Cep68 can be regulated by Nek2 and SCF complex
Keywords: Cep68; Nek2; Centrosome separation; SCF; Cell cycle;
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Thymopentin enhances the generation of T-cell lineage derived from human embryonic stem cells in vitro
Keywords: bFGF; basic fibroblast growth factor; BMP4; bone morphogenetic protein-4; CFU-E; erythroid-colony forming units; CFU-E/G; erythroid-granulocyte colony forming units; CFU-GM; granulo-macrophagic colony forming units; cyCD3-PE; cytoplasmic CD3-PE; DLL; de
High content and high throughput screening to assess the angiogenic and neurogenic actions of mesenchymal stem cells in vitro
Keywords: BMSC; Bone marrow-derived mesenchymal stem cell; VEGF; Vascular endothelial growth factor; FGF; Fibroblast growth factor; PDGF; Platelet-derived growth factor; NRG1; Neuroregulin-1; GDNF; Glial-derived neurotrophic factor; BDNF; Brain-derived neurotrophic
Human megakaryocyte progenitors derived from hematopoietic stem cells of normal individuals are MHC class II-expressing professional APC that enhance Th17 and Th1/Th17 responses
Keywords: MKp; megakaryocyte progenitor; MK; megakaryocyte; MEP; bipotent megakaryocyte/erythroid-progenitor; HSPC; hematopoietic stem and progenitor cells; HSC; hematopoietic stem cell; Tpo; thrombopoietin; SCF; stem cell factor; pDC; plasmacytoid dendritic cell
Tranilast: A review of its therapeutic applications
Keywords: ARH; aryl hydrocarbon receptor; bFGF; basic fibroblast growth factor; cAMP; cyclic AMP; CDK; cyclin-dependent kinase; COX-2; cyclooxsygenase-2; CTGF; connective tissue growth factor; CXCL; CX chemokine ligand; CXCR; CX chemokine receptor; EMT; epithelial-
Astaxanthin and withaferin A block paracrine cytokine interactions between UVB-exposed human keratinocytes and human melanocytes via the attenuation of endothelin-1 secretion and its downstream intracellular signaling
Keywords: WFA; withaferin A; SCF; stem cell factor; EDN; endothelin; MSH; melanocyte stimulating hormone; HEE; human epidermal equivalent; MAPK; mitogen activated protein kinase; MITF; microphthalmia-associated transcription factor; HMs; human melanocytes; TYRP1; t
Stem cell factor and granulocyte colony-stimulating factor exhibit therapeutic effects in a mouse model of CADASIL
Keywords: CADASIL; cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalophy; SCF; stem cell factor; G-CSF; granulocyte colony-stimulating factor; CAA; cerebral amyloid angiopathy; SVZ; the subventricular zone; BrdU; bromodeoxyuridine
Foodborne mycotoxicoses, risk assessment and underestimated hazard of masked mycotoxins and joint mycotoxin effects or interaction
Keywords: ALARA; As Low As Reasonably Achievable; BEN; Balkan Endemic Nephropathy; CAC; Codex Alimentarius Commission; CCFAC; Codex Committee on Food Additives and Contaminants; DALY; Disability Adjustment Life Year; DAS; Diacetoxyscirpenol; DON; Deoxynivalenol; EU
Maintenance of Clonogenic KIT+ Human Colon Tumor Cells Requires Secretion of Stem Cell Factor by Differentiated Tumor Cells
Keywords: Colorectal; Niche; Colon Cancer Model; Tumor Progression; CRC; colorectal cancer; DTC; differentiated tumor cell; EMT; epithelial to mesenchymal transition; FACS; fluorescence-activated cell sorting; GFP; green fluorescent protein; HIF; hypoxia-inducible
