دانلود مقالات ISI درباره Sirt1 + ترجمه فارسی

Platycodin D (PD) attenuates myocardial apoptosis mediated by JNK-SIRT1-HSF1-IGF-IIR-Caspase-3 signaling in hypertensive conditions

Keywords: Hypertension; IGF-IIR signaling; SIRT1; Apoptosis; platycodin D;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

SIRT1 protects cardiac cells against apoptosis induced by zearalenone or its metabolites α- and β-zearalenol through an autophagy-dependent pathway

Keywords: ZEN; zearalenone; α-ZOL; α-zearalenol; β-ZOL; β-zearalenol; SIRT1; silent mating type information regulator 2 homolog 1; RSV; resveratrol; CQ; chloroquine; ZEN; α-ZOL; β-ZOL; Apoptosis; Autophagy; SIRT1;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Betulinic acid derivative B10 inhibits glioma cell proliferation through suppression of SIRT1, acetylation of FOXO3a and upregulation of Bim/PUMA

Keywords: Betulinic acid derivative B10; Glioma; Apoptosis; SIRT1; FOXO3a; Bim/PUMA;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Downregulation of protein phosphatase 2A by apolipoprotein E: Implications for Alzheimer's disease

Keywords: AD; Alzheimer's disease; APP; β-amyloid precursor protein; ApoE; Apolipoprotein E; SirT1; Sirtuin 1; PP2A; Protein phosphatase-2A; PPP2R5E; regulatory B′ subunit of protein phosphatase 2A; PP2AC; catalytic C subunit of protein phosphatase 2A; PME-1; Pr

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Mitochondria elongation is mediated through SIRT1-mediated MFN1 stabilization

Keywords: TIP60; SIRT1; MFN1; Acetylation; De-acetylation; Mitochondrial quality control;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticleCelastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1

Keywords: Nonalcoholic fatty liver disease; Celastrol; Sirt1; Lipid metabolism; Chronic inflammation; Oxidative stress;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Salvianolic acid B protects against chronic alcoholic liver injury via SIRT1-mediated inhibition of CRP and ChREBP in rats

Keywords: Salvianolic acid B; SIRT1; Alcoholic liver injury; ChREBP; CRP;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Rhapontin ameliorates colonic epithelial dysfunction in experimental colitis through SIRT1 signaling

Keywords: Rhapontin; Inflammation; Intestinal barrier; NLRP3 inflammasome; SIRT1;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

SIRT1 inhibits releases of HMGB1 and HSP70 from human umbilical vein endothelial cells caused by IL-6 and the serum from a preeclampsia patient and protects the cells from death

Keywords: SIRT1; HMGB1; HSP70; Preeclampsia;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

The protective effects of compatibility of Aconiti Lateralis Radix Praeparata and Zingiberis Rhizoma on rats with heart failure by enhancing mitochondrial biogenesis via Sirt1/PGC-1α pathway

Keywords: Sirt1; Sirtuin 1; PGC-1α; peroxisome proliferator-activated receptor gamma coactivator 1α; NRF1; nuclear respiratory factor 1; NRF2; nuclear respiratory factor 2; CK; creatine kinase; LDH; lactate dehydrogenase; BNP; brain natriuretic peptide; cTnT; car

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Negative regulation of NLRP3 inflammasome by SIRT1 in vascular endothelial cells

Keywords: SIRT1; sirtuin 1; NLRP3; NOD-like receptor family pyrin domain-containing 3; ASC; apoptosis-associated speck-like protein containing a CARD; CD40; cluster of differentiation 40; HUVECs; human umbilical vein endothelial cells; ECs; endothelial cells; LPS;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

SIRT6 inhibits TNF-α-induced inflammation of vascular adventitial fibroblasts through ROS and Akt signaling pathway

Keywords: SIRT1; SIRT6; Vascular adventitial fibroblasts; Inflammation;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Rebamipide reduces amyloid-β 1-42 (Aβ42) production and ameliorates Aβ43-lowered cell viability in cultured SH-SY5Y human neuroblastoma cells

Keywords: Aβ; amyloid-beta; AD; Alzheimer's disease; ADAM; a disintegrin and metalloproteinase; APP; amyloid precursor protein; ASPD; amylospheroids; BCA; bicinchoninic acid; BACE1; β-site APP-cleaving enzyme-1; BDNF; brain-derived neurotrophic factor; BSA; bov

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation

Keywords: Acetylation; GCN5; Mitochondria; SIRT1; Deacetylase; PGC-1α; AMP; adenosine monophosphate; Ca2+; calcium; CBP; CREB-binding protein; Cre-MCK; creatine kinase promoter; CHO; carbohydrate; DAC; deacetylase; ETC; electron transport chain; ExT; endurance exe

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticleNegative regulation of Sirtuin 1 by AMP-activated protein kinase promotes metformin-induced senescence in hepatocellular carcinoma xenografts

Keywords: Metformin; Sirtuin 1; AMP-activated protein kinase; Cellular senescence; Hepatocellular carcinoma; SIRT1; Sirtuin 1; AMPK; AMP-activated Protein Kinase; TIS; therapy-induced senescence; SA-β-gal; senescence-associated β-galactosidase;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Metformin impairs systemic bile acid homeostasis through regulating SIRT1 protein levels

Keywords: Bile acid metabolism; Deacetylate; Foxa2; Metformin; SIRT1;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Propolis reversed cigarette smoke-induced emphysema through macrophage alternative activation independent of Nrf2

Keywords: COPD; chronic obstructive pulmonary disease; CS; cigarette smoke; ROS; reactive oxygen species; Nrf2; NF-E2-related factor 2; Keap1; Kelch-like ECH-associated protein 1; ARE; antioxidant response element; HO-1; heme-oxygenase-1; NQ-O1; (NAD(P)H:quinone ox

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Effect of sodium salt of Butrin, a novel compound isolated from Butea monosperma flowers on suppressing the expression of SIRT1 and Aurora B kinase-mediated apoptosis in colorectal cancer cells

Keywords: SIRT1; Sirtunin; AURKB; Aurora B kinase; CRC; Colorectal cancer; BMFC; Butea monosperma flower compounds; mRNA; Messenger ribonucleic acid GSK Glycogen synthase kinase; WHO; World health organization; HDAC; Histone deacetylase; CSCs; Cancer stem cells; Bm

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

PARP, transcription and chromatin modeling

Keywords: ABCA1; ATP-binding cassette transporter A1; ADP-ribosylation; adenosine diphosphate ribosylation; ALC1; amplified in-liver-cancer 1; AR; androgen receptor; ARH3; ADP-ribosylhydrolase 3; ART; ADP-ribosyl transferase; ASF/SF2; alternative splicing factor/sp

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticleSIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p

Keywords: SIRT1; microRNA; Colorectal cancer; Fatty-acid oxidation; Cancer metastasis;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Fisetin inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in mice

Keywords: Fisetin; Osteoarthritis; Inflammation; Chondrocyte; SIRT1;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Full length articleSIRT1 protects osteoblasts against particle-induced inflammatory responses and apoptosis in aseptic prosthesis loosening

Keywords: SIRT1; Osteoblast; Inflammatory responses; Apoptosis; Osteolysis; Aseptic loosening;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells-Implications for age-related macular degeneration (AMD)

Keywords: 9-1-1 complex; complex of Rad9 Rad1 and Hus1 proteins; A2E; N-retinylidene-N-retinylethanol-amine; AtRal; all-trans retinal; AMD; age-related macular degeneration; AMPK; AMP-activated protein kinase; Atg; autophagy-related gene; ATM; ataxia-telangiectasia

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Astaxanthin attenuated pressure overload-induced cardiac dysfunction and myocardial fibrosis: Partially by activating SIRT1

Keywords: AST; Astaxanthin; BNP; brain natriuretic peptide; BW; body weight; EX-527; a selective SIRT1 inhibitor, 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide; EF%; percentage ejection fraction; FS%; percentage fractional shortening; HCFs; human cardiac f

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

EGCG ameliorates diet-induced metabolic syndrome associating with the circadian clock

Keywords: EGCG; Epigallocatechin gallate; CLOCK; Circadian locomotor output cycles kaput; BMAL1; Brain and muscle arnt-like protein-1; CRY; Cryptochromes; PER; Period; SIRT1; Sirtuin 1; PGC1α; Peroxisome proliferator-activated receptor coactivator 1-α; IR; Insuli

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Anti-diabetic activity of fused PPARγ-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression

Keywords: Diabetes; PPAR; SIRT1; SGK1; Calorie restriction; Resveratrol; Body-weight gain;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

The NAMPT/E2F2/SIRT1 axis promotes proliferation and inhibits p53-dependent apoptosis in human melanoma cells

Keywords: Melanoma; NAMPT; SIRT1; Apoptosis; E2F2;

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2017 سفارش ترجمه

Bivalent SIRT1 inhibitors

Keywords: β-NAD+; β-nicotinamide adenine dinucleotide; NAM; nicotinamide; 2′-O-AADPR; 2′-O-acyl-ADP-ribose; RP-HPLC; reversed-phase high performance liquid chromatography; HRMS; high-resolution mass spectrometry; EDC-MeI; 1-(3-dimethylaminopropyl)-3-ethylcarb

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2017 سفارش ترجمه

The stress-response molecule NR4A1 resists ROS-induced pancreatic β-cells apoptosis via WT1

Keywords: NR4A1; nuclear receptor subfamily 4, group A member 1; 8-OHdG; 8-hydroxy deoxyguanosine; DAPI; 4,6-diamidino-2-phenyindole; ROS; reactive oxygen species; Caspase 3; cysteinyl aspartate specific proteinase 3; WT1; Wilms' tumor gene 1; SIRT1; Sirtuin type 1

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2017 سفارش ترجمه

Dual sphingosine kinase inhibitor SKI-II enhances sensitivity to 5-fluorouracil in hepatocellular carcinoma cells via suppression of osteopontin and FAK/IGF-1R signalling

Keywords: Hepatocellular carcinoma; Sphingosine kinase; SKI-II; Osteopontin; IGF-1R; SIRT1;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2017 سفارش ترجمه

Suv39h2 deficiency ameliorates diet-induced steatosis in mice

Keywords: Steatosis; Suv39h2; SIRT1; Epigenetics;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2017 سفارش ترجمه

MiR-34a contributes to diabetes-related cochlear hair cell apoptosis via SIRT1/HIF-1α signaling

Keywords: miR-34a; T2DM; Hearing impairment (HI); SIRT1; HIF-1α;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

The crosstalk between Sirt1 and Keap1/Nrf2/ARE anti-oxidative pathway forms a positive feedback loop to inhibit FN and TGF-β1 expressions in rat glomerular mesangial cells

Keywords: AGEs; advanced glycation-end products; ARE; anti-oxidant response element; BSA; bovine serum albumin; DCFH-DA; 2′, 7′-dichlorofluorescin diacetate; DN; diabetic nephropathy; ECM; extracellular matrix; EMSA; electrophoretic mobility shift assay; FN; fi

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2017 سفارش ترجمه

Vitamin D supplementation inhibits oxidative stress and upregulate SIRT1/AMPK/GLUT4 cascade in high glucose-treated 3T3L1 adipocytes and in adipose tissue of high fat diet-fed diabetic mice

Keywords: High glucose; Oxidative stress; Vitamin D; SIRT1/AMPK/IRS1/GLUT4; Glucose metabolism; 1,25(OH)2D3; 1,25-dihydroxyvitamin D3; AKT; serine/threonine protein kinase; AMPK; AMP activated protein kinase; GLUT1; glucose transporter 1; GLUT4; glucose transporter

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

Hepatic stellate cell-specific deletion of SIRT1 exacerbates liver fibrosis in mice

Keywords: Liver fibrosis; Transcriptional regulation; Hepatic stellate cell; SIRT1; Epigenetics;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

Resveratrol ameliorates hyperglycemia-induced renal tubular oxidative stress damage via modulating the SIRT1/FOXO3a pathway

Keywords: Resveratrol; Diabetic nephropathy; Oxidative stress; SIRT1; FOXO3a; Deacetylation;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2017 سفارش ترجمه

Horizontal transfer of miR-106a/b from cisplatin resistant hepatocarcinoma cells can alter the sensitivity of cervical cancer cells to cisplatin

Keywords: Cisplatin resistance; Exosomes; miR-106a/b; SIRT1;

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2017 سفارش ترجمه

The role of the TOR pathway in mediating the link between nutrition and longevity

Keywords: TOR; target of rapamycin; TSC; tuberous sclerosis complex; Rheb; Ras homologue enriched in brain; 4EBP; 4E binding protein; S6K; S6 kinase; PI3K; phosphatidylinositol-3-kinase; Raptor; regulatory-associated protein of mTOR; Deptor; DEP domain-containing m

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

SIRT1 as a potential biomarker of response to treatment with glatiramer acetate in multiple sclerosis

Keywords: SIRT1; Multiple sclerosis; Glatiramer acetate; Biomarker; Histone H3; Methylation;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor

Keywords: Diabetic retinopathy; Dyslipidemia; Liver X receptor; SIRT1; Glucose; Retinal inflammation; Bone marrow; Circulating angiogenic cells; Tumor necrosis factor alpha; Cholesterol metabolism; Reverse cholesterol transport; Cholesterol efflux; Retinal endothel

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

Decreased Serum Sirtuin-1 in COPD

Keywords: biomarker; COPD; emphysema; serum; sirtuin-1; 6MWD; 6-min walking distance; Aado2; alveolar-arterial oxygen difference; BODE; BMI, airflow obstruction, dyspnea, and exercise capacity; Dlco; diffusing capacity for carbon monoxide; DMEM; Dulbecco's Modified

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

Worsening of memory deficit induced by energy-dense diet in a rat model of early-Alzheimer's disease is associated to neurotoxic Aβ species and independent of neuroinflammation

Keywords: 3-TyrNO2; 3-nitrotyrosine; AβN3(pE); pyroglutamate-Aβ; iAβ; intraneuronal Aβ; BBB; blood-brain barrier; BHI; Bioenergetic Health Index; CRTC; CREB-regulated transcription coactivator; IDE; insulin degrading enzyme; IR; insulin resistance; MetS; metabo

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

Anti-inflammatory effect of strawberry extract against LPS-induced stress in RAW 264.7 macrophages

Keywords: Strawberry; Phenolic compounds; LPS; Inflammation; ROS; Prevention; 2,4 DNP; 2,4-Dinitrophenol; ACYs; anthocyanins; ARE; antioxidant responsive element; CDNB; 1-chloro-2,4-dinitro benzene; DMEM; Dulbecco's Modified Eagle Medium; DPPH; 2,2-DiPhenyl-1-Picry

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2017 سفارش ترجمه

Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy

Keywords: AMPK; Autophagy; Mitochondriogenesis; NAD+; PGC-1α; SIRT1;

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2017 سفارش ترجمه

Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK

Keywords: SRT1720; Phosphodiesterases; cAMP; AMPK; Sirt1; Epac; Type 2 diabetes; Obesity; Aging; Mitochondria;

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2017 سفارش ترجمه

Sirtuins in metabolism, stemness and differentiation

Keywords: Stem cells; Pluripotency; Differentiation; Metabolism; Sirtuins; SIRT1;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2017 سفارش ترجمه

Erythropoietin activates SIRT1 to protect human cardiomyocytes against doxorubicin-induced mitochondrial dysfunction and toxicity

Keywords: Erythropoietin; SIRT1; Doxorubicin; Mitochondrial dysfunction; Cardiotoxicity;

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2017 سفارش ترجمه

Probucol ameliorates renal injury in diabetic nephropathy by inhibiting the expression of the redox enzyme p66Shc

Keywords: DN; diabetic nephropathy; ROS; reactive oxygen species; HG; high-glucose; SIRT1; sirtuin-1; Ac-H3; acetyl-histone H3; STZ; streptozotocin; AMPK; AMP-activated protein kinase; ECM; extracellular matrix; Nox2; NADPH oxidase 2; EMT; tubular epithelial-mesenc

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2017 سفارش ترجمه

Sildenafil protects against bile duct ligation induced hepatic fibrosis in rats: Potential role for silent information regulator 1 (SIRT1)

Keywords: Sildenafil; Hepatic fibrosis; SIRT1; Inflammation; Oxidative stress;

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2017 سفارش ترجمه

Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription

Keywords: Hepatitis B virus; Sirtuin; HBx; cccDNA; SIRT1;

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2017 سفارش ترجمه