CRP promotes MMP-10 expression via c-Raf/MEK/ERK and JAK1/ERK pathways in cardiomyocytes
Keywords: مسیرهای سیگنالینگ; C-reactive protein; MMP-10; Signaling pathways; Cardiomyocytes;
مقالات ISI مسیرهای سیگنالینگ (ترجمه نشده)
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Des-acyl ghrelin exhibits pro-anabolic and anti-catabolic effects on C2C12 myotubes exposed to cytokines and reduces burn-induced muscle proteolysis in rats
Keywords: مسیرهای سیگنالینگ; DAG; des-acyl ghrelin; GHS-R1a; growth hormone secretagogue receptor 1a; GHRP-2; growth hormone releasing peptide 2; GSK3β; glycogen synthase kinase-3 beta; IGF-I; insulin-like growth factor 1; IL-6; interleukin-6; MAFbx; muscle atrophy F-box protein/atr
A novel approach to prevent endothelial hyperpermeability: The Crataegus extract WS® 1442 targets the cAMP/Rap1 pathway
Keywords: مسیرهای سیگنالینگ; Endothelium; Hyperpermeability; Crataegus extract; Signaling pathways;
Synthetic biology with surgical precision: Targeted reengineering of signaling proteins
Keywords: مسیرهای سیگنالینگ; Cell signaling; Signaling pathways; Arrestin; GPCR; Scaffold protein; Protein engineering; Cell survival; Cell death
Stress-activated protein kinases are involved in porcine reproductive and respiratory syndrome virus infection and modulate virus-induced cytokine production
Keywords: مسیرهای سیگنالینگ; PRRSV; p38 MAPK; JNK1/2; Signaling pathways; Cytokines; Viral replication; Porcine alveolar macrophages
Role of NADPH oxidase/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases
Keywords: مسیرهای سیگنالینگ; Antioxidants; Inflammation; NADPH oxidase; Reactive oxygen species; Respiratory inflammatory diseases; Signaling pathways
The role of protein tyrosine phosphatases in colorectal cancer
Keywords: مسیرهای سیگنالینگ; Protein tyrosine phosphatases; Colorectal cancer; Signaling pathways; Novel treatment targets
Hedgehog and Wnt coordinate signaling in myogenic progenitors and regulate limb regeneration
Keywords: مسیرهای سیگنالینگ; Regeneration; Blastema; Signaling pathways; Dedifferentiation;
3,5-Disubstituted-thiazolidine-2,4-dione analogs as anticancer agents: Design, synthesis and biological characterization
Keywords: مسیرهای سیگنالینگ; Thiazolidine-2,4-dione; Anticancer; Signaling pathways; Apoptosis; Multitarget molecule
Data driven linear algebraic methods for analysis of molecular pathways: Application to disease progression in shock/trauma
Keywords: مسیرهای سیگنالینگ; Systems biology; Signaling pathways; Trauma; Hypothesis generation; Biomedical informatics
Aberrant ROCK activation promotes the development of type I diabetes in NOD mice
Keywords: مسیرهای سیگنالینگ; Type 1 diabetes; IL-21; IL-17; Signaling pathways
Research reportNMDA preconditioning protects against quinolinic acid-induced seizures via PKA, PI3K and MAPK/ERK signaling pathways
Keywords: مسیرهای سیگنالینگ; NMDA preconditioning; Signaling pathways; PI3K; PKA; Neuroprotection; Quinolinic acid;
Chronic central leptin infusion differently modulates brain and liver insulin signaling
Keywords: مسیرهای سیگنالینگ; PTP1B; Leptin; Insulin-resistance; Insulin sensitivity; Signaling pathways; Hypothalamus; Liver
A novel method for producing mono-biotinylated, biologically active neurotrophic factors: An essential reagent for single molecule study of axonal transport
Keywords: مسیرهای سیگنالینگ; Nerve growth factor; Biotinylation; Quantum dots; Single molecule imaging; Axonal transport; Microfluidic nerve cell chamber; PC12 cells; Dorsal root ganglion; Signaling pathways; Receptors
The mitogenic effect of testosterone and 17β-estradiol on airway smooth muscle cells
Keywords: مسیرهای سیگنالینگ; ASMC, airway smooth muscle cell; COPD, chronic obstructive pulmonary disease; MAPK, mitogen activated protein kinases; PI3K, phosphoinositol 3 kinase; FBS, fetal bovine serumTestosterone; 17β-estradiol; ASMC; Proliferation; Signaling pathways
Bronchial epithelial cells release IL-6, CXCL1 and CXCL8 upon mast cell interaction
Keywords: مسیرهای سیگنالینگ; Bronchial epithelial cells; Mast cells; Cytokine; Chemokine; Signaling pathways;
Mitochondrial longevity pathways
Keywords: مسیرهای سیگنالینگ; Mitochondria; Reactive oxygen species; Life span; Oxidative stress; Signaling pathways; Aging
Human cardiac fibroblasts express ICAM-1, E-selectin and CXC chemokines in response to proinflammatory cytokine stimulation
Keywords: مسیرهای سیگنالینگ; Cardiac fibroblasts; Adhesion molecules; Cytokines; Chemokines; Signaling pathways
Reducción de la masa muscular mediada por miostatina en un modelo experimental de enfisema pulmonar
Keywords: مسیرهای سیگنالینگ; Enfisema pulmonar; Estrés oxidativo; Miostatina; Reducción de la masa muscular; Proteólisis; Vías de señalizaciónPulmonary emphysema; Oxidative stress; Myostatin; Reduction of muscle mass; Proteolysis; Signaling pathways
Synthetic biosensing systems
Keywords: مسیرهای سیگنالینگ; RBS; ribosome binding site; GPCR; G protein coupled receptor; RTK; receptor tyrosine kinase; MAPK; mitogen-activated protein kinase; GDP; guanosine diphosphate; GTP; guanosine triphosphate; GEF; guanine nucleotide exchange factor; GAP; GTPase activating p
Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster
Keywords: مسیرهای سیگنالینگ; Signaling pathways; Wnt; Hedgehog; Cancer; Drug target;
Shooting the messenger: Targeting signal transduction pathways in leukemia and related disorders
Keywords: مسیرهای سیگنالینگ; Leukemia; Myeloproliferative disorders; Signaling pathways; Therapeutics; BCR-ABL; JAK2; STAT5; PI 3-kinase; HDAC
Anaplastic large-cell lymphoma
Keywords: مسیرهای سیگنالینگ; Anaplastic large-cell lymphoma (ALCL); Peripheral T-cell lymphoma (PTCL); Phenotype; Immunohistochemistry; Molecular biology; Targeted therapy; Anaplastic lymphoma kinase (ALK); Chimeric fusion proteins; Signaling pathways
New aspects of melanocortin signaling: A role for PRCP in α-MSH degradation
Keywords: مسیرهای سیگنالینگ; Hypothalamus; Arcuate nucleus; POMC processing; α-MSH; Hormones; Fuel; Energy metabolism; Melanocortin receptors; Signaling pathways; PRCP
Homologous control of protein signaling networks
Keywords: مسیرهای سیگنالینگ; Sparse network reconstructions; Protein network models; Signaling pathways; Kinase inhibitors
The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer
Keywords: مسیرهای سیگنالینگ; Glutathione; Glutathione S-transferase; c-jun NH2 kinase; S-glutathionylation; Signaling pathways; Post-translational modification; Bone marrow; Myeloproliferation; Cancer drug development; Cancer; Genetic polymorphisms;
Cyclooxygenase-2 in oncogenesis
Keywords: مسیرهای سیگنالینگ; Cyclooxygenase-2; Tumors; Prostaglandin E2; Mechanisms; Signaling pathways
Arsenic-induced oxidative stress and its reversibility
Keywords: مسیرهای سیگنالینگ; GSH; glutathione; GSSG; glutathione disulfide; NAC; N-acetylcysteine; ROS; reactive oxygen species; RNS; reactive nitrogen species; O2â¢â; superoxide anion; â¢OH; hydroxyl radical; 1O2; singlet oxygen; MMAV; monomethyl arsonate; MMAIII; monomethyl ars
Glucose stimulation of protein acylation in the pancreatic β-cell
Keywords: مسیرهای سیگنالینگ; Glucose; Biphasic insulin secretion; Signaling pathways; Protein acylation
The pro-angiogenic activity of urotensin-II on human vascular endothelial cells involves ERK1/2 and PI3K signaling pathways
Keywords: مسیرهای سیگنالینگ; Angiogenesis; Human endothelial cells; Urotensin-II; Signaling pathways
Endothelial cell dysfunction in hyperglycemia: Phenotypic change, intracellular signaling modification, ultrastructural alteration, and potential clinical outcomes
Keywords: مسیرهای سیگنالینگ; Quiescence; Inflammation; Proliferation; Apoptosis; Transcription factors; Signaling pathways
Skin tumor promotion by argemone oil/alkaloid in mice: Evidence for enhanced cell proliferation, ornithine decarboxylase, cyclooxygenase-2 and activation of MAPK/NF-κB pathway
Keywords: مسیرهای سیگنالینگ; Argemone oil; Mouse skin; Tumor promoter; Cell proliferation; Signaling pathways
Functions of B56-containing PP2As in major developmental and cancer signaling pathways
Keywords: مسیرهای سیگنالینگ; PP2A; Regulatory subunit; B′; B56; PR61; Signaling pathways; Development; Tumorigenesis
The subcellular localization of MEK and ERK—A novel nuclear translocation signal (NTS) paves a way to the nucleus
Keywords: مسیرهای سیگنالینگ; Signaling pathways; MAPK cascades; ERK; MEK; Raf
Direct survival role of vascular endothelial growth factor (VEGF) on rat ovarian follicular cells
Keywords: مسیرهای سیگنالینگ; Ovary; Proliferation; Apoptosis; VEGF; Signaling pathways
Effector T cells driving monophasic vs. relapsing/remitting experimental autoimmune uveitis show unique pathway signatures
Keywords: مسیرهای سیگنالینگ; Autoimmune disease; Relapsing/remitting; T cells; Rodent; Gene expression; Signaling pathways
Signaling Mechanisms in Neuroendocrine Tumors as Targets for Therapy
Keywords: مسیرهای سیگنالینگ; Neuroendocrine tumor; Carcinoid; Medullary thyroid cancer; Signaling pathways;
Molecular insights and therapeutic targets for blood–brain barrier disruption in ischemic stroke: Critical role of matrix metalloproteinases and tissue-type plasminogen activator
Keywords: مسیرهای سیگنالینگ; Blood–brain barrier; Neurovascular unit; tPA; MMPs; Ischemic stroke; Signaling pathways
Immune Dysfunction in Autism: A Pathway to Treatment
Keywords: مسیرهای سیگنالینگ; Autism; immune system; autoimmunity; signaling pathways;
Cocoa flavonoids up-regulate antioxidant enzyme activity via the ERK1/2 pathway to protect against oxidative stress-induced apoptosis in HepG2 cells
Keywords: مسیرهای سیگنالینگ; Apoptosis; ROS; Signaling pathways; Glutathione peroxidase; Glutathione reductase; Polyphenols;
Initial receptor-ligand interactions modulate gene expression and phagosomal properties during both early and late stages of phagocytosis
Keywords: مسیرهای سیگنالینگ; Phagocytosis; Receptor-ligand interaction; Macrophage; Phagosome maturation; Phagocytic receptor; Phagosomal proteome; Gene expression; Signaling pathways; Immune response;
Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: Implications for future therapeutic approaches
Keywords: مسیرهای سیگنالینگ; Head and neck cancer; Lung cancer; EGFR; IL-6; Signaling pathways; JAK; STAT
The long road to colorectal cancer therapy: Searching for the right signals
Keywords: مسیرهای سیگنالینگ; Colorectal cancer; Signaling pathways; Biomarkers; Monoclonal antibodies; Tyrosine kinase inhibitors; IGF-1R; c-MET; Wnt signaling; Hedgehog signaling; Src family
New Frontiers in Pancreatic Cancer Research
Keywords: مسیرهای سیگنالینگ; Pancreatic cancer; Biomarkers; Cancer stem cells; Signaling pathways;
The gene network determining development of Drosophila melanogaster mechanoreceptors
Keywords: مسیرهای سیگنالینگ; Achaete–scute; Signaling pathways; Macrochaetes; Drosophila
Bacterial detection by Drosophila peptidoglycan recognition proteins
Keywords: مسیرهای سیگنالینگ; PGRP; PGN; Drosophila; Innate immunity; Signaling pathways
Mathematical modeling of heat shock protein synthesis in response to temperature change
Keywords: مسیرهای سیگنالینگ; Heat shock proteins; Signaling pathways; Cell stress
Toll-like récepteurs
Keywords: مسیرهای سیگنالینگ; TLR; Immunité innée; Immunité adaptative; Voies de signalisation; Perspectives thérapeutiquesTLR; Innate immunity; Adaptive immunity; Signaling pathways; Therapeutic prospects
In vitro enhancement effect of humic acid on the progression of lung cancer cells
Keywords: مسیرهای سیگنالینگ; Humic acid; Progression; Signaling pathways
Cardioprotective signaling to mitochondria
Keywords: مسیرهای سیگنالینگ; Mitochondrial KATP channel; Protein kinase C; Reactive oxygen species; Permeability transition; Signaling pathways