
Keywords: سرین هیدروکسی متیل ترانسفراز; One carbon metabolism; Cancer metabolism; Serine hydroxymethyltransferase; Isozymes; Enzyme inhibition; Pyrazolopyran scaffold; Pyridoxal 5â²-phosphate; PLP; serine hydroxymethyltransferase; SHMT; cytosolic SHMT; SHMT1; mitochondrial SHMT; SHMT2; Escheri