دانلود مقالات ISI درباره رابطه ساختار-فعالیت + ترجمه فارسی

Synthesis and biological evaluation of novel hybrids of highly potent and selective α4β2-Nicotinic acetylcholine receptor (nAChR) partial agonists

Keywords: رابطه ساختار-فعالیت; α4β2-nAChRs; Partial agonists; Hybrids; Antidepressant-like effects; CNS; central nervous system; AD; Alzheimer's disease; ADHD; attention deficit hyperactivity disorder; NIMH-PDSP; National Institute of Mental Health Psychoactive Drug Screening Program

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Structure-activity analysis and biological studies of chensinin-1b analogues

Keywords: رابطه ساختار-فعالیت; Chensinin-1b; Structure-activity relationship; Depolarization; Bacterial membrane; Lipopolysaccharide

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Combretastatins: In vitro structure-activity relationship, mode of action and current clinical status

Keywords: رابطه ساختار-فعالیت; Combretastatin; CA4P; Structure-activity relationship; SAR; Clinical trials;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Support effect of zinc tin oxide on gold catalyst for CO oxidation reaction

Keywords: رابطه ساختار-فعالیت; Gold catalyst; Zinc tin oxide; Carbon monoxide oxidation; X-ray absorption fine structure; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Structural differences in diarylheptanoids analogues from Alnus viridis and Alnus glutinosa influence their activity and selectivity towards cancer cells

Keywords: رابطه ساختار-فعالیت; Diarylheptanoids; Structure-activity relationship; Reactive oxygen species; Mitochondrial transmembrane potentialAV, Annexin-V-FITC; DHE, Dihydroethidium; JC-1, 5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolocarbocyanine iodide; PI, Propidium iodi

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Identification of N-(6-mercaptohexyl)-3-(4-pyridyl)-1H-pyrazole-5-carboxamide and its disulfide prodrug as potent histone deacetylase inhibitors with in vitro and in vivo anti-tumor efficacy

Keywords: رابطه ساختار-فعالیت; Histone deacetylase inhibitor; Thiol; Disulfide; Prodrug; Anti-tumor; Structure-activity relationship

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Characterization of substituted aryl meroterpenoids from red seaweed Hypnea musciformis as potential antioxidants

Keywords: رابطه ساختار-فعالیت; Seaweed; Hypnea musciformis; Antioxidant activity; Aryl meroterpenoids; Nuclear magnetic resonance spectroscopy; Structure-activity relationship

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

A study of structure-activity relationships of commercial tertiary amines for post-combustion CO2 capture

Keywords: رابطه ساختار-فعالیت; Carbon dioxide absorption; Tertiary amines; Structure-activity relationship; CO2 absorption rate; Equilibrium solubility; CO2 absorption heat;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors

Keywords: رابطه ساختار-فعالیت; Human African trypanosomiasis; Methionyl-tRNA synthetase; Structure-guided design; AP; auxiliary pocket; CNS; central nervous system; EMP; enlarged methionine pocket; HAT; human African trypanosomiasis; MetRS; methionyl-tRNA synthetase; SAR; structure-act

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Rapid screening of transferrin-binders in the flowers of Bauhinia blakeana Dunn by on-line high-performance liquid chromatography–diode-array detector–electrospray ionization–ion-trap–time-of-flight–mass spectrometry–transferrin–fluorescence detection sys

Keywords: رابطه ساختار-فعالیت; Bauhinia blakeana Dunn; On-line method; Structure-activity relationship; Transferrin; Transferrin-binding activity

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

A study of the structure-activity relationship of oligomeric ellagitannins on ruminal fermentation in vitro

Keywords: رابطه ساختار-فعالیت; gas production technique; willowherb; methane; structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Optimization and biological evaluation of aminopyrimidine-based IκB kinase β inhibitors with potent anti-inflammatory effects

Keywords: رابطه ساختار-فعالیت; IKKβ; Inhibitor; Structure-activity relationship; NO reduction; Anti-inflammatory effect;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Novel iodoacetamido benzoheterocyclic derivatives with potent antileukemic activity are inhibitors of STAT5 phosphorylation

Keywords: رابطه ساختار-فعالیت; STAT5 inhibitors; BCR/ABL expressing leukemia; Apoptosis; Structure-activity relationship; In vitro antiproliferative activity

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis, in vitro α-glucosidase inhibitory activity and molecular docking studies of new thiazole derivatives

Keywords: رابطه ساختار-فعالیت; Synthesis; Thiazole; In vitro α-glucosidase; Structure-activity relationship; In silico study

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

New telmisartan-derived PPARγ agonists: Impact of the 3D-binding mode on the pharmacological profile

Keywords: رابطه ساختار-فعالیت; PPARγ; Transactivation; Cytotoxicity; Binding mode; Molecular modeling; Amax; maximum intrinsic activity; BPO; benzoyl peroxide; DMEM; Dulbecco's modified Eagle medium; LBD; ligand binding domaine; mp; melting point; NBS; N-bromosuccinimide; PPAR; peroxi

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groups

Keywords: رابطه ساختار-فعالیت; S1P1 receptor agonist; Immunomodulator; Lymphocyte count; Aminomethyl pyridine; Aminomethyl benzene; Aminomethyl thiophene; Phototoxicity; BuLi; n-butyl lithium; CC; column chromatography; DCM; dichloromethane; DIPEA; diisopropylethylamine; DEAD; diethyl

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2016 سفارش ترجمه

Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies

Keywords: رابطه ساختار-فعالیت; FAAH; COX; Hybrid scaffold; Multitarget inhibitors; Structure-activity relationship; Inflammation

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2016 سفارش ترجمه

The molecular shape and the field similarities as criteria to interpret SAR studies for fragment-based design of platinum(IV) anticancer agents. Correlation of physicochemical properties with cytotoxicity

Keywords: رابطه ساختار-فعالیت; Platinum-based drugs; Anticancer agents; Cytotoxicity; Structure-activity relationship; Shape and field similarity; XED field; Drug likeness; Structure-related molecular properties; Stereo-electronic effects;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2016 سفارش ترجمه

A series of pyrido[2,3-b]pyrazin-3(4H)-one derivatives as aldose reductase inhibitors with antioxidant activity

Keywords: رابطه ساختار-فعالیت; Aldose reductase inhibitor; Antioxidant activity; Pyrido[2,3-b]pyrazin-3(4H)-one; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2016 سفارش ترجمه

Cardenolides from Calotropis gigantea as potent inhibitors of hypoxia-inducible factor-1 transcriptional activity

Keywords: رابطه ساختار-فعالیت; (HIF-) 1; hypoxia-inducible factor; (SAR); structure-activity relationship; (IC50); concentrations that reduced HIF-1 transcriptional activity or cell viability of MCF-7 or MCF-10A by 50%; Cardenolide; Calotropis gigantea; HIF-1 inhibitor; cytotoxicity; A

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2016 سفارش ترجمه

ReviewA review on chitosan-based flocculants and their applications in water treatment

Keywords: رابطه ساختار-فعالیت; Chitosan-based flocculants; Structure-activity relationship; Structural factors; Flocculation mechanism; Chemical modification; Water treatment;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis, characterization, and structure-activity relationship of the antimicrobial activities of dinuclear N-heterocyclic carbene (NHC)-silver(I) complexes

Keywords: رابطه ساختار-فعالیت; Dinuclear silver(I) complexes; N-heterocyclic carbene (NHC) ligands; Molecular structures; Antimicrobial activities; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2016 سفارش ترجمه

5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells

Keywords: رابطه ساختار-فعالیت; Glioblastoma; Apoptosis resistance; Multidrug resistance; Translation inhibition; Lycorine; Haemanthamine; ATCC; American Type Culture Collection; DAPI; 4′,6-diamidino-2-phenylindole; DMEM; Dulbecco's modified Eagle's medium; DMF; dimethylformamide; DMS

دانلود رایگان متن کامل مقاله ISI 54 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis, evaluation and structure-activity relationship of new 3-carboxamide coumarins as FXIIa inhibitors

Keywords: رابطه ساختار-فعالیت; Coumarins; Factor XIIa; Factor XII; FXII; Antithrombotic agents; Benzopyrans; ADME; absorption, distribution, metabolism and excretion; FXIIa; activated coagulation factor XII; FXa; activated coagulation factor X; THR; thrombin; FVIIa; activated factor VI

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis and biological evaluation of novel FK228 analogues as potential isoform selective HDAC inhibitors

Keywords: رابطه ساختار-فعالیت; FK228 analogues; Histone deacetylase inhibitors; Structure-activity relationship; Bicyclic depsipeptide; Total synthesis;

دانلود رایگان متن کامل مقاله ISI 59 صفحه سال انتشار : 2016 سفارش ترجمه

Phenyltetrazolyl-phenylamides: Substituent impact on modulation capability and selectivity toward the efflux protein ABCG2 and investigation of interaction with the transporter

Keywords: رابطه ساختار-فعالیت; ABC-transporter; ABCG2; BCRP inhibitor; Synthesis; Structure-activity relationship; Enzyme kinetics; ABC; ATP-binding cassette; BCRP; breast cancer resistance protein (ABCG2); CsA; cyclosporine A; FTC; fumitremorgin C; Imax; maximal inhibition; i-Pr; isop

دانلود رایگان متن کامل مقاله ISI 60 صفحه سال انتشار : 2016 سفارش ترجمه

Identification of ponatinib and other known kinase inhibitors with potent MEKK2 inhibitory activity

Keywords: رابطه ساختار-فعالیت; MEKK2; MAP3K2; Kinase; Inhibitor; Ponatinib; AT9283; MAPK; mitogen-activated protein kinase; EGF; epidermal growth factor; DMSO; dimethyl sulfoxide; ATP; adenosine triphosphate; ADP; adenosine diphosphate; SAR; structure-activity relationship; SD; standar

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Triterpenoid saponins and C-glycosyl flavones from stem bark of Erythrina abyssinica Lam and their cytotoxic effects.

Keywords: رابطه ساختار-فعالیت; Erythrina abyssinica; Triterpenoid saponins; C-glycosyl flavones; Structural elucidation; Cytotoxic activity; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Pd-Cu/C electrocatalysts synthesized by one-pot polyol reduction toward formic acid oxidation: Structural characterization and electrocatalytic performance

Keywords: رابطه ساختار-فعالیت; Palladium-copper; Nanoalloys; Polyol synthesis; Electrocatalysis; Formic acid oxidation; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

An integrated approach for discovery of highly potent and selective Mnk inhibitors: Screening, synthesis and SAR analysis

Keywords: رابطه ساختار-فعالیت; CGP57380; Eukaryotic initiation factor 4E; Mnk inhibitors; Structure-activity relationship; Thieno[2,3-d]pyrimidine; Virtual screening;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Advances in the discovery of novel antimicrobials targeting the assembly of bacterial cell division protein FtsZ

Keywords: رابطه ساختار-فعالیت; Antimicrobials; Biological activity; Bacterial cell division; Bacterial resistance; FtsZ; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

Discovery of InhA inhibitors with anti-mycobacterial activity through a matched molecular pair approach

Keywords: رابطه ساختار-فعالیت; Antibiotics; Enoyl-acyl carrier protein reductase (InhA); In silico drug screening; Mycobacterium tuberculosis; Matched molecular pair (MMP); TB; tuberculosis; MDR; multi-drug-resistant; XDR; extensively drug-resistant; HIV; human immunodeficiency virus;

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2015 سفارش ترجمه

Design, synthesis and antiproliferative activity of novel heterobivalent hybrids based on imidazo[2,1-b][1,3,4]thiadiazole and imidazo[2,1-b][1,3]thiazole scaffolds

Keywords: رابطه ساختار-فعالیت; Apoptosis; Structure-activity relationship; Imidazo[1,2-b][1,3,4]thiadiazole; In vitro antiproliferative activity; Caspases; BJDKBAIGGISABA-UHFFFAOYSA-N; KHHAFLWDTTYKSX-UHFFFAOYSA-N; DUQUTGOFCIEJGS-UHFFFAOYSA-N; HGDQUFSDVNLDHE-UHFFFAOYSA-N;

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2015 سفارش ترجمه

Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity. Part 5

Keywords: رابطه ساختار-فعالیت; Pyrido[1,2-c]pyrimidines; Antidepressants; Dual SSRI/5-HT1A activity; Quinoline derivatives; SERT; serotonin transporter; SAR; structure-activity relationship; 5-HT1AR; serotonin 5-HT1A receptors; 8-OH-DPAT; 8-hydroxy-2-(di-n-propylamino)tetralin; Ki; inh

دانلود رایگان متن کامل مقاله ISI 65 صفحه سال انتشار : 2015 سفارش ترجمه

A facile synthesis and microtubule-destabilizing properties of 4-(1H-benzo[d]imidazol-2-yl)-furazan-3-amines

Keywords: رابطه ساختار-فعالیت; Benzoimidazolfurazanamines; Inhibitors of tubulin polymerization; Sea urchin embryo; Cytotoxicity; BIFA; 4-(1H-benzo[d]imidazol-2-yl)-furazan-3-amine; SAR; structure-activity relationship; CZSWDLNVZBRZKA-UHFFFAOYSA-N; OVKMKVJRZIKUQA-UHFFFAOYSA-N; RZHUNSKD

دانلود رایگان متن کامل مقاله ISI 133 صفحه سال انتشار : 2015 سفارش ترجمه

Structure-activity relationship and properties optimization of a series of Quinazoline-2,4-diones as inhibitors of the canonical Wnt pathway

Keywords: رابطه ساختار-فعالیت; Wnt pathway; β-catenin; Small molecule; Structure-activity relationship; Glioblastoma; Fz; Frizzled; LRP; lipoprotein receptor-related protein; ACN; acetonitrile; APC; adenomatous polyposis coli; B/P; brain to plasma ratio; CDI; N,N′-carbonyl-diimida

دانلود رایگان متن کامل مقاله ISI 136 صفحه سال انتشار : 2015 سفارش ترجمه

Structure-activity relationships of fatty acid amide ligands in activating and desensitizing G protein-coupled receptor 119

Keywords: رابطه ساختار-فعالیت; G protein-coupled receptor 119; Fatty acid amides; Structure-activity relationship

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Effects of method of preparation on catalytic activity of Co–Zn double-metal cyanide catalysts for copolymerization of CO2 and epoxide

Keywords: رابطه ساختار-فعالیت; Carbon dioxide; Double-metal cyanide; Polycarbonate; Copolymerization of CO2 and cyclohexene oxide; CO2 utilization; Structure-activity relationship

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Structure dependent catalytic activity of Ce0.8Tb0.2O2−δ and TiO2 supported Ce0.8Tb0.2O2−δ solid solutions for CO oxidation

Keywords: رابطه ساختار-فعالیت; Ceria-terbia; Solid solution; Characterization; CO oxidation; Lattice defects; Structure-activity relationship

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Tumoral cytotoxic and antioxidative phenylpropanoid glycosides in Smilax riparia A. DC

Keywords: رابطه ساختار-فعالیت; Smilax riparia; Phenylpropanoid glycoside; Cytotoxicity; Antioxidant; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Encapsulation of Drug Molecules into Calix[n]arene Nanobaskets. Role of Aminocalix[n]arenes in Biopharmaceutical Field

