دانلود مقالات ISI درباره رابطه ساختار-فعالیت + ترجمه فارسی

Examination of α-exosite inhibitors against Botulinum neurotoxin A protease through structure-activity relationship studies of chicoric acid

Keywords: رابطه ساختار-فعالیت; Botulinum neurotoxins; Chicoric acid; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives as a new class of histone lysine demethylase 4D (KDM4D) inhibitors

Keywords: رابطه ساختار-فعالیت; KDM4D; Histone lysine demethylase; Epigenetics; Small molecule inhibitor; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and in vitro anti-mycobacterial evaluation of gatifloxacin-1H-1,2,3-triazole-isatin hybrids

Keywords: رابطه ساختار-فعالیت; Gatifloxacin; Isatin; 1,2,3-Triazole; Hybrids; Anti-tubercular activity; Anti-mycobacterial activity; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of a class of diheteroaromatic amines as orally bioavailable CDK1/4/6 inhibitors

Keywords: رابطه ساختار-فعالیت; QZIGYFRGIAUNBD-UHFFFAOYSA-N; Cyclin-dependent kinase; CDK inhibitor; Structure-activity relationship; In vitro and in vivo profiling;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and structure-activity relationship study of pyrazolo[3,4-d]pyrimidines as tyrosine kinase RET inhibitors

Keywords: رابطه ساختار-فعالیت; Tyrosine kinase RET; Pyrazolo[3,4-d]pyrimidine; Anticancer; Cell proliferation; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis, and SAR study of 3-(benzo[d][1,3]dioxol-5-yl)-N-benzylpropanamide as novel potent synergists against fluconazole-resistant Candida albicans

Keywords: رابطه ساختار-فعالیت; Fluconazole; Synergistic; Antifungal activity; Structure-activity relationship; Synthesis;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

The structure-antifungal activity relationship of 5,7-dihydroxyflavonoids against Penicillium italicum

Keywords: رابطه ساختار-فعالیت; 5,7-Dihydroxyflavonoids; P. italicum; Spore germination; Respiration; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis, biological activities and SAR studies of new 3-substitutedphenyl-4-substitutedbenzylideneamino-1,2,4-triazole Mannich bases and bis-Mannich bases as ketol-acid reductoisomerase inhibitors

Keywords: رابطه ساختار-فعالیت; 1,2,4-Triazole thione; Mannich base; Ketol-acid reductoisomerase inhibitors; Fungicidal activity; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Structure-activity relationship of a recombinant hybrid Manganese superoxide dismutase of Staphylococcus saprophyticus/S. equorum

Keywords: رابطه ساختار-فعالیت; Structure-activity relationship; Superoxide dismutase; Thermostable;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

New hydrazine and hydrazide quinoxaline 1,4-di-N-oxide derivatives: In silico ADMET, antiplasmodial and antileishmanial activity

Keywords: رابطه ساختار-فعالیت; ACTs; artemisinin-based combination therapies; QdNO; quinoxaline 1,4-di-N-oxide; SAR; structure-activity relationship; VL; virtual library; SI; selectivity index; TPSA; topological polar surface area; %ABS; human intestinal absorption; Malaria; Leishmania

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Structure-activity relationship between Zn2 +-chelated alkylated poly(1-vinylimidazole) and gene transfection

Keywords: رابطه ساختار-فعالیت; Zinc ion (Zn2 +); Alkylated poly(1-vinylimidazole); Gene transfection; Structure-activity relationship; Chelation;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

A novel benzothiazinethione analogue SKLB-TB1001 displays potent antimycobacterial activities in a series of murine models

Keywords: رابطه ساختار-فعالیت; TB; tuberculosis; MDR; multidrug-resistant; XDR; extensively drug-resistant; TDR; totally drug-resistant; INH; isoniazid; SM; Streptomycin; BCG; bacillus Calmette-Guérin; SAR; structure-activity relationship; WHO; World Health Organization; DprE1/DprE2;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Structure-activity relationship of a novel series of inhibitors for cancer type transporter L-type amino acid transporter 1 (LAT1)

Keywords: رابطه ساختار-فعالیت; L-type amino acid transporter 1 (LAT1); Inhibitor; Structure-activity relationship; Anti-cancer agent;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

The structure-activity relationship between polysaccharides from Sargassum thunbergii and anti-tumor activity

Keywords: رابطه ساختار-فعالیت; Heteropolysaccharide; Anti-tumor activity; Sargassum thunbergii; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Structure-activity relationship study of β-oxidation resistant indole-based 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) receptor antagonists

Keywords: رابطه ساختار-فعالیت; AA; arachidonic acid; 5-HETE; 5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid; 5-oxo-ETE; 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid; 5-HEDH; 5-hydroxyeicosanoid dehydrogenase; 5-HpETE; 5-hydroperoxyeicosatetraenoic acid; LT; leukotriene; NADP+; nicotinamide

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

The structure features of umami hexapeptides for the T1R1/T1R3 receptor

Keywords: رابطه ساختار-فعالیت; Umami peptides; Identification; Structure-activity relationship; Molecular mechanism;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Importance of N- and C-terminal residues of substance P 1-7 for alleviating allodynia in mice after peripheral administration

Keywords: رابطه ساختار-فعالیت; Neuropathic pain; Spared nerve injury (SNI); SP1-7; Neuropeptides; Plasma stability; Structure-activity relationship; Message-address concept;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and evaluation of sulfonamide derivatives as potent Human Uric Acid Transporter 1 (hURAT1) inhibitors

Keywords: رابطه ساختار-فعالیت; hURAT1 inhibitor; Bioisostere; Sulfonamide; Structure-activity relationship; Pharmacokinetic studies; Gout disease;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

A matrix-focused structure-activity and binding site flexibility study of quinolinol inhibitors of botulinum neurotoxin serotype A

Keywords: رابطه ساختار-فعالیت; BoNTs; botulinum neurotoxins; BoNT/A; botulinum neurotoxin serotype A; HC; heavy chain; LC; light chain; SNARE; soluble N-ethylmaleimide-sensitive factor attachment protein receptor; SNAP-25; 25 kDa synaptosomal-associated protein; BIG-IV; Botulism Immun

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Carboxylated aurone derivatives as potent inhibitors of xanthine oxidase

Keywords: رابطه ساختار-فعالیت; Aurone derivatives; Xanthine oxidase; Enzyme inhibition; Structure-activity relationship; Molecular docking;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and evaluation of novel dual BRD4/HDAC inhibitors

Keywords: رابطه ساختار-فعالیت; BET bromodomain; BRD4; HDAC; Benzoyladenine; Structure-activity relationship; Polypharmacology;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and insecticidal activities of novel anthranilic diamides containing fluorinated groups as potential ryanodine receptors activitors

Keywords: رابطه ساختار-فعالیت; Anthranilic diamides; Fluorinated moieties; Insecticidal activities; Structure-activity relationship; Synthesis;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis, antimicrobial activity, structure-activity relationship and cytotoxic studies of a new series of functionalized (Z)-3-(2-oxo-2-substituted ethylidene)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-ones

Keywords: رابطه ساختار-فعالیت; 2-Oxo-benzo[1,4]oxazines; Antimicrobial; Antibacterial; Antifungal; Structure-activity relationship; Cytotoxicity;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

4-Hydroxy-2-pyridones: Discovery and evaluation of a novel class of antibacterial agents targeting DNA synthesis

Keywords: رابطه ساختار-فعالیت; Antibacterial; Gram-negative; 4-Hydroxy-2-pyridone; Structure-activity relationship; DNA synthesis inhibitor;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Identification of survival-promoting OSIP108 peptide variants and their internalization in human cells

Keywords: رابطه ساختار-فعالیت; SAR; structure-activity relationship; CT; cisplatin tolerance; MTT; 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide; AUC; area under the curve; TB; Trypan blue; MCT-2; minimal peptide concentration required to increase CT of the culture b

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Short-step synthesis and structure-activity relationship of cortistatin A analogs

Keywords: رابطه ساختار-فعالیت; Cortistatin A; Anti-angiogenesis; Marine sponge; Analog synthesis; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and evaluation of analogs of 5′-(((Z)-4-amino-2-butenyl)methylamino)-5′-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity

Keywords: رابطه ساختار-فعالیت; AdoMet; S-adenosyl-l-methionine; AdoMetDC; S-adenosylmethionine decarboxylase; BBB; bloodbrain barrier; Boc; tert-butoxycarbonyl; BSA; N,O-bis(trimethylsilyl)acetamide; CNS; central nervous system; DEAD; diethyl azodicarboxylate; DIAD; diisopropyl azodica

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Dialkylpyrazolium ionic liquids as novel catalyst for efficient fixation of CO2 with metal- and solvent-free

Keywords: رابطه ساختار-فعالیت; dialkylpyrazolium ionic liquids; CO2; cycloaddition reaction; structure-activity relationship; DFT;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L

Keywords: رابطه ساختار-فعالیت; CatL; cathepsin L; HUVECs; human umbilical vein endothelial cells; SAR; structure-activity relationship; MMP; matrix metalloprotease; ALP; alkaline phosphatase; Cysteine protease inhibitor; Anti-metastatic agent; Thiosemicarbazone; Benzophenone; Phosphate

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Anti-proliferation activity of terpenoids isolated from Euphorbia kansui in human cancer cells and their structure-activity relationship

Keywords: رابطه ساختار-فعالیت; Terpenoids; Anti-proliferation activity; Human cancer cells; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Physicochemical and biological properties of novel amide-based steroidal inhibitors of NMDA receptors

Keywords: رابطه ساختار-فعالیت; Neurosteroid; NMDA receptor; Structure-activity relationship; Amide; Blood-brain-barrier permeability; Caco-2 assay;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

A structure-activity relationship study of ABCC2 inhibitors

Keywords: رابطه ساختار-فعالیت; ABC; ATP binding cassette; ABCC2; ATP binding cassette protein subfamily C member 2; CDCF; 5(6)-Carboxy-2′,7′-dichlorofluorescein; SAR; Structure-activity relationship; Transporter; MRP2; Modulator; Vesicle assay; Pharmacophore;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Investigation of novel dexrazoxane analogue JR-311 shows significant cardioprotective effects through topoisomerase IIbeta but not its iron chelating metabolite

Keywords: رابطه ساختار-فعالیت; Bis-dioxopiperazine; Cardioprotection; JR-311; Structure-activity relationship; Topoisomerase;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Crystal structure of Porphyromonas gingivalis dipeptidyl peptidase 4 and structure-activity relationships based on inhibitor profiling

Keywords: رابطه ساختار-فعالیت; Dipeptidyl peptidase 4; Peptidase inhibitor; Porphyromonas gingivalis; Biofilm; Dipeptidyl peptidase 9; DPP; dipeptidyl peptidase; hDPP4; human dipeptidyl peptidase 4; MAD; Multiwavelength Anomalous Dispersion; pgDPP4; Porphyromonas gingivalis dipeptidyl

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Structure, synthesis and biological properties of the pentacyclic guanidinium alkaloids

Keywords: رابطه ساختار-فعالیت; PGA; pentacyclic guanidinium alkaloid; Guanidinium alkaloids; Marine natural products; Chemical probe; Structure-activity relationship; Mechanism of action;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery and characterization of novel indole and 7-azaindole derivatives as inhibitors of β-amyloid-42 aggregation for the treatment of Alzheimer's disease

Keywords: رابطه ساختار-فعالیت; Alzheimer's disease; Aβ aggregation; Inhibitors; Structure-activity relationship; Indole derivatives; Azaindole derivatives;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Prediction of biodegradability of aromatics in water using QSAR modeling

Keywords: رابطه ساختار-فعالیت; Biodegradability; Aromatics; Photooxidative degradation; Half-life; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity

Keywords: رابطه ساختار-فعالیت; Sodium channel; Use-dependence; Myotonia; Membrane hyperexcitability; Tocainide derivative; Mexiletine; TRR; time of righting reflex; 9-AC; anthracene-9-carboxylic acid; SAR; structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis, in vitro β-glucuronidase inhibitory activity and in silico studies of novel (E)-4-Aryl-2-(2-(pyren-1-ylmethylene)hydrazinyl)thiazoles

Keywords: رابطه ساختار-فعالیت; Synthesis; In vitro; β-glucuronidase; In silico; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and in vitro evaluation of 5-substituted benzovesamicol analogs containing N-substituted amides as potential positron emission tomography tracers for the vesicular acetylcholine transporter

Keywords: رابطه ساختار-فعالیت; ACh; acetylcholine; VAChT; vesicular acetylcholine transporter; PET; positron emission tomography; AD; Alzheimer's disease; PD; Parkinson's disease; vesamicol; (±)-trans-2-(4-phenylpiperidino)cyclohexanol; benzovesamicol; 3-(4-phenyl-piperidin-1-yl)-1,2,

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of indolin-2-one derivatives as potent PAK4 inhibitors: Structure-activity relationship analysis, biological evaluation and molecular docking study

Keywords: رابطه ساختار-فعالیت; p21-Activated kinase; PAK4 inhibitor; Indolin-2-one; Structure-activity relationship; Molecular docking;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Structure-based design, synthesis, and biological evaluation of withaferin A-analogues as potent apoptotic inducers

Keywords: رابطه ساختار-فعالیت; Withaferin A; Compound library; Cytotoxicity; Apoptosis; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Importance of 5/6-aryl substitution on the pharmacological profile of 4ʹ-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1ʹ-biphenyl]-2-carboxylic acid derived PPARγ agonists

Keywords: رابطه ساختار-فعالیت; Peroxisome proliferator-activated receptor γ; Pharmacological profile; Coactivator recruitment; Transactivation assay; Molecular modeling; H; helix; LBD; ligand binding domain; PDB; Protein Data Bank; PPAR; peroxisome proliferator-activated receptor; PPR

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Syntheses of 4,6-dihydroxypyrimidine diones, their urease inhibition, in vitro, in silico, and kinetic studies

Keywords: رابطه ساختار-فعالیت; Thiobarbiturates; Urease inhibitors; Structure-activity relationship; Kinetic; In silico studies;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and evaluation of (E)-2-(5-phenylpent-2-en-4-ynamido)cyclohex-1-ene-1-carboxylate derivatives as HCA2 receptor agonists

Keywords: رابطه ساختار-فعالیت; LDL; low-density lipoprotein; HDL; high-density lipoprotein; cAMP; 3′-5′-cyclic adenosine monophosphate; SAR; structure-activity relationship; RLB; radioligand binding; GPCR; G-protein coupled receptor; BSA; bovine serum albumin; DCM; dichloromethane;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

Wüstite-based catalyst for ammonia synthesis: Structure, property and performance

Keywords: رابطه ساختار-فعالیت; Wüstite catalyst; Single phase theory; Disproportionation of Fe1-xO; Effect of promoter; Acidic-basic synergy; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

SAR study of 5-alkynyl substituted quinazolin-4(3H)-ones as phosphoinositide 3-kinase delta (PI3Kδ) inhibitors

Keywords: رابطه ساختار-فعالیت; Chronic lymphocytic leukemia; PI3Kδ; Structure-activity relationship; 5-Alkynyl; Quinazolinone;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and in vitro anticancer activity of novel quinoline and oxadiazole derivatives of ursolic acid

Keywords: رابطه ساختار-فعالیت; Ursolic acid; Quinoline; Oxadiazole; Anticancer; Structure-activity relationship; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and evaluation of 4-substituted anthra[2,1-c][1,2,5]thiadiazole-6,11-dione derivatives as novel non-camptothecin topoisomerase I inhibitors

Keywords: رابطه ساختار-فعالیت; Topoisomerase I inhibitors; Anthrathiadiazole; Antiproliferative activity; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Diverse amide analogs of sulindac for cancer treatment and prevention

Keywords: رابطه ساختار-فعالیت; NSAID; non-steroidal anti-inflammatory drug; COX; cyclooxygenase; SSA; sulindac sulfide amide; SAR; structure-activity relationship; AA; amino acid; ALL; acute lymphoblastic leukemia; CPC; choroid plexus carcinoma; TPSA; topological polar surface area; Li

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه