Keywords: اسپینوزین کیناز 1; Sphingosine kinase 1; Sphingosine-1-phosphate; Fingolimod; Pramipexole; Parkinson's disease;
مقالات ISI اسپینوزین کیناز 1 (ترجمه نشده)
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Keywords: اسپینوزین کیناز 1; Pancreatic cancer; Sphingosine-1-phosphate; Sphingosine kinase 1; Sphingosine kinase 2; CRISPR/Cas9; Lipid mediator;
Keywords: اسپینوزین کیناز 1; AML; acute myeloid leukaemia; CERK; ceramide kinase; Des1; dihydroceramide desaturase; EGF; epidermal growth factor; ER; endoplasmic reticulum; GPCRs; G protein-coupled receptors; LPP; lipid phosphate phosphatase; SPP; sphingosine phosphate phosphatase SK
Keywords: اسپینوزین کیناز 1; AMP; antimicrobial peptide; CAMP; cathelicidin antimicrobial peptide; ER; endoplasmic reticulum; KC; keratinocytes; K6PCN-5; N-(1,3-dihydroxyisopropyl)-2-hexyl-3-oxo-decanamide MHP, (S)-methyl 2-(hexanamide)-3-(4-hydroxyphenyl) propanoate; SPHK; sphingosi
Keywords: اسپینوزین کیناز 1; AL; Ad libitum; CR; Calorie restriction; SPT; Serine palmitoyl transferase; GCS; Glucosylceramide synthase; CGT; Ceramide galactosyl transferase; CERK; Ceramide kinase; SMS1; Sphingomyelin synthase 1; SMS2; Sphingomyelin synthase 2; SPK1; Sphingosine kina
Keywords: اسپینوزین کیناز 1; SphK1; sphingosine kinase 1; S1P1; sphingosine-1-phosphate (S1P) receptor 1; ECs; endothelial cells; E2; 17β-estradiol; ER; estrogen receptor; Akt; protein kinase B; eNOS; endothelial nitric oxide (NO) synthase; HUVEC; human umbilical vein endothelial ce
Keywords: اسپینوزین کیناز 1; Liver; Sphingosine kinase 1; Ceramide; Triacylglycerol; Diacylglycerol; Glucose tolerance;
Keywords: اسپینوزین کیناز 1; Cerebral ischemia; Sphingosine kinase 1; Neuroinflammation; Microglia
Keywords: اسپینوزین کیناز 1; Sphingosine kinase 1; Diabetic wound healing; Diabetic rats
Keywords: اسپینوزین کیناز 1; ATP; adenosine triphosphate; ADP; adenosine diphosphate; Cer; ceramide; ERK-1/2; extra-cellular signal-regulated kinase 1/2; HDAC; histone deacetylase; LDH; lactate dehydrogenase; S1P; sphingosine-1-phosphate; SAR; structure-activity relationship; Sph;
Keywords: اسپینوزین کیناز 1; Ap3A; diadenosine triphosphate; ERK; extracellular signal regulated kinase; FHIT; fragile histidine triad protein; GSSG; oxidized glutathione; GSH; reduced glutathione; LC3; microtubule associated protein 1 light chain 3; NAC; N-acetyl-cysteine; NADPH; ni
Resveratrol inhibits monocrotaline-induced pulmonary arterial remodeling by suppression of SphK1-mediated NF-κB activation
Keywords: اسپینوزین کیناز 1; Sphingosine kinase 1; Resveratrol; Vascular remodeling; Pulmonary hypertension;
Intracellular S1P Levels Dictate Fate of Different Regions of the Hippocampus following Transient Global Cerebral Ischemia
Keywords: اسپینوزین کیناز 1; OGD; Oxygen glucose deprivation; S1P; Sphingosine-1-phosphate; S1Pr; Sphingosine-1-phosphate receptor; Sgpl1; Sphingosine-1-phosphate lyase; SPH; Sphingosine; SphK1; Sphingosine kinase 1; SphK2; Sphingosine Kinase 2; Spns2; Spinster 2; tGCI; Transient glo
Physcion 8-O-β-glucopyranoside exhibits anti-leukemic activity through targeting sphingolipid rheostat
Keywords: اسپینوزین کیناز 1; Acute lymphoblastic leukemia; Physcion 8-O-β-glucopyranoside; Sphingosine kinase 1; Apoptosis;
Pramipexole and Fingolimod exert neuroprotection in a mouse model of Parkinson's disease by activation of sphingosine kinase 1 and Akt kinase
Keywords: اسپینوزین کیناز 1; Sphingosine kinase 1; Sphingosine-1-phosphate; Fingolimod; Pramipexole; Parkinson's disease; MPTP;
Sphk1 mediates neuroinflammation and neuronal injury via TRAF2/NF-κB pathways in activated microglia in cerebral ischemia reperfusion
Keywords: اسپینوزین کیناز 1; Sphk1; Sphingosine kinase 1; S1P; Sphingosine-1-phosphate; IL17; Interleukin-17; IRI; Ischemia reperfusion injury; OGDR; Oxygen-glucose deprivation reperfusion; TNFR2; Tumor necrosis factor receptor2; TRAF2; Tumor necrosis factor receptor-associated facto
Sphingolipids and glycerophospholipids - The “ying and yang” of lipotoxicity in metabolic diseases
Keywords: اسپینوزین کیناز 1; AA; arachidonic acid; AKT; RAC-alpha serine/threonine-protein kinase; CCTα; choline-phosphate cytidylyltransferase A; CERK; Ceramide Kinase; C1P; ceramide-1-phosphate; CerS; ceramide synthase; CERT; ceramide transport protein; HDL; high-density lipoprote
AAV-mediated gene delivery attenuates neuroinflammation in feline Sandhoff disease
Keywords: اسپینوزین کیناز 1; AAV; adeno-associated virus; CNS; central nervous system; DCN; deep cerebellar nuclei; GFAP; glial fibrillary acidic protein; Hex; β-N-acetylhexosaminidase; Iba1; ionized calcium-binding protein 1; ICV; intracerebroventricular; IL-1β; interleukin 1 beta
Sphingosine kinase 1 (SK1) allosteric inhibitors that target the dimerization site
Keywords: اسپینوزین کیناز 1; SK; sphingosine kinase; S1P; sphingosine-1-phosphate; PKC-α; protein kinase C alpha; MAPK; mitogen-activated protein kinase; PI3K; phosphatidylinositol kinase; CKII; casein kinase II; EGFR; epidermal growth factor receptor; sphingosine kinase 1; alloster
Sphingosine 1-phosphate signaling axis mediates fibroblast growth factor 2-induced proliferation and survival of murine auditory neuroblasts
Keywords: اسپینوزین کیناز 1; DMEM; Dulbecco's Modified Eagle Medium; FBS; fetal bovine serum; BSA; bovine serum albumin; PBS; phosphate buffered saline; DTT; dithiothreitol; INF-γ; interferon-γ; IGF1; insulin-like growth factor1; S1P; sphingosine 1-phosphate; SK1; sphingosine kinas
Concurrent targeting Akt and sphingosine kinase 1 by A-674563 in acute myeloid leukemia cells
Keywords: اسپینوزین کیناز 1; Acute myeloid leukemia; A-674563; Akt; Sphingosine kinase 1;
Sphingosine-1-phosphate, regulated by FSH and VEGF, stimulates granulosa cell proliferation
Keywords: اسپینوزین کیناز 1; Sphingosine 1-phosphate; Sphingosine kinase 1; Granulosa cell culture; FSH; VEGF; Bovine;
Micronome revealed miR-19a/b as key regulator of SOCS3 during cancer related inflammation of oral squamous cell carcinoma
Keywords: اسپینوزین کیناز 1; OSCC; Oral Squamous Cell Carcinoma; miRNA; MicroRNA; NGS; Next Generation Sequencing; STRING; Search Tool for Retrieval of Interacting Genes/Proteins; ACTREC; Advanced Centre for Treatment Research and Education in Cancer; HNOCDB; Head Neck Oral Cancer Da
Polydatin attenuates AGEs-induced upregulation of fibronectin and ICAM-1 in rat glomerular mesangial cells and db/db diabetic mice kidneys by inhibiting the activation of the SphK1-S1P signaling pathway
Keywords: اسپینوزین کیناز 1; Diabetic nephropathy; Advanced glycation-end products; Polydatin; Sphingosine kinase 1; Fibronectin; Intercellular adhesion molecule-1AGEs, advanced glycation-end products; AP-1, activator protein 1; BUN, blood urea nitrogen; C17–S1P, C17-D-erythro-sphing
Targeting colorectal cancer cells by a novel sphingosine kinase 1 inhibitor PF-543
Keywords: اسپینوزین کیناز 1; Colorectal cancer; Sphingosine kinase 1; PF-543; Programmed necrosis;
A practical process for the preparation of [32P]S1P and binding assay for S1P receptor ligands
Keywords: اسپینوزین کیناز 1; Competitive binding assay; Phosphorus-32; Radioligand; Sphingosine 1-phosphate; Sphingosine 1-phosphate Receptors; Sphingosine kinase 1;
SphK1 inhibitor II (SKI-II) inhibits acute myelogenous leukemia cell growth in vitro and in vivo
Keywords: اسپینوزین کیناز 1; Acute myeloid leukemia; Sphingosine kinase 1; SKI-II; Ceramide; Chemotherapy
Sphingolipids in pulmonary fibrosis
Keywords: اسپینوزین کیناز 1; Sphingosine-1-phosphate; TGF-β; Sphingosine kinase 1; S1P lyase; Autophagy; Pulmonary fibrosis;
Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia-Impact on enzyme activity and response to cytotoxics
Keywords: اسپینوزین کیناز 1; DMT; N-desmethyltamoxifen; AC; acid ceramidase; AML; acute myelogenous leukemia; SphK1; sphingosine kinase 1; S1-P; sphingosine 1-phosphate; GC; glucosylceramide; 4-HPR; fenretinide; GCS; glucosylceramide synthase; P-gp; P-glycoprotein; ATCC; American Typ
A novel chimeric aequorin fused with caveolin-1 reveals a sphingosine kinase 1-regulated Ca2Â + microdomain in the caveolar compartment
Keywords: اسپینوزین کیناز 1; Caveolin-1; Aequorin; Sphingosine kinase 1; Sphingosine-1-phosphate; Calcium; Plasma membrane;
Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor
Keywords: اسپینوزین کیناز 1; Bcr-Abl1; B-cell receptor-Abelson tyrosine kinase 1; Brms1; breast carcinoma metastasis suppressor 1; cyto; cytoplasmic preparation; ER; estrogen receptor; ERM; Ezrin, Radixin, Moesin protein; ERK; extracellular signal regulated kinase; GAPDH; glyceraldeh
AP-1 regulates sphingosine kinase 1 expression in a positive feedback manner in glomerular mesangial cells exposed to high glucose
Keywords: اسپینوزین کیناز 1; DN; diabetic nephropathy; FN; fibronectin; ECM; extracellular matrix; TGF-β1; transforming growth factor-β1; GMCs; glomerular mesangial cells; S1P; sphingosine 1-phosphate; SphK; sphingosine kinase; HG; high glucose; AP-1; activator protein-1; ChIP; chr
Curcumin ameliorates diabetic nephropathy by inhibiting the activation of the SphK1-S1P signaling pathway
Keywords: اسپینوزین کیناز 1; AGE; Advanced glycation end product; AP-1; Activator protein 1; BUN; Blood urea nitrogen; Cr; Serum creatinine; Cur; Curcumin; DN; Diabetic nephropathy; ECM; Extracellular matrix; FBG; Fasting blood glucose; FN; Fibronectin; GBM; Glomerular basement membr
Sphingosine kinase 1 expression is downregulated during differentiation of Friend cells due to decreased c-MYB
Keywords: اسپینوزین کیناز 1; SPHK1; Sphingosine kinase 1; SPL; Sphingolipid; S1P; Sphingosine 1-phosphate; HMBA; Hexamethylene bisacetamide; WT; Wild-type; DN; Dominant negative; EMSA; Electrophoresis mobility shift assay; ChIP; Chromatin immunoprecipitation; Friend cell; SPHK1; c-MY
Acetylation of sphingosine kinase 1 regulates cell growth and cell-cycle progression
Keywords: اسپینوزین کیناز 1; Acetylation; Cell growth; Cell-cycle progression; Sphingosine kinase 1; acetyl-CoA; acetyl coenzyme A; Ad; adenovirus; CBP; CREB-binding protein; CREB; cAMP-response element-binding protein; EGFP; enhanced green fluorescent protein; FBS; fetal bovine seru
Inhibition of sphingosine kinase 1 enhances cytotoxicity, ceramide levels and ROS formation in liver cancer cells treated with selenite
Keywords: اسپینوزین کیناز 1; SK1; sphingosine kinase 1; PDMP; 1-Phenyl-2-decanoylamino-3-morpholino-1-propanol; ROS; reactive oxygen species; S1P; sphingosine 1 phosphate; SMase; sphingomyelinases; 3-OMS; 3-O-methylsphingosine; GCS; glycosylceramide synthase; SK1-II; 2-(p-hydroxyanil
Fumonisin B1 and the kidney: Modes of action for renal tumor formation by fumonisin B1 in rodents
Keywords: اسپینوزین کیناز 1; AP; aminopentol; aSMase; acid sphingomyelinase; FB1; fumonisin B1; JNK; c-Jun N-terminal kinase; CYP; cytochrome P450 superfamiliy; ERK; extracellular regulated kinase; GCS; glucosylceramide synthase; GSH; glutathione; HFB1; hydrolyzed FB1; MAPK; mitogen-
Altered expression of sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 in mouse hippocampus after kainic acid treatment
Keywords: اسپینوزین کیناز 1; Kainic acid; Sphingosine kinase 1; Sphingosine-1-phosphate receptor 1; Hippocampus; Mice;
FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells
Keywords: اسپینوزین کیناز 1; Sphingosine kinase 1; Cancer; Proteasome; Fingolimod; Apoptosis; Sphingosine 1-phosphate signalling;
Enhancement of sphingosine kinase 1 catalytic activity by deletion of 21 amino acids from the COOH-terminus
Keywords: اسپینوزین کیناز 1; Sphingosine-1-phosphate; Sphingosine kinase 1; Plasma membrane; Subcellular localization; PMA; Protein phosphorylation
Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia
Keywords: اسپینوزین کیناز 1; sphingosine kinase 1; sphingosine-1-phosphate; microglia; inflammation; cytokines; nitric oxidebp, basepairs; DAPI, 4'-6-diamidino-2-phenylindole; DMEM, dulbecco's modified eagles medium; DMS-N, N Dimethylsphingosine; ELISA, enzyme linked immunosorbent as
Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease
Keywords: اسپینوزین کیناز 1; Sphingosine 1-phosphate; Sphingosine kinase 1; Lipid phosphate phosphatase; Spatial; Survival; Cancer; Hypoxia; Inflammation
Sphingosine kinase 1 localized to the plasma membrane lipid raft microdomain overcomes serum deprivation induced growth inhibition
Keywords: اسپینوزین کیناز 1; Sphingosine-1-phosphate; Sphingosine kinase 1; Plasma membrane; Lipid raft microdomain; Phosphatidylserine; Subcellular localization
Role of sphingosine kinase 1 in allergen-induced pulmonary vascular remodeling and hyperresponsiveness
Keywords: اسپینوزین کیناز 1; Pulmonary arterial hypertension; allergen-induced lung inflammation; vascular remodeling; perfused mouse lung; sphingosine kinase; sphingosine 1-phosphate; BAL; Bronchoalveolar lavage; CT; Threshold cycle; G-CSF; Granulocyte colony-stimulating factor; HPR
Epigenetic regulation of established human type 1 versus type 2 cytokine responses
Keywords: اسپینوزین کیناز 1; Human; PBMCs; TH1/TH2; cytokine; HAT; Histone acetyltransferase; HDAC; Histone deacetylase; PHA; Phytohemagglutinin; SPHK1; Sphingosine kinase 1; TSA; Trichostatin A; TSST-1; Toxic shock syndrome toxin 1;
Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway
Keywords: اسپینوزین کیناز 1; Sphingosine kinase 1; Fibroblast growth factor 1; Copper; Non-classical release; Angiogenesis
High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation
Keywords: اسپینوزین کیناز 1; Sphingosine kinase 1; S1P receptors; Chemotherapy-resistance; Camptothecin; Prostate cancer