Sirt1 activation prevents anti-Thy 1.1 mesangial proliferative glomerulonephritis in the rat through the Nrf2/ARE pathway
Keywords: MsPGN; Sirt1; Nrf2-ARE anti-oxidative pathway;
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SIRT1 reverses senescence via enhancing autophagy and attenuates oxidative stress-induced apoptosis through promoting p53 degradation
Keywords: SIRT1; Apoptosis; Autophagy; Senescence; Oxidative stress;
Expression and significance of Sirt1 in renal allografts at the early stage of chronic renal allograft dysfunction
Keywords: Chronic renal allograft dysfunction; Sirt1; Inflammation; Interstitial fibrosis;
Phosphorylated SIRT1 as a biomarker of relapse and response to treatment with glatiramer acetate in multiple sclerosis
Keywords: SIRT1; PBMCs; Multiple sclerosis; Histone trimethylation; Glatiramer acetate; Biomarker; AUC; area under the curve; CNS; central nervous system; CPT; cell preparation tubes; EAE; experimental autoimmune encephalomyelitis; EDSS; expanded disability status
Neuroprotective effect of linagliptin against cuprizone-induced demyelination and behavioural dysfunction in mice: A pivotal role of AMPK/SIRT1 and JAK2/STAT3/NF-κB signalling pathway modulation
Keywords: Cuprizone; Demyelination; Multiple sclerosis; Linagliptin; SIRT1; AMPK;
The IRF9-SIRT1-P53 axis is involved in the growth of human acute myeloid leukemia
Keywords: Acute myeloid leukemia; IRF9; SIRT1; p53;
Modulating SIRT1 activity variously affects thymic lymphoma development in mice
Keywords: NMU; N-nitroso-N-methylurea; NPM-ALK; nucleophosmin anaplastic lymphoma kinase fusion; PBS; phosphate buffered saline; 4-OHT; 4-hydroxytamoxifen; SIRT1; Lymphoma; Cancer; Thymus; Oncogene;
Perturbations in the p53/miR-34a/SIRT1 pathway in the R6/2 Huntington's disease model
Keywords: Huntington's disease; miR-34a; SIRT1; p53;
SIRT1 regulates inflammation response of macrophages in sepsis mediated by long noncoding RNA
Keywords: lncRNA; long noncoding RNA; SIRT1; silent information regulator2; LPS; lipopolysaccharide; TNF-α; tumor necrosis factor alpha; IL-1β; interleukin 1beta; IL-6; interleukin 6; PM; peritoneal macrophage; BMM; bone marrow-derived monocyte; MCP-1; monocyte c
Fluoride induces apoptosis via inhibiting SIRT1 activity to activate mitochondrial p53 pathway in human neuroblastoma SH-SY5Y cells
Keywords: Fluoride; Apoptosis; Neurotoxicity; p53; SIRT1;
Metformin overcomes high glucose-induced insulin resistance of podocytes by pleiotropic effects on SIRT1 and AMPK
Keywords: Podocyte; Metformin; Hyperglycemia; Insulin resistance; SIRT1; AMPK;
Overexpression of Sirt1 in mesenchymal stem cells protects against bone loss in mice by FOXO3a deacetylation and oxidative stress inhibition
Keywords: ALP; alkaline phosphatase; Bmi-1; B cell-specific Moloney murine leukemia virus integration site 1; Bmi-1â/â; Bmi1 deficiency; Bmi-1+/â; Bmi-1 heterozygous; Col-I; type I collagen; Col-II; type II collagen; FOXO; Forkhead box O; GPX1; Glutathione pe
Sirtuin 1 and Alzheimer's disease: An up-to-date review
Keywords: Sirtuins; SIRT1; Alzheimer's disease; Cognition; Neurodegeneration;
Leptin induces SIRT1 expression through activation of NF-E2-related factor 2: Implications for obesity-associated colon carcinogenesis
Keywords: Leptin; SIRT1; Nrf2; Obesity-associated cancer; Colon carcinogenesis;
SIRT1 and HIF1α signaling in metabolism and immune responses
Keywords: Metabolism; HIF1α; SIRT1; Glycolytic signal; Innate immunity; Adaptive immunity; Immune cell differentiation; Immune cell functions;
Efferocytosis in atherosclerotic lesions: Malfunctioning regulatory pathways and control mechanisms
Keywords: ABC; ATP-binding cassette; ABCA1; ATP-binding membrane cassette transporter A1; ABCG1; ATP binding cassette transporter G1; ABCA7; ATP-binding cassette transporters A7; Abs; Antibodies; ACs; Apoptotic cells; AICAR; 5-aminoimidazole-4-carboxamide-1-β-d-ri
Mutant p53 prevents GAPDH nuclear translocation in pancreatic cancer cells favoring glycolysis and 2-deoxyglucose sensitivity
Keywords: Mutant p53; Pancreas cancer; GAPDH; AMPK; AKT; SIRT1;
Melinjo (Gnetum gnemon L.) seed extract induces uncoupling protein 1 expression in brown fat and protects mice against diet-induced obesity, inflammation, and insulin resistance
Keywords: Melinjo Seed Extract; Brown Adipose Tissue; Uncoupling Protein 1; Obesity; Diabetes; Sirtuin 1; MSE; melinjo (Gnetum gnemon L.) seed extract; BAT; Brown adipose tissue; WAT; white adipose tissue; UCP1; uncoupling protein 1; (TRP) channels; temperature-sen
Mitochondria as pharmacological targets in Down syndrome
Keywords: AD; Alzheimer's disease; AGO; Argonaute proteins; AMPK; AMP-activated protein kinase; ANTs; adenine nucleotide translocators; AK; adenylate kinase; APP; amyloid-β precursor protein; ASD; autism spectrum disorder; CAT; catalase; CNS; central nervous syste
Lacking ketohexokinase-A exacerbates renal injury in streptozotocin-induced diabetic mice
Keywords: Diabetic kidney disease; Fructose metabolism; Ketohexokinase; Tubular injury; Oxidative stress; NAD metabolism; AKR1B3; aldo-keto reductase family 1 member 3; COL4; collagen 4; CTGF; connective tissue growth factor; DAG; diacylglycerol; DHAP; dihydroxyace
SIRT1 activator E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression
Keywords: SIRT1; LXRα; ABCA1; Cholesterol and lipid metabolism;
Curcumin suppresses oncogenicity of human colon cancer cells by covalently modifying the cysteine 67 residue of SIRT1
Keywords: Colorectal cancer; SIRT1; Curcumin; Tetrahydrocurcumin; Thiol modification;
CHM-1, a novel microtubule-destabilizing agent exhibits antitumor activity via inducing the expression of SIRT2 in human breast cancer cells
Keywords: CHM-1; SIRT1; SIRT2; Antimitotic agent; Prodrug;
Effect of a long-term treatment with metformin in dystrophic mdx mice: A reconsideration of its potential clinical interest in Duchenne muscular dystrophy
Keywords: DMD; Duchenne muscular dystrophy; DGC; dystrophin-associated glycoprotein complex; ECM; extracellular matrix; SIRT1; Sirtuin1; PGC-1α; peroxisome proliferator-activated receptor γ coactivator 1α; PPARγ; peroxisome proliferator-activated receptor γ; B
Molecular mechanisms of neuroprotective effect of adjuvant therapy with phenytoin in pentylenetetrazole-induced seizures: Impact on Sirt1/NRF2 signaling pathways
Keywords: Pentylenetetrazole; Sirt1; Alpha-tocopherol; Coenzyme Q10; Nuclear factor erythroid 2-related factor;
Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients
Keywords: Multiple sclerosis; CCL20; SIRT1;
Research ArticlePterostilbene, a dimethylated analog of resveratrol, promotes energy metabolism in obese rats
Keywords: FAS; fatty acid synthase; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; OLETF; Otsuka Long-Evans Tokushima fatty; PPAR; peroxisome proliferator-activated receptor; RQ; respiratory quotient; SIRT1; silent mating type information regulation 2 homolog-1;
SIRT1 and NADÂ + precursors: Therapeutic targets in multiple sclerosis a review
Keywords: Multiple sclerosis; EAE; Neurodegeneration; NAD; SIRT1;
Resveratrol improves smooth muscle carcinogenesis in the progression of chronic prostatitis via the downregulation of c-kit/SCF by activating Sirt1
Keywords: Chronic prostatitis; Smooth muscle; Carcinogenesis; Resveratrol; C-kit/SCF; Sirt1;
MiR-181b regulates steatosis in nonalcoholic fatty liver disease via targeting SIRT1
Keywords: MiR-181b; NAFLD; Steatosis; SIRT1;
Melatonin protects chondrocytes from impairment induced by glucocorticoids via NAD+-dependent SIRT1
Keywords: Melatonin; Glucocorticoids; Osteoarthritis; Chondrocytes; NAD+; SIRT1;
Original articleMagnolol attenuates the inflammation and apoptosis through the activation of SIRT1 in experimental stroke rats
Keywords: Magnolol; SIRT1; Ischemic stroke; Apoptosis; Inflammation;
Sirt7 stabilizes rDNA heterochromatin through recruitment of DNMT1 and Sirt1
Keywords: Sirt7; Sirt1; DNMT1; rDNA repeats; Heterochromatin; Nucleolus;
Identification of miR-601 as a novel regulator in the development of pancreatic cancer
Keywords: Pancreatic cancer; miR-601; SIRT1;
Blocking SIRT1 inhibits cell proliferation and promotes aging through the PI3K/AKT pathway
Keywords: SIRT1; AKT; SH-SY5Y; Alzheimer's disease (AD); Aging;
Effect of Sirtuin 1 inhibition on matrix metalloproteinase 2 and Forkhead box O3a expression in breast cancer cells
Keywords: Breast cancer; FOXO3a; MMP2; SIRT1; Sirtinol;
Methylation changes of SIRT1, KLF4, DAPK1 and SPG20 in B-lymphocytes derived from follicular and diffuse large B-cell lymphoma
Keywords: NHL; Non-Hodgkin lymphoma; Foll hyp; follicular hyperplasias; FL; follicular lymphomas; DLBCL; diffuse large-B cell lymphomas; SIRT1; silent information regulator 1; FFPE; formalin-fixed paraffin-embedded; IHC; immunohistochemistry; miRNA; micro-RNA; GC;
Regulation of stem cell aging by SIRT1 - Linking metabolic signaling to epigenetic modifications
Keywords: Sirtuin; SIRT1; Aging; Stem cells; Metabolism; Epigenetics;
Berberine suppresses LPS-induced inflammation through modulating Sirt1/NF-κB signaling pathway in RAW264.7 cells
Keywords: Berberine; Inflammation; Macrophage; Sirt1; NF-κB;
Research reportMutant presenilin2 promotes apoptosis through the p53/miR-34a axis in neuronal cells
Keywords: The p53/miR-34a axis; Alzheimer's disease; Presenilin 2; Apoptosis; Sirt1; Bcl-2;
The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis
Keywords: Atherosclerosis; CVD; Sirtuin; SIRT1; SIRT3; SIRT6; Oxidative stress; Lipid metabolism; ABC; Adenosine triphosphate binding cassette; ABCG; ABC sub-family G member; ADP; Adenosine diphosphate; AMPK; Adenosine monophosphate-activated protein kinase; eNOS;
MicroRNA-34a targets regulator of calcineurin 1 to modulate endothelial inflammation after fetal cardiac bypass in goat placenta
Keywords: MicroRNAs; Placental insufficiency; Endothelial cells; Inflammation; Fetus; Cardiopulmonary bypass; miRNA; microRNA; miR-34a; miRNA-34a; mRNA; messenger RNA; 3'-untranslated regions (UTRs); untranslated region; RCAN1; regulator of calcineurin 1; NFATC1;
SIRT1 regulates lipopolysaccharide-induced CD40 expression in renal medullary collecting duct cells by suppressing the TLR4-NF-κB signaling pathway
Keywords: SIRT1; CD40; TLR4; NF-κB; Inner medullary collecting duct cells; Inflammation;
AHR toxicity and signaling: Role of TIPARP and ADP-ribosylation
Keywords: Aryl hydrocarbon receptor; 2,3,7,8-Tretrachlorodibenzo-p-dioxin; ADP-ribosylation; TCDD-inducible poly-ADP-ribose polymerase; AHR; aryl hydrocarbon receptor; AHRE; AHR response element; ARH; ADP-ribosyl hydrolases; ARNT; AHR nuclear translocator; ARTD; AD
Design, synthesis of allosteric peptide activator for human SIRT1 and its biological evaluation in cellular model of Alzheimer's disease
Keywords: Sirtuin; Activator; Peptide; Aβ25-35; IMR-32; Allosteric; MCI; (Mild Cognitive Impairment); AD; (Alzheimer's disease); SIRT1; Sirtuin1; SPR; surface Plasmon resonance; RU; resonance unit; PVDF; Polyvinylidene fluoride; NTD; N domain; AFU; (arbitrary fl
Resveratrol alleviates cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasome activation through Sirt1-dependent autophagy induction
Keywords: Resveratrol; Sirt1; Autophagy; NLRP3 inflammasome; Neuroprotection; Ischemia-reperfusion;
Highly sensitive electrochemical immunoassay integrated with polymeric nanocomposites and enhanced SiO2@Au core-shell nanobioprobes for SirT1 determination
Keywords: SirT1; Polymeric nanocomposites; Core-shell nanobioprobes; Immunoassay; Electrochemistry;
Betulinic acid derivative B10 inhibits glioma cell proliferation through suppression of SIRT1, acetylation of FOXO3a and upregulation of Bim/PUMA
Keywords: Betulinic acid derivative B10; Glioma; Apoptosis; SIRT1; FOXO3a; Bim/PUMA;
SIRT1 protects cardiac cells against apoptosis induced by zearalenone or its metabolites α- and β-zearalenol through an autophagy-dependent pathway
Keywords: ZEN; zearalenone; α-ZOL; α-zearalenol; β-ZOL; β-zearalenol; SIRT1; silent mating type information regulator 2 homolog 1; RSV; resveratrol; CQ; chloroquine; ZEN; α-ZOL; β-ZOL; Apoptosis; Autophagy; SIRT1;
Platycodin D (PD) attenuates myocardial apoptosis mediated by JNK-SIRT1-HSF1-IGF-IIR-Caspase-3 signaling in hypertensive conditions
Keywords: Hypertension; IGF-IIR signaling; SIRT1; Apoptosis; platycodin D;