miRNAs in stem cell aging and age-related disease
Keywords: Ageing; Somatic stem cell; MicroRNA; Senescence; SASP;
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Anti-inflammatory effects of Brucea javanica oil emulsion by suppressing NF-κB activation on dextran sulfate sodium-induced ulcerative colitis in mice
Keywords: UC; Ulcerative colitis; BJOE; Brucea javanica oil emulsion; SASP; Sulfasalazine; AZA; Azathioprine; TNF-α; Tumor necrosis factor-α; IL-1β; Interleukin-1β; IL-6; Interleukin-6; IL-8; Interleukin-8; IL-17; Interleukin-17; IFN-γ; Interferon-γ; MPO; mye
The matrikine N-acetylated proline-glycine-proline induces premature senescence of nucleus pulposus cells via CXCR1-dependent ROS accumulation and DNA damage and reinforces the destructive effect of these cells on homeostasis of intervertebral discs
Keywords: IVD; intervertebral disc; IDD; intervertebral disc degeneration; SASP; senescence-associated secreted phenotype; NP; nucleus pulposus; AF; annulus fibrosus; SA-β-Gal; senescence-associated β-galactosidase; ECM; extracellular matrix; DDR; DNA damage resp
Relationship of inflammatory profile of elderly patients serum and senescence-associated secretory phenotype with human breast cancer cells proliferation: Role of IL6/IL8 ratio
Keywords: Inflammation; SASP; Proliferation; IL-6; IL-8; Senescence; Aging;
Functional relevance of miRNAs in premature ageing
Keywords: CRP; C-reactive protein; DDR; DNA damage response; DSB; double-strand breaks; HATs; histone acetyltransferases; HDACs; histone deacetylases; hMSCs; human mesenchymal stem cells; HRR; homologous recombination repair; MEFs; mouse embryonic fibroblast; ROS;
Neovascular deterioration, impaired NADPH oxidase and inflammatory cytokine expression in adipose-derived multipotent cells from subjects with metabolic syndrome
Keywords: APC; allophycocyanin; ASC; adipose tissue-derived multipotent mesenchymal cells; BMI; body mass index; CEBPα; CCAAT/enhancer binding protein α; EBM; endothelial basal medium; FBS; fetal bovine serum; FCS; fetal calf serum; FITC; fluorescein isothiocyana
Ionizing radiation induces long-term senescence in endothelial cells through mitochondrial respiratory complex II dysfunction and superoxide generation
Keywords: IR; irradiation; ROS; reactive oxygen species; DDR; DNA damage response; SASP; senescence-associated secretory phenotype; O/N; overnight; Senescence; Endothelial cell; Mitochondrial oxidative stress; Ionizing radiation;
Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence
Keywords: AD; Alzheimer's Disease;; AGEs; advanced glycation endproducts; ALP; autophagy-lysosome pathway; ARF; alternate reading frame; ATGs; autophagy-related proteins; BAG3; Bcl2-associated athanogene 3; Bcl-2; B-cell lymphoma 2; BrdU; 5-bromodeoxyuridine;; CMA;
ASPL-TFE3 Oncoprotein Regulates Cell Cycle Progression and Induces Cellular Senescence by Up-Regulating p21
Keywords: ASPS; alveolar soft part sarcoma; ChIP; chromatin immunoprecipitation; FACS; fluorescence-activated cell sorting; MSCs; mesenchymal stem cells; OIS; oncogene-induced senescence; SA-β-gal; senescence-associated β-galactosidase; SASP; senescence-associate
Chemical composition and “in vitro” anti-inflammatory activity of Vitis vinifera L. (var. Sangiovese) tendrils extract
Keywords: CAD; coronary artery disease; CVD; cardiovascular disease; DPPH; diphenylpicrylhydrazyl; HPLC-DAD; high-performance liquid chromatography with diode-array detection; IRAK-1; IL-1 receptor-associated kinase 1; LPS; lipopolysaccharide; MIRAKIL; biomarkers a
Inactivation techniques for MALDI-TOF MS analysis of highly pathogenic bacteria - A critical review
Keywords: Inactivation; Highly pathogenic bacteria; MALDI-TOF mass spectrometry; Identification; Gamma-irradiation; Ethanol/formic acid extraction; TFA inactivation; Inactivation of spore formers; BSL; biosafety level; CDC; Centers for Disease Control and Preventio
Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) for the identification of highly pathogenic bacteria
Keywords: Highly pathogenic bacteria; MALDI-TOF mass spectrometry; Assignment of MS biomarkers; Bacillus anthracis; Burkholderia mallei; Burkholderia pseudomallei; Francisella tularensis; Brucella abortus; Yersinia pestis; ANN; artificial neural network; FA; formic
Histone demethylase JMJD3 at the intersection of cellular senescence and cancer
Keywords: Cancer; Senescence; Inflammation; Aging; Jumonji; JMJD3; SASP; H3K27;
Sustained activation of ADP/P2ry12 signaling induces SMC senescence contributing to thoracic aortic aneurysm/dissection
Keywords: TAAD; thoracic aortic aneurysm/dissection; SMC; smooth muscle cell; ECM; extracellular matrix; SA-β-gal; senescence-associated β-galactosidase; ADP; adenosine diphosphate; P2ry12; P2Y G protein-coupled receptor 12; DAMPs; damage-associated molecular pat
Quality control mechanisms in cellular and systemic DNA damage responses
Keywords: DNA damage; Ageing; Ubiquitin proteasome system; DNA repair; Progeroid syndromes; Genome stability; ARF; adenosine diphosphate ribosylation factor; AT; ataxia telangiectasia; ATM; ataxia telangiectasia mutated; ATP; adenosine triphosphate; BER; base excis
Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer
Keywords: DNA damage; Stress response; Treatment failure; Cancer; MYBBP1A; Myb-binding protein 1A; OPSCC; oropharyngeal squamous cell carcinoma; HNSCC; head and neck squamous cell carcinoma; SA-β-Gal; senescence-associated β-galactosidase; SAHF; senescence-associ
Effects of flavonoids on senescence-associated secretory phenotype formation from bleomycin-induced senescence in BJ fibroblasts
Keywords: Flavonoid; Senescence; SASP; Chronic low-grade inflammation; IκBζ
ReviewAutophagy and senescence in fibrosing cholangiopathies
Keywords: BA; biliary atresia; EMT; epithelial-mesenchymal transition; PAMP; pathogen-associated molecular patterns; PBC; primary biliary cirrhosis; PSC; primary sclerosing cholangitis; SASP; senescence-associated secretory phenotype; TLR; Toll-like receptor; TRAIL
The Nuclear Factor κB pathway: A link to the immune system in the radiation response
Keywords: Nuclear Factor κB; Immune system; Cellular radiation response; Linear energy transfer; Bystander effect; Chemokines; A20 (TNFAIP3); tumor necrosis factor inducible protein 3; ARD; ankyrin repeat domain; ATM; ataxia telangiectasia mutated protein; β-TrCP
TRIM28/KAP1 regulates senescence
Keywords: Senescence; SASP; TRIM28; p16
Loss of HuR leads to senescence-like cytokine induction in rodent fibroblasts by activating NF-κB
Keywords: SASP, senescence-associated secretory phenotype; HuR, human antigen R; IL-6, interleukin 6; MEF, mouse embryonic fibroblast; sh-RNA, short hairpin RNA; DDR, DNA damage response; IR, ionizing radiation; UV, ultravioletSenescence; SASP; HuR; NF-κB
Senescent stroma promotes prostate cancer progression: The role of miR-210
Keywords: Senescence; Prostate cancer; Tumor microenvironment; miR-210; CAF; cancer associated fibroblast; CM; conditioned medium; COX; cyclooxygenase; EPC; endothelial progenitor cell; HIF; hypoxia-inducible factor; HPF; human prostate fibroblasts; HUVEC; human um
Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells
Keywords: CRC; colorectal cancer; CPT; camptothecin; DSBs; double-strand breaks; DDR; DNA damage response; γ-H2AX; phosphorylated histone H2AX; ATM; ataxia telangiectasia mutated; Chk2; check-point kinase; AMPK; AMP-activated protein kinase; TSC2; tuberous scleros
Anti-inflammatory effect of ubiquinol-10 on young and senescent endothelial cells via miR-146a modulation
Keywords: miR-146a; Replicative senescence; HUVEC; Coenzyme Q10; SASP; IL-6; Free radicals;
Mesenchymal stroma: primary determinant and therapeutic target for epithelial cancer
Keywords: stromal microenvironment; senescence; SASP; skin cancer; autophagy
Bystander senescence in human peritoneal mesothelium and fibroblasts is related to thrombospondin-1-dependent activation of transforming growth factor-β1
Keywords: Cellular senescence; Peritoneal cavity; SASP; Thrombospondin-1; Transforming growth factor-β1
Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)
Keywords: AP-1; activator protein-1; ASC; apoptosis-associated speck-like protein containing a CARD domain; ASK; apoptosis signal-regulating kinase; ATM; Ataxia Telangiectasia Mutated; ATR; ATM and Rad 3-related; BRCA1; breast cancer 1; CARD; caspase activation and
Anti-inflammatory effects of iridoid glycosides fraction of Folium syringae leaves on TNBS-induced colitis in rats
Keywords: IBD; inflammatory bowel disease; UC; ulcerative colitis; TNBS; 2,4,6-trinitrobenzenesulfonic acid; SASP; salicylazosulfapyridine; PBS; phosphate-buffered saline; DAB; 3,3â²-diaminobenzidine; CMC-Na; sodium carboxymethycellulose; NF-κBp65; nuclear factor
Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2
Keywords: ADT; androgen deprivation therapy; AIPC; androgen-independent prostate cancer; AR; androgen receptor; CS; charcoal-stripped fetal bovine serum; EMT; epithelial-to-mesenchymal transition; HP1β; heterochromatin protein 1β; IL-8; interleukin-8; IGFBP3; ins
Pathophysiology of vascular calcification: Pivotal role of cellular senescence in vascular smooth muscle cells
Keywords: Cellular senescence; Vascular calcification; Vascular smooth muscle; Ageing; RUNX-2; SASP; CESP
Randomized, Controlled Trial of Spaced Education to Urology Residents in the United States and Canada
Keywords: urology; education; medical; graduate; educational technology; memory; ABU; American Board of Urology; AUA; American Urological Association; ISE; In-Service Examination; SASP; AUA Self-Assessment Study Program;