Increase in both angiogenic and angiostatic mediators in patients with idiopathic pulmonary fibrosis
Keywords: Idiopathic pulmonary fibrosis; VEGF; TSP-1; SCF; AngiogenesisFibrose pulmonaire idiopathique (FPI); VEGF; TSP-1; SCF; Angiogenèse
βTrCP-mediated ubiquitylation regulates protein stability of Mis18β in a cell cycle-dependent manner
Keywords: SCF; Skp1/Cul1/F-box protein complex; CDK; cyclin-dependent kinase; CHX; cycloheximide; H3S10ph; phosphorylation at 10th serine residue of histone H3; aa; amino acid; Mis18β; βTrCP; Ubiquitylation; Protein stability; Mitosis; Centromere;
Design of a PROTAC that antagonizes and destroys the cancer-forming X-protein of the hepatitis B virus
Keywords: aa; amino acid; CPP; cell-penetrating peptide; HBV; hepatitis B virus; HCC; hepatocellular carcinoma; HIF; hypoxia-inducible factor; ODD; oxygen-dependent degradation; pRb; retinoblastoma protein; PROTAC; proteolysis targeting chimeric molecule; SCF; Skp1
An overview on in situ micronization technique – An emerging novel concept in advanced drug delivery
Keywords: Particle size; Dissolution rate; In-situ micronization; SCF; Jet milling; Spray drying
hIL-15 gene-modified human natural killer cells (NKL-IL15) augments the anti-human hepatocellular carcinoma effect in vivo
Keywords: CIK; cytokine-induced killer; DC; dendritic cells; ELISA; enzyme-linked immunosorbent assay; GMP; Good Manufacturing Practice; HCC; hepatocellular carcinoma; IFN-γ; interferon gamma; IL; interleukin; LAK; lymphokine activated killer; MHC; major histocomp
Alternative splicing variants of human Fbx4 disturb cyclin D1 proteolysis in human cancer
Keywords: Fbx4; F-box only protein 4; Ub; ubiquitin; SCF; Skp-cullin-F-box; HCC; hepatocellular carcinoma; Fbx4; Alternative splicing; Cyclin D1; Cancer;
Lipopolysaccharide inhibits the self-renewal of spermatogonial stem cells in vitro via downregulation of GDNF expression in Sertoli cells
Keywords: LPS; lipopolysaccharide; GDNF; glial cell-derived neurotrophic factor; SSCs; spermatogonial stem cells; SCF; stem cell factor; BMP4; bone morphogenetic protein 4; Sohlh2; spermatogenesis and oogenesis specific basic helix-loop-helix 2; PLZF; promyelocytic
Protein degradation during the diatom cell cycle: Annotation and transcriptional analysis of SCF and APC/C ubiquitin ligase genes in Phaeodactylum tricornutum
Keywords: CDK; cyclin dependent kinase; SCF; Skp Cullin F-box; APC/C; anaphase promoting complex/cyclosome; CUL; cullin; CSM; CDH1-specific motif; D-box; destruction box; CKI; CDK inhibitor; RBX; RING box protein; SKP1; S-phase kinase-associated protein 1; CCS52; c
Molecular characterization of gdf9 and bmp15 genes in rare minnow Gobiocypris rarus and their expression upon bisphenol A exposure in adult females
Keywords: actb; actin beta; Af; atretic follicle; AR; androgen receptor; AHR; aryl hydrocarbon receptor; BPA; bisphenol A; Bmp15; bone morphogenetic protein 15; Coc; cortical alveolus oocytes; KL; c-Kit ligand; dpf; days post-fertilization; DMSO; dimethyl sulfoxide
BMP4 is required for the initial expression of MITF in melanocyte precursor differentiation from embryonic stem cells
Keywords: bFGF; basic fibroblast growth factors; BMP; bone morphogenetic protein; DCT; dopachrome tautomerase; EDN3; endothelin 3; EBs; embryoid bodies; ES; embryonic stem cell; MITF; microphthalmia-associated transcription factor; RA; retinoic acid; SCF; stem cell
Estrogenic regulation of testicular expression of stem cell factor and c-kit: implications in germ cell survival and male fertility
Keywords: Apoptosis; c-kit; estrogens; male infertility; SCF;
Management of contaminated marine marketable resources after oil and HNS spills in Europe
Keywords: Oil spill; Contaminated seafood; Hazardous and noxious substances (HNS); Risk assessment; Lift fishery bans; Decision criteria; ALARA; as low as reasonably achievable; B[a]P; Benzo[a]pyrene; BaPE; Benzo[a]pyrene equivalents; BMDL10; benchmark lower limit
The β-catenin E3 ubiquitin ligase SIAH-1 is regulated by CSN5/JAB1 in CRC cells
Keywords: AP-1; activator protein-1; APC; adenomatous polyposis coli; CK1; casein kinase 1; CoIP; co-immunoprecipitation; CRC; colorectal cancer; CRL; cullin RING E3 ubiquitin ligase; CSN; COP9 signalosome; CSN5; fifth subunit of the CSN; Cul1; cullin-1; GSK-3β; g
The safety of β-carotene from Yarrowia lipolytica
Keywords: ANS; Panel on Food Additives and Nutrient Sources added to Food; DMSO; dimethyl sulfoxide; EFSA; European Food Safety Authority; FDA; Food and Drug Administration; GLP; Good Laboratory Practice; GRAS; Generally Recognized As Safe; HOSO; high oleic sunflow
Mechanisms of allergy and clinical immunologyMastocytosis associated with a rare germline KIT K509I mutation displays a well-differentiated mast cell phenotype
Keywords: KIT; K509I; mastocytosis; germline; mast cells; well differentiated; EM; Electron microscopy; FITC; Fluorescein isothiocyanate; HuMC; CD34+ derived human mast cell; PE; Phycoerythrin; PGD2; Prostaglandin D2; SCF; Stem cell factor; WDSM; Well-differentiate
Malabaricone C-containing mace extract inhibits safrole bioactivation and DNA adduct formation both in vitro and in vivo
Keywords: BMD; benchmark dose; BMDL10; the lower confidence limit of the benchmark dose causing 10% extra tumor incidence; EDI; estimated daily intake; GSH; glutathione reduced; 7HC; 7-hydroxycoumarin; 7HCS; 7-hydroxycoumarin sulfate; HPLC; high performance liquid
The tyrosine phosphatase SHP2 is required for cell transformation by the receptor tyrosine kinase mutants FIP1L1-PDGFRα and PDGFRα D842V
Keywords: PDGFRA; PTPN11; SHP2; STAT5; Chronic eosinophilic leukemia; ERK; extracellular signal-regulated kinase; FBS; fetal bovine serum; FLT3; Fms-like tyrosine kinase 3; FPα; FIP1L1-PDGFRα; GIST; gastrointestinal stromal tumors; MAPK; mitogen-activated protein
Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis
Keywords: APC/C; Anaphase Promoting Complex/Cyclosome; AOM; azoxymethane; Bub3; budding uninhibited by benzimidazole protein 3; BubR1; bub1-related protein; Cdc20; cell division cycle 20; Cdh1; Cdc20 homologue protein 1; DMBA; 7,12-dimethylbenz-α-anthracene; Emi1;
Density and viscosity of the binary polyethylene glycol/CO2 systems
Keywords: Phase equilibrium; SCF; Density; Viscosity of PEG/CO2 systems; Magnetic suspension balance;
Interphase evaluation and nano-mechanical responses of UHMWPE/SCF/nano-SiO2 hybrid composites
Keywords: Nanoindentation; Nanoscratching; UHMWPE; SCF; Nano-SiO2;
A novel nonradioactive CFDA assay to monitor the cellular immune response in myeloid leukemia
Keywords: allo-HSCT; allogeneic hematopoietic stem cell transplantation; AML; acute myeloid leukemia; APC; allophycocyanin; CML; chronic myeloid leukemia; CFDA; 5,6-carboxyfluorescein diacetate succinimidyl ester; DLT; donor lymphocyte transfusions; ELISPOT; enzyme
NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway
Keywords: AKT; v-akt murine thymoma viral oncogene; CRC; colorectal cancer; FDR; false discovery rate; HECT; homologous to E6AP C terminus; KEGG; Kyoto Encyclopedia of Genes and Genomes; mut; mutated; NCBI; National Center for Biotechnology Information; PBS; phosph
New insights into the human metabolism of the Fusarium mycotoxins deoxynivalenol and zearalenone
Keywords: 3ADON; 3-acetyl-deoxynivalenol; α/β-ZEL; α/β-zearalenole; α/β-ZEL-GlcA; α/β-zearalenole-glucuronide; DON; deoxynivalenol; DON-3-Glc; deoxynivalenol-3-glucoside; DON-3-GlcA; deoxynivalenol-3-glucuronide; DON-15-GlcA; deoxynivalenol-15-glucuronide;
Distinct functions of erythropoietin and stem cell factor are linked to activation of mTOR kinase signaling pathway in human erythroid progenitors
Keywords: EPO; Erythropoietin; SCF; Stem Cell Factor; IL-3; Interleukin-3; Erythropoietin; Stem cell factor; mTOR; Protein synthesis;
Thujone and thujone-containing herbal medicinal and botanical products: Toxicological assessment
Keywords: Thujone; Risk assessment; Toxicity; Metabolism; Pharmacokinetics; ADI; acceptable daily intake; BMDL; benchmark dose (lower confidence limit); CNS; central nerve system; CYP; cytochrome P450; EMA; European Medicines Agency; GABAA; gamma-aminobutyric acid
STAT3 interacts with Skp2/p27/p21 pathway to regulate the motility and invasion of gastric cancer cells
Keywords: Ace-tubulin; Acetylated-tubulin; ANOVA; analysis of variance; DAPI; 4â²,6-diamidino-2-phenylindole; E-cad; E-cadherin; ELISA; enzyme-linked immunosorbent assay; FAK; focal adhesion kinase; FITC; fluorescein isothiocyanate; GAPDH; glyceraldehyde-3-phospha
Research ArticleActivated human hepatic stellate cells induce myeloid derived suppressor cells from peripheral blood monocytes in a CD44-dependent fashion
Keywords: HSC; hepatic stellate cell; IFN; interferon; MDSC; myeloid derived suppressor cell; PGE2; prostaglandin E2; SCF; stem cell factor; siRNA; small interfering RNA; shRNA; small hairpin RNA; VEGF; vascular endothelial growth factor; Hepatic stellate cell; Mye
Inhibition of methyleugenol bioactivation by the herb-based constituent nevadensin and prediction of possible in vivo consequences using physiologically based kinetic modeling
Keywords: Methyleugenol; PBK; Nevadensin; Inhibition; Bioactivation; In vivo; NTP; National Toxicology Program; SCF; Scientific Committee on Food; FEMA; Flavor and Extract Manufacturers Association; PBK; physiologically based kinetic; NEV; nevadensin; DMSO; dimethy
Material propertiesNanoindentation and nanoscratching responses of PEEK based hybrid composites reinforced with short carbon fibers and nano-silica
Keywords: Nanoindentation; Nanoscratching; PEEK; SCF; Nano-SiO2;
Glycogen synthase kinase 3 regulates expression of nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) and inhibits pro-survival function of Nrf1
Keywords: ARE; antioxidant response element; CNC-BZIP; Cap 'n' Collar-type basic leucine zipper; CPD; Cdc4 phosphodegron domain; ER; endoplasmic reticulum; GSK3; glycogen synthase kinase 3; Nrf1; nuclear factor E2-related factor-1; SCF; Skp1-Cul1-F-box; UPS
The Src homology 2 protein Shb promotes cell cycle progression in murine hematopoietic stem cells by regulation of focal adhesion kinase activity
Keywords: 5-FU; 5-fluorouracil; BrdU; 5-bromo-2â²-deoxyuridine; FACS; fluorescence activated cell sorting; FAK; focal adhesion kinase; GMP; granulocyte-monocyte progenitor; HPC; hematopoietic progenitor cell; KLS; c-Kit+lineageâSca-1+; LT-HSC; long-term hemato
Characterisation and toxicological assessment of Neutral Methacrylate Copolymer for GRAS evaluation
Keywords: BCA; bicinchoninic acid; bw; body weight; CAS; Chemical Abstract Service; DMEM; Dulbecco's Modified Eagle's Medium; DMF; drug master file; DMSO; dimethyl sulphoxide; DNFCS; Dutch National Food Consumption Survey; EA; ethyl acrylate; EC; European Counc
Efficient cytokine-induced IL-13 production by mast cells requires both IL-33 and IL-3
Keywords: Mast cells; basophils; allergic inflammation; cytokines; signal transducer and activator of transcription 5; tyrosine phosphorylation; BAC transgenic mouse; DsRed fluorochrome; BAC; Bacterial artificial chromosome; BMMC; Bone marrow-derived mast cell; I
A novel KIT-deficient mouse mast cell model for the examination of human KIT-mediated activation responses
Keywords: Ag, antigen; BMMCs, bone marrow-derived mast cells; FcεRI, high affinity IgE receptor; hu, human; MC, mast cell; m, mouse; SCF, stem cell factorDegranulation; FcεRI; KIT; Mast cells; KIT; SCF
Human mast cells drive memory CD4+ T cells toward an inflammatory IL-22+ phenotype
Keywords: Mast cells; TH cells; IL-22; immunologic synapse; inflammation; psoriasis; APC; Antigen-presenting cell; CLA; Cutaneous lymphocyte-associated antigen; DC; Dendritic cell; hMC; Human mast cell; hMCIFN-γ; hMC treated for 72 hours with IFN-γ; IHC; Immunohi
A novel automated bioreactor for scalable process optimisation of haematopoietic stem cell culture
Keywords: HSCs; haematopoietic stem cells; ambrâ¢; advanced microscale bioreactor; rpm; revolutions per minute; μ; mean; SEM; standard error of the mean; FITC; Fluorescein isothiocyanate; dO2; dissolved oxygen; ANOVA; analysis of variance; SCF; stem cell factor;
Regulatory modules: Coupling protein stability to phopshoregulation during cell division
Keywords: Phosphodegron; Cell cycle; SCF; APC;
The Nogo receptor 2 is a novel substrate of Fbs1
Keywords: Nogo receptor 2; Fbs1; SCF; Degradation; Proteasome; Alzheimer's disease;
Rab27b regulates c-kit expression by controlling the secretion of stem cell factor
Keywords: Rab27b; c-Kit; Lysosome; SCF;
Transmyocardial Revascularization Induces Mesenchymal Stem Cell Engraftment in Infarcted Hearts
Keywords: Ctrl; Control; CXCL12; chemokine ligand 12; CXCR4; chemokine receptor type 4; ddH2O; distilled deionized water; DNA; deoxyribonucleic acid; EF; ejection fraction; EPC; endothelial progenitor cell; FAS; fractional area shortening; FBS; fetal bovine serum;
Inula japonica extract inhibits mast cell-mediated allergic reaction and mast cell activation
Keywords: IFE; Inulae Flos extract; BMMCs; bone marrow-derived mast cells; IL-3; interleukin-3; LTC4; leukotriene C4; SCF; stem cell factor; cPLA2; cytosolic phospholipase A2; MAPKs; mitogen-activated protein kinases; PLCγ; phospholipase Cγ; AA; arachidonic acid;