کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8285274 1535638 2011 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1
چکیده انگلیسی
▶ miR-34a and miR-93 are up-regulated in old rat liver. ▶ Four genes, Nrf2, Sp1, Sirt1 and Mgst1, are suppressed by miR-34a, and the latter 3 by miR-93 also. ▶ Sp1 and Nrf2 are transcription factors (TFs) for Mgst1, and the former for Sirt1 as well. ▶ A double-edged microRNA sword silences both gene messages and the TFs for their activation in aging rat liver.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 132, Issue 3, March 2011, Pages 75-85
نویسندگان
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