Leptin upregulates telomerase activity and transcription of human telomerase reverse transcriptase in MCF-7 breast cancer cells
Keywords: Leptin; Telomerase; hTERT; STAT3;
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OSU-03012 sensitizes TIB-196 myeloma cells to imatinib mesylate via AMP-activated protein kinase and STAT3 pathways
Keywords: Myeloma; OSU-03012; Imatinib mesylate; AMPK; STAT3
Interleukin-6 upregulates the expression of PMP22 in cultured rat Schwann cells via a JAK2-dependent pathway
Keywords: Interleukin-6; Peripheral myelin protein 22; gp130; JAK2; STAT3; Schwann cell
Enhanced CD8 T cell cross-presentation by macrophages with targeted disruption of STAT3
Keywords: Cytotoxic; CD8; STAT3
Deguelin suppresses cell proliferation via the inhibition of survivin expression and STAT3 phosphorylation in HTLV-1-transformed T cells
Keywords: Deguelin; Survivin; Hsp90; STAT3; HTLV-1
Role of ERp57 in the signaling and transcriptional activity of STAT3 in a melanoma cell line
Keywords: STAT3; ERp57; Transcription regulation; STAT3-associated proteins, CRP
α-Lipoic acid activates dimethylarginine dimethylaminohydrolase in cultured endothelial cells
Keywords: ADMA; α-Lipoic acid; DDAH; Endothelial cell; STAT3
Sorafenib exerts anti-glioma activity in vitro and in vivo
Keywords: Glioma; Sorafenib; Stat3; Apoptosis; Autophagy
Research ArticleActivation of human liver sinusoidal endothelial cell by human platelets induces hepatocyte proliferation
Keywords: LSECs; liver sinusoidal endothelial cells; IL-6; interleukin-6; VEGF; vascular endothelial growth factor; S1P; sphingosine 1-phosphate; HGF; hepatocyte growth factor; EGF; epidermal growth factor; PDGF; platelet-derived growth factor; STAT3; signal transd
Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562
Keywords: Cucurbitacin B; STAT3; Raf/MEK/ERK pathway; K562; Leukemia
Dual action of sphingosine 1-phosphate in eliciting proinflammatory responses in primary cultured rat intestinal smooth muscle cells
Keywords: Sphingosine 1-phosphate; Inflammation; Intestinal smooth muscle cells; Egr-1; STAT3;
Angiotensin II activates JAK2/STAT3 pathway and induces interleukin-6 production in cultured rat brainstem astrocytes
Keywords: Angiotensin II; Interleukin-6; JAK2; STAT3; Astrocytes; Proliferation
The IGFR1 inhibitor NVP-AEW541 disrupts a pro-survival and pro-angiogenic IGF-STAT3-HIF1 pathway in human glioblastoma cells
Keywords: Insulin-like growth factors; Hypoxia-inducible factor-1; STAT3; Glioblastoma; IGF-1 receptor inhibitor
The rGel/BLyS fusion toxin inhibits STAT3 signaling via down-regulation of interleukin-6 receptor in diffuse large B-cell lymphoma
Keywords: Diffuse large B-cell lymphoma; Fusion toxin; Interleukin-6 receptor; STAT3; Apoptosis
Triptolide ameliorates IL-10-deficient mice colitis by mechanisms involving suppression of IL-6/STAT3 signaling pathway and down-regulation of IL-17
Keywords: Triptolide; IL-10-deficient mice; IL-6; STAT3; IL-17
AAV/hSTAT3-gene delivery lowers aortic inflammatory cell infiltration in LDLR KO mice on high cholesterol
Keywords: Atherosclerosis; STAT3; Inflammation; Gene therapy; Adeno-associated virus
Activation of STAT3 by specific Gα subunits and multiple Gβγ dimers
Keywords: G proteins; G14; G16; Gβγ; STAT3
Dendritic cells integrate signals from the tumor microenvironment to modulate immunity and tumor growth
Keywords: Dendritic cells; Tumor microenvironment; Stat3
Growth inhibition of human ovarian cancer cells by blocking STAT3 activation with small interfering RNA
Keywords: Human; Ovarian cancer; STAT3; RNA interference
Granulocyte colony-stimulating factor negatively regulates Toll-like receptor agonist-induced cytokine production in human neutrophils
Keywords: Neutrophil; G-CSF; STAT3; Toll-like receptor; Proinflammatory cytokines
The induction of tumor apoptosis in B16 melanoma following STAT3 siRNA delivery with a lipid-substituted polyethylenimine
Keywords: siRNA; STAT3; Melanoma; Cancer therapy; Polyethylenimine; Nanomedicine
Interleukin-26: An IL-10-related cytokine produced by Th17 cells
Keywords: IL-26; Th17 cells; IL-20R1; STAT3; Inflammation
Phosphorylation–acetylation switch in the regulation of STAT1 signaling
Keywords: STAT1; STAT2; STAT3; Acetylation; Phosphorylation; Histone deacetylase; Interferon; TCP45
Signal Transducer and Activator of Transcription 3 Protects From Liver Injury and Fibrosis in a Mouse Model of Sclerosing Cholangitis
Keywords: Stat3; Liver; Conditional Mouse Model; Cholestasis; CA; cholic acid; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; GSEA; Gene Set Enrichment Analysis; IGF-1; insulin-like growth factor 1; IL; interleukin; mdr2â/â; multidrug res
Loss of RegI in conjunction with gastrin deficiency in mice facilitates efficient gastric ulcer healing but is dispensable for hyperplasia and tumourigenesis
Keywords: Gastric cancer; STAT3; Reg family; Regeneration; Ulceration
STAT1 activation regulates proliferation and differentiation of renal progenitors
Keywords: STAT1; STAT3; Kidney; Wilms tumor; Mesenchymal-epithelial transition; Development;
A new regulation of IL-6 production in adult cardiomyocytes by β-adrenergic and IL-1β receptors and induction of cellular hypertrophy by IL-6 trans-signalling
Keywords: β-Adrenergic receptors; cAMP; IL-6; IL-1; STAT3; Cardiac hypertrophy;
Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism
Keywords: Flavonoids; Hypoxia; HIF; VEGF; Angiogenesis; STAT3
Gα16 activates Ras by forming a complex with tetratricopeptide repeat 1 (TPR1) and Son of Sevenless (SOS)
Keywords: ERK; extracellular signal-regulated kinase; GPCRs; G protein-coupled receptors; HEK 293; human embryonic kidney 293; IKK; IκB kinase; NFκB; nuclear factor κB; PLCβ; phospholipase Cβ; STAT3; signal transducer and activator of transcription 3; TPR1; te
Non-cell-autonomous stimulation of stem cell proliferation following ablation of Tcf3
Keywords: Embryonic stem cell; Stat3; Tcf3; Wnt
Down-regulation of the JAK2/PI3K-mediated signaling activation is involved in Taiwan cobra cardiotoxin III-induced apoptosis of human breast MDA-MB-231 cancer cells
Keywords: Akt; Cobra venom; Cardiotoxin; JAK2; MDA-MB-231 cells; PI3K; STAT3
Noradrenaline acting at central β-adrenoceptors induces interleukin-10 and suppressor of cytokine signaling-3 expression in rat brain: Implications for neurodegeneration
Keywords: IL-10; SOCS3; Noradrenaline; β-Adrenoceptor; STAT3; Brain; Anti-inflammatoryTyk2, non-receptor tyrosine-protein kinase 2; Jak1, Janus kinase 1; SOCS3, suppressor of cytokine signalling 3; STAT3, signal transducer and activator of transcription 3; SBE, STA
A novel small-molecule disrupts Stat3 SH2 domain–phosphotyrosine interactions and Stat3-dependent tumor processes
Keywords: Stat3; S3I-201; S3I-201.1066; Small-molecule inhibitor; Antitumor effects; Antitumor cell effects
Loss of Single Immunoglobulin Interlukin-1 Receptor-Related Molecule Leads to Enhanced Colonic Polyposis in Apcmin Mice
Keywords: TIR8; Cyclin D1; c-Myc; Stat3; Apc; adenomatous polyposis coli; 4EBP; 4E binding protein; GSK3β; glycogen synthase kinase 3β; IL; interleukin; IL-1R; interleukin-1 receptor; LOH; loss of heterozygosity; LPS; lipopolysaccharide; mTOR; mammalian target of
A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy
Keywords: chronic kidney disease; renal interstitial fibroblasts; STAT3; transforming growth factor; unilateral ureteral obstruction
Immune responses to malignancies
Keywords: Cancer; immunity; tumor escape; immune suppression; effector T cells; Anx; Annexin V; APC; Antigen-presenting cell; APM; Antigen-processing machinery; β2 m; β2-microglobulin; CTL; Cytolytic T lymphocyte; DC; Dendritic cell; FasL; Fas ligand; FOXP3; Fork
Low level exposure to monomethyl arsonous acid-induced the over-production of inflammation-related cytokines and the activation of cell signals associated with tumor progression in a urothelial cell model
Keywords: ErbB2; epidermal growth factor receptor B2; Erk2; extracellular signal-regulated kinase 2; HIF-a; hypoxia factor 1-α; iNOS; inducible nitric oxide sintetase; IL-; Interleukin; MAPKs; mitogen-activated protein kinases; MIP-2; macrophage inflammatory prote
Biological activities and molecular interactions of the C-terminal residue of thrombospondin-4, an epitome of acidic amphipathic peptides
Keywords: Cell penetrating peptide; DNA replication; Hepatitis C virus; Integrins; NS5A; Papillomavirus; Posttranscriptional regulation; RNA recognition motifs; ROD1; STAT3; Transcriptional activator E2
Estrogen receptor alpha and G-protein coupled receptor 30 mediate the neuroprotective effects of 17β-estradiol in novel murine hippocampal cell models
Keywords: glutamate; immortalization; cell biology; signal transduction; hippocampus; membrane estrogen receptor; Akt; homologous enzyme sequence of viral oncogene v-akt isolated from AKR mouse spontaneous thymoma cell line and also called protein kinase B; AR; and
PI 3-kinase/Akt and STAT3 are required for the prevention of TGF-β-induced Hep3B cell apoptosis by autocrine motility factor/phosphoglucose isomerase
Keywords: AMF/PGI; TGF-β; PI 3-kinase; Akt; STAT3
Inflammation and Colon Cancer
Keywords: Colon Cancer; Inflammation; Immunity; Cytokines; AOM; azoxymethane; APC; adenomatous polyposis coli; CAC; colitis-associated cancer; COX2; cyclooxygenase 2; CRC; colorectal cancer; DC; dendritic cells; DSS; dextran sodium sulfate; EGF; epidermal growth fa
FGF Receptors 1 and 2 Control Chemically Induced Injury and Compound Detoxification in Regenerating Livers of Mice
Keywords: Liver Disease; Cirrhosis; Drug Toxicity; Cytoprotection; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BrdU; 5-bromo-2â²deoxyuridine; CCl4; carbon tetrachloride; Cyp; cytochrome P450; Dbp; D site albumin promoter binding protein; Erk1/2
Design, synthesis, and evaluation of peptidomimetics containing Freidinger lactams as STAT3 inhibitors
Keywords: STAT3; Small-molecule inhibitors; Peptidomimetics; Freidinger lactams
Serpin B3/B4, activated by STAT3, promote survival of squamous carcinoma cells
Keywords: STAT3; Serpin B3/B4 squamous cancer
Epstein–Barr virus-derived EBNA2 regulates STAT3 activation
Keywords: STAT3; EBV; EBNA2; LMP1; LIF; Transcription
Novel high-throughput screening system for identifying STAT3–SH2 antagonists
Keywords: STAT3; SH2; Transcription; Anticancer; Screening; Porphyrin
Nuclear protein IκB-ζ inhibits the activity of STAT3
Keywords: IκB-ζ; STAT3; Inhibition; Transcription; Apoptosis
Leptin enhances CC-chemokine ligand expression in cultured murine macrophage
Keywords: Leptin; Chemokine; CCL3; CCL4; CCL5; STAT3
STAT3 induces muscle stem cell differentiation by interaction with myoD
Keywords: stat3; MyoD; LIF; C2C12 cell; AG490;
STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation
Keywords: Brk; STAP-2; Phosphorylation; STAT3; Transcription