinucleated cells; Cytokinesis;
Subcellular localization and membrane association of SARS-CoV 3a protein
Keywords: SARS; severe acute respiratory syndrome; PBS; phosphate-buffered saline; SARS-CoV; SARS-associated coronavirus; rep; replicase; S; spike; E; envelope; M; membrane; N; nucleocapsid; ORF; open reading frame; DMEM; Dulbecco's modified Eagel medium; EGFP; enh
Identification of murine CD8 T cell epitopes in codon-optimized SARS-associated coronavirus spike protein
Keywords: SARS-CoV; CD8 T cells; MHC class I epitope; Codon optimization; Promoter optimization; Replication-defective adenoviral vaccine vectors;
Development of antiviral therapy for severe acute respiratory syndrome
Keywords: Anti-viral therapy; SARS-CoV; Ribavirin;
Rational monoclonal antibody development to emerging pathogens, biothreat agents and agents of foreign animal disease: The antigen scale
Keywords: mAb; monoclonal antibody; SARS-CoV; severe acute respiratory syndrome coronavirus; FMD virus; foot-and-mouth disease virus; PA; protective antigen of Bacillus anthracis; BSA; bovine serum albumin; FBS; fetal bovine serum; HAT; hypoxanthine-aminopterinâ