Mutational analysis reveals separable DNA binding and trans-activation of Drosophila STAT92E
Keywords: آمار; JAK; STAT; SH2 domain; DNA binding; Transcriptional activation
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Rapid flow cytometric measurement of cytokine-induced phosphorylation pathways [CIPP] in human peripheral blood leukocytes
Keywords: آمار; Flow cytometry; Phosphorylation; STAT; Signaling; PBMC; ERK; MAPK; Cytokine
8-hydroxydeoxyguanosine suppresses NO production and COX-2 activity via Rac1/STATs signaling in LPS-induced brain microglia
Keywords: آمار; ROS; reactive oxygen species; oh8dG; 8-hydroxydeoxyguanosine; 8-oxo-dG; 8-oxo-deoxyguanosine; oh8G; 8-hydroxyguanosine; 8-oxo-G; 8-oxo-guanosine; dG; deoxyguanosine; G; guanosine; oh8dGTP; 8-hydroxydeoxyguanosine triphosphate; 8-oxo-deoxyguanosine triphos
Granulocyte colony-stimulating factor stimulates neurogenesis via vascular endothelial growth factor with STAT activation
Keywords: آمار; NSC, neural stem cell; DG, dentate gyrus; GCL, granule cell layer; SGL, subgranular layer; SVZ, subventricular zone; RMS, rostral migratory stream; OB, olfactory bulbGranulocyte colony-stimulating factor (G-CSF); Neurogenesis; G-CSFR; STAT; VEGF
Strategies for targeting T-cells in allergic diseases and asthma
Keywords: آمار; AHR; airway hyperreactivity; AP; activator protein; APC; antigen-presenting cell; BAL; bronchoalveolar lavage; cAMP; cyclic adenosine monophosphate; CBP; CREB-binding protein; CpG DNA; CpG-containing immunostimulatory deoxyribonucleic acid; CsA; cyclospor
Chronic Myeloid Leukemia: Diagnosis and Treatment
Keywords: آمار; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; AP; accelerated phase; ATP; adenosine triphosphate; BP; blast phase; CCGR; complete cytogenetic response; CHR; complete hematologic response; CML; chronic myeloid leukemia; CP; chronic phase;
Biology of Platelet-Derived Growth Factor and Its Involvement in Disease
Keywords: آمار; bFGF; basic fibroblast growth factor; CMML; chronic myelomonocytic leukemia; DFPS; dermatofibrosarcoma protuberans; EC; endothelial cell; EGF; epidermal growth factor; FIP1L1; Fip1-like 1; FS; fibrosarcomatous; GIST; gastrointestinal stromal tumor; HES; h
Therapeutic role of beta-interferons in multiple sclerosis
Keywords: آمار; Multiple sclerosis; Interferon-β; IFNAR; STAT; Kinase; Immunology; Lymphocytes; Pivotal trials; MRI; Natalizumab; SLE; NAbAPC, antigen presenting cell; BBB, blood–brain barrier; CNS, central nervous system; DMA, disease modifying agent; EC, endothelial ce
Lisofylline: a potential lead for the treatment of diabetes
Keywords: آمار; FFA; free fatty acids; LSF; lisofylline; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; NOD mouse; nonobese diabetic mouse; PA; phosphatidic acid; scid; severe combined immune deficiency; STAT; signal transducers and activators of tran
Genetic regulation of IgE responses: Achilles and the tortoise
Keywords: آمار; Allergy; genetics; single nucleotide polymorphisms; functional genomics; IL-13; LD; Linkage disequilibrium; SNP; Single nucleotide polymorphism; STAT; Signal transducer and activator of transcription;
Susceptibility to exogenously added interferon-β protein depends on intracellular interferon-β mRNA level in human glioma cells
Keywords: آمار; Human interferon (HuIFN)-β; Antiproliferative effect; siRNA for HuIFN-β; HuIFN; human interferon; JAK; Janus kinases; STAT; signal transducer and activation transcription; IRF; interferon regulatory factor; ISGF; interferon stimulated gene factor; AAF;
Nordihydroguaiaretic acid inhibits IFN-γ-induced STAT tyrosine phosphorylation in rat brain astrocytes
Keywords: آمار; Inflammation; Interferon-γ; 5-Lipoxygenase; STAT; NDGA;
Involvement of human natural killer cells in asthma pathogenesis: Natural killer 2 cells in type 2 cytokine predominance
Keywords: آمار; Natural killer cells; cytokine; predominance; asthma; DC; Dendritic cell; NK; Natural killer; PE; Phycoerythrin; STAT; Signal transducer and activator of transcription; Tc2; Type II cytotoxic T lymphocyte;
Estrogen receptor-α regulates SOCS-3 expression in human breast cancer cells
Keywords: آمار; Estrogen receptor; SOCS-3; Cytokine; STAT; Chromatin immunoprecipitation; Nuclear receptor; Promoter cloning;
Nucleocytoplasmic shuttling revealed by FRAP and FLIP technologies
Keywords: آمار; EGFP; enhanced green fluorescent protein; FLIP; fluorescence loss in photobleaching; FRAP; fluorescence recovery after photobleaching; GFP; green fluorescent protein; IFN; interferon; STAT; signal transducer and activator of transcription;
Sensing and signaling during infection in Drosophila
Keywords: آمار; DAP; diaminopimelic acid; DD; death domain; DREDD; death-related ced-3/Nedd2-like DD; FADD; Fas-associated DD-containing protein; GNBP; Gram-negative binding protein; IκB; inhibitory NF-κB; IKK; IκB kinase; JNK; Jun amino-terminal kinase; JAK; Janus fa
Oncostatin M causes eotaxin-1 release from airway smooth muscle: Synergy with IL-4 and IL-13
Keywords: آمار; Signal transducer and activator of transcription 3; extracellular signal-regulated kinase; c-Jun N-terminal kinase; IL-4Rα; monocyte chemoattractant protein 1; vascular endothelial growth factor; CNTF; Ciliary neutrophic factor; ERK; Extracellular signal
In silico identification of the key components and steps in IFN-γ induced JAK-STAT signaling pathway
Keywords: آمار; IFN-γ; interferon gamma; JAK; Janus kinase; STAT; signal transducers and activators of transcription; IFNR; interferon-γ receptor; RJ; IFNR-JAK complex; STAT1; signal transducer and activator of transcription 1; SHP-2; SH2 domain-containing tyrosine p
Airway smooth muscle: A modulator of airway remodeling in asthma
Keywords: آمار; Asthma; signal transduction; smooth muscle; proliferation; synthetic function; ADAM; A disintegrinase and metalloproteinase; ASM; Airway smooth muscle; ECM; Extracellular matrix; ERK; Extracellular signal-regulated kinase; GPCR; G protein-coupled recept
Respiratory syncytial virus infection in the absence of STAT1 results in airway dysfunction, airway mucus, and augmented IL-17 levels
Keywords: آمار; Viral; inflammation; rodent; cytokines; mucus; IL-17; IL-23; AHR; Airway hyperresponsiveness; BAL; Bronchoalveolar lavage; ECP; Eosinophil cationic protein; KO; Knockout; PAS; Periodic acid-Schiff; PFU; Plaque-forming units; RSV; Respiratory syncytial v
The improvement of sensitivity in lead and cadmium determinations using flame atomic absorption spectrometry
Keywords: آمار; STAT; Sensitivity improvement; Flame atomic absorption spectrometry; Lead; Cadmium; Thyroid;
Leishmania inhibits STAT1-mediated IFN-γ signaling in macrophages: increased tyrosine phosphorylation of dominant negative STAT1β by Leishmania mexicana
Keywords: آمار; Interferon γ; Macrophage; STAT; Leishmania; Phosphorylation;
Cis-9,Trans-11-CLA exerts anti-inflammatory effects in human bronchial epithelial cells and eosinophils: Comparison to Trans-10,Cis-12-CLA and to linoleic acid
Keywords: آمار; AA; arachidonic acid; AP; activator protein; CLA; conjugated linoleic acids; COX; cyclooxygenase; ECP; eosinophil cationic protein; IL; interleukin; LA; linoleic acid; LPS; lipopolysaccharide; NF; nuclear factor; PG; prostaglandin; PPAR; peroxisome prolif
Type IV collagen induces STAT5 activation in MCF7 human breast cancer cells
Keywords: آمار; Ab; antibody; BSA; bovine serum albumine; BM; basement membrane; Col-IV; type IV collagen; DMEM; Dulbecco's modified Eagle's medium; ECM; extracellular matrix; EGF; epidermal growth factor; EMSA; electrophoretic mobility shift assay; HEPES; 4-(2-hydroxyet
Evaluation of the automated coagulation analyzer Sysmex® CA-7000
Keywords: آمار; ANOVA; analysis of variance; aPTT; activated partial thromboplastin time; AT; antithrombin; CI; confidence interval; CV; coefficient of variance; INR; international normalized ratio; NCCLS; National Committee for Clinical Laboratory Standards; PT; prothro
Body Trait Profiles in Holstein-Friesians Modeled Using Random Regression
Keywords: آمار; type trait; body condition score; random regression; ANG; angularity; BD; body depth; CubS; cubic spline; CW; chest width; LegP; Legendre polynomial; LogL; Log likelihood; RR; random regression; STAT; stature;
Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPβ
Keywords: آمار; iNOS; inducible nitric oxide synthase; IL-4; interleukin-4; STAT; signal transducer and activator of transcription; C/EBP; CCAAT/enhancer binding protein; BAC; bacterial artificial chromosome; PCR; polymerase chain reaction; EMSA; electrophoretic mobility
SOCS genes: Critical regulators of cytokine signaling and immune responses
Keywords: آمار; IL; interleukin; IFN; interferon; TNF; tumor necrosis factor; IBD; inflammatory bowel diseases; RA; rheumatoid antithesis; LPS; lipopolysaccharide; TLR; toll-like receptor; KIR; kinase inhibitory region; STAT; signal transducers and activators of the tran
PU.1-mediated transcriptional regulation of prophenin-2 in primary bone marrow cells
Keywords: آمار; PF-2; prophenin-2; PR-39; proline arginine-39; GM-CSF; granulocyte-macrophage colony stimulating factor; IL-3; interleukin 3; LL-37; leucine leucine-37; AML-1; acute myeloid leukemia-1; C/EBP; CCAAT enhancer binding protein; MZF-1; myeloid zinc finger-1;
Distinct signaling pathways for induction of type II NOS by IFNγ and LPS in BV-2 microglial cells
Keywords: آمار; BSA; bovine serum albumin; CNS; central nervous system; DMEM; Dulbecco's Modified Eagle Medium; ERK; extracellular signal-regulated kinase; GAS; interferon-γ-activated site; IFN; interferon; IκB; NF-κB inhibitory protein; JAK; Janus kinase; LPS; lipopo
A novel functional activator of the Drosophila JAK/STAT pathway, unpaired2, is revealed by an in vivo reporter of pathway activation
Keywords: آمار; STAT; JAK; Signal transduction; Embryogenesis; Unpaired; Gene expression; Transgene;
Involvement of the small protein tyrosine phosphatases TC-PTP and PTP1B in signal transduction and diseases: From diabetes, obesity to cell cycle, and cancer
Keywords: آمار; EGFR; epidermal growth factor receptor; GHR; growth hormone receptor; IGF-IR; insulin-like growth factor I receptor; IR; insulin receptor; IRS; insulin receptor substrate; JAK; janus kinase; KO; knockout; LeptinR; leptin receptor; PDGFR; platelet derived
Local delivery of soluble interleukin-6 receptors to improve the outcome of alpha-toxin producing Staphylococcus aureus infection in mice
Keywords: آمار; Staphylococcus; Interleukin-6 receptor; ELISA; enzyme-linked immunosorbent assay; IFN; interferon; IL; interleukin; sIL-6R; soluble IL-6 receptor; MCP; monocyte chemoattractant protein; NF-κB; nuclear factor κB; PLF; peritoneal lavage fluid; STAT; signa
Interferons (IFNs) are key cytokines in both innate and adaptive antiviral immune responses-and viruses counteract IFN action
Keywords: آمار; Interferons; Innate antiviral immunity; Interferon-regulatory factor; Toll-like receptors; AP-1; activating protein 1; CARD; caspase recruitment domain; CpG DNA; unmethylated double-stranded DNA; DC; dendritic cell; dsRNA; double-stranded RNA; GAS; IFN ga
Signalling pathways regulating the invasive differentiation of human trophoblasts: a review
Keywords: آمار; Human trophoblast; Signal transduction; Differentiation; Cell invasion; ALKs; activin-receptor-like kinases; bHLH; basic helix-loop-helix; CaMKII; Ca/calmodulin-dependent kinase II; CTB; cytotrophoblast; eCTB; endovascular cytotrophoblast; ECM; extracellu
Airway remodeling contributes to the progressive loss of lung function in asthma: An overview
Keywords: آمار; Asthma; airway; remodeling; inflammation; AHR; Airways hyperresponsiveness; ASM; Airway smooth muscle; β2-AR; β2-Adrenergic receptor; MUC; Mucin glycoprotein; RBM; Reticular basement membrane; STAT; Signal transducer and activator of transcription; VEGF
Erythropoietin promotes regeneration of adult CNS neurons via Jak2/Stat3 and PI3K/AKT pathway activation
Keywords: آمار; Bcl; B_cell leucemia/lymphoma protein; CNTF; ciliary_derived neurotrophic factor; (rh)EPO; (recombinant human) erythropoietin; GCL; ganglion cell layer; HIF; hypoxia inducible factor; Jak; Janus kinase; mTOR; mammalian target of rapamycin; ON; optic nerve
Gene-inducing program of human dendritic cells in response to BCG cell-wall skeleton (CWS), which reflects adjuvancy required for tumor immunotherapy
Keywords: آمار; ADA; adenosine deaminase; ANOVA; analysis of variance; AP-1; activating protein-1; BCG-CWS; bacillus Calmette-Guérin cell-wall skeleton; BIGM103; BCG-induced gene in monocyte, clone 103; CCL; chemokine (C-C motif) ligand; CD; cluster of differentiation;
The role of STAT-3 in the mediation of smooth muscle cell response to cyclic strain
Keywords: آمار; Cyclic strain; Hemodynamic forces; Signal transduction; STAT; Vascular smooth muscle cell;
Mechanisms Underlying the Maintenance of Muscle Hypercontractility in a Model of Postinfective Gut Dysfunction
Keywords: آمار; COX; cyclooxygenase; IFN; interferon; IL; interleukin; JAK; janus kinase; LMMP; longitudinal muscle layer myenteric plexus; PG; prostaglandin; PI; postinfective; R; receptor; STAT; signal transducer and activator of transcription; Th; T helper; TGF; trans
Role of regulatory T cells in human diseases
Keywords: آمار; Regulatory T cells; Foxp3; dysregulation polyendocrinopathy enteropathy-X-linked; X-linked autoimmunity-allergic dysregulation; allergy; autoimmunity; lymphoproliferation; immunotherapy; IgE; CTLA-4; Cytotoxic T lymphocyte-associated antigen 4; IL-2
Persistent STAT3 Activation in Colon Cancer Is Associated with Enhanced Cell Proliferation and Tumor Growth
Keywords: آمار; Colorectal cancer; JAWSTAT pathway; STAT3; xenograft; cell proliferation; CRC; colorectal carcinoma; EMSA; electrophoretic mobility shift assay; IL; interleukin; JAK; Janus kinase; STAT; signal transducer and activator of transcription;
Leukemia inhibitory factor blocks early differentiation of skeletal muscle cells by activating ERK
Keywords: آمار; Ad; adenovirus; LIF; leukemia inhibitory factor; LIFRβ; leukemia inhibitory factor receptor β; IL-6; Interleukin 6; bFGF; basic fibroblast growth factor; TGF-β; transforming growth factor-β; IGF-I; insulin like growth factor-I; Man-6-P; mannose 6-phos
The tyrosine 974 within the LIF-R-chain of the gp130/LIF-R heteromeric receptor complex mediates negative regulation of LIF signalling
Keywords: آمار; CLC; CT-1-like factor; CNTF; ciliary neurotrophic factor; CT-1; cardiotrophin-1; IL; interleukin; JAK; Janus kinase; LIF; leukaemia inhibitory factor; MAPK; mitogen-activated protein kinase; OSM; oncostatin M; PI3K; phosphatidylinositol-3-kinase; SHP; SH2
Characterization of the infection-responsive bovine lactoferrin promoter
Keywords: آمار; aa; amino acid(s); AP; activator protein; bp; base pair(s); BAC; bacterial artificial chromosome; cDNA; DNA complementary to RNA; CMV; cytomegalovirus; kb; kilobase(s); kDa; kilodalton(s); LPS; lipopolysaccharide; nt; nucleotide(s); NF-κB; nuclear factor
Downregulation of IL-4-induced signalling in hippocampus contributes to deficits in LTP in the aged rat
Keywords: آمار; Age; IL-4; IL-1β; Long-term potentiation (LTP); Dentate gyrus; JAK; STAT; c-Jun N-terminal kinase (JNK);
Inhibition of survival signalling by dietary polyphenols and indole-3-carbinol
Keywords: آمار; Chemoprevention; Survival signalling; Curcumin; Epigallocatechin gallate; Indole-3-carbinol; Resveratrol; MAPK; PI3K; NF-κB; STAT
'In vivo' effects of Bisphenol A in Mytilus hemocytes: modulation of kinase-mediated signalling pathways
Keywords: آمار; Endocrine disrupters; Hemocytes; Lysosomal membrane stability; Kinase-mediated cell signalling; Immunity; MAPK; STAT; CREB;
Lipoxin A4 inhibits TNF-α-induced production of interleukins and proliferation of rat mesangial cells
Keywords: آمار; lipoxin; tumor necrosis factor; interleukin; nuclear factor-kappa B; SHP-2; cyclin; Akt; p27; STAT; mesangial cells;
The JAK2V617F Tyrosine Kinase Mutation in Myeloproliferative Disorders: Status Report and Immediate Implications for Disease Classification and Diagnosis
Keywords: آمار; AML; acute myeloid leukemia; ATP; adenosine triphosphate; CMD; chronic myeloid disorders; CML; chronic myeloid leukemia; CMML; chronic myelomonocytic leukemia; CNL; chronic neutrophilic leukemia; CPTK; cytoplasmic PTK; EEC; endogenous erythroid colony; Ep