Keywords: رابطه ساختار-فعالیت; low molecular weight heparin; heparin lyase; ultrafiltration; anticoagulant; NMR; mass spectrometry; surface plasmon resonance; polymeric drugs; structure-activity relationship; enzymes;
مقالات ISI رابطه ساختار-فعالیت (ترجمه نشده)
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Keywords: رابطه ساختار-فعالیت; Drug design; Lead optimization; Structure-activity relationship; Protein–ligand binding; Molecular recognition; Thermolysinbn, benzyl; i-Bu, isobutyl; n-Bu, normal butyl; sec-Bu, secondary butyl; tert-Bu, tertiary butyl; Et, ethyl; Eq., equation; ITC, iso
Inhibition of α-amylase by flavonoids: Structure activity relationship (SAR)
Keywords: رابطه ساختار-فعالیت; SAR; structure-activity relationship; HES; hesperetin; LUT; luteolin; QUE; quercetin; CAT; catechin; RUT; rutin; ACA; acarbose; PC; polyphenolic compounds; pNPG5; p-nitrophenyl-α-d-maltopentoside; Flavonoids; α-Amylase; Interactions; Inhibition; Structu
Total syntheses and endoplasmic reticulum stress suppressive activities of hericenes AâC and their derivatives
Keywords: رابطه ساختار-فعالیت; Geranyl resorcylate; Total synthesis; Structure-activity relationship; Endoplasmic reticulum stress; Neuroprotective agent;
Design, synthesis and in vitro anti-mycobacterial activities of homonuclear and heteronuclear bis-isatin derivatives
Keywords: رابطه ساختار-فعالیت; Isatin; Homonuclear; Heteronuclear; Dimer; Anti-mycobacterial; Structure-activity relationship;
Acaricidal activity and structure-activity relationships of Spiro-Butyrolactone derivatives against Tetranychus cinnabarinus
Keywords: رابطه ساختار-فعالیت; Spiro-butyrolactone; Acaricidal activity; T. cinnabarinus; Structure-activity relationship;
Synthesis of quaternary 8-(1-acylethene-1-yl)-13-methylcoptisine chlorides and their selective growth inhibitory activity between human cancer cell lines and normal intestinal epithelial cell-6
Keywords: رابطه ساختار-فعالیت; Quaternary 8-(1-acylethene-1-yl)-13-methylcoptisine chlorides; α, β-Unsaturated ketone group; Thioredoxin reductases; Synthesis; Selective growth inhibitory activity; Human cancer cell lines; Normal intestinal epithelial cell-6; Structure-activity relat
Thioether-bridged arylalkyl-linked N-phenylpyrazole derivatives: Design, synthesis, insecticidal activities, structure-activity relationship and molecular-modeling studies
Keywords: رابطه ساختار-فعالیت; N-Phenylpyrazole derivatives; Thioether bridge; Insecticidal activities; Structure-activity relationship; Molecular-modeling studies;
Design, synthesis and biological evaluation of substituted (+)-SG-1 derivatives as novel anti-HIV agents
Keywords: رابطه ساختار-فعالیت; HIV; NNRTIs; SG-1; Structure-activity relationship; NNRTI-resistant;
Synthesis and evaluation of N-(4-benzylphenyl)piperazines as VGF inducers
Keywords: رابطه ساختار-فعالیت; VGF inducer; Cytoprotection; Structure-activity relationship; SUN N8075; SH-SY5Y;
Design, synthesis, and structure-activity relationships of new benzofuro[3,2-b]pyridin-7-ols as DNA topoisomerase II inhibitors
Keywords: رابطه ساختار-فعالیت; Fused heterocycles; Benzofuro[3,2-b]pyridin-7-ol; Hydroxyl-substituent; Topoisomerase inhibition; Antiproliferative activity; Structure-activity relationship;
Synthesis, biological evaluation and SAR of naftopidil-based arylpiperazine derivatives
Keywords: رابطه ساختار-فعالیت; Synthesis; Derivatives; Prostate cancer; CCK-8; Structure-activity relationship;
Antinociceptive effect of neo-clerodane diterpenes obtained from Baccharis flabellata
Keywords: رابطه ساختار-فعالیت; Baccharis flabellata; Furan neoclerodane; Diene-acid clerodane dimer; Agonists of kappa receptors; AMSL; Above mean sea level; i.p.; Administered via the intraperitoneal route; ANMAT; Administración Nacional de Medicamentos, Alimentos y TecnologÃa Médi
Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu4 positive allosteric modulators that mitigate CYP1A2 induction liability
Keywords: رابطه ساختار-فعالیت; mGlu4 PAM; Positive allosteric modulator; CYP induction; Parkinson's disease; Structure-activity relationship;
Synthesis and biological evaluation of nannocystin analogues toward understanding the binding role of the (2R,3S)-Epoxide in nannocystin A
Keywords: رابطه ساختار-فعالیت; Structure-activity relationship; Anticancer; Eukaryotic elongation factor 1α; Inhibitor;
A small diversity library of α-methyl amide analogs of sulindac for probing anticancer structure-activity relationships
Keywords: رابطه ساختار-فعالیت; NSAID; non-steroidal anti-inflammatory drug; COX; cyclooxygenase; PG; prostaglandin; FAP; familial adenomatous polyposis; SSA; sulindac sulfide amide; SAR; structure-activity relationship; qHTS; quantitative high-throughput screen; CPC; choroid plexus car
Modulation of GABA and glycine receptors in rat pyramidal hippocampal neurones by 3α5β-pregnanolone derivatives
Keywords: رابطه ساختار-فعالیت; Neurosteroid; GABA receptor; Glycine receptor; Pregnanolone; Structure-activity relationship;
Identification of tagitinin C from Tithonia diversifolia as antitrypanosomal compound using bioactivity-guided fractionation
Keywords: رابطه ساختار-فعالیت; 1D and 2D NMR; One and two-dimensional nuclear magnetic resonance; BALB//3T3; Mouse fibroblasts; CH2Cl2/MeOH; Methylene chloride/Methanol; DMSO; Dimethylsulfoxide; HAT; Human African Trypanosomiasis; NTDs; Neglected tropical diseases; SAR; Structure-activ
Determination of aromatic amines in the urine of smokers using a porous organic framework (JUC-Z2)-coated solid-phase microextraction fiber
Keywords: رابطه ساختار-فعالیت; Porous organic framework; Solid-phase microextraction; Determination; Aromatic amines; Structure-activity relationship;
Cyanobacteria-derived peptide antibiotics discovered since 2000
Keywords: رابطه ساختار-فعالیت; Cyanobacteria; Depsipeptide; Lipopeptide; Cyclamide; Antibiotic activity; Structure-activity relationship;
Structure-activity relationship of clovamide and its related compounds for the inhibition of amyloid β aggregation
Keywords: رابطه ساختار-فعالیت; Alzheimer's disease; Amyloid aggregation; Clovamide; Structure-activity relationship; Catechol;
Design, synthesis and structure-activity relationship evaluation of novel LpxC inhibitors as Gram-negative antibacterial agents
Keywords: رابطه ساختار-فعالیت; Gram-negative bacteria infection; LpxC inhibitor; Structure-activity relationship; Zinc binding group; Liver microsomal stability;
Microcystins: Synthesis and structure-activity relationship studies toward PP1 and PP2A
Keywords: رابطه ساختار-فعالیت; Adda; (2S,3S,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid; Amba; (2S,3S)-3-amino-2-methylbutanoic acid; Boc; tert-butoxycarbonyl; BOP; benzotriazol-1-yloxy-tris-dimethylaminophosphoniumhexafluoro phosphate; Cbz; carboxybenzyl; D
A pivotal peptide (Val-Ser-Glu-Glu) from duck egg white promotes calcium uptake and structure-activity relationship study
Keywords: رابطه ساختار-فعالیت; FOS; fructo-oligosaccharides; GOS; galacto-oligosaccharides; CPPs; casein phosphopeptides; PPPs; phosvitin phosphopeptides; DPs; desalted duck egg white peptides; TRPV6; transient receptor potential vanilloid 6; VSEE; Val-Ser-Glu-Glu; Val-Ser-Glu-Glu (VSE
Synthesis and biological evaluation of estrone 3-O-ether derivatives containing the piperazine moiety
Keywords: رابطه ساختار-فعالیت; Synthesis; Estrone derivatives; Prostate cancer; Piperazines; Structure-activity relationship;
Synthesis, antitumor activity evaluation and mechanistic study of novel hederacolchiside A1 derivatives bearing an aryl triazole moiety
Keywords: رابطه ساختار-فعالیت; Hederacolchiside A1; Antitumor activity; Structure-activity relationship; Apoptosis; Saponin;
1-[(4â²-Chlorophenyl) carbonyl-4-(aryl) thiosemicarbazide derivatives as potent urease inhibitors: Synthesis, in vitro and in silico studies
Keywords: رابطه ساختار-فعالیت; Synthesis; Thiosemicarbazide; Urease inhibitory activity; In vitro; Structure-activity relationship; In silico;
Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB
Keywords: رابطه ساختار-فعالیت; ACh; acetylcholine; AChBP; acetylcholine-binding protein; ECD; extracellular domain; gAuIB; globular AuIB; ICD; intracellular domain; nAChR; nicotinic acetylcholine receptor; rAuIB; ribbon AuIB; SAR; structure-activity relationship; TMD; transmembrane dom
Structure-dependent activity of CeO2 supported Ru catalysts for CO2 methanation
Keywords: رابطه ساختار-فعالیت; CO2 methanation; CeO2 nano-shapes; Ru particle size; Structure-activity relationship; Oxygen vacancy concentration;
Structural and kinetic insights into Pt/CNT catalysts during hydrogen generation from ammonia borane
Keywords: رابطه ساختار-فعالیت; Structure-activity relationship; Kinetic and isotopic analyses; Catalyst surface and electronic properties; Hydrogen generation; Catalyst durability;
Isolation, modification and cytotoxic evaluation of stilbenoids from Acanthopanax leucorrhizus
Keywords: رابطه ساختار-فعالیت; Cytotoxicity; Stilbenoids; Acanthopanax leucorrhizus; Structure-activity relationship;
Lycorine: A prospective natural lead for anticancer drug discovery
Keywords: رابطه ساختار-فعالیت; Lycorine; Anti-cancer mechanism; Structure-activity relationship;
Eight new triterpenoids with inhibitory activity against HMG-CoA reductase from the medical mushroom Ganoderma leucocontextum collected in Tibetan plateau
Keywords: رابطه ساختار-فعالیت; Ganoderma leucocontextum; Triterpenoids; HMG-CoA reductase inhibitor; Structure-activity relationship;
Aim for the core: suitability of the ubiquitin-independent 20S proteasome as a drug target in neurodegeneration
Keywords: رابطه ساختار-فعالیت; 20S; core 20S proteasome; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ATP; adenosine triphosphate; BBB; blood-brain barrier; DUB; deubiquitinating enzyme; HbYX; hydrophobic-tyrosine-unspecified residue 'X'; IDP; intrinsically disorder
Structure-activity relationships in a new class of non-substrate-like covalent inhibitors of the bacterial glycosyltransferase LgtC
Keywords: رابطه ساختار-فعالیت; Glycosyltransferase; Covalent inhibitor; Structure-activity relationship; Bacterial virulence; Serum resistance;
Design, synthesis and biological evaluation of bitopic arylpiperazine-hexahydro-pyrazinoquinolines as preferential dopamine D3 receptor ligands
Keywords: رابطه ساختار-فعالیت; Dopamine D3 receptor ligands; Bitopic ligands; Arylpiperazine-hexahydropyrazinoquinolines analogues; Binding affinity; Structure-activity relationship;
Synthesis, molecular docking and xanthine oxidase inhibitory activity of 5-aryl-1H-tetrazoles
Keywords: رابطه ساختار-فعالیت; 5-Aryl-1H-tetrazoles; Xanthine oxidase Inhibition; Hyperuricemia; Gout; Uric acid; Structure-activity relationship;
Chalcones and bis-chalcones: As potential α-amylase inhibitors; synthesis, in vitro screening, and molecular modelling studies
Keywords: رابطه ساختار-فعالیت; Chalcones; Bis-chalcones; In vitro α-amylase inhibitory activity; Structure-activity relationship; In silico studies;
