کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2562790 1127284 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protein deacetylation by SIRT1: An emerging key post-translational modification in metabolic regulation
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Protein deacetylation by SIRT1: An emerging key post-translational modification in metabolic regulation
چکیده انگلیسی

The biological function of most proteins relies on reversible post-translational modifications, among which phosphorylation is most prominently studied and well recognized. Recently, a growing amount of evidence indicates that acetylation–deacetylation reactions, when applied to crucial mediators, can also robustly affect the function of target proteins and thereby have wide-ranging physiological impacts. Sirtuin 1 (SIRT1), which functions as a nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase, deacetylates a wide variety of metabolic molecules in response to the cellular energy and redox status and as such causes significant changes in metabolic homeostasis. This review surveys the evidence for the emerging role of SIRT1-mediated deacetylation in the control of metabolic homeostasis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Research - Volume 62, Issue 1, July 2010, Pages 35–41
نویسندگان
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