کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5850613 | 1561779 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The safety of β-carotene from Yarrowia lipolytica
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کلمات کلیدی
EFSAFDAGLPNOAELSCFOECDIOMNCEHOSOGRASPCEYarrowia lipolyticaDMSO - DMSOβ-carotene - β-کاروتنEuropean Food Safety Authority - اداره ایمنی اروپاpolychromatic erythrocytes - اریتروسیت های چند رنگیnormochromatic erythrocytes - اریتروسیتهای نورموشروماتیکstandard deviation - انحراف معیارgenerally recognized as safe - به طور کلی به عنوان امن شناخته شده استGood Laboratory Practice - تمرین خوب آزمایشگاهیDimethyl sulfoxide - دیمتیل سولفواکسیدhigh oleic sunflower oil - روغن آفتابگردان با کیفیت بالا oleicSubchronic - زیرشاخه ایFood and Drug Administration - سازمان غذا و داروOrganization for Economic Cooperation and Development - سازمان همکاری های اقتصادی و توسعهANS - سالToxicity - سمی بودنGenotoxicity - سمیت ژنتیکیInstitute of Medicine - موسسه پزشکیNo observed adverse effect level - هیچ عوارض جانبی مشاهده نشدهScientific Committee on Food - کمیته علمی مواد غذایی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Crystalline β-carotene from genetically modified Yarrowia lipolytica is an alternative source of β-carotene for use as a nutritional supplement. To support the use of β-carotene from Y. lipolytica as a food ingredient, the genotoxic and subchronic toxicity potential of this compound was determined. Genotoxicity was examined using Salmonella typhimurium and Escherichia coli (Ames test), a chromosomal aberration assay in Chinese Hamster Ovary WBL cells, and the micronucleus test in CD-1 mice. All three assays showed no significant results due to β-carotene from Y. lipolytica. In a subchronic toxicity study in SD rats, β-carotene from Y. lipolytica was administered by oral gavage for 13 weeks at 0, 125, 250 or 500 mg/kg per day. Adverse effects were not observed following clinical, clinical pathology and gross- and histopathological evaluations of dosed rats; thus, the no-observed-adverse effect level (NOAEL) for β-carotene from Y. lipolytica was 500 mg/kg, the highest dose used in the study. In conclusion, β-carotene derived from Y. lipolytica was shown in genotoxicity models and a standard rat subchronic rat study to have a safety profile similar to that of the current commercial products (synthetic and natural) with no unexpected finding attributable to the alternative source.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 65, March 2014, Pages 1-11
Journal: Food and Chemical Toxicology - Volume 65, March 2014, Pages 1-11
نویسندگان
Daniel Grenfell-Lee, Samuel Zeller, Renato Cardoso, Kresimir Pucaj,