Identification of the free phenolic profile of Adlay bran by UPLC-QTOF-MS/MS and inhibitory mechanisms of phenolic acids against xanthine oxidase
Keywords: رابطه ساختار-فعالیت; Adlay bran; UPLC-QTOF-MS/MS; Phenolic acids; Xanthine oxidase inhibitory mechanism; Structure-activity relationship; Interaction;
Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4
Keywords: رابطه ساختار-فعالیت; ABC; Activated B Cell-like; BTK; Bruton's Tyrosine Kinase; CD79; Cluster of Differentiation 79; CDK; Cyclin Dependent Kinase; CLK; CDC-Like Kinase; DCM; dichloromethane; DDQ; 2,3-Dichloro-5,6-DicyanobenzoQuinone; DIPEA; N,N-diisopropylethylamine; DLBCL;
Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51
Keywords: رابطه ساختار-فعالیت; Antifungal activity; Azole antifungals; CYP51; Structure-activity relationship;
Synthetic nicotinic/isonicotinic thiosemicarbazides: In vitro urease inhibitory activities and molecular docking studies
Keywords: رابطه ساختار-فعالیت; Synthesis; Nicotinic/isonicotinic; Thiosemicarbazide; Urease inhibition; In vitro; In silico; Structure-activity relationship;
Synthesis and structure-activity relationships of asymmetric dimeric β-carboline derivatives as potential antitumor agents
Keywords: رابطه ساختار-فعالیت; Harmine; Asymmetric dimeric β-carboline; Cytotoxic; Antitumor; Structure-activity relationship;
Discovery of orally efficacious RORγt inverse agonists. Part 2: Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives
Keywords: رابطه ساختار-فعالیت; RORγt; retinoic acid receptor-related orphan receptor-gamma t; EAE; experimental autoimmune encephalomyelitis; BODIPY; boron-dipyrromethene; TR-FRET; time-resolved fluorescence resonance energy transfer; SAR; structure-activity relationship; IFN-γ; inte
Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer
Keywords: رابطه ساختار-فعالیت; Casein kinase 1 delta and epsilon; Kinase; Inhibitor; Structure-activity relationship; Breast cancer;
Novel 6-aryl substituted 4-pyrrolidineaminoquinazoline derivatives as potent phosphoinositide 3-kinase delta (PI3Kδ) inhibitors
Keywords: رابطه ساختار-فعالیت; PI3Kδ inhibitors; 6-Aryl; 4-Pyrrolidineaminoquinazoline; Structure-activity relationship; Anti-proliferation;
Pharmacophore requirements for HIV-1 reverse transcriptase inhibitors that selectively “Freeze” the pre-translocated complex during the polymerization catalytic cycle
Keywords: رابطه ساختار-فعالیت; HIV-1; human immunodeficiency virus type 1; RT; reverse transcriptase; PPi; inorganic pyrophosphate; NTP; nucleoside triphosphate; NDP; nucleoside diphosphate; PFA; phosphonoformic acid, foscarnet; RNase H; ribonuclease H; CPHM; [2-(2-(4-chlorophenyl)hydr
Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrido[4,3-c]azepin-5-one-based novel chemotype CCR2 antagonists via scaffold hopping strategy
Keywords: رابطه ساختار-فعالیت; 6,7,8,9-Tetrahydro-5H-pyrido[43-c]azepin-5-one; 3,4-Dihydro-2,6-naphthyridin-1(2H)-one; CCR2 antagonist; Scaffold hopping; Structure-activity relationship; Selectivity of CCR2 over CCR5;
Synthesis, in vitro urease inhibitory activity, and molecular docking studies of thiourea and urea derivatives
Keywords: رابطه ساختار-فعالیت; Synthesis; Urea; Thiourea; In vitro urease activity; Structure-activity relationship; Molecular docking studies;
Discovery of novel piperonyl derivatives as diapophytoene desaturase inhibitors for the treatment of methicillin-, vancomycin- and linezolid-resistant Staphylococcus aureus infections
Keywords: رابطه ساختار-فعالیت; CrtN inhibitor; STX biosynthesis; Pigment inhibitory activity; Resistant S. aureus; S. aureus; Staphylococcus aureus; MRSA; methicillin-resistant Staphylococcus aureus; STX; staphyloxanthin; NTF; naftifine hydrochloride; CrtM; dehydrosqualene synthase;