Keywords: رابطه ساختار-فعالیت; antiinfectives; calixarene; complexation; excipients; inclusion compounds; interaction; nanoparticles; structure-activity relationship; surfactants;

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2013 سفارش ترجمه

Structure-Activity Relationship Modeling for Predicting Interactions with Pregnane X Receptor by Recursive Partitioning

Keywords: رابطه ساختار-فعالیت; pregnane X receptor; structure-activity relationship; ligand-based modeling; recursive partitioning; text mining; classification tree

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Synthesis and biological evaluation of 8-substituted berberine derivatives as novel anti-mycobacterial agents

Keywords: رابطه ساختار-فعالیت; Berberine; Anti-tubercular; Structure-activity relationship; Drug-resistance; H37Rv

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Herba epimedii flavonoids suppress osteoclastic differentiation and bone resorption by inducing G2/M arrest and apoptosis

Keywords: رابطه ساختار-فعالیت; Icariin; Baohuoside-1; Osteoclast; Bone resorption; G2/M arrest; Apoptosis; SAR; structure-activity relationship; RANKL; receptor activator of NF-κB ligand; TRAP; tartrate-resistant acid phosphatase; CA II; carbonic anhydrase II; CTSK; cathepsin K; MMP-9

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Metabolism-based synthesis, biologic evaluation and SARs analysis of O-methylated analogs of quercetin as thrombin inhibitors

Keywords: رابطه ساختار-فعالیت; Quercetin; Metabolism; Thrombin; Structure-activity relationship; FPLMIPQZHHQWHN-UHFFFAOYSA-N; WEPBGSIAWZTEJR-UHFFFAOYSA-N; VNWKTOKETHGBQD-UHFFFAOYSA-N; VNWKTOKETHGBQD-UHFFFAOYSA-N; ZLLCVNHIASSRDK-UHFFFAOYSA-N; IZQSVPBOUDKVDZ-UHFFFAOYSA-N; KPCRYSMUMBNTCK-

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Convulsion-related activities of Scutellaria flavones are related to the 5,7-dihydroxyl structures

Keywords: رابطه ساختار-فعالیت; Baicalein; Oroxylin A; Anticonvulsant; GABA; Structure-activity relationship

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Δ9-Tetrahydrocannabinol and Its Major Metabolite Δ9-Tetrahydrocannabinol-11-oic Acid as 15-Lipoxygenase Inhibitors

Keywords: رابطه ساختار-فعالیت; 15-lipoxygenase; atherosclerosis; Δ9-Tetrahydrocannabinol; metabolism. oxidation; inhibition; Δ9-THC-11-oic acid; lipid/lipoprotein; low-density lipoprotein; structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Flavanones and rotenoids from the roots of Amorpha fruticosa L. that inhibit bacterial neuraminidase

Keywords: رابطه ساختار-فعالیت; δ; chemical shift; DMSO; dimethyl sulfoxide; HMBC; heteronuclear multiple bond correlation; 1H-1H; correlation spectroscopy; HPLC; high performance liquid chromatography; I; intensity at ex: 365 nm, em: 450 nm; IC50; the inhibitor concentration leadi

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Semi-synthesis and antitumor activity of 6-isomers of 5, 8-O-dimethyl acylshikonin derivatives

Keywords: رابطه ساختار-فعالیت; Shikonin derivatives; Semi-synthesis; Antitumor activity; Positional isomer; Structure-activity relationship

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity. part 3

Keywords: رابطه ساختار-فعالیت; Antidepressants; Pyrido[1,2-c]pyrimidines; Dual 5-HT1A/SERT activity; SERT; serotonin transporter; SAR; structure-activity relationship; 5-HT; serotonin; 8-OH-DPAT; 8-hydroxy-2-(di-n-propylamino)tetraline; Ki; inhibitor constant; TMS; tetramethylsilane; S

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه