کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3001176 | 1180372 | 2006 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Biology of Platelet-Derived Growth Factor and Its Involvement in Disease
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کلمات کلیدی
EGFCMMLbFGFIFPmPDPDGFSTAT - آمارmyeloproliferative disorder - اختلال میلولپرولیفراتیوHES - او هستGastrointestinal stromal tumor - تومور استرومائی گوارشیDermatofibrosarcoma Protuberans - درماتوفیبروسارکوم ProtuberansEndothelial cell - سلول های اندوتلیالHypereosinophilic syndrome - سندرم HypereosinophilicIMF - صندوق بین المللی پولepidermal growth factor - عامل رشد اپیدرمیVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)platelet-derived growth factor - فاکتور رشد حاصل از پلاکتbasic fibroblast growth factor - فاکتور رشد فیبروبلاست پایهInterstitial fluid pressure - فشار مایع بینابینیchronic myelomonocytic leukemia - لوسمی میلوومونوسیتی مزمنsignal transducer and activators of transcription - مبدل سیگنال و فعال کننده های رونویسیGist - مشتاقIdiopathic myelofibrosis - میلوفیفروس ایدیوپاتیکJAK - چگونه
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Platelet-derived growth factor (PDGF) is mainly believed to be an important mitogen for connective tissue, especially for fibroblasts that serve in wound healing. However, PDGF also has important roles during embryonal development, and its overexpression has been linked to different types of fibrotic disorders and malignancies. Platelet-derived growth factor is synthesized by many different cell types, and its expression is broad. Its synthesis is in response to external stimuli, such as exposure to low oxygen tension, thrombin, or stimulation by other cytokines and growth factors. In addition, PDGF may function in autocrine stimulation of tumor cells, regulation of interstitial fluid pressure, and angiogenesis. Recently, several drugs were developed that are potent inhibitors of the tyrosine kinase activity of PDGF receptors. Thus, it is important to understand the physiology of PDGF and its receptors and the role of PDGF in different diseases. This review summarizes the physiologic activity of PDGF, the expression of PDGF during embryonal development, and the roles of PDGF expression in nonmalignant disease and in different tumors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mayo Clinic Proceedings - Volume 81, Issue 9, September 2006, Pages 1241-1257
Journal: Mayo Clinic Proceedings - Volume 81, Issue 9, September 2006, Pages 1241-1257
نویسندگان
Ricardo H. MD, Hagop M. MD, Jorge E. MD,