کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9282995 | 1224998 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome
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کلمات کلیدی
TNFNF-κBSARS-associated coronavirusSARS-CoVFBSTGFPBMCIFN-γCTRMCP-1ALTS.D. - SD.COV - THEAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST aminotransferase - آمینوترانسفرازstandard deviation - انحراف معیارimmunoglobulin - ایمونوگلوبولینinterferon γ - اینترفرون γinterleukin - اینترلوکینtransforming growth factor - تبدیل فاکتور رشدanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceELISA - تست الیزاEnzyme-linked immunosorbent assay - تست الیزاImmune system - دستگاه ایمنی یا سیستم ایمنیSARS - سارسfetal bovine serum - سرم جنین گاوPeripheral blood mononuclear cell - سلول تک هسته ای خون محیطیsevere acute respiratory syndrome - سندرم شدید حاد تنفسیtumor necrosis factor - فاکتور نکروز تومورnuclear factor κB - فاکتور هسته ای κBComplement - متممRANTES - مطالبImmune monitoring - نظارت بر ایمنیmonocyte chemoattractant protein-1 - پروتئین شیمیایی monocyte chemoattractant-1Coronavirus - کروناویروسControl - کنترل
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
To define the dynamics of the immune spectrum in SARS, serum levels of cytokines, chemokines, immunoglobulins, complement and specific antibodies against SARS-associated coronavirus (SARS-CoV) were assayed by enzyme-linked immunosorbent assay (ELISA), and phenotypes of peripheral lymphocytes were analyzed by flow cytometry in 95 SARS-infected patients. Results showed that interleukin (IL)-10 and transforming growth factor β (TGF-β) were continuously up-regulated during the entirety of SARS. Regulated on activation normally T cell-expressed and secreted (RANTES) levels were decreased, while monocyte chemoattractant protein-1 (MCP-1) was elevated in acute patients. Immunoglobulins and complement were elevated during the first month of SARS. Both serum-positive rates and titers of specific IgM and IgG antibodies responding to SARS-CoV peaked at days 41-60 from the onset of SARS. CD4+ and CD8+ T lymphocytes decreased significantly in acute-phase. CD3+CD8+CD45RO+ T lymphocytes were decreased by 36.78% in the convalescent patients. Conclusion: SARS-CoV seemed to elicit effective humoral immunity but inhibited cellular immunity, especially CD8+ memory T lymphocytes over time. Prolonged overproduction of IL-10 and TGF-β may play an important role in the disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbes and Infection - Volume 7, Issue 3, March 2005, Pages 427-436
Journal: Microbes and Infection - Volume 7, Issue 3, March 2005, Pages 427-436
نویسندگان
Jia-Ling Huang, Jian Huang, Zhao-Hui Duan, Jing Wei, Jun Min, Xiao-Hong Luo, Jian-Guo Li, Wei-Ping Tan, Li-Zhi Wu, Ran-Yi Liu, Yan Li, Jing Shao, Bi-Jun Huang, Yi-Xin Zeng, Wenlin Huang,