Inhibition of Stat3 increases doxorubicin sensitivity in a human metastatic breast cancer cell line
Keywords: Apoptosis; Breast cancer; Doxorubicin; Satraplatin; Stat3
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Catalytic characterization and cytokine mediated regulation of cytochrome P450 4Fs in rat hepatocytes
Keywords: Cytochrome P450 4F; Eicosanoids; Cytokines; STAT3; Inflammation; Interleukin-6; Leukotriene B4
Identification of cardiac myocytes as the target of interleukin 11, a cardioprotective cytokine
Keywords: Interleukin-11; STAT3; Ischemia/reperfusion; Cardioprotection; Cytokine therapy
Excessive nitric oxide attenuates leptin-mediated signal transducer and activator of transcription 3 activation
Keywords: Obesity; Leptin resistance; Nitric oxide; Leptin receptor; STAT3; JAK2; High fat diet
Angiotensin II induces IL-6 expression and the Jak-STAT3 pathway in aortic adventitia of LDL receptor-deficient mice
Keywords: Angiotensin II; Interleukin-6; STAT3; Atherosclerosis; LDL receptor knock-out mouse; Cytokine; Inflammation
Integration of HIV-1 caused STAT3-associated B cell lymphoma in an AIDS patient
Keywords: HIV-1; Integration; AIDS-related lymphoma; STAT3
Interferon alpha induces cell death through interference with interleukin 6 signaling and inhibition of STAT3 activity
Keywords: Interferon; Apoptosis; STAT1; STAT3; IL-6
The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing–remitting multiple sclerosis
Keywords: Leptin; Transcription factors; SOCS3; STAT3; Multiple sclerosis
Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling
Keywords: Trps1; Stat3; Chondrocytes; Growth plate; Apoptosis; Proliferation
Liver regeneration is suppressed in alcoholic cirrhosis: correlation with decreased STAT3 activation
Keywords: Alcohol; STAT3; Liver regeneration; Cirrhosis; HCV; Cell proliferationHCV, hepatitis C virus; STAT3, signal transducer and activator of transcription 3; AST, aspartate transaminase; ALP, alkaline phosphatase
Regulation of IL-21 signaling by suppressor of cytokine signaling-1 (SOCS1) in CD8+ T lymphocytes
Keywords: SOCS1; Cytokine; IL-21; IL-15; STAT3; STAT5; T lymphocyte; Homeostasis; CD8 T cells
Extracellular ATP-dependent upregulation of the transcription cofactor LMO4 promotes neuron survival from hypoxia
Keywords: LMO4; ATP; Stat3; hypoxia; cIAP2; ERK; CREB
Chalcone inhibits the activation of NF-κB and STAT3 in endothelial cells via endogenous electrophile
Keywords: Chalcone; ICAM-1; STAT3; NF-κB; Glutathione; Electrophile
Altered levels of STAT1 and STAT3 influence the neuronal response to interferon gamma
Keywords: Cytokine; Signal transduction; Gene regulation; Neuron; Interferon gamma; STAT1; STAT3
EGF-induced apoptosis in A431 cells is dependent on STAT1, but not on STAT3
Keywords: A431 cells; Epidermal growth factor; STAT1; STAT3; Apoptosis; shRNA;
Diversity of the intracellular mechanisms underlying the anti-tumor properties of indirubins
Keywords: Indirubin; Indigo; Kinase; Cancer; Alzheimer's disease; Stat3; Arylhydrocarbon receptor
Modulation of apolipoprotein D expression and translocation under specific stress conditions
Keywords: apoD; apolipoprotein D; AP-1; activating protein 1; APRE; acute phase responsive element; BFA; Brefeldin A; BrdU; Bromodeoxyuridine; C/EBP; CCAAT/enhancer binding protein; CPT; camptothecin; ERE; estrogen responsive element; FGF; fibroblast growth factor;
Choroid plexus epithelial cells co-express the long and short form of the leptin receptor
Keywords: JAK, Janus kinases; Ob-Ra, short form of leptin receptor; Ob-Rb, long form of leptin receptor; STAT3, signal transducer and activator of transduction 3; pSTAT3, phosphorylated STAT3Leptin; Ob-Ra; Ob-Rb; STAT3; pSTAT3; Desensitization
Induction of SOCS-3 is insufficient to confer IRS-1 protein degradation in 3T3-L1 adipocytes
Keywords: Adipocyte; IRS-1; SOCS-3; STAT3; Degradation
Leptin activates AMP-activated protein kinase in hepatic cells via a JAK2-dependent pathway
Keywords: Leptin; Leptin receptor; JAK2; STAT3; AMPK
Dual regulation of the ΔNp63 transcriptional activity by ΔNp63 in human nasopharyngeal carcinoma cell
Keywords: p63; Promoter; STAT3; Npc
Regulation of Stat3 transcriptional activity by the conserved LPMSP motif for OSM and IL-6 signaling
Keywords: Stat3; IL-6; Oncostatin M; Transcription; Serine phosphorylation
Trichostatin A increases the thermosensitivity of human glioblastoma A172 cells
Keywords: Trichostatin A; Hyperthermia; Apoptosis; STAT3; Glioblastoma
G-CSF protects human cerebral hybrid neurons against in vitro ischemia
Keywords: G-CSF; Ischemia; Neuronal death; Neuroprotection; G-CSFR; STAT3
Differential expression of STAT5 and Bcl-xL, and high expression of Neu and STAT3 in non-small-cell lung carcinoma
Keywords: Lung cancer; NSCLC; Neu; STAT3; STAT5; Bcl-xL
Neuropoietin induces neuroepithelial cells to differentiate into astrocytes via activation of STAT3
Keywords: Neuropoietin; IL-6 family of cytokines; Astrocyte; STAT3; Differentiation
Characterization of STAT3-expressing cells in the postnatal rat brain
Keywords: Brain development; STAT3; Astrocyte; Neuron; Immunohistochemistry;
Novel interaction between HMGA1a and StIP1 in murine terminally differentiated retina
Keywords: HMGA1a; StIP1; STAT3; HIPK2; Retina;
STAT3-mediated Constitutive Expression of SOCS3 in an Undifferentiated Rat Trophoblast-like Cell Line
Keywords: SOCS3; Trophoblast; STAT3; ERK/MAP kinase
A critical role for interleukin-6 family-mediated Stat3 activation in osteoblast differentiation and bone formation
Keywords: Stat3; Conditional; Gp130; Osteoblast; Differentiation
hCG Secretion in Human Choriocarcinoma JAR Cells is MAPK but not Stat3 Dependent: Contributions of TNFα and IL-1β to Inflammation-induced hCG Secretion
Keywords: Trophoblast; Human chorionic gonadotropin; MAP kinase; Stat3; IL-1β; TNFαPBMC, peripheral blood mononuclear cells; hCG, Human chorionic gonadotropin
15-Deoxy-Δ12,14-prostaglandin J2 suppresses IL-6-induced STAT3 phosphorylation via electrophilic reactivity in endothelial cells
Keywords: 15d-PGJ2; IL-6; STAT3; Endothelial cells
Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-κB activation
Keywords: Dendritic cells; Immunosuppression; Chemokine; NF-κB; STAT3; SOCS1
Regulation of matrilysin expression in endothelium by fibroblast growth factor-2
Keywords: Endothelium; Matrilysin; MMP7; FGF-2; Stat1; Stat3; AP-1; Lef/Tcf;
A novel cis-acting element in Her2 promoter regulated by Stat3 in mammary cancer cells
Keywords: Her2; Promoter; cis-Acting element; Stat3; Breast cancer cells
Activation of the AKT and STAT3 pathways and prolonged survival by a mutant EGFR in human lung cancer cells
Keywords: EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; HRG-1, heregulin-1; NSCLC, non-small cell lung cancers; RT-PCR, reverse-transcriptase polymerase chain reaction; TGF-α, transforming growth factor-alphaEGFR; Mutation; AKT; STAT3; Lung
Immunohistochemical Study of STAT3 Expression in Feline Injection-site Fibrosarcomas
Keywords: cat; doxorubicin; injection-site fibrosarcoma; STAT3; tumour
WNT/β-catenin pathway up-regulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells
Keywords: Embryonic stem cells; Growth factors; Pluripotency; Mouse; WNT/β-catenin; STAT3
Interferon-gamma-induced dephosphorylation of STAT3 and apoptosis are dependent on the mTOR pathway
Keywords: Interferon-gamma; STAT3; STAT1; mTOR; ApoptosisIFN-γ, interferon-gamma; IFN-α, interferon-alpha; IFN-β, interferon-beta; JAK, Janus kinase; STAT, signal transducers and activators of transcription; SOCS, the suppressors of cytokine signaling; siRNA, small
Characterization and expression analysis of a chicken interleukin-6 receptor alpha
Keywords: Chicken; IL-6; IL-6R(; gpl30; STAT3; Immunoglobulin-like (IG) domain; Fibronectin-type III (FN III) domain; WSXWS motif, Liver, Chicken hepatoma cells; Chicken hybridoma, cellsIL-6, interleukin-6; IL-6R(, interleukin-6 receptor alpha; rchIL-6, recombinant
Systemic evaluation of total Stat3 and Stat3 tyrosine phosphorylation in normal human tissues
Keywords: Stat3; Human tissues; Tissue microarray slides
Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells
Keywords: Stat3; Peptidomimetics; Cell-to-cell adhesion; Apoptosis; Neoplastic transformation; Cell proliferation
STAT3-dependent pathfinding and control of axonal branching and target selection
Keywords: STAT3; Transcription factor; Pathfinding; Motoneuron; Zebrafish
Trophoblast invasion: tuning through LIF, signalling via Stat3
Keywords: Pregnancy; Placenta; Decidua; STAT3; LIF; Invasion; Choriocarcinoma; Trophoblast;
Penetrating brain injury leads to activation of ciliary neurotrophic factor receptors
Keywords: Growth factor receptors; STAT3; Rat; Brain injury; Motor neuron; Neurotrauma;
The transcription factor Stat3 is dispensable for pancreatic β-cell development and function
Keywords: Stat3; Pdx1-Cre; RIP-Cre; Islets of Langerhans; β-cells; Glucose homeostasis;
Reduced STAT3 activity in mice mimics clinical disease syndromes
Keywords: STAT3; Transcription; S727A mutation;
Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma
Keywords: Jak3; Stat3; ALK; Anaplastic large cell lymphoma;
Differential expression of cyclin D3 in ALK+ and ALKâ anaplastic large cell lymphoma
Keywords: Anaplastic large cell lymphoma; Cyclin D3; STAT3;
Transcriptional signaling from membrane raft-associated glucocorticoid receptor
Keywords: Glucocorticoid receptor; Membrane rafts; IL-6; STAT3; Caveolin-1; Transcriptional signaling;