SOCS proteins in infectious diseases of mammals
Keywords: CIS; SOCS; Infectious diseases; Cytokines; Mammals
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Loss of Protein Tyrosine Phosphatase Nonreceptor Type 22 Regulates Interferon-γ-Induced Signaling in Human Monocytes
Keywords: SOCS1; ICAM1; MCP1; Th17; CD; Crohn's disease; ERK; extracellular signal-regulated kinase; IBD; inflammatory bowel disease; ICAM; intracellular adhesion molecule; IFN-γ; interferon γ; IκB; inhibitor of κB; IL; interleukin; Jak; Janus kinase; JNK; c-
Engagement of T-cell antigen receptor and CD4/CD8 co-receptors induces prolonged STAT activation through autocrine/paracrine stimulation in human primary T cells
Keywords: TCR; T-cell antigen receptor; MHC; major histocompatibility complex; ZAP-70; zeta-associated protein kinase of 70Â kD; IL; interleukin; JAK; Janus kinase; SOCS; suppressor of cytokine signaling; CIS; cytokine-inducible SH2-containing protein; NFAT; nuclea
Interleukin-6: A multifunctional targetable cytokine in human prostate cancer
Keywords: Interleukin-6; Prostate cancer; Androgen receptor; Apoptosis; Therapy; SOCS;
Scaffold protein Homer 1: Implications for neurological diseases
Keywords: EVH1; Enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) homology 1; IEG; immediate-early gene; P motif; proline-containing motif; mGluR; metabotropic glutamate receptor; IP3R; inositol 1,4,5-trisphosphate receptor; TRPC; transient receptor potentia
Intrathymic IL-7: The where, when, and why of IL-7 signaling during T cell development
Keywords: Thymus; IL-7 receptor; Thymocytes; SOCS; Positive selection
A novel obatoclax derivative, SC-2001, induces apoptosis in hepatocellular carcinoma cells through SHP-1-dependent STAT3 inactivation
Keywords: HCC; hepatocellular carcinoma; STAT3; signal transducers and activators of transcription 3; SOCS; suppressor of cytokine signaling; SHP-1; Src homology region 2 domain-containing phosphatase 1; PARP; poly ADP-ribose polymerase; DMEM; Dulbecco's modified
The many roles of IL-7 in B cell development; Mediator of survival, proliferation and differentiation
Keywords: B cell; IL-7; Pro-B; Pre-B; SOCS
Fullerene derivative prevents cellular transformation induced by JAK2 V617F mutant through inhibiting c-Jun N-terminal kinase pathway
Keywords: Cdk4; cyclin-dependent kinase 4; DCFH; dichlorodihydrofluorescein; DMSO; dimethyl sulfoxide; Epo; erythropoetin; ERK; extracellular signal-regulated kinase; FBS; fetal bovine serum; i.p.; intraperitoneal; i.v.; intravenous; Jak; Janus kinase; JNK; c-Jun N
ReviewSTAT proteins - Key regulators of anti-viral responses, inflammation, and tumorigenesis in the liver
Keywords: CCl4; carbon tetrachloride; Con A; concanavalin A; HCC; hepatocellular carcinoma; HCV; hepatitis C virus; IL; interleukin; JAK; Janus kinase; NK; natural killer; SNP; single nucleotide polymorphism; SOCS; suppressor of cytokine signaling; STAT; signal tra
Peripheral regulation of the growth hormone-insulin-like growth factor system in fish and other vertebrates
Keywords: cAMP; cyclic adenosine monophosphate; ERK; extracellular signal-regulated kinase; E2; 17β-estradiol; GH; growth hormone; GHR; growth hormone receptor; GHBP; growth hormone binding protein; HNF; hepatocyte nuclear factor; IGF; insulin-like growth factor;
Role of the SOCS in monocytes/macrophages-related pathologies. Are we getting closer to a new pharmacological target?
Keywords: SOCS; macrophages; monocytes; cytokine; inflammation
A Requirement for SOCS-1 and SOCS-3 Phosphorylation in Bcr-Abl-Induced Tumorigenesis
Keywords: SOCS; suppressor of cytokine signaling; JAK; Janus tyrosine kinase; STAT; signal transducers and activators of transcription; CML; chronic myelogenous leukemia;
CCL2-Induced Migration and SOCS3-Mediated Activation of Macrophages Are Involved in Cerulein-Induced Pancreatitis in Mice
Keywords: Immune Response; Signaling; Mouse Model; Chemokine; APC; antigen-presenting cell; BM; bone marrow; cDC; classical dendritic cells; cKO; conditional knockout; IL; interleukin; L-Arg; L-arginine; LPS; lipopolysaccharide; MDSC; myeloid-derived suppressor cel
Expression of SOCS1-7 and CIS mRNA in porcine tissues
Keywords: Pig; CIS; SOCS; Reference genes; Messenger RNA
STAT1 as a novel therapeutical target in pro-atherogenic signal integration of IFNγ, TLR4 and IL-6 in vascular disease
Keywords: STAT1; Therapeutical target; IFNγ; TLR4; IL-6; SOCS; Atherosclerosis;
Negative impact of rAAV2 mediated expression of SOCS3 on the regeneration of adult retinal ganglion cell axons
Keywords: SOCS; Adeno-associated viral vectors; Growth inhibition; Cytokines; Axonal regeneration; Peripheral nerve graft;
Evolutionary conserved pro-inflammatory and antigen presentation functions of zebrafish IFNγ revealed by transcriptomic and functional analysis
Keywords: B2M; β-2-microglobulin; COX-2; cyclooxygenase-2; dpf; days post-fertilization; dpi; days post-injection; EPC; epithelioma papulosum cyprinid; hpi; hours post-injection; HSCs; hematopoietic stem cells; ISGs; IFN-stimulated genes; IRF; IFN regulatory facto
Serine phosphorylation regulates disabled-1 early isoform turnover independently of Reelin
Keywords: ApoER2; apolipoprotein E receptor 2; CsA; cyclosporine A; Cdk; cyclin dependent kinase; Dab1; Disabled-1; CHX; cycloheximide; CPTS; 3,4',4â³,4-copper phthalocyanine tetrasulfonic acid, tetrasodium salt; CsA; cyclosporine A; ED; embryonic day; GSK3; glyco
Bioactivity studies of rainbow trout (Oncorhynchus mykiss) interleukin-6: Effects on macrophage growth and antimicrobial peptide gene expression
Keywords: Interleukin-6; Cathelicidin; Hepcidin; SOCS; JAK/STAT;
JAK-STAT signalling is required throughout telotrophic oogenesis and short-germ embryogenesis of the beetle Tribolium
Keywords: Telotrophic oogenesis; Tribolium castaneum; Epithelial patterning; Stalk cells; JAK-STAT signalling; Domeless; SOCS; Segment polarity; Pair-rule genes; Gap genes; Short germ; Segmentation
Original scientific articleGender-Based Differences in Cytokine Production after Burn Injury: A Role of Interleukin-6
Keywords: Con A; Concanavalin A; IFN-γ; interferon-γ; IL; interleukin; SOCS; suppressors of cytokine signaling; TH; T-helper;
Mathematical modelling of interferon-γ signalling in pancreatic stellate cells reflects and predicts the dynamics of STAT1 pathway activity
Keywords: STAT; signal transducer and activator of transcription; IFN; interferon; PSC; pancreatic stellate cell; SOCS; suppressor of cytokine signalling; ECM; extracellular matrix; JAK; Janus kinase; IRF; interferon regulatory factor; IMDM; Iscove's modified Dulbe
High glucose induces suppression of insulin signalling and apoptosis via upregulation of endogenous IL-1β and suppressor of cytokine signalling-1 in mouse pancreatic beta cells
Keywords: FoxO, Forkhead family of transcription factors; IL-1β, Interleukin-1β; IL-1R, Interleukin-1β receptor; IFN-γ, γ-interferon; IR, Insulin receptor; IRS, Insulin receptor substrate; JAK, Janus-kinase; NF-κB, Nuclear factor-κB; PKB/Akt, Protein kinase B; SOCS
Epithelial induction of porcine suppressor of cytokine signaling 2 (SOCS2) gene expression in response to Entamoeba histolytica
Keywords: Entamoeba histolytica; SOCS; Intestinal epithelial cells; Swine; Reference genes
Differential expression and potential role of SOCS1 and SOCS3 in Wallerian degeneration in injured peripheral nerve
Keywords: SOCS; Macrophage; Cytokine; Inflammation; Wallerian degeneration; Peripheral nerve;
Regulation of cytokine signaling and T-cell recruitment in the aging mouse brain in response to central inflammatory challenge
Keywords: Leukocytes; Interferon-γ; Tumor necrosis factor-α; ICAM-1; SOCS; CXCL9/MIG; MMP 12; Astrocytes; Microglia; Choroid plexus
Feedback inhibitors of the epidermal growth factor receptor signaling pathways
Keywords: Mig-6; RALT; Gene 33; FRS2β; SNT-2; FRS3; SOCS; LRIG; Ubiquitinylation; Biomarker; Cancer; EGF; ErbB; HER;
Increased SOCS expression in peripheral blood mononuclear cells of end stage renal disease patients is related to inflammation and dialysis modality
Keywords: End stage renal disease; Inflammation; SOCS; Peripheral blood mononuclear cells
Constitutive JAK2/STAT1 activation regulates endogenous BACE1 expression in neurons
Keywords: AD; Amyloid-β; BACE1; JAK2/STAT1; SOCS; IFN-γ; Neuron; Astrocyte;
Restoration of SOCS3 suppresses human lung adenocarcinoma cell growth by downregulating activation of Erk1/2, Akt apart from STAT3
Keywords: SOCS; Lung carcinoma; Erk1/2; STAT3; Akt;
Down modulation of IFN-γ signaling in alveolar macrophages isolated from smokers
Keywords: AM; alveolar macrophage; LPS; bacterial lipopolysaccharide; IFN-γ; interferon-γ; IFN-γR; IFN-γ receptor; IRF-1; interferon regulatory factor-1; NSCLC; non-small cell lung cancer; PNGase F; peptide N-glycosidase F; SCLC; small cell lung cancer; SOCS; s
Knocking off the suppressors of cytokine signaling (SOCS): their roles in mammalian pregnancy
Keywords: Pregnancy; SOCS; JAK/STAT; Knockout mice; LIF; IL-6
Body mass index and phenotype in subjects with mild-to-moderate persistent asthma
Keywords: Asthma; obesity; treatment; severity; ACRN; Asthma Clinical Research Network; BAGS; The Addition of Regular-use to Intermittent Rescue β-Agonist for Patients with Mild Asthma; BARGE; β-Agonist Response by Genotype; BMI; Body mass index; DICE; Dose of In
Divergence of the vertebrate sp1A/ryanodine receptor domain and SOCS box-containing (Spsb) gene family and its expression and regulation within the mouse brain
Keywords: B30.2/SPRY; SOCS; Spsb; Gene family; Gene expression; Evolution
RSV replication is attenuated by counteracting expression of the suppressor of cytokine signaling (SOCS) molecules
Keywords: RSV; IFN; SOCS; siRNA; JAK/STAT
IL-4 alters expression patterns of storage components of vascular endothelial cell-specific granules through STAT6- and SOCS-1-dependent mechanisms
Keywords: Ang-2; angiopoietin-2; EC; endothelial cell; LAMP-3; lysosomal-associated membrane protein 3; OPG; osteoprotegerin; qRT-PCR; quantitative real-time reverse transcription-polymerase chain reaction; SOCS; suppressor of cytokine signaling; STAT6; signal tran
Forced expression of suppressor of cytokine signaling 3 in T cells protects the development of concanavalin A-induced hepatitis in mice
Keywords: Concanavalin A;; Fas;; Hepatotoxicity;; NKT cells;; SOCS;; T cells;; Th1 cytokine;; Transcription factor
STIM1 but not STIM2 is an essential regulator of Ca2+ influx-mediated NADPH oxidase activity in neutrophil-like HL-60 cells
Keywords: 2-APB; 2-aminoethoxydiphenyl borane; [Ca2+]c; cytosolic free calcium concentration; fMLF; N-formyl-l-methionyl-l-leucyl-l-phenylalanine; siRNA; small interfering RNA; SOCE; store-operated Ca2+ entry; SOCs; store-operated Ca2+ channels; STIM; stromal-inter
The epidermal growth factor receptor ligand amphiregulin is a negative regulator of hepatic acute-phase gene expression
Keywords: APR; acute-phase reaction; APP; acute-phase protein; IL; interleukin; EGFR; epidermal growth factor receptor; AR; amphiregulin; OSM; oncostatin M; STAT; signal transducer and activator of transcription; TNF; tumour necrosis factor; JAK; Janus-activated ki
Histone deacetylase (HDAC) inhibitors reduce the glial inflammatory response in vitro and in vivo
Keywords: Transcription; NFκB; c-FOS; Microglia; SOCS; microRNA-146
Suppressor of cytokine signaling-1 reduces high glucose-induced TGF-β1 and fibronectin synthesis in human mesangial cells
Keywords: High glucose; SOCS-1; JAK2/STAT; Glomerular mesangial cell; SOCS; suppressor of cytokine signaling; HG; high glucose; HMC; human mesangial cell; DN; diabetic nephropathy; ECM; extracellular matrix; JAK; Janus kinase; STAT; signal transducers and activator
SOCS in situ expression in tuberculous lymphadenitis in an endemic area
Keywords: Tuberculosis; Human; Lymph nodes; SOCS; Immunophenotype
SOCS-1 deficiency does not prevent diet-induced insulin resistance
Keywords: Insulin resistance; Diabetes; Obesity; Cytokines; SOCS; Inflammation; High fat diet
Increased expression of SOCS3 in monocytes and SOCS1 in lymphocytes correlates with progressive loss of renal function and cardiovascular risk factors in chronic kidney disease
Keywords: Inflammation; SOCS; Chronic kidney disease; Peripheral blood mononuclear cell
Vitamin D3 cannot revert desensitization of growth hormone (GH)-induced STAT5-signaling in GH-overexpressing mice non-calcemic tissues
Keywords: GH signaling; GH desensitization; Vitamin D; GH; GHR; STAT5; CIS; SOCS
SOCS regulation of the JAK/STAT signalling pathway
Keywords: Cytokine signalling; SOCS; SH2 domain; SOCS box; Inflammation;
Interleukin-10 is a protective factor against diet-induced insulin resistance in liver
Keywords: NAFLD; non-alcoholic fatty-liver disease; NASH; non-alcoholic steatohepatitis; TNF-1 alfa; tumor necrosis factor-1 alpha; SOCS; suppressor of cytokine signaling; Non-alcoholic steatohepatitis; Inflammation; Insulin; Metabolism;
Erythropoietin promotes axonal growth in a model of neuronal polarization
Keywords: Axon growth; SOCS; LIF; Akt; Neuronal polarization; Hippocampal neurons
The many faces of the SOCS box
Keywords: Signal transduction; Cytokine receptor; SOCS; SOCS box; E3 ligase