دانلود مقالات ISI درباره Sirt1 + ترجمه فارسی

p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescence

Keywords: CKII; protein kinase CKII (also known as casein kinase II); DRB; 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole; HDAC; histone deacetylase; MBP; maltose binding protein; NOX; NADPH oxidase; PBS; phosphate-buffered saline; ROS; reactive oxygen species; SA-

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Roles of SIRT1 in High Glucose-induced Endothelial Impairment: Association with Diabetic Atherosclerosis

Keywords: SIRT1; Type 2 diabetes mellitus; Endothelial cells; Atherosclerosis; Nitric oxide; E-selectin; Endothelial nitric oxide synthase; Resveratrol

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

The controversial links among calorie restriction, SIRT1, and resveratrol

Keywords: Ac; acetate; AMPK; AMP-activated kinase; CAECs; coronary arterial endothelial cells; CR; calorie restriction; CSE; cigarette smoke extract; eNOS; endothelial nitric oxide synthase; EX-527; 6-chloro-2,3,4,9-tetrahydro-1-H-carbazole-1-carboxamide; F⁎; flu

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Resveratrol with antioxidant activity inhibits matrix metalloproteinase via modulation of SIRT1 in human fibrosarcoma cells

Keywords: Resveratrol; SIRT1; MMPs; HT1080

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cells

Keywords: miR-34a; 5-FU; Drug-resistance; Sirt1; Colon cancermRNA, messenger RNA; PCR, polymerase chain reaction; siRNA, small interfering RNA; UTR, untranslated region; PI3K, phosphoinositide 3-kinase

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Acetylation-mediated epigenetic regulation of glucocorticoid receptor activity: Circadian rhythm-associated alterations of glucocorticoid actions in target tissues

Keywords: ACTH; adrenocorticotropic hormone; Dbp; albumin gene D site-binding protein; AMPK; AMP-activated protein kinase; AR; androgen receptor; AVP; arginine vasopressin; bHLH; basic helix-loop-helix; Bmal1; brain-muscle-arnt-like protein 1; CNS; central nervous

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Lithospermic acid B protects beta-cells from cytokine-induced apoptosis by alleviating apoptotic pathways and activating anti-apoptotic pathways of Nrf2-HO-1 and Sirt1

Keywords: Magnesium lithospermate B; Diabetes; Islet; Cytokine; Nrf2-HO-1; Sirt1;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Nucleus-specific effects of meal duration on daily profiles of Period1 and Period2 protein expression in rats housed under restricted feeding

Keywords: circadian clock gene; dorsomedial hypothalamic nucleus; oval nucleus of the bed nucleus of the stria terminalis; central nucleus of the amygdala; basolateral amygdala; dentate gyrus; AL; ad libitum food access; BLA; basolateral amygdala; BNSTov; oval nucl

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Oxidative stress, insulin signaling, and diabetes

Keywords: AGE; advanced glycated end product; CAP; c-Cbl-associated protein; DAG; diacylglycerol; eNOS; endothelial nitric oxide synthase; ERK; extracellular signal-regulated kinase; ETC; electron transport chain; GH; growth hormone; GLUT4; glucose transporter type

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

The peroxisome proliferator-activated receptor β/δ (PPARβ/δ) agonist GW501516 prevents TNF-α-induced NF-κB activation in human HaCaT cells by reducing p65 acetylation through AMPK and SIRT1

Keywords: AMPK; AMP-activated protein kinase; NF-κB; nuclear factor κB; PPAR; peroxisome proliferator-activated receptors; SIRT1; silent information regulator T1; TNFα; tumor necrosis factor α;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

The first bromodomain of the testis-specific double bromodomain protein Brdt is required for chromocenter organization that is modulated by genetic background

Keywords: Brdt; Bromodomain; Chromocenter; Spermiogenesis; Sirt1

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1

Keywords: microRNA; Aging; Liver; Sirt1; Mgst1;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Delivery of Oct4 and SirT1 with cationic polyurethanes-short branch PEI to aged retinal pigment epithelium

