کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5846962 1128582 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Down modulation of IFN-γ signaling in alveolar macrophages isolated from smokers
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Down modulation of IFN-γ signaling in alveolar macrophages isolated from smokers
چکیده انگلیسی

The master cytokine, IFN-γ possesses a wide spectrum of biological effects and is crucial for development of the highly activated macrophage phenotype characteristically found during inflammation. However, no data exists regarding the potential influence of cigarette smoke on the status of the expression of the cell surface receptor for IFN-γ (IFN-γR) on alveolar macrophages (AM) of smokers. Here in, we report reduction in the expression of the IFN-γR α-chain on AM of cigarette smokers, when compared with non-smokers. Ensuing from the loss of receptor expression on the AM of smokers there was a decrease in IFN-γ-mediated cell signaling. This included a decrease in the phosphorylation of signal transducer and activator of transcription (STAT)-1 and induction of interferon regulatory factor (IRF)-1. Further, diminished activation/induction of transcription factors did not appear to result from induction of known members of the 'suppressors of cytokine signaling (SOCS)' family. Decreased IFN-γ signal transduction in AM from smokers may have an important implication regarding the use of therapeutic IFN-γ in the lungs of patients that develop respiratory disorders as a result of tobacco use.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology and Applied Pharmacology - Volume 237, Issue 1, 15 May 2009, Pages 22-28
نویسندگان
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