HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A
Keywords: STAT3; PP2A; HDAC3; Dephosphorylation; Transcriptional regulation;
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Islet-1 is required for ventral neuron survival in Xenopus
Keywords: Islet-1; Islet-2; Xenopus; Motoneuron; Apoptosis; Cell proliferation; Stat3;
Capsaicin inhibits the IL-6/STAT3 pathway by depleting intracellular gp130 pools through endoplasmic reticulum stress
Keywords: Capsaicin; gp130; STAT3; Interleukin-6; Endoplasmic reticulum stress;
The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation
Keywords: Cytokine; STAT3; Y14; MAGOH; Exon-junction complex; Gene expression; Signal transduction
Aspirin induces apoptosis through the blockade of IL-6-STAT3 signaling pathway in human glioblastoma A172 cells
Keywords: Aspirin; STAT3; IL-6; Apoptosis; A172 glioblastoma cells
STAT3 deletion sensitizes cells to oxidative stress
Keywords: STAT1; STAT3; Apoptosis; Ischemia; Myocardial infarction; Oxidative stress;
Association of early phase of colorectal carcinogenesis with STAT3 activation and its relevance in apoptosis regulation
Keywords: Apoptosis; Bcl2; Colorectal carcinoma; CRC cells; Cyclin D1; Caspase 3; Peripheral blood mononuclear cells; STAT3
Autonomic Regulation of Liver Regeneration After Partial Hepatectomy in Mice
Keywords: liver regeneration; vagus nerve; Kupffer cells; IL-6; STAT3; acetylcholine
The dysfunction and abnormal signaling pathway of dendritic cells loaded by tumor antigen can be overcome by neutralizing VEGF in multiple myeloma
Keywords: Dendritic cells; Myeloma; Anti-VEGF antibody; STAT3
A redox-silent analogue of tocotrienol acts as a potential cytotoxic agent against human mesothelioma cells
Keywords: Mesothelioma; Tocotrienol; Redox-silent analogue; Src; Stat3
Kahweol blocks STAT3 phosphorylation and induces apoptosis in human lung adenocarcinoma A549 cells
Keywords: Kahweol; Apoptosis; STAT3
NADPH oxidase and ERK1/2 are involved in cadmium induced-STAT3 activation in HepG2 cells
Keywords: Cadmium; NADPH oxidase; Hsp70; STAT3
Stat3 downstream genes serve as biomarkers in human lung carcinomas and chronic obstructive pulmonary disease
Keywords: Stat3; Adenocarcinoma; Squamous cell carcinoma; COPD; Biomarkers; Real-Time qRT-PCR;
Ciliary neurotrophic factor (CNTF) signals through STAT3–SOCS3 pathway and protects rat pancreatic islets from cytokine-induced apoptosis
Keywords: STAT3; CNTF; Pancreatic islets; SOCS3; Apoptosis
Restoration of SOCS3 suppresses human lung adenocarcinoma cell growth by downregulating activation of Erk1/2, Akt apart from STAT3
Keywords: SOCS; Lung carcinoma; Erk1/2; STAT3; Akt;
A novel non-phosphorylated potential antitumoral peptide inhibits STAT3 biological activity
Keywords: STAT3; Peptide inhibitor; Immunofluorescence; Cellular effects; Ahx; 6-amino hexanoic acid; Antp; Antennapedia sequence; BOP; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; DIPEA; diisopropylethylamine; GPK; GMP-protein dependan
Leptin Affects System A Amino Acid Transport Activity in the Human Placenta: Evidence for STAT3 Dependent Mechanisms
Keywords: Placenta; Leptin; System A amino acid transporter; STAT3;
Mechanisms of dexamethasone-mediated chemokine down-regulation in mild and severe acute pancreatitis
Keywords: Acute pancreatitis; Chemokines; Dexamethasone; MAPK; NF-κB; STAT3
Interleukin-6 (IL-6) released by macrophages induces IL-6 secretion in the human colon cancer HT-29 cell line
Keywords: IL-6; Macrophages; STAT3; HT-29; Colon cancer
Expression of the signal transducer and activator of transcription factor 3 and Janus kinase 3 in colorectal carcinomas, colonic adenomas and ulcerative colitis
Keywords: Colorectal carcinoma; Ulcerative colitis; Colonic adenomas; Immunohistochemistry; STAT3; JAK3
STAT3 in CD4+ T helper cell differentiation and inflammatory diseases
Keywords: STAT3; T cell lineage commitment; CNS inflammatory diseases; Th17 and Treg development; Cytokine signaling pathways
Hyperactivated STAT3 in ALK–positive diffuse large B-cell lymphoma with clathrin-ALK fusion
Keywords: ALK; B-cell lymphoma; STAT3; STAT5; Survivin; BCL-XL
Synergistic Effect of Radiation and Interleukin-6 on Hepatitis B Virus Reactivation in Liver Through STAT3 Signaling Pathway
Keywords: Radiotherapy; Interleukin-6; Hepatitis B virus; Reactivation; Signal transducer and activator of transcription-3; STAT3;
ZD6474 inhibits Src kinase leading to apoptosis of imatinib-resistant K562 cells
Keywords: Src; Bcl-2; Bax; STAT3; Imatinib-resistant;
IL-6 augments angiotensinogen in primary cultured renal proximal tubular cells
Keywords: IL-6; Angiotensinogen; STAT3; Renal proximal tubular epithelial cell
Stat3 activation is required for the growth of U87 cell-derived tumours in mice
Keywords: Apoptosis; Angiogenesis; Glioblastoma multiforme; Hypoxia; Stat3; VEGF
Oleic acid inhibits hepatic insulin signaling through deregulation of STAT3 activation and C/EBPα expression
Keywords: C/EBPα; IRS1; Oleic acid; SOCS3; STAT3
Knockdown of Stat3 activity in vivo prevents diabetic glomerulopathy
Keywords: collagen IV; diabetic nephropathy; glomerulosclerosis; mesangial cells; Stat3
In vivo GSH depletion induces c-myc expression by modulation of chromatin protein complexes
Keywords: BSO, l-buthionine-(S,R)-sulfoximine; PH, partial hepatectomy; HDAC, histone deacetylase; ROS, reactive oxygen species; ChIP, chromatin immunoprecipitationGSH; c-myc; Chromatin remodeling; Histone acetylation; Id2; STAT3; Free radicals
Visfatin through STAT3 activation enhances IL-6 expression that promotes endothelial angiogenesis
Keywords: Visfatin; STAT3; IL-6; Angiogenesis; Human endothelial cell
BCR-ABL induces opposite phenotypes in murine ES cells according to STAT3 activation levels
Keywords: BCR-ABL; STAT3; ERK; Leukemic stem cells; Embryonic stem cells; Self-renewal; Differentiation
Myricetin directly targets JAK1 to inhibit cell transformation
Keywords: Myricetin; EGF; JAK1; STAT3; JB6 cells
Ablation of Stat3 by siRNA Alters Gene Expression Profiles in JEG-3 Cells: A Systems Biology Approach
Keywords: Trophoblast; Jeg-3; Stat3; Small interfering RNA; Microarray; Inflammation
Oligonol, a lychee fruit-derived low molecular weight polyphenol formulation, inhibits UVB-induced cyclooxygenase-2 expression, and induces NAD(P)H:quinone oxidoreductase-1 expression in hairless mouse skin
Keywords: Oligonol; Cyclooxygenase-2; Mouse skin; Msk1; JAK2; STAT3; NAD(P)H:quinine oxidoreductase-1; Photoprotection
Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression
Keywords: Fibronectin type III; p48.2; Cyclin D1; STAT3; G1 arrest;
Cytokine signalling via gp130 in gastric cancer
Keywords: gp130; Gastric cancer; IL-11; STAT3; Cytokine
Interleukin-11 increases invasiveness of JEG-3 choriocarcinoma cells by modulating STAT3 expression
Keywords: IL-11; STAT1; STAT3; ERK1/2; Proliferation; Trophoblast invasion; JEG-3
Kupffer Cells Mediate Leptin-Induced Liver Fibrosis
Keywords: αSMA; α-smooth muscle actin; collagen I; collagen 1α1; CTGF/CCN2; connective tissue growth factor; ERK1/2; extracellular signal-related kinase 1 and 2; KCs; Kupffer cells; HSCs; hepatic stellate cells; SECs; sinusoidal endothelial cells; TGF-β1; trans
Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib
Keywords: Doxorubicin; Sunitinib; Anti-angiogenesis; P-glycoprotein; Drug transport; Hypoxia; High-dose; Glycolysis; ATP levels; Energy metabolism; Kinases; Tumor stroma; Hedgehog; HIF-1; STAT3; Quantitative resistance assays
Myeloid STAT3 Inhibits T Cell-Mediated Hepatitis by Regulating T Helper 1 Cytokine and Interleukin-17 Production
Keywords: MCP-1; monocyte chemoattractant protein-1; STAT3; signal transducer and activator of transcription factor 3; STAT3T-cellâ/â mice; T-cell-specific STAT3 knock out mice; STAT3Myeâ/â mice; myeloid cell-specific STAT3 knock out mice; MPO; myeloperoxid
The transcriptional repressor ZBP-89 and the lack of Sp1/Sp3, c-Jun and Stat3 are important for the down-regulation of the vimentin gene during C2C12 myogenesis
Keywords: ZBP-89; Vimentin; Myogenesis; Sp1/Sp3; c-Jun; Stat3; C2C12
Exogenous CNTF stimulates axon regeneration of retinal ganglion cells partially via endogenous CNTF
Keywords: Optic nerve; Oncomodulin; Axon regeneration; Retinal ganglion cells; Lens injury; Astrocyte; CNS; STAT3; CNTF
CNTF induces photoreceptor neuroprotection and Müller glial cell proliferation through two different signaling pathways in the adult zebrafish retina
Keywords: CNTF; Stat3; light-induced retinal damage; retinal regeneration; Müller glia; neuroprotection; zebrafish; SB 203580; MAP kinase inhibitor;
Cross talk Initiated by Endothelial Cells Enhances Migration and Inhibits Anoikis of Squamous Cell Carcinoma Cells through STAT3/Akt/ERK Signaling
Keywords: CM; conditioned medium; CXCL8; interleukin-8; EBM; endothelial cell basal medium; EGF; epidermal growth factor; ERK; extracellular signal-regulated kinase; HDMEC; human dermal microvascular endothelial cell; HNSCC; head and neck squamous cell carcinoma; I
c-Met Confers Protection Against Chronic Liver Tissue Damage and Fibrosis Progression After Bile Duct Ligation in Mice
Keywords: AFP; α-fetoprotein; Alb-Cre; albumin promoter-Cre transgenic animals; Alfp-Cre; albumin/AFP promoter/enhancer; BDL; bile duct ligation; BrdU; bromodeoxyuridine; c-Met; mesenchymal-epithelial transition factor; DAPI; 6-diamidino-2-phenylindole; HGF; hep
Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome
Keywords: Autosomal recessive hyper-IgE syndrome; human gene mutation; DOCK8; primary immunodeficiency; molluscum contagiosum; recurrent infection; T cells; TH17 cells; eosinophils; IgE regulation; copy number variations; genomic deletions; AR; Autosomal-recessive;
Overexpression of phosphorylated ATF2 and STAT3 in eccrine porocarcinoma and eccrine poroma
Keywords: ATF2 (AP-1); STAT3; Eccrine porocarcinoma; Eccrine poroma;
An RNA biding protein, Y14 interacts with and modulates STAT3 activation
Keywords: Cytokine; STAT3; Y14; RNA-binding protein; Gene expression; Signal transduction
Discovery of the catechol structural moiety as a Stat3 SH2 domain inhibitor by virtual screening
Keywords: Virtual screening; Catechol; Stat3; SH2; Inhibitors
The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction
Keywords: IL-6; LIF; SENP1; SUMO; STAT3; PML; Transcriptional regulation