Keywords: Polyurethane-short branch polyethylenimine; Oct4; SirT1; Retinal pigment epithelium cells; Age-related macular degeneration; ReprogrammingPolyurethane-short branch polyethylenimine, PU-PEI; Retinal pigment epithelium cells, RPEs; Age-related macular degen

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Chemical modifications of resveratrol for improved protein kinase C alpha activity

Keywords: PKC; protein kinase C; DAG; diacylglycerol; TPA; 12-O-tetradecanoylphorbol-13-acetate; PDB; protein data bank; NMR; nuclear magnetic resonance; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; HEK; human embryonic kidney; PDS; 4,4′-dip

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease

Keywords: COPD; Oxidants; Smokers; Inflammation; Epigenetics; NF-κB; SIRT1

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2011 سفارش ترجمه

Energy metabolism in adult neural stem cell fate

Keywords: ACC; adenylate cyclase complex; AICAR; aminoimidazole carboxamide ribonucleotide; AMPK; AMP-activated protein kinase; Aspm; abnormal spindle-like microcephaly-associated; BDNF; brain-derived neurotrophic factor; bFGF; basic fibroblast growth factor; bHLH;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2011 سفارش ترجمه

SIRT1 variants are associated with aging in a healthy Han Chinese population

Keywords: Aging; SIRT1; Association study; Single-nucleotide polymorphism; Han population

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Disruption of Igfbp1 fails to rescue the phenotype of Sirt1−/− mice

Keywords: Genetic interaction; Igfbp1; Sirt1

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Is systemic activation of Sirt1 beneficial for ageing-associated metabolic disorders?

Keywords: AMP-activated kinase (AMPK); Caloric restriction; Metabolic syndrome; Sirt1;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

MicroRNA-34a regulation of endothelial senescence

Keywords: MicroRNA; MiR-34a; Endothelial cell; SIRT1; Senescence

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Role of resveratrol in FOXO1-mediated gluconeogenic gene expression in the liver

Keywords: Resveratrol; FOXO1; SIRT1; Gluconeogenesis

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Dual role of Zn2+ in maintaining structural integrity and suppressing deacetylase activity of SIRT1

Keywords: Zinc ion; SIRT1; Protein deacetylation; Zinc-finger motif; Noncompetitive inhibitor

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

SIRT1 and p53, effect on cancer, senescence and beyond

Keywords: SIRT1; p53; Acetylation; Deacetylation; Cancer; Senescence

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Naringenin, a citrus flavonoid, increases muscle cell glucose uptake via AMPK

Keywords: Naringenin; Myotubes; Glucose uptake; AMPK; Akt; SIRT1;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Sirtuins regulate key aspects of lipid metabolism

Keywords: SIRT1; Lipid; Metabolism; PPARα; PGC-1α; LXR

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Sirt1 plays an important role in mediating greater functionality of human ES/iPS-derived vascular endothelial cells

Keywords: Stem cells; Endothelium; Sirt1

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells

Keywords: SIRT1; Neurite outgrowth; PC12 cell; NGF;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

A possibility of nutriceuticals as an anti-aging intervention: Activation of sirtuins by promoting mammalian NAD biosynthesis

Keywords: NAD-dependent deacetylases; Sirtuins; SIRT1; NAD biosynthesis; Nicotinamide phosphoribosyltransferase; NAMPT; Anti-aging medicine; Pharmaceuticals; Nutriceuticals; Aging; Metabolism

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1α Expression in experimental stroke

Keywords: Icariin; SIRT1; PGC-1α; Neuroprotection; Ischemic stroke

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol

Keywords: Cigarette smoke; Oxidants; SIRT1; eNOS; Endothelial dysfunction;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Protein deacetylation by SIRT1: An emerging key post-translational modification in metabolic regulation

Keywords: SIRT1; NAD; Deacetylation; Metabolic homeostasis

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

“Clocks” in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging

Keywords: SIRT1; NAMPT; NAD biosynthesis; Circadian rhythm; CLOCK; BMAL1; NAD; Metabolic oscillator; NAD World; Metabolism; Aging; Aging clock

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Cigarette smoke-induced autophagy is regulated by SIRT1–PARP-1-dependent mechanism: Implication in pathogenesis of COPD

Keywords: SIRT1; PARP-1; Resveratrol; Cigarette smoke; Autophagy

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells

Keywords: SIRT1; p53-mediated apoptosis; Suramin; Sirtinol

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Resveratrol prevents RANKL-induced osteoclast differentiation of murine osteoclast progenitor RAW 264.7 cells through inhibition of ROS production

Keywords: Osteclasts; Resveratrol; Sirt1; Reactive oxygen species (ROS)

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity

Keywords: SIRT1; Oxidants; NAD+; PARP-1; Cigarette smoke

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: Involvement of SIRT1 and TGF-β1 pathway

Keywords: Diabetic nephropathy; Mesangial cell; SIRT1; TGF-β1; 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside (TSG)

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Nutrient-dependent regulation of PGC-1α's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5

Keywords: PGC-1α; GCN5; Sirt1; Acetylation

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Differential effects of exercise and dietary docosahexaenoic acid on molecular systems associated with control of allostasis in the hypothalamus and hippocampus

Keywords: stress; metabolism; synaptic plasticity; homeostasis; depression; anxiety; AMPK; AMP-activated protein kinase; BDNF; brain-derived neurotrophic factor; DHA; docosahexaenoic acid; DHA/Exc; DHA supplemental diet/exercise; DHA/Sed; DHA supplemental diet/sede

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

MicroRNA-34a: A Novel Tumor Suppressor in p53-mutant Glioma Cell Line U251

Keywords: Glioma; p53; microRNA-34a; Apoptosis; SIRT1

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

An antagonism between the AKT and beta-adrenergic signaling pathways mediated through their reciprocal effects on miR-199a-5p

Keywords: Hif-1α; hypoxia-inducible factor 1alpha; Sirt1; sirtuin-1; HPC; hypoxia preconditioning; miRNA; microRNA; IPC; ischemia preconditioning; TAC; transverse aortic constriction; caAKT; constitutively active AKT; ILK; integrin-linked kinase; βAR; beta-adrene

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Substrate specificity of SIRT1-catalyzed lysine Nε-deacetylation reaction probed with the side chain modified Nε-acetyl-lysine analogs

Keywords: Nε-acetyl-lysine; Analogs; SIRT1; Protein deacetylation

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Biochemical effects of SIRT1 activators

Keywords: SIRT1; Resveratrol; SRT1720; Longevity; Sirtuin; Polyphenol; Nad

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

SIRT1-dependent regulation of chromatin and transcription: Linking NAD+ metabolism and signaling to the control of cellular functions

Keywords: SIRT1; NAD+; Deacetylation; Transcription; Chromatin; Metabolism

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Role of SIRT1 in homologous recombination

Keywords: SIRT1; Single-strand-annealing; Werner helicase; Nibrin; Ku70; Genomic stability

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease

Keywords: Resveratrol; SIRT1; PGC-1α; Huntington's disease; Mitochondria; Mouse; Motor impairment and survival; Brown adipose tissue; Pathology

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Regulation of SIRT1 in cellular functions: Role of polyphenols

Keywords: Polyphenols; SIRT1; Oxidants; Resveratrol; Inflammation

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

Decreased SIRT1 deacetylase activity in sporadic inclusion-body myositis muscle fibers

Keywords: SIRT1; Sporadic inclusion-body myositis; Human muscle; Endoplasmic reticulum-stress; Acetylation; Nuclear factor-κB; Histone H4; Cultured human muscle fibers; Neuromuscular junction; Aging

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

NAD: A master regulator of transcription

Keywords: NAD, Nicotinamide adenine dinucleotide; NAD(H), NAD+ and/or NADH; SIR, Silent information regulator; NAM, Nicotinamide; ADPR, ADP-ribose; OAADPR, O-acetyl-ADP-ribose; CR, Calorie restrictionNAD; Chromatin; Transcription; Histone; Sir2; Sirt1; Sirt6; Sirt7

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه

High-affinity Na+-dependent dicarboxylate cotransporter promotes cellular senescence by inhibiting SIRT1

Keywords: Cellular senescence; Energy metabolism; NAD+/NADH ratio; NaDC3; SIRT1

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه